Abstract:
:We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohimbine caused an approximately parallel shift of the concentration-response curve to 5-HT, with a pA2 of 5.48, much lower than its pA2 against noradrenaline in the absence (6.36) or presence (7.06) of cocaine. It is concluded that there are two components to the contractile response to 5-HT in human saphenous vein: at low concentrations 5-HT activates a yohimbine-sensitive receptor, and at higher concentrations 5-HT activates a 5-HT2-receptor.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Docherty JR,Hyland Ldoi
10.1111/j.1476-5381.1986.tb11122.xsubject
Has Abstractpub_date
1986-09-01 00:00:00pages
77-81issue
1eissn
0007-1188issn
1476-5381journal_volume
89pub_type
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journal_title:British journal of pharmacology
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