Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats.


OBJECTIVE:To evaluate the effect of thrombopoietin on liver regeneration after hepatectomy and antifibrosis under conditions of liver cirrhosis in rats. SUMMARY BACKGROUND DATA:We revealed that platelets induced by thrombopoietin administration promote liver regeneration after hepatectomy in the normal liver. METHODS:Seventy percent hepatectomy was carried out in rats, which were subsequently divided into 4 groups: (1) normal group without any treatment, (2) liver cirrhosis (LC) group, (3) combined thrombopoietin and liver cirrhosis (LC+TPO) group, and (4) combined thrombopoietin, antiplatelet serum and liver cirrhosis (LC+TPO+APS) group. Growth kinetics in the liver regeneration and growth factors were analyzed. Liver fibrotic area and activation of hepatic stellate cells were also investigated. RESULTS:In LC group, liver regeneration was significantly delayed compared with normal group 24 hours after hepatectomy. On the other hand, liver regeneration of LC+TPO group increased significantly compared with LC group, to a level that was the same as that recorded in normal group. In LC group, liver fibrotic area before hepatectomy was significantly higher compared with the normal group. Liver fibrosis of LC+TPO group was significantly reduced compared with LC group. The antifibrotic and liver regeneration promoting effects of LC+TPO group were inhibited by antiplatelet serum in LC+TPO+APS group. CONCLUSION:The administration of thrombopoietin reduces liver fibrosis and stimulates regeneration after hepatectomy through increment and accumulation of platelets in the cirrhotic liver. This could be a potentially useful treatment for liver cirrhosis.


Ann Surg


Annals of surgery


Murata S,Hashimoto I,Nakano Y,Myronovych A,Watanabe M,Ohkohchi N




Has Abstract


2008-11-01 00:00:00














  • What Promotes Surgeon Practice Change? A Scoping Review of Innovation Adoption in Surgical Practice.

    abstract:OBJECTIVE:The goal of this scoping review was to summarize the literature on facilitators and barriers to surgical practice change. This information can inform research to implement best practices and evaluate new surgical innovations. BACKGROUND:In an era of accelerated innovations, surgeons face the difficult decisi...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Arroyo NA,Gessert T,Hitchcock M,Tao M,Smith CD,Greenberg C,Fernandes-Taylor S,Francis DO

    更新日期:2020-08-26 00:00:00

  • Five to twenty year followup after surgery for chronic pancreatitis in 148 patients.

    abstract::One-hundred and forty eight patients operated upon for chronic pancreatitis were reviewed retrospectively in 5-20 year followup. Treatment was by drainage of the duct of Wirsung to adefunctionalized jejunal loop, distal pancreatectomy, pancreato-duodenectomy, splanchnicectomy with an operative mortality of 5%. Influen...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Leger L,Lenriot JP,Lemaigre G

    更新日期:1974-08-01 00:00:00

  • Overestimation of hereditary breast cancer risk.

    abstract:OBJECTIVE:To find out how women with breast or ovarian cancer rate their chances of carrying hereditary factors for these cancers and to determine the extent to which they overestimate their risk. SUMMARY BACKGROUND DATA:BRCA1 and BRCA2 are genes that cause breast and ovarian cancer when they are inherited in families...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Iglehart JD,Miron A,Rimer BK,Winer EP,Berry D,Shildkraut MJ

    更新日期:1998-09-01 00:00:00

  • Recognition and surgical management of patent but hemodynamically failed arterial grafts.

    abstract::During a five-year period, 34 patients had persistence or recurrence of abnormal hemodynamic measurements in limbs after arterial reconstruction depsite graft patency documented by arteriography. Initial operations included aortofemoral (four), femorofemoral (ten), femoropopliteal (18), and femorotibial (two) bypass. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: O'Mara CS,Flinn WR,Johnson ND,Bergan JJ,Yao JS

    更新日期:1981-04-01 00:00:00

  • The Objective Structured Clinical Examination. The new gold standard for evaluating postgraduate clinical performance.

    abstract:OBJECTIVE:The authors determine the reliability, validity, and usefulness of the Objective Structured Clinical Examination (OSCE) in the evaluation of surgical residents. SUMMARY BACKGROUND DATA:Interest is increasing in using the OSCE as a measurement of clinical competence and as a certification tool. However, conce...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Sloan DA,Donnelly MB,Schwartz RW,Strodel WE

