Prophylactic antibiotics in vascular surgery. Topical, systemic, or both?

Abstract:

:A prospective, randomized, blinded study was performed to determine whether prophylactic antibiotics would reduce the incidence of infection in peripheral vascular surgery and whether the route of antibiotic administration was important. Patients undergoing a vascular procedure with a groin incision were allocated to one of four groups with respect to prophylactic antibiotics. Group I received no antibiotic. Group II had topical cephradine instilled in their incisions prior to closure. Group III received a 24-hour perioperative course of intravenous cephradine, and Group IV received both topical and intravenous cephradine. Groin and abdominal incisional infections were significantly reduced (p < 0.01) among patients who received prophylactic antibiotics by either the topical, systemic, or combined routes of administration. No significant differences were noted among the three antibiotic groups. Profundoplasty, femoral embolectomy, and femoral aneurysm repair were each associated with an increased incidence of infection (p < 0.01). Other risk factors were only important in patients not receiving antibiotics. Either intraoperative topical antibiotics or perioperative systemic antibiotics prevent infection in peripheral vascular surgery, but antibiotic administration by both routes is unnecessary.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Pitt HA,Postier RG,MacGowan AW,Frank LW,Surmak AJ,Sitzman JV,Bouchier-Hayes D

doi

10.1097/00000658-198009000-00011

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

356-64

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

192

pub_type

临床试验,杂志文章,随机对照试验
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