当前位置： SCI文献检索 > BRITISH JOURNAL OF PHARMACOLOGY期刊下所有文献 > Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase.

Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase.

Abstract：

:1. In isolated Langendorff-perfused, electrically-paced, hearts of guinea-pigs, global low-flow-ischaemia (LFI; at 0.7 ml min-1) resulted in marked increases in the rates of release of lactate, lactate dehydrogenase (LDH) and creatine kinase (CK) over a 30 min period. At the end of the LFI period, tissue ATP content was significantly reduced from a control value of 11.8 +/- 0.8 (5) to 5.6 +/- 0.8 (5) mumol g-1 dry weight. 2. The presence of ranolazine [(+/-)-N-(2,6-dimethyl-phenyl)-4[2-hydroxy-3-(2-methoxy-phenoxyl)- propyl] - l-piperazine acetamide dihydro-chloride; RS-43285-193] at 10 microM, from 20 min prior to and during LFI, resulted in significant reductions in the release of lactate, LDH and CK during the ischaemic period and a significant preservation of tissue ATP (9.0 +/- 1.1 (6) mumol g-1 dry wt.). Ranolazine did not prevent the reductions in creatine phosphate or glycogen observed in LFI, nor did it have any significant effects on any contractile parameters before or during the LFI period. 3. Neither ranolazine nor LFI affected the total amounts of tissue pyruvate dehydrogenase (PDH) activity; however, the significant reduction in the amount of active, non-phosphorylated PDH caused by LFI (from 88.2 +/- 5.5 to 44.2 +/- 3.2% of total activity) was partially but significantly prevented by ranolazine (67.2 +/- 6.8%). This effect of ranolazine on PDH may be part of the mechanism whereby the compound reduces lactate release and preserves tissue ATP during ischaemia.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Clarke B,Spedding M,Patmore L,McCormack JG

doi

10.1111/j.1476-5381.1993.tb13637.x

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

748-50

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

109

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF PHARMACOLOGY文献大全
  • Electrophysiological effects of anandamide on rat myocardium.

    abstract：BACKGROUND AND PURPOSE:The endocannabinoid, anandamide, has anti-arrhythmic effects. The aim of the present study was to explore the electrophysiological effects of anandamide on rat myocardium. EXPERIMENTAL APPROACH:Evoked action potentials (APs) were recorded using intracellular recording technique in rat cardiac pa...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2009.00518.x

    authors： Li Q,Ma HJ,Zhang H,Qi Z,Guan Y,Zhang Y

    更新日期：2009-12-01 00:00:00

  • Amlodipine, but not verapamil or nifedipine, dilates rabbit femoral artery largely through a nitric oxide- and kinin-dependent mechanism.

    abstract：:1. We investigated the nitric oxide (NO) dependence of vasorelaxation in response to different calcium channel blockers (CCB), in rabbit femoral artery in vivo. 2. Anaesthetized rabbits underwent femoral artery ligation, and blood from the proximal artery was returned distal to the ligature through a constant infusion...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0704753

    authors： Xu B,Xiao-hong L,Lin G,Queen L,Ferro A

    更新日期：2002-06-01 00:00:00

  • Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action.

    abstract：:1. The class III antiarrhythmic azimilide has previously been shown to inhibit I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance I(Kr), in human heart, the effects of azimilide on HERG channels expressed in Xenopus oocyt...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0701575

    authors： Busch AE,Eigenberger B,Jurkiewicz NK,Salata JJ,Pica A,Suessbrich H,Lang F

    更新日期：1998-01-01 00:00:00

  • Nerve-mediated inhibition of mechanical activity in rabbit duodenum and the effects of desensitization to adenosine and several of its derivatives.

    abstract：:1. Inhibition of mechanical activity in longitudinal muscle strips of rabbit duodenum was induced by perivascular and intramural nerve stimulation.2. The effects of perivascular stimulation were abolished by phentolamine + propranolol, guanethidine, reserpine and by tetrodotoxin. The effects of intramural stimulation ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1973.tb06916.x

    authors： Weston AH

    更新日期：1973-06-01 00:00:00

  • Feedback inhibition of nitric oxide synthase activity by nitric oxide.

    abstract：:1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2. The decline in the...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1993.tb12886.x

    authors： Assreuy J,Cunha FQ,Liew FY,Moncada S

    更新日期：1993-03-01 00:00:00

  • Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids.

    abstract：:1. The modulation of the gamma-aminobutyric acidA (GABAA) receptor by reduced metabolites of progesterone and deoxycorticosterone has been compared with that produced by depressant barbiturates in: (a) voltage-clamp recordings from bovine enzymatically isolated chromaffin cells in cell culture, and (b) an assay of the...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1988.tb11646.x

    authors： Peters JA,Kirkness EF,Callachan H,Lambert JJ,Turner AJ

    更新日期：1988-08-01 00:00:00

  • Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells.

    abstract：BACKGROUND AND PURPOSE:Quercetin is a natural polyphenolic flavonoid that displays anti-diabetic properties in vivo. Its mechanism of action on insulin-secreting beta cells is poorly documented. In this work, we have analysed the effects of quercetin both on insulin secretion and on the intracellular calcium concentrat...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12194

    authors： Bardy G,Virsolvy A,Quignard JF,Ravier MA,Bertrand G,Dalle S,Cros G,Magous R,Richard S,Oiry C

    更新日期：2013-07-01 00:00:00

  • The action of Hoe 140 on the bradykinin-induced splenic pressor reflex of the anaesthetized cat.

    abstract：:1. Intrasplenic injection of bradykinin (BK) induced a dose-dependent pressor response in the anaesthetized cat, with an ED50 of 0.98 +/- 0.43 nmol. In contrast, intrasplenic administration of desArg9bradykinin (desArg9BK) was without significant effect at doses of up to 200 nmol. 2. Intravenously administered BK indu...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1993.tb13962.x

    authors： Louttit JB,Coleman RA

    更新日期：1993-12-01 00:00:00

  • Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach.

    abstract：:1. Effects of indomethacin, the selective cyclo-oxygenase (COX)-2 inhibitors NS-398 and DFU, and dexamethasone on gastric damage induced by 30 min ischaemia followed by 60 min reperfusion (I-R) were investigated in rats. Modulation of gastric levels of COX-1 and COX-2 mRNA by I-R was evaluated using Northern blot and ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0702966

    authors： Maricic N,Ehrlich K,Gretzer B,Schuligoi R,Respondek M,Peskar BM

    更新日期：1999-12-01 00:00:00

  • The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts.

    abstract：BACKGROUND AND PURPOSE:The Na+/Ca2+ exchanger (NCX) may contribute to triggered activity and transmural dispersion of repolarization, which are substrates of torsades de pointes (TdP) type arrhythmias. This study examined the effects of selective inhibition of the NCX by SEA0400 on the occurrence of dofetilide-induced ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2008.00096.x

    authors： Farkas AS,Makra P,Csík N,Orosz S,Shattock MJ,Fülöp F,Forster T,Csanády M,Papp JG,Varró A,Farkas A

    更新日期：2009-03-01 00:00:00

  • Evidence for the involvement of different receptor subtypes in the pre- and postjunctional actions of angiotensin II at rat sympathetic neuroeffector sites.

    abstract：:1. The effects of the nonpeptide angiotensin II receptor (AT) antagonists losartan and PD 123319 on actions of angiotensin II in the rat caudal artery and rat vas deferens preparations were investigated. 2. Angiotensin II (1.0 microM) increased perfusion pressure in isolated segments of the rat caudal artery. This inc...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1995.tb13313.x

    authors： Cox SL,Ben A,Story DF,Ziogas J

    更新日期：1995-03-01 00:00:00

  • Comparison of human serum, parotid and mixed saliva levels of phenoxymethylpenicillin, ampicillin, cloxacillin and cephalexin.

    abstract：:1. A study has been made of serum, mixed and parotid salivary levels attained in normal volunteers following oral dosage of 500 mg phenoxymethylpenicillin tablets, 500 mg crushed phenoxymethylpenicillin tablets in capsules, 500 mg ampicillin, 500 mg cloxacillin and 500 mg cephalexin.2. High mixed saliva levels were ob...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1971.tb07173.x

    authors： Speirs CF,Stenhouse D,Stephen KW,Wallace ET

    更新日期：1971-09-01 00:00:00

  • Genetic predisposition to albuminuria is associated with increased arterial stiffness: role of elastin.

    abstract：BACKGROUND AND PURPOSE:The Munich Wistar Frömter (MWF) rat strain represents an experimental model to study cardiovascular alterations under conditions of progressive albuminuria. The aim of this study was to evaluate the association between genetic predisposition to albuminuria and the development of arterial stiffnes...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.13223

    authors： Gil-Ortega M,García-Prieto CF,Ruiz-Hurtado G,Steireif C,González MC,Schulz A,Kreutz R,Fernández-Alfonso MS,Arribas S,Somoza B