    更新日期:1995-12-01 00:00:00

  • Effects of hemorrhagic shock on adrenal response in a rat model.

    abstract:INTRODUCTION:There is a documented association between critically ill patients who are in refractory shock and adrenal insufficiency. The underlying pathophysiology may be related to ischemia, necrosis, reperfusion, or resuscitative dilution. We hypothesize this blunted adrenal response is due to ischemia and necrosis ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Rushing GD,Britt RC,Britt LD

    更新日期:2006-05-01 00:00:00

  • Workload, Recurrence, Quality of Life and Long-term Efficacy of Endoscopic Therapy for High-grade Dysplasia and Intramucosal Esophageal Adenocarcinoma.

    abstract:OBJECTIVE:To review the workload, type and frequency of recurrence, long-term quality of life (QOL), and late oncologic outcomes with endoscopic therapy. BACKGROUND:The short-term oncologic efficacy of endoscopic resection (ER) and ablation for patients with high-grade dysplasia (HGD) or intramucosal adenocarcinoma (I...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Schwameis K,Zehetner J,Green KM,DeMeester SR

    更新日期:2020-04-01 00:00:00

  • Treatment trends in early-stage invasive lobular carcinoma: a report from the National Cancer Data Base.

    abstract:OBJECTIVE:To examine treatment trends in invasive lobular carcinoma (ILC) over the last 15 years and, in particular, to compare rates of recurrence and disease-free survival associated with breast conservation therapy compared with mastectomy. SUMMARY BACKGROUND DATA:The biologic characteristics of ILC make it difficu...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Singletary SE,Patel-Parekh L,Bland KI

    更新日期:2005-08-01 00:00:00

  • Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

    abstract::A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exe...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Hafner GH,Herrera L,Petrelli NJ

    更新日期:1992-01-01 00:00:00

  • Cultured epidermis for the coverage of massive burn wounds. A single center experience.

    abstract::Seven patients with a mean burn size of 69.6% total body-surface area underwent skin grafting with autologous cultured epidermis. They were compared with a historical group of 18 controls, with a mean burn size of 60%, who underwent grafting with conventional meshed split-thickness autograft. There were no statistical...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Munster AM,Weiner SH,Spence RJ

    更新日期:1990-06-01 00:00:00

  • Multiple subcritical arterial stenoses: effect on poststenotic pressure and flow.

    abstract::Diminished poststenotic pressure and flow accompanied experimental application of multiple subcritical arterial stenoses in series. Effects of additional stenoses, causing equivalent constrictions, were cumulative in a nonlinear fashion. Seven-hundred-twenty measurements were performed using 10 cm ileofemoral canine a...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Flanigan DP,Tullis JP,Streeter VL,Whitehouse WM Jr,Fry WJ,Stanley JC

    更新日期:1977-11-01 00:00:00

  • Route and type of nutrition influence mucosal immunity to bacterial pneumonia.

    abstract:OBJECTIVE:To develop a model of established respiratory immunity against Pseudomonas aeruginosa pneumonia and to investigate the effects of route and type of nutrition on this immunity. SUMMARY BACKGROUND DATA:Diet influences the ability of gut-associated lymphoid tissue (GALT) to maintain mucosal immunity. Complex en...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: King BK,Kudsk KA,Li J,Wu Y,Renegar KB

    更新日期:1999-02-01 00:00:00

  • "Sideways": results of repair of biliary injuries using a policy of side-to-side hepatico-jejunostomy.

    abstract:BACKGROUND:The Hepp-Couinaud technique describes side-to-side HJ to the main left hepatic duct but a side-to-side approach is not consistently used when repairing other ducts. Compared with end-to-side repairs, side-to-side anastomoses require less dissection, theoretically preserving blood supply to the bile ducts, an...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Winslow ER,Fialkowski EA,Linehan DC,Hawkins WG,Picus DD,Strasberg SM

    更新日期:2009-03-01 00:00:00

  • An evaluation of information transfer through the continuum of surgical care: a feasibility study.

    abstract:OBJECTIVE:To evaluate information transfer and communication (ITC) across the surgical care pathway with the use of Information Transfer and Communication Assessment Tool for Surgery (ITCAS). BACKGROUND:Communication failures are the leading cause of surgical errors and adverse events. It is vital to assess the ITC ac...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Nagpal K,Vats A,Ahmed K,Vincent C,Moorthy K

