A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.

Abstract:

BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors determined the minimum alveolar concentration (MAC) for halothane in normothermic, normocarbic ventilated Sprague-Dawley rats previously subjected to a freezing injury of the parietal cortex. METHODS:Injury was produced in halothane-anesthetized rats by applying a cold (-70 degrees C), 4-mm-diameter brass rod to the exposed dura for 5 or 15 s. Animals then were studied 3 days after injury, a time when cerebral metabolism in the ipsilateral hemisphere reaches a minimum. Minimum alveolar concentration was determined using a tail-clamp stimulus, combined with end-tidal anesthetic sampling. In addition, exploratory activity was measured by the open field test just before MAC determination, and spontaneous nocturnal motility was monitored by an electronic motion sensor during the night before testing. RESULTS:In normal animals subjected only to preparatory surgery, MAC was 1.10 +/- 0.07% (mean +/- SD). Almost identical values were found in rats subjected to 5- and 15-s cryogenic injuries (1.11 +/- 0.07% and 1.08 +/- 0.06%, respectively). There were no intergroup differences in open field test results or in spontaneous nocturnal activity. CONCLUSIONS:These results indicate that a focal cortical brain injury that has no obvious neurologic or behavioral effects in the awake rat does not alter halothane requirements.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Todd MM,Weeks JB,Warner DS

doi

10.1097/00000542-199307000-00020

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

139-43

issue

1

eissn

0003-3022

issn

1528-1175

journal_volume

79

pub_type

杂志文章
  • Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model.

    abstract:BACKGROUND:Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal-fetal hemodynamic instability and fetal myocardial depression. The authors' preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane sup...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318283c954

    authors: Ngamprasertwong P,Michelfelder EC,Arbabi S,Choi YS,Statile C,Ding L,Boat A,Eghtesady P,Holland K,Sadhasivam S

    更新日期:2013-04-01 00:00:00

  • Intrathecal opioids and lower urinary tract function: a urodynamic evaluation.

    abstract:BACKGROUND:Intrathecal administration of opioids may cause lower urinary tract dysfunction. In this study, the authors compared the effects of morphine and sufentanil administered intrathecally in a randomized double-blind fashion (two doses each) on lower urinary tract function in healthy male volunteers. METHODS:Uro...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200406000-00023

    authors: Kuipers PW,Kamphuis ET,van Venrooij GE,van Roy JP,Ionescu TI,Knape JT,Kalkman CJ

    更新日期:2004-06-01 00:00:00

  • Postoperative pain facilitates nonthermoregulatory tremor.

    abstract:BACKGROUND:Spontaneous tremor is relatively common in normothermic patients after operation and has been attributed to many causes. The hypothesis that nonthermoregulatory shivering-like tremor is facilitated by postoperative pain was tested. In addition, the effects of intravenous lidocaine on nonthermoregulatory trem...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-199910000-00017

    authors: Horn EP,Schroeder F,Wilhelm S,Sessler DI,Standl T,von dem Busche K,Schulte am Esch J

    更新日期:1999-10-01 00:00:00

  • Postoperative pain control with methadone: influence of supplementary methadone doses and blood concentration--response relationships.

    abstract::The aim of the study was to establish whether there exists a relationship between blood methadone concentration and analgesic response and the intrasubject and intersubject variability in this relationship. Sixteen general surgical (upper abdominal) and orthopedic (spinal fusion) patients were administered methadone (...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:

    authors: Gourlay GK,Willis RJ,Wilson PR

    更新日期:1984-07-01 00:00:00

  • Comparison of the effects of convulsant and depressant barbiturate stereoisomers on AMPA-type glutamate receptors.

    abstract:BACKGROUND:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the a...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199906000-00028

    authors: Kamiya Y,Andoh T,Furuya R,Hattori S,Watanabe I,Sasaki T,Ito H,Okumura F

    更新日期:1999-06-01 00:00:00

  • Prediction of Bispectral Index during Target-controlled Infusion of Propofol and Remifentanil: A Deep Learning Approach.

    abstract:BACKGROUND:The discrepancy between predicted effect-site concentration and measured bispectral index is problematic during intravenous anesthesia with target-controlled infusion of propofol and remifentanil. We hypothesized that bispectral index during total intravenous anesthesia would be more accurately predicted by ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000001892

    authors: Lee HC,Ryu HG,Chung EJ,Jung CW

    更新日期:2018-03-01 00:00:00

  • Consumption of vitamin B12 during sodium nitroprusside administration in humans.

    abstract::In view of evidence suggesting possible participation of cobalamin in cyanide metabolism, the effects of sodium nitroprusside (SNP) infusion on blood cyanide and plasma thiocyanate levels and serum vitamin B12 levels were examined in ten patients undergoing major orthopedic procedures. Whole blood cyanide concentratio...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198104000-00009

    authors: Fahmy NR

    更新日期:1981-04-01 00:00:00

  • Neither xenon nor fentanyl induces neuroapoptosis in the newborn pig brain.

    abstract:BACKGROUND:Some inhalation anesthetics increase apoptotic cell death in the developing brain. Xenon, an inhalation anesthetic, increases neuroprotection when combined with therapeutic hypothermia after hypoxic-ischemic brain injury in newborn animals. The authors, therefore, examined whether there was any neuroapoptoti...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e318294934d

    authors: Sabir H,Bishop S,Cohen N,Maes E,Liu X,Dingley J,Thoresen M

    更新日期:2013-08-01 00:00:00

  • Anterior shift of the dominant EEG rhytham during anesthesia in the Java monkey: correlation with anesthetic potency.

    abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-197704000-00005

    authors: Tinker JH,Sharbrough FW,Michenfelder JD

    更新日期:1977-04-01 00:00:00

  • Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents.

    abstract:BACKGROUND:Insufficient data exist on the production of compound A during closed-system sevoflurane administration with newer carbon dioxide absorbents. METHODS:A modified PhysioFlex apparatus (Dräger, Lübeck, Germany) was connected to an artificial test lung (inflow at the top of the bellow approximately/= 160 ml/min...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200109000-00030

    authors: Versichelen LF,Bouche MP,Rolly G,Van Bocxlaer JF,Struys MM,De Leenheer AP,Mortier EP

    更新日期:2001-09-01 00:00:00

  • Does perioperative myocardial ischemia lead to postoperative myocardial infarction?

    abstract::To determine if a relationship exists between perioperative myocardial ischemia (ST segment depression greater than or equal to 0.1 mV) and postoperative myocardial infarction (PMI), nonparticipating observers recorded all ECG, hemodynamic, and other events between arrival of patients in the operating room and onset o...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198502000-00002

    authors: Slogoff S,Keats AS

    更新日期:1985-02-01 00:00:00

  • Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.

    abstract:BACKGROUND:Prescription opioid abuse is a significant concern in treating chronic pain, yet few studies examine how neuropathic pain alters the abuse liability of commonly abused prescription opioids. METHODS:Normal and spinal nerve ligated (SNL) rats were implanted with electrodes into the left ventral tegmental area...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3182330448

    authors: Ewan EE,Martin TJ

    更新日期:2011-12-01 00:00:00

  • Automated echocardiographic analysis. Examination of serial intraoperative measurements.

    abstract:BACKGROUND:Although transesophageal echocardiography allows continuous intraoperative cardiac monitoring, the technique has been limited by the lack of a method for realtime, quantitative assessment of cardiac chamber size and systolic function. Automated border detection (ABD), based on an analysis of integrated backs...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199508000-00008

    authors: Perrino AC Jr,Luther MA,O'Connor TZ,Cohen IS

    更新日期:1995-08-01 00:00:00

  • Human subthalamic neuron spiking exhibits subtle responses to sedatives.

    abstract:BACKGROUND:During deep brain stimulation implant surgery, microelectrode recordings are used to map the location of targeted neurons. The effects produced by propofol or remifentanil on discharge activity of subthalamic neurons were studied intraoperatively to determine whether they alter neuronal activity. METHODS:Mi...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e3182217126

    authors: Maciver MB,Bronte-Stewart HM,Henderson JM,Jaffe RA,Brock-Utne JG

    更新日期:2011-08-01 00:00:00

  • Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery.

    abstract:BACKGROUND:Memory function under anesthesia is undesired but may arise from light hypnosis as well as stress-enhanced learning during surgery. The bispectral index (BIS, Aspect Medical Systems, Norwood, MA) is a monitor of hypnotic state that can help to avoid light hypnosis (i.e., BIS above 60). This study tested the ...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e3181b05f0b

    authors: Kerssens C,Gaither JR,Sebel PS

    更新日期:2009-09-01 00:00:00

  • Hamilton acute pain service safety study: using root cause analysis to reduce the incidence of adverse events.

    abstract:BACKGROUND:Although intravenous patient-controlled analgesia opioids and epidural analgesia offer improved analgesia for postoperative patients treated on an acute pain service, these modalities also expose patients to some risk of serious morbidity and even mortality. Root cause analysis, a process for identifying the...

    journal_title:Anesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ALN.0b013e3182a76f59

    authors: Paul JE,Buckley N,McLean RF,Antoni K,Musson D,Kampf M,Buckley D,Marcoux M,Frketich R,Thabane L,Cheng J

    更新日期:2014-01-01 00:00:00

  • Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling.

    abstract:BACKGROUND:Whether the fetus can experience pain remains controversial. During the last half of pregnancy, the neuroanatomic connections for nociception are in place, and the human fetus mounts sizable stress responses to physical insults. Analgesia has been recommended for intrauterine procedures or late termination, ...

    journal_title:Anesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000542-200110000-00008

    authors: Fisk NM,Gitau R,Teixeira JM,Giannakoulopoulos X,Cameron AD,Glover VA

    更新日期:2001-10-01 00:00:00

  • Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.

    abstract:BACKGROUND:Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neur...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0000000000000017

    authors: Harris RE,Napadow V,Huggins JP,Pauer L,Kim J,Hampson J,Sundgren PC,Foerster B,Petrou M,Schmidt-Wilcke T,Clauw DJ

    更新日期:2013-12-01 00:00:00

  • A new noninvasive method to measure blood pressure: results of a multicenter trial.

    abstract:BACKGROUND:Blood pressure (BP) monitoring with arterial waveform display requires an arterial cannula. We evaluated a new noninvasive device, Vasotrac (Medwave, Arden Hills, MN) that provides BP measurements approximately every 12-15 beats and displays pulse rate and a calibrated arterial waveform for each BP measureme...

    journal_title:Anesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00000542-199909000-00021

    authors: Belani K,Ozaki M,Hynson J,Hartmann T,Reyford H,Martino JM,Poliac M,Miller R

    更新日期:1999-09-01 00:00:00

  • A Practical Training Program for Peripheral Radial Artery Catheterization in Adult Patients: A Prospective, