Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats.

Abstract:

OBJECTIVE:To evaluate the effect of thrombopoietin on liver regeneration after hepatectomy and antifibrosis under conditions of liver cirrhosis in rats. SUMMARY BACKGROUND DATA:We revealed that platelets induced by thrombopoietin administration promote liver regeneration after hepatectomy in the normal liver. METHODS:Seventy percent hepatectomy was carried out in rats, which were subsequently divided into 4 groups: (1) normal group without any treatment, (2) liver cirrhosis (LC) group, (3) combined thrombopoietin and liver cirrhosis (LC+TPO) group, and (4) combined thrombopoietin, antiplatelet serum and liver cirrhosis (LC+TPO+APS) group. Growth kinetics in the liver regeneration and growth factors were analyzed. Liver fibrotic area and activation of hepatic stellate cells were also investigated. RESULTS:In LC group, liver regeneration was significantly delayed compared with normal group 24 hours after hepatectomy. On the other hand, liver regeneration of LC+TPO group increased significantly compared with LC group, to a level that was the same as that recorded in normal group. In LC group, liver fibrotic area before hepatectomy was significantly higher compared with the normal group. Liver fibrosis of LC+TPO group was significantly reduced compared with LC group. The antifibrotic and liver regeneration promoting effects of LC+TPO group were inhibited by antiplatelet serum in LC+TPO+APS group. CONCLUSION:The administration of thrombopoietin reduces liver fibrosis and stimulates regeneration after hepatectomy through increment and accumulation of platelets in the cirrhotic liver. This could be a potentially useful treatment for liver cirrhosis.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Murata S,Hashimoto I,Nakano Y,Myronovych A,Watanabe M,Ohkohchi N

doi

10.1097/SLA.0b013e31818584c7

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

821-8

issue

5

eissn

0003-4932

issn

1528-1140

pii

00000658-200811000-00018

journal_volume

248

pub_type

杂志文章
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    authors: Sugerman HJ,Wolfe LG,Sica DA,Clore JN

    更新日期:2003-06-01 00:00:00

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    abstract:OBJECTIVES:The American Joint Committee on Cancer (AJCC) staging system for gastric cancer bases N status on absolute number of metastatic nodes, regardless of the number of examined nodes. We examined a modified staging system utilizing node ratio (Nr), the ratio of metastatic to examined nodes. METHODS:A total of 18...

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    doi:10.1097/SLA.0b013e31824857e2

    authors: Wang J,Dang P,Raut CP,Pandalai PK,Maduekwe UN,Rattner DW,Lauwers GY,Yoon SS

    更新日期:2012-03-01 00:00:00

  • Biologic determinants of tumor growth in healing wounds.

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    journal_title:Annals of surgery

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    doi:10.1097/00000658-197902000-00009

    authors: Pendergrast WJ Jr,Futrell JW

    更新日期:1979-02-01 00:00:00

  • Sampling procedures in estrogen receptor determinations.

    abstract::To determine the significance of proteolysis and delayed freezing of tumor samples on estrogen receptor levels, values from 19 of 31 biopsy specimens were compared with that in remaining tumor at the completion of mastectomy. There was a 15-100% decrease in receptor content. Time-decay studies on selected postmastecto...

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    pub_type: 杂志文章

    doi:10.1097/00000658-198105000-00003

    authors: Newsome JF,Avis FP,Hammond JE,Sherwood S

    更新日期:1981-05-01 00:00:00

  • Experience with 100 consecutive simultaneous kidney-pancreas transplants with bladder drainage.

    abstract::From December 1985 to December 1989, 100 consecutive simultaneous pancreas-kidney (SPK) transplants were performed at the University of Wisconsin Hospital and Clinics. Bladder drainage technique was used for all grafts. One- and three-year patient survival was 93% and 90%; kidney survival, 90% and 85%; and pancreas su...

    journal_title:Annals of surgery

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    authors: Sollinger HW,Knechtle SJ,Reed A,D'Alessandro AM,Kalayoglu M,Belzer FO,Pirsch J

    更新日期:1991-12-01 00:00:00

  • Local Recurrence and Breast Oncological Surgery in Young Women With Breast Cancer: The POSH Observational Cohort Study.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

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    authors: Maishman T,Cutress RI,Hernandez A,Gerty S,Copson ER,Durcan L,Eccles DM

    更新日期:2017-07-01 00:00:00

  • The pregnant motor vehicle accident casualty: adherence to basic workup and admission guidelines.

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    authors: Sela HY,Weiniger CF,Hersch M,Smueloff A,Laufer N,Einav S

    更新日期:2011-08-01 00:00:00

  • Chronic respiratory symptoms and occult gastroesophageal reflux. A prospective clinical study and results of surgical therapy.

    abstract::Seventy-seven patients with a primary complaint of persistent cough, wheezing, and/or recurrent pneumonia were evaluated for the presence of occult gastroesophageal reflux disease. Fifty-four patients (70%) had increased esophageal acid exposure on 24-hour pH monitoring of the distal esophagus. In 28% of these patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199003000-00005

    authors: DeMeester TR,Bonavina L,Iascone C,Courtney JV,Skinner DB

    更新日期:1990-03-01 00:00:00

  • Defining lower limb lymphedema after inguinal or ilio-inguinal dissection in patients with melanoma using classification and regression tree analysis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31817ed7c3

    authors: Spillane AJ,Saw RP,Tucker M,Byth K,Thompson JF

    更新日期:2008-08-01 00:00:00

  • Individualized Metabolic Surgery Score: Procedure Selection Based on Diabetes Severity.

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    pub_type: 杂志文章

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    authors: Aminian A,Brethauer SA,Andalib A,Nowacki AS,Jimenez A,Corcelles R,Hanipah ZN,Punchai S,Bhatt DL,Kashyap SR,Burguera B,Lacy AM,Vidal J,Schauer PR

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  • Adrenergic control of adipocyte lipolysis in trauma and sepsis.

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    pub_type: 杂志文章

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    authors: Forse RA,Leibel R,Askanazi J,Hirsch J,Kinney JM

    更新日期:1987-12-01 00:00:00

  • Malignant fibrous histiocytoma of the pulmonary artery.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198702000-00017

    authors: Van Damme H,Vaneerdeweg W,Schoofs E

    更新日期:1987-02-01 00:00:00

  • Improved kidney graft function after preservation using a novel hypothermic machine perfusion device.

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    pub_type: 杂志文章

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    更新日期:2007-12-01 00:00:00

  • Analysis of the First 217 Appendectomies of the German NOTES Registry.

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    更新日期:2017-03-01 00:00:00

  • The physiologic effects of pneumoperitoneum in the morbidly obese.

    abstract:OBJECTIVE:To review the physiologic effects of carbon dioxide (CO2) pneumoperitoneum in the morbidly obese. SUMMARY BACKGROUND DATA:The number of laparoscopic bariatric operations performed in the United States has increased dramatically over the past several years. Laparoscopic bariatric surgery requires abdominal in...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.sla.0000151791.93571.70

    authors: Nguyen NT,Wolfe BM

    更新日期:2005-02-01 00:00:00

  • Advanced leg salvage of the critically ischemic leg with major tissue loss by vascular and plastic surgeon teamwork: Long-term outcome.

    abstract:OBJECTIVE:To assess long-term outcome and prognostic factors for extreme surgery by vascular and plastic surgical teamwork for leg salvage in patients with critically ischemic large tissue defects. SUMMARY BACKGROUND DATA:Combined vascular reconstruction and microvascular free-flap transfer has been used to improve di...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000247985.45541.e8

    authors: Tukiainen E,Kallio M,Lepäntalo M

    更新日期:2006-12-01 00:00:00

  • Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial.

    abstract:BACKGROUND:Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether antiviral therapy is useful in reducing recurrence in patients with lo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002727

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    更新日期:2018-12-01 00:00:00

  • Effect of prolonged selective intramesenteric arterial vasodilator therapy on intestinal viability after acute segmental mesenteric vascular occlusion.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200107000-00016

    authors: Meilahn JE,Morris JB,Ceppa EP,Bulkley GB

    更新日期:2001-07-01 00:00:00

  • Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion.

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    pub_type: 杂志文章

    doi:10.1097/00000658-200007000-00013

    authors: Koike K,Yamamoto Y,Hori Y,Ono T

    更新日期:2000-07-01 00:00:00

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    abstract::The University of Rochester, Department of Surgery, in response to an experimental community-wide limit on hospital budgets, studied high-cost general surgical patients as a potential source of leverage for containment of hospital costs. It was found that a small number of patients impact significantly on hospital cos...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198309000-00005

    authors: Drucker WR,Gavett JW,Kirshner R,Messick WJ,Ingersoll G

    更新日期:1983-09-01 00:00:00

  • Appraisal of laparoscopic cholecystectomy.

    abstract::This paper reports the experience of three general surgeons performing 304 laparoscopic cholecystectomies in three private hospitals between October 1989 and November 1990. Laparoscopic cholecystectomy boasts two major advantages over the conventional procedure: the remarkable reduction in postoperative pain and econo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199106000-00017

    authors: Graves HA Jr,Ballinger JF,Anderson WJ

    更新日期:1991-06-01 00:00:00

  • A simple test to identify coarctation of the aorta.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

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    更新日期:1976-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002753

    authors: Gemenetzis G,Groot VP,Blair AB,Laheru DA,Zheng L,Narang AK,Fishman EK,Hruban RH,Yu J,Burkhart RA,Cameron JL,Weiss MJ,Wolfgang CL,He J

    更新日期:2019-08-01 00:00:00

  • Clinical experience with the use of a valve-bearing conduit to construct a second left ventricular outflow tract in cases of unresectable intra-ventricular obstruction.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197609000-00009

    authors: Dembitsky WP,Weldon CS

    更新日期:1976-09-01 00:00:00

  • Tacrolimus and Single Intraoperative High-dose of Anti-T-lymphocyte Globulins Versus Tacrolimus Monotherapy in Adult Liver Transplantation: One-year Results of an Investigator-driven Randomized Controlled Trial.

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    authors: Starling JR,Reichelderfer MO,Pellett JR,Belzer FO

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    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000624

    authors: Moore L,Stelfox HT,Turgeon AF,Nathens A,Bourgeois G,Lapointe J,Gagné M,Lavoie A

    更新日期:2014-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1097/00000658-197606000-00003

    authors: Vansant JH,Baker JW Jr

    更新日期:1976-06-01 00:00:00

  • The American Association of Endocrine Surgeons Guidelines for the Definitive Surgical Management of Thyroid Disease in Adults.

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    doi:10.1097/SLA.0000000000003580

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