    更新日期:2010-08-01 00:00:00

  • Does surgical quality improve in the American College of Surgeons National Surgical Quality Improvement Program: an evaluation of all participating hospitals.

    abstract:BACKGROUND/OBJECTIVE:The National Surgical Quality Improvement Program (NSQIP) has demonstrated quality improvement in the VA and pilot study of 14 academic institutions. The objective was to show that American College of Surgeons (ACS)-NSQIP helps all enrolled hospitals. METHODS:ACS-NSQIP data was used to evaluate im...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Hall BL,Hamilton BH,Richards K,Bilimoria KY,Cohen ME,Ko CY

    更新日期:2009-09-01 00:00:00

  • Phospholipase A2 isoforms are altered in chronic pancreatitis.

    abstract:OBJECTIVE:To determine if phospholipase A2 (PLA2) type II and type IV mRNA expression and protein are altered in chronic pancreatitis. SUMMARY BACKGROUND DATA:PLA2s have an important regulatory function in several signaling pathways, especially in inflammation. In this study, we examined the expression of three PLA2 i...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

    更新日期:1998-02-01 00:00:00

  • Myocardial revascularization: a rebuttal of the cooperative study.

    abstract::From January 1972 through December 1974, at Saint Louis University Medical Center (SLU), 345 patients similar to those of the VA Cooperative Coronary Artery Study received CABG. Operative mortality was SLU 2.3%, VA 5.6% (p < 0.05). Perioperative myocardial infarction rate was SLU 8.4%, VA 18% (p < 0.005). One year gra...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kaiser GC,Barner HB,Tyras DH,Codd JE,Mudd JG,Willman VL

    更新日期:1978-09-01 00:00:00

  • Lessons learned from more than 1,000 pancreas transplants at a single institution.

    abstract:OBJECTIVE:To determine outcome in diabetic pancreas transplant recipients according to risk factors and the surgical techniques and immunosuppressive protocols that evolved during a 33-year period at a single institution. SUMMARY BACKGROUND DATA:Insulin-dependent diabetes mellitus is associated with a high incidence o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审


    authors: Sutherland DE,Gruessner RW,Dunn DL,Matas AJ,Humar A,Kandaswamy R,Mauer SM,Kennedy WR,Goetz FC,Robertson RP,Gruessner AC,Najarian JS

    更新日期:2001-04-01 00:00:00

  • A Study of Clinical Coding Accuracy in Surgery: Implications for the Use of Administrative Big Data for Outcomes Management.

    abstract:BACKGROUND:Clinical coding is the translation of clinical activity into a coded language. Coded data drive hospital reimbursement and are used for audit and research, and benchmarking and outcomes management purposes. METHODS:We undertook a 2-center audit of coding accuracy across surgery. Clinician-auditor multidisci...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究


    authors: Nouraei SA,Hudovsky A,Frampton AE,Mufti U,White NB,Wathen CG,Sandhu GS,Darzi A

    更新日期:2015-06-01 00:00:00

  • Incidence and Risk Factors of Postoperative Mortality and Morbidity After Elective Versus Emergent Abdominal Surgery in a National Sample of 8193 Patients With Cirrhosis.

    abstract:OBJECTIVE:To describe the incidence and risk factors for mortality and morbidity in patients with cirrhosis undergoing elective or emergent abdominal surgeries. BACKGROUND:Postoperative morbidity and mortality are higher in patients with cirrhosis; variation by surgical procedure type and cirrhosis severity remain unc...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Johnson KM,Newman KL,Green PK,Berry K,Cornia PB,Wu P,Beste LA,Itani K,Harris AHS,Kamath PS,Ioannou GN

    更新日期:2019-10-23 00:00:00

  • Chest Wall Resection for Recurrent Breast Cancer in the Modern Era: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To review the literature on chest wall resection for recurrent breast cancer and evaluate overall survival (OS) and quality-of-life (QOL) outcomes. BACKGROUND:Full-thickness chest wall resection for recurrent breast cancer is controversial, as historically these recurrences have been thought of as a harbinge...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析


    authors: Wakeam E,Acuna SA,Keshavjee S

    更新日期:2018-04-01 00:00:00

  • A randomized trial of hemithyroidectomy versus Dunhill for the surgical management of asymmetrical multinodular goiter.