    更新日期：2015-09-01 00:00:00

  • Translational neuropharmacology: the use of human isolated gastrointestinal tissues.

    abstract：:Translational sciences increasingly emphasize the measurement of functions in native human tissues. However, such studies must confront variations in patient age, gender, genetic background and disease. Here, these are discussed with reference to neuromuscular and neurosecretory functions of the human gastrointestinal...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1476-5381.2012.02198.x

    authors： Sanger GJ,Broad J,Kung V,Knowles CH

    更新日期：2013-01-01 00:00:00

  • Extracellular nucleotides induce vasodilatation in human arteries via prostaglandins, nitric oxide and endothelium-derived hyperpolarising factor.

    abstract：:1. The present study was aimed at examining P2 receptor-mediated vasodilatation in human vessels. The isometric tension was recorded in isolated segments of the human left internal mammary artery branches precontracted with 1 microM noradrenaline. 2. Endothelial denudation abolished the dilator responses. 3. The selec...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0705186

    authors： Wihlborg AK,Malmsjö M,Eyjolfsson A,Gustafsson R,Jacobson K,Erlinge D

    更新日期：2003-04-01 00:00:00

  • Two distinct membrane currents activated by cyclopiazonic acid-induced calcium store depletion in single smooth muscle cells of the mouse anococcygeus.

    abstract：:1. By use of the whole-cell configuration of the patch-clamp technique, membrane currents induced by cyclopiazonic acid (CPA; an inhibitor of the sarcoplasmic reticulum (SR) calcium-ATPase) were investigated in single smooth muscle cells freshly dispersed from the mouse anococcygeus. Voltage-dependent calcium currents...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1996.tb15228.x

    authors： Wayman CP,McFadzean I,Gibson A,Tucker JF

    更新日期：1996-02-01 00:00:00

  • Losartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation.

    abstract：BACKGROUND AND PURPOSE:PPAR-γ has been reported to be a protective regulator in ischaemia/reperfusion (I/R) injury. The receptor for advanced glycation end-products (RAGE) plays a major role in the innate immune response, and its expression is associated with PPAR-γ activation. Several angiotensin receptor blockers pos...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.12229

    authors： Koh EJ,Yoon SJ,Lee SM

    更新日期：2013-07-01 00:00:00

  • Modulation of visceral pain and inflammation by protease-activated receptors.

    abstract：:The gastrointestinal (GI) tract is exposed to a large array of proteases, under both physiological and pathophysiological conditions. The discovery of G protein-coupled receptors activated by proteases, the protease-activated receptors (PARs), has highlighted new signaling functions for proteases in the GI tract, part...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjp.0705750

    authors： Vergnolle N

    更新日期：2004-04-01 00:00:00

  • Embryonic exposure to valproic acid affects the histaminergic system and the social behaviour of adult zebrafish (Danio rerio).

    abstract：BACKGROUND AND PURPOSE:Histamine modulates several behaviours and physiological functions, and its deficiency is associated with neuropsychiatric disorders. Gestational intake of valproic acid (VPA) is linked to autism spectrum disorder (ASD), characterized by impaired sociability and stereotypies. VPA effects on the n...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.14124

    authors： Baronio D,Puttonen HAJ,Sundvik M,Semenova S,Lehtonen E,Panula P

    更新日期：2018-03-01 00:00:00

  • TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability.

    abstract：BACKGROUND AND PURPOSE:Chromosomal instability is not only a hallmark of cancer but also an attractive therapeutic target. A diverse set of mitotic kinases maintains chromosomal stability. One of these is monopolar spindle 1 (Mps1, also known as TTK), which is essential for chromosome alignment and for the spindle asse...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.13782

    authors： Choi M,Min YH,Pyo J,Lee CW,Jang CY,Kim JE

    更新日期：2017-06-01 00:00:00

  • Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

    abstract：BACKGROUND AND PURPOSE:Due to their potent bronchodilator properties, beta(2)-adrenoceptor agonists are a mainstay of therapy in asthma. However, the effects of beta(2)-adrenoceptor agonists on inflammation are less clear. Accordingly, we have investigated the effects of beta(2)-adrenoceptor agonists on inflammatory me...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.2010.00708.x

    authors： Holden NS,Rider CF,Bell MJ,Velayudhan J,King EM,Kaur M,Salmon M,Giembycz MA,Newton R

