Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats.

Abstract:

OBJECTIVE:To evaluate the effect of thrombopoietin on liver regeneration after hepatectomy and antifibrosis under conditions of liver cirrhosis in rats. SUMMARY BACKGROUND DATA:We revealed that platelets induced by thrombopoietin administration promote liver regeneration after hepatectomy in the normal liver. METHODS:Seventy percent hepatectomy was carried out in rats, which were subsequently divided into 4 groups: (1) normal group without any treatment, (2) liver cirrhosis (LC) group, (3) combined thrombopoietin and liver cirrhosis (LC+TPO) group, and (4) combined thrombopoietin, antiplatelet serum and liver cirrhosis (LC+TPO+APS) group. Growth kinetics in the liver regeneration and growth factors were analyzed. Liver fibrotic area and activation of hepatic stellate cells were also investigated. RESULTS:In LC group, liver regeneration was significantly delayed compared with normal group 24 hours after hepatectomy. On the other hand, liver regeneration of LC+TPO group increased significantly compared with LC group, to a level that was the same as that recorded in normal group. In LC group, liver fibrotic area before hepatectomy was significantly higher compared with the normal group. Liver fibrosis of LC+TPO group was significantly reduced compared with LC group. The antifibrotic and liver regeneration promoting effects of LC+TPO group were inhibited by antiplatelet serum in LC+TPO+APS group. CONCLUSION:The administration of thrombopoietin reduces liver fibrosis and stimulates regeneration after hepatectomy through increment and accumulation of platelets in the cirrhotic liver. This could be a potentially useful treatment for liver cirrhosis.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Murata S,Hashimoto I,Nakano Y,Myronovych A,Watanabe M,Ohkohchi N

doi

10.1097/SLA.0b013e31818584c7

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

821-8

issue

5

eissn

0003-4932

issn

1528-1140

pii

00000658-200811000-00018

journal_volume

248

pub_type

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    authors: Leger L,Lenriot JP,Lemaigre G

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    更新日期:2005-08-01 00:00:00

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    doi:10.1097/00000658-199201000-00009

    authors: Hafner GH,Herrera L,Petrelli NJ

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    journal_title:Annals of surgery

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    doi:10.1097/00000658-199006000-00005

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    authors: King BK,Kudsk KA,Li J,Wu Y,Renegar KB

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    pub_type: 杂志文章,多中心研究

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    doi:10.1097/SLA.0000000000003480

    authors: Wren SM,Balch CM,Doherty GM,Finlayson SR,Kauffman GL,Kibbe MR,Haider AH,Minter RM,Mock C,Muguti GI,Numann PJ,Olutoye OO,Roy N,Weigel RJ

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