    abstract:OBJECTIVE:To assess the immediate and long-term clinical results of 2 different surgical procedures for the treatment of asymmetrical multinodular goiter (AMG). BACKGROUND:Half of the patients presenting with a single benign thyroid nodule have contralateral subclinical disease. There is a controversy whether these pa...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sancho JJ,Prieto R,Dueñas JP,Ribera C,Ripollés J,Larrad A,Sitges-Serra A

    更新日期:2012-11-01 00:00:00

  • Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials.

    abstract:OBJECTIVES:To compare the effects of intraoperative goal-directed fluid therapy (GDFT) with conventional fluid therapy, and determine whether there was a difference in outcome between studies that did and did not use Enhanced Recovery After Surgery (ERAS) protocols. METHODS:Meta-analysis of randomized controlled trial...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析


    authors: Rollins KE,Lobo DN

    更新日期:2016-03-01 00:00:00

  • Brush border transport of glutamine and other substrates during sepsis and endotoxemia.

    abstract::The effects of severe infection on luminal transport of amino acids and glucose by the small intestine were investigated. Studies were done in endotoxin-treated rats and in septic patients who underwent resection of otherwise normal small bowel. In rats the kinetics of the brush border glutamine transporter and the gl...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Salloum RM,Copeland EM,Souba WW

    更新日期:1991-05-01 00:00:00

  • Perioperative granulocyte colony-stimulating factor does not prevent severe infections in patients undergoing esophagectomy for esophageal cancer: a randomized placebo-controlled clinical trial.

    abstract:OBJECTIVE:Esophagectomy for esophageal cancer is associated with substantial postoperative morbidity as a result of infectious complications. In a prior phase II study, granulocyte colony-stimulating factor (G-CSF) was shown to improve leukocyte function and to reduce infection rates after esophagectomy. The aim of the...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Schaefer H,Engert A,Grass G,Mansmann G,Wassmer G,Hubel K,Loehlein D,Ulrich BC,Lippert H,Knoefel WT,Hoelscher AH

    更新日期:2004-07-01 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.

    abstract:OBJECTIVE:These studies were designed to elucidate the mechanism by which signals delivered by anti-CD2 monoclonal antibody (MoAb) interfere with activational signals delivered by anti-CD3 MoAb and induce long-term graft survival and tolerance. SUMMARY BACKGROUND DATA:Anti-CD2 or anti-CD3 MoAb can prolong allograft su...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Chavin KD,Qin L,Lin J,Woodward JE,Baliga P,Bromberg JS

    更新日期:1993-10-01 00:00:00

  • K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.

    abstract:OBJECTIVE:To evaluate clinical parameters, presurgical diagnostic tests, histologic findings, and the presence of K-ras oncogene mutations in cystic tumors of the pancreas to determine which best predict malignancy. SUMMARY BACKGROUND DATA:Because presurgical, intraoperative, and final pathologic differentiation is di...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Bartsch D,Bastian D,Barth P,Schudy A,Nies C,Kisker O,Wagner HJ,Rothmund M

    更新日期:1998-07-01 00:00:00

  • Academic Advancement in Global Surgery: Appointment, Promotion, and Tenure: Recommendations From the American Surgical Association Working Group on Global Surgery.

    abstract::: There is growing interest in global surgery among US academic surgical departments. As academic global surgery is a relatively new field, departments may have minimal experience in evaluation of faculty contributions and how they integrate into the existing academic paradigm for promotion and tenure. The American Su...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Wren SM,Balch CM,Doherty GM,Finlayson SR,Kauffman GL,Kibbe MR,Haider AH,Minter RM,Mock C,Muguti GI,Numann PJ,Olutoye OO,Roy N,Weigel RJ

    更新日期:2020-02-01 00:00:00

  • Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank.

    abstract:OBJECTIVE:Venous thromboembolic events (VTE) are potentially preventable causes of morbidity and mortality after injury. We hypothesized that the current clinical incidence of VTE is relatively low and that VTE risk factors could be identified. METHODS:We queried the ACS National Trauma Data Bank for episodes of deep ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Knudson MM,Ikossi DG,Khaw L,Morabito D,Speetzen LS

    更新日期:2004-09-01 00:00:00