Abstract:
BACKGROUND:TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported. STUDY DESIGN AND METHODS:This study was an observational study carried out in a single hospital. RESULTS:Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI. The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused. CONCLUSION:TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to HLA class II antigens should be looked for routinely when investigating a possible case of TRALI.
journal_name
Transfusionjournal_title
Transfusionauthors
Wallis JP,Lubenko A,Wells AW,Chapman CEdoi
10.1046/j.1537-2995.2003.00466.xsubject
Has Abstractpub_date
2003-08-01 00:00:00pages
1053-9issue
8eissn
0041-1132issn
1537-2995pii
466journal_volume
43pub_type
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