Effects of a stable prostacyclin analog on experimental ischemic acute renal failure.

Abstract:

:The effect of OP-41483, a stable prostacyclin (PGI2) analog, on ischemic acute renal failure (ARF) was investigated in dogs. Administration of OP-41483 for three days after ischemia significantly increased renal cortical blood flow (RCBF) when compared with dogs treated with the saline vehicle. In the OP-41483-treated group, serum creatinine levels remained relatively low during postoperative days 1-3 and mean survival time was prolonged. Injection of a silicone rubber vascular casting compound (Microfil) revealed increased numbers of visible renal cortical glomeruli and microvessels compared to the saline vehicle group. Histologic sections showed only very limited tubular necrosis, whereas sections of kidneys treated with saline showed extensive tubular necrosis. In conclusion, this stable prostacyclin analog provided a significant degree of protection for the kidneys from ischemic injury and may be useful in a clinical setting.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Tobimatsu M,Ueda Y,Saito S,Tsumagari T,Konomi K

doi

10.1097/00000658-198807000-00009

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

65-70

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

208

pub_type

杂志文章
  • Interferon regulatory factor expression in human breast cancer.

    abstract:OBJECTIVE:To investigate the expression of interferon regulatory factors 1 and 2 (IRF-1 and IRF-2) in human breast cancer. SUMMARY BACKGROUND DATA:Interferon regulatory factors 1 and 2 are transcription factors in the interferon gamma signal transduction pathway. IRF-1 acts as the effector arm of the interferon gamma ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200105000-00005

    authors: Doherty GM,Boucher L,Sorenson K,Lowney J

    更新日期:2001-05-01 00:00:00

  • Critical operative management of small bowel obstruction.

    abstract::The records of 238 patients with the diagnosis of small bowel obstruction at the University of Illinois Hospital from 1967 through the spring of 1976 were reviewed. Mortality, intra-operative management, and clinical findings were evaluated. Previous reports list a mortality of gangrenous small bowel obstruction, seco...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197802000-00017

    authors: Stewardson RH,Bombeck CT,Nyhus LM

    更新日期:1978-02-01 00:00:00

  • High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality.

    abstract:OBJECTIVE:To identify patient characteristics associated with the development of local recurrence and the effect of local recurrence on subsequent morbidity and mortality in patients with intermediate- to high-grade extremity soft tissue sarcomas. SUMMARY BACKGROUND DATA:Numerous studies on extremity soft tissue sarco...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000048448.56448.70

    authors: Eilber FC,Rosen G,Nelson SD,Selch M,Dorey F,Eckardt J,Eilber FR

    更新日期:2003-02-01 00:00:00

  • Incidence and Risk Factors of Postoperative Mortality and Morbidity After Elective Versus Emergent Abdominal Surgery in a National Sample of 8193 Patients With Cirrhosis.

    abstract:OBJECTIVE:To describe the incidence and risk factors for mortality and morbidity in patients with cirrhosis undergoing elective or emergent abdominal surgeries. BACKGROUND:Postoperative morbidity and mortality are higher in patients with cirrhosis; variation by surgical procedure type and cirrhosis severity remain unc...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003674

    authors: Johnson KM,Newman KL,Green PK,Berry K,Cornia PB,Wu P,Beste LA,Itani K,Harris AHS,Kamath PS,Ioannou GN

    更新日期:2019-10-23 00:00:00

  • Pedal vasomotor tone following aortofemoral reconstructions: a randomized study of concomitant lumbar sympathectomy.

    abstract::A prospective randomized trial was undertaken to evaluate effects of lumbar sympathectomy as an adjunct to reconstructive surgery of the lower limb. The objective of this study was to assess the early postoperative effect of these procedures on pedal vasomotor tone. A pedal arterial resistance index (PARI) at rest was...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197602000-00009

    authors: Shanik GD,Ford J,Hayes AC,Baker WH,Barnes RW

    更新日期:1976-02-01 00:00:00

  • Can We Predict Incisional Hernia?: Development of a Surgery-specific Decision-Support Interface.

    abstract:OBJECTIVE:The aim of this study was to identify procedure-specific risk factors independently associated with incisional hernia (IH) and demonstrate the feasibility of preoperative risk stratification through the use of an IH risk calculator app and decision-support interface. SUMMARY BACKGROUND DATA:IH occurs after 1...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003472

    authors: Basta MN,Kozak GM,Broach RB,Messa CA 4th,Rhemtulla I,DeMatteo RP,Serletti JM,Fischer JP

    更新日期:2019-09-01 00:00:00

  • Pulmonary microembolism associated with massive transfusion: II. The basic pathophysiology of its pulmonary effects.

    abstract::In animals pulmonary hypertension, a decrease in total body O2 consumption and metabolic acidosis occur after transfusion of blood with an elevated screen filtration pressure (SFP) through standard blood transfusion filters. The purpose of this study was to define in detail the pulmonary abnormalities that develop fol...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197507000-00011

    authors: Barrett J,Dawidson I,Dhurandhar HN,Miller E,Litwin MS

    更新日期:1975-07-01 00:00:00

  • Comparison of Postoperative Outcomes Between Donation After Circulatory Death and Donation After Brain Death Liver Transplantation Using the Comprehensive Complication Index.

    abstract:OBJECTIVE:To test the total burden of complications in the early postoperative period after liver transplantation (LT) between donation after circulatory death (DCD) and donation after brain death (DBD) grafts with the novel Comprehensive Complication Index (CCI). BACKGROUND:LT is complex surgery and the increasing us...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002419

    authors: Kalisvaart M,de Haan JE,Polak WG,Metselaar HJ,Wijnhoven BPL,IJzermans JNM,de Jonge J

    更新日期:2017-11-01 00:00:00

  • Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience.

    abstract:OBJECTIVE:The objective of the study was to achieve limb salvage in patients with locally advanced soft tissue sarcomas that can only be treated by amputation or functionally mutilating surgery by performing an isolated limb perfusion (ILP) with tumor necrosis factor (TNF) + melphalan (M) as induction biochemotherapy t...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00000658-199612000-00011

    authors: Eggermont AM,Schraffordt Koops H,Klausner JM,Kroon BB,Schlag PM,Liénard D,van Geel AN,Hoekstra HJ,Meller I,Nieweg OE,Kettelhack C,Ben-Ari G,Pector JC,Lejeune FJ

    更新日期:1996-12-01 00:00:00

  • The effects of regionalization on cost and outcome for one general high-risk surgical procedure.

    abstract:PURPOSE:The effects of regionalization of tertiary care were studied by analyzing cost and outcome for pancreaticoduodenectomies in a state in which the majority of these high-risk procedures were performed in one hospital. METHODS:Using Maryland inpatient discharge data via a retrospective study, the authors compared...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199501000-00005

    authors: Gordon TA,Burleyson GP,Tielsch JM,Cameron JL

    更新日期:1995-01-01 00:00:00

  • Endovascular repair of abdominal aortic aneurysms: risk stratified outcomes.

    abstract:OBJECTIVE:The impact of co-morbid conditions on early and late clinical outcomes after endovascular treatment of abdominal aortic aneurysm (AAA) was assessed in concurrent cohorts of patients stratified with respect to risk for intervention. SUMMARY BACKGROUND DATA:As a minimally invasive strategy for the treatment of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200206000-00011

    authors: Chaikof EL,Lin PH,Brinkman WT,Dodson TF,Weiss VJ,Lumsden AB,Terramani TT,Najibi S,Bush RL,Salam AA,Smith RB 3rd

    更新日期:2002-06-01 00:00:00

  • "Keyhole" coronary artery bypass surgery.

    abstract:OBJECTIVE:The objective of this study was to identify the utility of "keyhole" thoracotomy approaches to single vessel coronary artery bypass surgery. SUMMARY BACKGROUND DATA:Although minimally invasive surgery is efficacious in a wide variety of surgical disciplines, it has been slow to emerge in cardiac surgery. Amo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199610000-00004

    authors: Landreneau RJ,Mack MJ,Magovern JA,Acuff TA,Benckart DH,Sakert TA,Fetterman LS,Griffith BP

    更新日期:1996-10-01 00:00:00

  • Sciatic and Femoral Nerve Resection During Extended Radical Surgery for Advanced Pelvic Tumours: Long-term Survival, Functional, and Quality-of-life Outcomes.

    abstract:OBJECTIVE:To report survival, functional, and quality-of-life (QoL) outcomes after extended radical resection for advanced pelvic tumors with en bloc sciatic or femoral nerve resection. BACKGROUND:Advanced pelvic tumors involving the sciatic or femoral nerve have traditionally been considered inoperable. Small studies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003390

    authors: Brown KGM,Solomon MJ,Lau YC,Steffens D,Austin KKS,Lee PJ

    更新日期:2019-06-07 00:00:00

  • Endorectal ileoanal anastomosis with isoperistaltic ileal reservoir after colectomy and mucosal proctectomy.

