Avian serum esterases: species and temporal variations and their possible consequences.

abstract：:Metabolism of the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats was compared to metabolism in primary lung and liver cells. Untreated rats and rats pretreated with phenobarbital, acetone or phenethyl isothiocyanate (PEITC) were used for all experiments. Also the influence of...

journal_title：Chemico-biological interactions

authors： Schneider T,Frei E,Wiessler M

更新日期：1999-04-15 00:00:00

abstract：:Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene-butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefully enumerated stud...

journal_title：Chemico-biological interactions

authors： Acquavella JF,Leonard RC

更新日期：2001-06-01 00:00:00

abstract：:Except for their extra- and intra-cellular interfaces, cell membranes are hydrophobic and inhibit the transport of hydrophilic molecules. Metalloids in aqueous solutions form chemical species with oxygen and hydroxyl groups and, therefore, exist as hydrophilic neutral polar solutes or as hydrophilic anions. This chara...

journal_title：Chemico-biological interactions

authors： Zangi R,Filella M

更新日期：2012-04-15 00:00:00

abstract：:Diabetes mellitus is the world's most common endocrine disease involving metabolic disorders of carbohydrate, protein and fat. This study was undertaken to investigate the anti-diabetic activity of corilagin, a member of polyphenolic tannins used against hyperglycemia and many other diseases in well-known animal model...

journal_title：Chemico-biological interactions

authors： Nandini HS,Naik PR

更新日期：2019-02-01 00:00:00

abstract：:Oral administration of O,O,S-trimethyl phosphorothioate (OOS), an impurity present in widely used organophosphorus insecticides, causes delayed toxicity in rats, i.e., death occurring as late as 28 days after the treatment. The signs of toxicity include body weight loss (maximum on day 3), red staining around the nose...

journal_title：Chemico-biological interactions

authors： Imamura T,Hasegawa L,Gandy J,Fukuto TR

更新日期：1983-07-01 00:00:00

abstract：:The reduction of hexavalent chromium (Cr(VI] by rat liver microsomes was studied. With 15-120 microM Na2CrO4 microsomes (0.5 mg protein/ml) effectively reduced Cr(VI) in the presence of NADPH provided anaerobic conditions. Phenobarbital (PB) and Aroclor 1254 (PCB) pretreatment increased microsomal Cr(VI) reduction whi...

journal_title：Chemico-biological interactions

authors： Mikalsen A,Alexander J,Ryberg D

更新日期：1989-01-01 00:00:00

abstract：:Copper (Cu) accumulating in a form bound to metallothionein (MT) in the liver of Long-Evans rats with a cinnamon-like coat color (LEC rats), an animal model of Wilson disease, was removed with ammonium tetrathiomolybdate (TTM), and the fate of the Cu complexed with TTM and mobilized from the liver was determined. TTM ...

journal_title：Chemico-biological interactions

authors： Komatsu Y,Sadakata I,Ogra Y,Suzuki KT

更新日期：2000-02-01 00:00:00

abstract：:4-Methylcyclophosphamide, an analogue of the antitumour agent cyclophosphamide, exists in cis and trans forms, each of which comprises a pair of optical isomers. The extents of metabolism by rat liver microsomes during 20 min were compared for the four steroisomers incubated separately, and for the racemic cis and tra...

journal_title：Chemico-biological interactions

authors： Farmer PB,Jarman M,Facchinetti T,Pankiewicz K,Stec WJ

更新日期：1977-07-01 00:00:00

abstract：:The carcinogenic activity of the synthetic estrogen hexestrol was measured in male Syrian hamsters. Between 90% and 100% of the animals treated with hexestrol or with 3',3",5',5"-tetradeuteriohexestrol, implanted subcutaneously as 25-mg pellets, were found with renal carcinoma after 6-7 months. In vitro hexestrol meta...

journal_title：Chemico-biological interactions

authors： Liehr JG,Ballatore AM,Dague BB,Ulubelen AA

更新日期：1985-10-01 00:00:00

abstract：:Buttiauxella strain S19-1 is a new marine bacterium, isolated from the Baltic Sea, which can degrade steroids. In this report, a meta-genomic approach was used to isolate estradiol inducible genes from S19-1. SalI-fragments from the chromosomal DNA of S19-1 were ligated into plasmid pKEGFP2 bearing an EGFP gene as the...

journal_title：Chemico-biological interactions

authors： Zhang T,Xiong G,Maser E

更新日期：2013-02-25 00:00:00

abstract：:We investigated the permeabilities of lipid bilayers to the neurotoxin methylmercuric chloride (MMC). This mercurial is an efficient collisional quencher of the fluorescence of N-alkyl carbazole derivatives. Quenching of the fluorescence of beta-(3-(9-carbazole)-propionyl-L-alpha-phosphatidylcholine (CPA-PC) in vesicl...

journal_title：Chemico-biological interactions

authors： Lakowicz JR,Anderson CJ

更新日期：1980-06-01 00:00:00

abstract：:In order to assess the role played respectively by the pseudothiourea group and the alkylic chain in the inhibition of protein synthesis and tumour growth caused by compound AHR-1911, a series of eight related substances were studied. The blockade of protein synthesis on liver and Walker carcinoma ribosomes and on sus...

journal_title：Chemico-biological interactions

authors： Carmona A,Gonzalez-Cadavid NF

更新日期：1978-09-01 00:00:00

abstract：:Selenocysteine Se-conjugates (e.g. methylselenocysteine) have been shown to be potent chemopreventive and chemoprotective agents, and inducers of apoptosis. Although the mechanism of action remains to be elucidated, beta-elimination of these compounds by beta-lyase enzymes into corresponding selenols, pyruvate and amm...

journal_title：Chemico-biological interactions

authors： Rooseboom M,Vermeulen NP,Groot EJ,Commandeur JN

更新日期：2002-08-15 00:00:00

abstract：:Alcohol dehydrogenase 3 (ADH3) has emerged as an important regulator of protein S-nitrosation in its function as S-nitrosoglutathione (GSNO) reductase. GSNO depletion is associated with various disease conditions, emphasizing the potential value of a specific ADH3 inhibitor. The present study investigated inhibition o...

journal_title：Chemico-biological interactions

authors： Staab CA,Hellgren M,Grafström RC,Höög JO

更新日期：2009-06-15 00:00:00

abstract：:Butyrylcholinesterase (BuChE) is found to have a brain distribution pattern that is distinct from that of acetylcholinesterase (AChE). Neurons containing BuChE are particularly located in the amygdala, hippocampal formation and the thalamus, structures involved in the normal functions of cognition and behavior that ty...

journal_title：Chemico-biological interactions

authors： Darvesh S

更新日期：2013-03-25 00:00:00

abstract：:The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflamma...

journal_title：Chemico-biological interactions

authors： Wang Y,Wei Y,Oguntayo S,Doctor BP,Nambiar MP

更新日期：2013-03-25 00:00:00

abstract：:The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with pa...

journal_title：Chemico-biological interactions

authors： Senthilnathan P,Padmavathi R,Banu SM,Sakthisekaran D

更新日期：2006-02-25 00:00:00

abstract：:Metabolism is a prerequisite for the development of benzene-mediated myelotoxicity. Benzene is initially metabolized via cytochromes P450 (primarily CYP2E1 in liver) to benzene-oxide, which subsequently gives rise to a number of secondary products. Benzene-oxide equilibrates spontaneously with the corresponding oxepin...

journal_title：Chemico-biological interactions

authors： Monks TJ,Butterworth M,Lau SS

更新日期：2010-03-19 00:00:00

abstract：:Human 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1 is an enzyme that acts at the pre-receptor level. It catalyzes the NADPH-dependent reduction of the weak estrogen estrone into the most potent estrogen 17β-estradiol, which exerts proliferative effects via estrogen receptors. Overexpression of 17β-HSD type 1 in e...

journal_title：Chemico-biological interactions

authors： Starčević S,Kocbek P,Hribar G,Rižner TL,Gobec S

更新日期：2011-05-30 00:00:00

abstract：:Tumor cells are able to survive and proliferate in spite of their increased oxidative stress. This was taken as a hint for the implication of oxidants/antioxidants in the proliferation of glial-tumor cells. In the present study, an anti-proliferative effect of Naringenin, an antioxidant against cerebrally implanted C6...

journal_title：Chemico-biological interactions

authors： Sabarinathan D,Mahalakshmi P,Vanisree AJ

更新日期：2011-01-15 00:00:00

abstract：:MicroRNAs (miRNAs) have been regarded as potential modulators in varying ocular diseases, including age-related cataract (ARC). However, the roles of miR-221 in ARC progression and its underlying mechanism remain poorly understood. In this study, human lens epithelial cell line (SRA01/04) was used to investigate the p...

