Interferon regulatory factor expression in human breast cancer.

Abstract:

OBJECTIVE:To investigate the expression of interferon regulatory factors 1 and 2 (IRF-1 and IRF-2) in human breast cancer. SUMMARY BACKGROUND DATA:Interferon regulatory factors 1 and 2 are transcription factors in the interferon gamma signal transduction pathway. IRF-1 acts as the effector arm of the interferon gamma response; IRF-2 binds to the same DNA consensus sequence and opposes IRF-1 activity. Previous work in the authors' laboratory has shown the tumor suppressor activity of IRF-1 expression and the oncogenic effect of IRF-2 in human and murine tumor models, including human breast cancer cell lines. The authors' hypothesis is that this pathway is involved in human tumor development, and alterations in the expression of IRF-1 and IRF-2 may occur in breast cancer tissue compared with normal breast tissue, and between more and less differentiated breast cancers. METHODS:Formalin-fixed paraffin-embedded human archival tissue specimens were obtained from 33 patients with pure ductal carcinoma in situ (DCIS) and 49 women with invasive ductal cancer. Adjacent areas of normal breast tissue were assayed in 31 women. These specimens were stained with polyclonal IRF-1 and IRF-2 antibodies using an avidin-biotin-peroxidase complex technique after epitope retrieval. RESULTS:Most normal breast tissue showed expression of IRF-1 and no expression of IRF-2 by immunohistochemistry. High-grade DCIS or node-positive invasive ductal cancers were less likely to express the tumor suppressor IRF-1 than normal tissue. More strikingly, high-grade DCIS and invasive ductal cancers were much more likely to express the oncogenic IRF-2 protein than was normal tissue. CONCLUSIONS:Expression of IRF-1 and IRF-2 is altered in human breast cancer compared with normal adjacent tissue. The loss of IRF-1 expression is consistent with tumor suppressor loss and the development of IRF-2 expression with oncogenic activation. These data support the hypothesis that this pathway is involved in human breast oncogenesis, which warrants further investigation regarding prognostic and therapeutic implications.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Doherty GM,Boucher L,Sorenson K,Lowney J

doi

10.1097/00000658-200105000-00005

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

623-9

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

233

pub_type

杂志文章
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    abstract::One hundred and forty patients with an intractable ascites complicating a chronic liver disease received a peritoneovenous shunt (PVS) using the LeVeen valve. Operative mortality was ten per cent but was 25% in patients with severe liver failure. Intraoperative drainage of ascites sharply decreased postoperative compl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198504000-00014

    authors: Smadja C,Franco D

    更新日期:1985-04-01 00:00:00

  • Prophylactic antibiotics in vascular surgery. Topical, systemic, or both?

    abstract::A prospective, randomized, blinded study was performed to determine whether prophylactic antibiotics would reduce the incidence of infection in peripheral vascular surgery and whether the route of antibiotic administration was important. Patients undergoing a vascular procedure with a groin incision were allocated to ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198009000-00011

    authors: Pitt HA,Postier RG,MacGowan AW,Frank LW,Surmak AJ,Sitzman JV,Bouchier-Hayes D

    更新日期:1980-09-01 00:00:00

  • Side-to-side isoperistaltic strictureplasty in extensive Crohn's disease: a prospective longitudinal study.

    abstract:OBJECTIVE:To report on the results of a prospective longitudinal study of a new bowel-sparing procedure (side-to-side isoperistaltic strictureplasty [SSIS]) in patients with extensive Crohn's disease. METHODS:Between January 1992 and April 1999, the authors operated on 469 consecutive patients for Crohn's disease of t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200009000-00012

    authors: Michelassi F,Hurst RD,Melis M,Rubin M,Cohen R,Gasparitis A,Hanauer SB,Hart J

    更新日期:2000-09-01 00:00:00

  • Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer: long-term outcomes and prognostic significance of pathologic nodal status (KROG 09-01).