    abstract::Forty-nine patients with chronic ulcerative colitis refractory to medical therapy and four with multiple polyposis have undergone total colectomy, mucosal protectomy, and endorectal ileal pull-through with ileoanal anastomosis at the UCLA Medical Center during the past 12 years (mean age, 19.4 years). Thirty-eight pat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198402000-00003

    authors: Fonkalsrud EW

    更新日期:1984-02-01 00:00:00

  • Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors.

    abstract:OBJECTIVE:Arginine transport was characterized and studied in human liver. SUMMARY BACKGROUND DATA:Plasma arginine uptake may regulate hepatocyte intracellular availability and the subsequent biosynthesis of nitric oxide (NO), but little is known about arginine transport across the human hepatocyte plasma membrane. M...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199309000-00014

    authors: Inoue Y,Bode BP,Beck DJ,Li AP,Bland KI,Souba WW

    更新日期:1993-09-01 00:00:00

  • Influence of the postoperative state on the intracellular free amino acids in human muscle tissue.

    abstract::Five patients were studied before and two to three days after major, uncomplicated abdominal operation. Muscle tissue was obtained by needle biopsy from m. quadriceps femoris after eight hours overnight fast. Plasma free amino acids were analyzed in simultaneously obtained samples. In the homogenized muscle samples th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197512000-00001

    authors: Vinnars E,Bergstöm J,Fürst P

    更新日期:1975-12-01 00:00:00

  • Wait times for cancer surgery in the United States: trends and predictors of delays.

    abstract:BACKGROUND:Patients frequently voice concerns regarding wait times for cancer treatment; however, little is known about the length of wait times from diagnosis to surgery in the United States. Our objectives were (1) to assess changes in wait times over the past decade and (2) to identify patient, tumor, and hospital f...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318211cc0f

    authors: Bilimoria KY,Ko CY,Tomlinson JS,Stewart AK,Talamonti MS,Hynes DL,Winchester DP,Bentrem DJ

    更新日期:2011-04-01 00:00:00

  • Outcomes of Posterior Component Separation With Transversus Abdominis Muscle Release and Synthetic Mesh Sublay Reinforcement.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of transversus abdominis muscle release (TAR) with retrorectus synthetic mesh reinforcement in a large series of complex hernia patients. BACKGROUND:Posterior component separation via TAR during abdominal wall reconstruction (AWR) continues to gain popularity. Although our...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001673

    authors: Novitsky YW,Fayezizadeh M,Majumder A,Neupane R,Elliott HL,Orenstein SB

    更新日期:2016-08-01 00:00:00

  • Nationwide Procedural Trends for Renal Trauma Management.

    abstract:OBJECTIVE:To characterize national trends in procedural management of renal trauma. BACKGROUND:Management of renal trauma has evolved to favor a more conservative approach. For patients requiring intervention, there is a paucity of information to characterize the nature of procedural therapy administered. METHODS:A r...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002475

    authors: Colaco M,Navarrete RA,MacDonald SM,Stitzel JD,Terlecki RP

    更新日期:2019-02-01 00:00:00

  • Long-term results of brachial thrombectomy following cardiac catheterization.

    abstract::The late results of brachial thrombectomy following cardiac catheterization were evaluated in 20 patients. All patients had a radial pulse present and no symptoms or signs of ischemia of the hand at the time of discharge from the hospital. Late evaluation of these 20 patients revealed 8 in whom the long-term results w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197604000-00019

    authors: Nicholas GG,DeMuth WE Jr

    更新日期:1976-04-01 00:00:00

  • Thoracoscopic surgery for diseases of the lung and pleura. Effectiveness, changing indications, and limitations.

    abstract:OBJECTIVE:This study compared the results of video-assisted thoracic surgery (VATS) with thoracoscopic surgery (TS) for diseases of the lung and pleura. SUMMARY BACKGROUND DATA:No studies exist that compare the capabilities of VATS with advanced video systems and instrumentation to that of TS which has been done for 8...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199305010-00018

    authors: Daniel TM,Kern JA,Tribble CG,Kron IL,Spotnitz WB,Rodgers BM

    更新日期:1993-05-01 00:00:00

  • Posterior retroperitoneoscopic adrenalectomy: preferred technique for removal of benign tumors and isolated metastases.

    abstract:OBJECTIVE:Posterior retroperitoneoscopic adrenalectomy (PRA) is a minimally invasive approach to removal of the adrenal gland. This anatomically direct approach, popularized by Walz, minimizes dissection and affords early access to the adrenal vein. We report the largest experience to date of PRA in the United States. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818a1d2a

    authors: Perrier ND,Kennamer DL,Bao R,Jimenez C,Grubbs EG,Lee JE,Evans DB

    更新日期:2008-10-01 00:00:00

  • Colorectal carcinoma in patients under age 40.