    更新日期：2010-05-01 00:00:00

  • Effects of beta-adrenoceptor agonists in human bronchial smooth muscle.

    abstract：:1. We have investigated the potency and duration of action of isoprenaline and a range of beta-adrenoceptor agonists as relaxants of inherent tone in human superfused, isolated bronchial smooth muscle, a tissue reported to contain a homogeneous population of beta 2-adrenoceptors. 2. All of the beta-adrenoceptor agonis...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1993.tb13929.x

    authors： Nials AT,Coleman RA,Johnson M,Magnussen H,Rabe KF,Vardey CJ

    更新日期：1993-11-01 00:00:00

  • kappa-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat.

    abstract：:1. Nociceptive thresholds to noxious mechanical (paw pressure) and thermal (tail flick) stimuli were recorded in conscious rats. The effects of three selective kappa-opioid receptor agonists on the responses to these stimuli were determined following intravenous, intracerebroventricular or intrathecal administration. ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1988.tb10310.x

    authors： Leighton GE,Rodriguez RE,Hill RG,Hughes J

    更新日期：1988-03-01 00:00:00

  • Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets.

    abstract：:Homocysteine is a sulphur-containing non-proteinogenic amino acid. Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a result of an imbalance of its metabolism, is an independent risk factor for various vascular diseases, such as atherosclerosis, hypertension, vascular calcification and ...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bph.13988

    authors： Fu Y,Wang X,Kong W

    更新日期：2018-04-01 00:00:00

  • Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease.

    abstract：BACKGROUND AND PURPOSE:The ω-3 polyunsaturated fatty acids (PUFAs) mediate protective effects on several metabolic disorders. However, the functions of their metabolites in the early stage of nonalcoholic fatty liver disease (NAFLD) are largely unknown. EXPERIMENTAL APPROACH:Mice were fed a control diet, high-fat diet...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/bph.13844

    authors： Wang C,Liu W,Yao L,Zhang X,Zhang X,Ye C,Jiang H,He J,Zhu Y,Ai D

    更新日期：2017-07-01 00:00:00

  • Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers.

    abstract：:Using an in vitro mouse cerebellar slice preparation and whole-cell electrophysiological recording techniques we have characterized Purkinje and basket cell inhibitory post-synaptic currents (IPSCs), and examined the effects of a number of selective peptidergic K+ channel blockers. Spontaneous IPSC amplitude ranged fr...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0702218

    authors： Southan AP,Robertson B

    更新日期：1998-11-01 00:00:00

  • Baclofen and phaclofen modulate GABA release from slices of rat cerebral cortex and spinal cord but not from retina.

    abstract：:1. The effects of (-)-baclofen, muscimol and phaclofen on endogenous gamma-aminobutyric acid (GABA) release from rat cortical slices, spinal cord slices and entire retinas were studied. 2. The spontaneous resting release of GABA from the three tissues was 3 to 6 pmol mg-1 wet wt 10 min-1. Depolarization of cortical sl...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1989.tb16869.x

    authors： Neal MJ,Shah MA

    更新日期：1989-09-01 00:00:00

  • A neuromodulatory role for neuronal nitric oxide in the rabbit renal artery.

    abstract：:1. The effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on vasoconstrictor responses to transmural electrical nerve stimulation and noradrenaline were examined in the rabbit isolated renal artery with and without an intact endothelium. In addition, the effect of removing the end...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0701141

    authors： Vials AJ,Crowe R,Burnstock G

    更新日期：1997-05-01 00:00:00

  • An examination of 5-hydroxytryptamine receptors in human saphenous vein.

    abstract：:We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohi...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1476-5381.1986.tb11122.x

    authors： Docherty JR,Hyland L

    更新日期：1986-09-01 00:00:00

  • Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.

    abstract：:1. The possible mechanisms of the antiproliferative and apoptotic effects of curcumin (diferuloylmethane), a polyphenol in the spice turmeric, on vascular smooth muscle cells were studied in rat aortic smooth muscle cell line (A7r5). 2. The proliferative response was determined from the uptake of [3H]-thymidine. Curcu...

    journal_title：British journal of pharmacology

    pub_type： 杂志文章

    doi：10.1038/sj.bjp.0701914

    authors： Chen HW,Huang HC

    更新日期：1998-07-01 00:00:00