    abstract:OBJECTIVE:To investigate long-term outcomes of locally advanced rectal cancer (LARC) patients with postchemoradiotherapy (post-CRT) pathologic complete response of primary tumor (ypT0) and determine prognostic significance of post-CRT pathologic nodal (ypN) status. BACKGROUND:LARC patients with post-CRT pathologic com...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f3f1b1

    authors: Yeo SG,Kim DY,Kim TH,Chang HJ,Oh JH,Park W,Choi DH,Nam H,Kim JS,Cho MJ,Kim JH,Park JH,Kang MK,Koom WS,Kim JS,Nam TK,Chie EK,Kim JS,Lee KJ

    更新日期:2010-12-01 00:00:00

  • Outcome following surgical management of corrosive strictures of the esophagus.

    abstract:OBJECTIVE:To analyze the short- and long-term outcomes following surgical treatment for corrosive stricture of the esophagus. BACKGROUND:Surgery is a well-established treatment for corrosive strictures of the esophagus and involves either resection or bypass of the damaged esophagus and replacement by a conduit. The n...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182125ce7

    authors: Javed A,Pal S,Dash NR,Sahni P,Chattopadhyay TK

    更新日期:2011-07-01 00:00:00

  • Troponin Elevation After Colorectal Surgery: Significance and Management.

    abstract:OBJECTIVE:The aim of this study is to identify the association between early postoperative troponin elevations and outcomes after major colorectal surgery. BACKGROUND:Myocardial infarction is the leading cause of death after noncardiac surgery. Most postoperative myocardial infarctions are clinically silent, and asymp...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001854

    authors: Gorgun E,Lan BY,Aydinli HH,Reed GW,Menon V,Sessler DI,Stocchi L,Remzi FH

    更新日期:2016-10-01 00:00:00

  • Serum transferrin as a prognostic indicator of spontaneous closure and mortality in gastrointestinal cutaneous fistulas.

    abstract:OBJECTIVE:This study determined whether there are any laboratory or other features that will enable prediction of spontaneous closure in patients with gastrointestinal cutaneous fistulas. SUMMARY BACKGROUND DATA:Although the anatomic criteria for spontaneous closure of gastrointestinal cutaneous fistulas have been pre...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199306000-00003

    authors: Kuvshinoff BW,Brodish RJ,McFadden DW,Fischer JE

    更新日期:1993-06-01 00:00:00

  • Percutaneous transhepatic bile drainage.

    abstract::Percutaneous transhepatic bile drainage was performed in 13 patients with obstructive jaundice, using a combination of the PTC technique and a Seldinger angiography catheter. In 11 cases, the outflow of bile through the catheter was satisfactory and complications were few. Since the risk of the procedure is low and it...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197701000-00018

    authors: Mori K,Misumi A,Sugiyama M,Okabe M,Matsuoka T

    更新日期:1977-01-01 00:00:00

  • Paradigm shift in the management of gastroesophageal reflux disease.

    abstract:OBJECTIVE:To compare the short-term results of the radiofrequency treatment of the gastroesophageal junction known as the Stretta procedure versus laparoscopic fundoplication (LF) in patients with gastroesophageal reflux disease (GERD). SUMMARY BACKGROUND DATA:The Stretta procedure has been shown to be safe, well tole...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.SLA.0000064358.25509.36

    authors: Richards WO,Houston HL,Torquati A,Khaitan L,Holzman MD,Sharp KW

    更新日期:2003-05-01 00:00:00

  • Chemical debridement of burns.

    abstract::The development of effective, non-toxic (local and systemic) methods for the rapid chemical (enzymatic and non-enzymatic) debridement of third degree burns would dramatically reduce the morbidity and mortality of severely burned patients. Sepsis is still the major cause of death of patients with extensive deep burns. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00032

    authors: Levenson SM,Kan D,Gruber C,Crowley LV,Lent R,Watford A,Seifter E

    更新日期:1974-10-01 00:00:00

  • Twenty-three-year follow-up of separated ischiopagus tetrapus conjoined twins.

    abstract::This paper presents a 23-year follow-up of the separation of ischiopagus tetrapus conjoined twins reported in Annals of Surgery in December 1966. One twin died of septicemia at age 2 years after bilateral pelvic osteotomies for the treatment of her marked pelvic diastasis. The surviving twin has done reasonably well, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-198911000-00017

    authors: Hoyle RM,Thomas CG Jr

    更新日期:1989-11-01 00:00:00

  • Ten-year experience with cyclosporine as primary immunosuppression in recipients of renal allografts.

    abstract::Cyclosporine has been used as primary immunosuppression in renal allograft recipients in our unit for the past decade. The overall clinical experience and long-term effects of the agent are reviewed. There were 461 consecutive recipients of kidney grafts; 379 received grafts from cadaver donors (CAD) and 82 from livin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199107000-00007

    authors: Tilney NL,Chang A,Milford EL,Whitley WD,Lazarus JM,Ramos EL,Strom TB,Carpenter CB,Kirkman RL

    更新日期:1991-07-01 00:00:00

  • Carotid endarterectomy in the community hospital in patients age 80 and older.

    abstract:OBJECTIVE:To determine whether the rates of death and complications of carotid endarterectomy (CE) were different in the octogenarian population than in patients younger than age 80. SUMMARY BACKGROUND DATA:The utility of CE depends on the ability of the surgeon and hospital to attain low rates of death and complicati...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200006000-00001

    authors: Maxwell JG,Taylor AJ,Maxwell BG,Brinker CC,Covington DL,Tinsley E Jr

    更新日期:2000-06-01 00:00:00

  • The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVE AND BACKGROUND:Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. METHODS:Analyses were carried out to assess the association between clinical characteristics a...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000002557

    authors: Ghaneh P,Kleeff J,Halloran CM,Raraty M,Jackson R,Melling J,Jones O,Palmer DH,Cox TF,Smith CJ,O'Reilly DA,Izbicki JR,Scarfe AG,Valle JW,McDonald AC,Carter R,Tebbutt NC,Goldstein D,Padbury R,Shannon J,Dervenis C,G

    更新日期:2019-03-01 00:00:00

  • Management of Five Hundred Patients With Gut Failure at a Single Center: Surgical Innovation Versus Transplantation With a Novel Predictive Model.

    abstract:OBJECTIVE(S):To define the evolving role of integrative surgical management including transplantation for patients gut failure (GF). METHODS:A total of 500 patients with total parenteral nutrition-dependent catastrophic and chronic GF were referred for surgical intervention particularly transplantation and comprised t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003523

    authors: Abu-Elmagd KM,Armanyous SR,Fujiki M,Parekh NR,Osman M,Scalish M,Newhouse E,Fouda Y,Lennon E,Shatnawei A,Kirby D,Steiger E,Khanna A,Radhakrishnan K,Quintini C,Hashimoto K,Barnes J,Costa G

    更新日期:2019-10-01 00:00:00

  • Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial.

    abstract:OBJECTIVE:The authors assess the effect of surgical margin width on recurrence rates after intestinal resection of Crohn's Disease (CD). BACKGROUND:The optimal width of margins when resecting DC of the small bowel is controversial. Most studies have been retrospective and have had conflicting results. METHODS:Patient...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199610000-00014

    authors: Fazio VW,Marchetti F,Church M,Goldblum JR,Lavery C,Hull TL,Milsom JW,Strong SA,Oakley JR,Secic M

    更新日期:1996-10-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

    abstract::Current treatment modalities for thrombotic thrombocytopenic purpura (TTP) include plasmapheresis (PP), splenectomy, steroids, dextran, other antiplatelet agents, and vinca alkaloids. Prior to the development of PP and use of multimodality treatment for TTP, mortality rates exceeded 50%. This report reviews 11 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00007

    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • A Clinical Feasibility Trial for Identification of Exceptional Responders in Whom Breast Cancer Surgery Can Be Eliminated Following Neoadjuvant Systemic Therapy.

    abstract:OBJECTIVE:To determine the accuracy of fine-needle aspiration (FNA) and vacuum-assisted core biopsy (VACB) in assessing the presence of residual cancer in the breast after neoadjuvant systemic therapy (NST). SUMMARY BACKGROUND DATA:Pathologic complete response (pCR) rates after NST have improved dramatically, suggesti...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000002313

    authors: Kuerer HM,Rauch GM,Krishnamurthy S,Adrada BE,Caudle AS,DeSnyder SM,Black DM,Santiago L,Hobbs BP,Lucci A Jr,Gilcrease M,Hwang RF,Candelaria RP,Chavez-MacGregor M,Smith BD,Arribas E,Moseley T,Teshome M,Miggins MV,Vale

    更新日期:2018-05-01 00:00:00

  • Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children with Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

    abstract:OBJECTIVE:To determine the impact of tumor characteristics and treatment approach on (1) local recurrence, (2) scoliosis development and (3) patient-reported quality of life in children with sarcoma of the chest wall. SUMMARY BACKGROUND DATA:Children with chest wall sarcoma require multimodal therapy including chemoth...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004579

    authors: Harris CJ,Helenowski I,Murphy AJ,Mansfield SA,LaQuaglia MP,Heaton TE,Cavalli M,Murphy JT,Newman E,Overmen RE,Kartal TT,Cooke-Barber J,Donaher A,Malek MM,Kalsi R,Kim ES,Zobel MJ,Goodhue CJ,Naik-Mathuria BJ,Jefferson

    更新日期:2020-11-04 00:00:00

  • The surgical management of acute occlusion of the superior mesenteric artery.

    abstract::A study of 103 cases of acute occlusion of the superior mesenteric artery is presented. The relation of site of occlusion to etiology, extent of infarction, and survival following resection and revascularization is described. Included is an analysis of the technical factors contributing to successful revascularization...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197812000-00003

    authors: Ottinger LW

    更新日期:1978-12-01 00:00:00

  • Histologic Subtype Defines the Risk and Kinetics of Recurrence and Death for Primary Extremity/Truncal Liposarcoma.

    abstract:OBJECTIVE:We sought to define the prognostic significance of histologic subtype for extremity/truncal liposarcoma (LPS). BACKGROUND:LPS, the most common sarcoma, is comprised of 5 histologic subtypes. Despite their distinct behaviors, LPS outcomes are frequently reported as a single entity. METHODS:We analyzed data o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003453

    authors: Bartlett EK,Curtin CE,Seier K,Qin LX,Hameed M,Yoon SS,Crago AM,Brennan MF,Singer S

    更新日期:2019-07-05 00:00:00

  • Adhesion prevention during laparotomy: long-term follow-up of a randomized clinical trial.

    abstract:OBJECTIVE:The objective of the study was to determine the long-term effect of the use of a hyaluronic acid-carboxymethylcellulose membrane (Seprafilm) on the incidence of adhesions and subsequent small-bowel obstruction and chronic abdominal complaints after colorectal surgery (Hartmann's procedure). BACKGROUND:Adhesi...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e318217e99c

    authors: van der Wal JB,Iordens GI,Vrijland WW,van Veen RN,Lange J,Jeekel J

    更新日期:2011-06-01 00:00:00

  • Reconsideration of postoperative oral intake tolerance after pancreaticoduodenectomy: prospective consecutive analysis of delayed gastric emptying according to the ISGPS definition and the amount of dietary intake.

    abstract:OBJECTIVE:A prospective consecutive study was planned to evaluate the postpancreaticoduodenectomy (PD) oral intake tolerance. The occurrence of delayed gastric emptying (DGE), as defined by the International Study Group of Pancreatic Surgery (ISGPS), and the amount of dietary intake were analyzed. The risk factors for ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181a63c4c

    authors: Akizuki E,Kimura Y,Nobuoka T,Imamura M,Nagayama M,Sonoda T,Hirata K

    更新日期:2009-06-01 00:00:00

  • Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symptoms and mortality rate in a model of systemic inflammation.

    abstract:OBJECTIVE:The central question tested in this study was whether dichloromethylene-diphosphonate (CL2MDP) liposome-mediated elimination of hepatic and splenic macrophages would influence zymosan-induced bacterial translocation and the zymosan-induced generalized inflammatory response. SUMMARY BACKGROUND DATA:Both an un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199312000-00014

    authors: Nieuwenhuijzen GA,Haskel Y,Lu Q,Berg RD,van Rooijen N,Goris RJ,Deitch EA

    更新日期:1993-12-01 00:00:00

  • Per-oral Pyloromyotomy (POP) for Medically Refractory Gastroparesis: Short Term Results From the First 100 Patients at a High Volume Center.

    abstract:OBJECTIVE:For patients with gastroparesis, temporary pyloric disruption has been shown to improve symptoms and gastric emptying. Per-oral pyloromyotomy (POP) is an innovative endoscopic procedure to divide the pylorus from within a submucosal tunnel, as a corollary to surgical pyloromyotomy. Here we evaluate subjective...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002927

    authors: Rodriguez J,Strong AT,Haskins IN,Landreneau JP,Allemang MT,El-Hayek K,Villamere J,Tu C,Cline MS,Kroh M,Ponsky JL

    更新日期:2018-09-01 00:00:00

  • Clinical significance of the mesorectal extension of rectal cancer: a Japanese multi-institutional study.

    abstract:OBJECTIVE:The aim of this study was to emphasize the importance of a subclassification in the TNM staging system of rectal cancer. BACKGROUND:The clinical significance of the mesorectal extension of rectal cancer is unclear. PATIENTS AND METHODS:Data from 463 consecutive patients with stage IIa disease (T3N0) undergo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0b013e3182119331

    authors: Shirouzu K,Akagi Y,Fujita S,Ueno H,Takii Y,Komori K,Ito M,Sugihara K,Japanese Society for Cancer of the Colon and Rectum (JSCCR) on Clinical Significance of the Mesorectal Extension of Rectal Cancer.

    更新日期:2011-04-01 00:00:00

  • Nonfunctioning islet cell tumors.

    abstract::In nonfunctioning islet cell tumors of the pancreas, hormone production is not clinically evident. This type of tumor constituted 15% of all islet cell tumors seen at the Mayo Clinic from 1960 through 1978. Although identical to functioning islet cell tumors embryologically and histologically, the nonfunctioning tumor...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198102000-00010

    authors: Kent RB 3rd,van Heerden JA,Weiland LH

    更新日期:1981-02-01 00:00:00

  • The role of immunosuppression in the efficacy of cancer gene therapy using adenovirus transfer of the herpes simplex thymidine kinase gene.

    abstract:OBJECTIVE:To determine whether the immune system limits or improves the therapeutic efficacy of an adenovirus vector expressing the herpes simplex thymidine kinase (HSVtk) gene in a subcutaneous tumor model. BACKGROUND DATA:Enhanced immune reactions against tumors may be therapeutically useful. However, recent studies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199509000-00008

    authors: Elshami AA,Kucharczuk JC,Sterman DH,Smythe WR,Hwang HC,Amin KM,Litzky LA,Albelda SM,Kaiser LR

    更新日期:1995-09-01 00:00:00

  • Variability in length of stay after colorectal surgery: assessment of 182 hospitals in the national surgical quality improvement program.

    abstract:BACKGROUND:Length of postoperative stay (LOS) has gained increasing attention as a potential indicator of surgical efficiency. Our objective was to examine the feasibility of assessing LOS at 182 hospitals to identify institutions with outlying performance. METHODS:Patients were identified who underwent colorectal sur...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/sla.0b013e3181b2a948

    authors: Cohen ME,Bilimoria KY,Ko CY,Richards K,Hall BL

    更新日期:2009-12-01 00:00:00

  • 24-hour ambulatory dual gastroduodenal pH monitoring. The role of acid in duodenal ulcer disease.

    abstract::A new system for long-term, 24-hour, ambulatory dual gastroduodenal pH monitoring is described. Eighteen patients with active duodenal ulcers and ten healthy subjects were studied. Simultaneous gastric and duodenal bulb pH were measured during fasting, the ingestion of a solid meal, and for the remainder of the 24-hou...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00005

    authors: Eriksen CA,Sadek SA,Cuschieri A

    更新日期:1988-12-01 00:00:00