    abstract::Patients under the age of 40 with colorectal cancer (29 females, 18 males) were compared with similar patients in our general hospital population and analyzed for patterns of presentation, stage at diagnosis, degree of tumor differentiation, and survival. There was a higher incidence of poorly differentiated tumors in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198511000-00013

    authors: Behbehani A,Sakwa M,Ehrlichman R,Maguire P,Friedman S,Steele GD Jr,Wilson RE

    更新日期:1985-11-01 00:00:00

  • Accuracy of the first endoscopic procedure in the differential diagnosis of gastric lesions.

    abstract::The accuracy of endoscopy and directed biopsy in the differential diagnosis of gastric lesions was evaluated by comparing the diagnoses of one endoscopic procedure (endoscopy and multiple directed biopsies) with the definitive diagnoses in 333 patients. The overall endoscopic and bioptic accuracy rate for all patients...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198202000-00018

    authors: Llanos O,Guzmán S,Duarte I

    更新日期:1982-02-01 00:00:00

  • Preoperative and long-term cardiac risk assessment. Predictive value of 23 clinical descriptors, 7 multivariate scoring systems, and quantitative dipyridamole imaging in 360 patients.

    abstract::A total of 360 patients underwent preoperative cardiac risk assessment using 23 clinical parameters, seven multivariate clinical scoring systems, and quantitative dipyridamole-thallium imaging to predict postoperative and long-term myocardial infarction and cardiac death after noncardiac surgery. There were 30 postope...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199208000-00010

    authors: Lette J,Waters D,Bernier H,Champagne P,Lassonde J,Picard M,Cerino M,Nattel S,Boucher Y,Heyen F

    更新日期:1992-08-01 00:00:00

  • Intraoperative blood salvage during liver resection: a randomized controlled trial.

    abstract:OBJECTIVE:A randomized controlled trial was conducted to clarify the effectiveness of intraoperative blood salvage in reducing blood loss. BACKGROUND:Although reduction of central venous pressure (CVP) is thought to decrease blood loss during liver resection, no consistently effective and safe method for obtaining the...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000255562.60215.3b

    authors: Hashimoto T,Kokudo N,Orii R,Seyama Y,Sano K,Imamura H,Sugawara Y,Hasegawa K,Makuuchi M

    更新日期:2007-05-01 00:00:00

  • Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity.

    abstract:OBJECTIVES:We recently reported increased CD4 CD25 T regulatory (Treg) activity after burn injury in mice. This study sought to determine if Tregs mediate the reduction in TH1-type immunity after serious injury in man and if Treg function is altered by injury. METHODS:Peripheral blood was withdrawn from 19 consenting ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000239031.06906.1f

    authors: MacConmara MP,Maung AA,Fujimi S,McKenna AM,Delisle A,Lapchak PH,Rogers S,Lederer JA,Mannick JA

    更新日期:2006-10-01 00:00:00

  • Surgical management of acute cholecystitis in patients 65 years of age and older.

    abstract::The proportion of the population of the U.S. 65 years of age and over is increasing. Biliary tract disease is estimated to involve 15% of the adult population. A review of 12,200 patients treated surgically at one medical center reveals that 2401 (20%) had acute cholecystitis. There were 93 deaths, for a mortality rat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00009

    authors: Glenn F

    更新日期:1981-01-01 00:00:00

  • Reconstruction of the pharynx after resection for cancer. A comparison of methods.

    abstract::Repair of the pharynx after extirpation of malignancy may require the introduction of independently vascularized tissue either at the time of resection (primary reconstruction) or later for undesirable sequelae, such as fistula or stenosis. A ten-year retrospective study compares two methods of pharyngeal reconstructi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198905000-00007

    authors: Coleman JJ 3rd

    更新日期:1989-05-01 00:00:00

  • A stapling instrument for end-to-end inverting anastomoses in the gastrointestinal tract.

    abstract::A stapling instrument is described for end-to-end inverting anastomoses applicable principally to low rectal anastomosis or esophagogastric or esophagojejunal anastomosis. The instrument creates an inverting anastomosis held by a double staggered row of stainless steel wire staples creating an anastomosis 21.2 mm inte...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197906000-00017

    authors: Ravitch MM,Steichen FM

    更新日期:1979-06-01 00:00:00