journal_title：Chemico-biological interactions

authors： Gong W,Li J,Wang Y,Meng J,Zheng G

更新日期：2019-06-01 00:00:00

abstract：:The relative toxicities of particulate beryllium phosphate, soluble beryllium sulphate and a beryllium sulphosalicylate complex to a rat liver parencymal derived cell line have been examined in culture. Due to the propensity of beryllium salts to form beryllium phosphate in solution the incubation medium used was free...

journal_title：Chemico-biological interactions

authors： Skilleter DN,Paine AJ

更新日期：1979-01-01 00:00:00

abstract：:This paper reports on time-resolved microfluorimetric measurements on hematoporphyrin-derivative (HpD)-treated lymphocytes. HpD is at present widely used as a tumor-locating and photosensitizing drug. It is therefore of great importance to study the extent to which the HpD uptake process depends on cell functional and...

journal_title：Chemico-biological interactions

authors： Docchio F,Ramponi R,Sacchi CA,Bottiroli G,Freitas I

更新日期：1984-07-01 00:00:00

abstract：:Many benzo[b]furan lignans are known to be biologically active in nature. 2-(3'-Methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]furan-3-carbaldehyde (XH-14) is found as a bioactive component isolated from the plant Salvia miltiorrhiza, commonly known as Danshen, which is a traditional Chinese medicine...

journal_title：Chemico-biological interactions

authors： Sung HY,Jun JG,Kang SW,Kim HS,Shin D,Kang IJ,Kang YH

更新日期：2010-12-05 00:00:00

abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

journal_title：Chemico-biological interactions

authors： Liu H,Yuan L,Yang X,Wang K

更新日期：2003-07-25 00:00:00

abstract：:The relationship between dimethylnitrosamine (DMN) demethylase activity and DMN-induced mutagenesis was investigated in Drosophila melanogaster. The activity of DMN-demethylase was at least 10-fold greater in the Hikone-R strain than in three other Drosophila strains. However, the sex-linked recessive lethal (SLRL) mu...

journal_title：Chemico-biological interactions

authors： Waters LC,Nix CE,Epler JL

更新日期：1983-08-15 00:00:00

abstract：:The effects of norharman (NH) on the metabolism of dibenzo[a,e]-fluoranthene (DBF) and on its fixation on DNA, RNA and proteins have been studied in vitro by incubation with S-9 and microsomes from rats and mice. NH causes a decrease of the activity of microsome monooxygenases proportionally to its concentration but h...

journal_title：Chemico-biological interactions

authors： Perin-Roussel O,Ekert B,Zajdela F

更新日期：1981-10-01 00:00:00

abstract：:An important antitumour effect of SYD-1 (3-[4-chloro-3-nitrophenyl]-1,2,3-oxadiazolium-5-olate) has been shown. We now report the effects of this mesoionic compound on mitochondrial metabolism. SYD-1 (1.5 micromol mg(-1) protein) dose-dependently inhibited the respiratory rate by 65% and 40% in state 3 using sodium gl...

journal_title：Chemico-biological interactions

authors： Halila GC,de Oliveira MB,Echevarria A,Belém AC,Rocha ME,Carnieri EG,Martinez GR,Noleto GR,Cadena SM

更新日期：2007-09-20 00:00:00

abstract：:Intracellular calcium (Ca(2+)i) overload induced by chronic hypoxia alters Ca(2+)i homeostasis, which plays an important role on mediating myocardial injury. We tested the hypothesis that treatment with trimetazidine (TMZ) would improve Ca(2+)i handling in hypoxic myocardial injury. Cardiomyocytes isolated from neonat...

journal_title：Chemico-biological interactions

authors： Wei J,Xu H,Shi L,Tong J,Zhang J

更新日期：2015-07-05 00:00:00

abstract：:American oysters (Crassostrea virginica) were exposed to 0.1 ppm cadmium for 0--15 days in a flowing seawater system and then placed into clean flowing seawater for 24 h prior to sacrifice. Whole oysters were homogenized and a cadmium-binding protein isolated and purified by a process of centrifugation, heat-treatment...

journal_title：Chemico-biological interactions

authors： Ridlington JW,Fowler BA

更新日期：1979-05-01 00:00:00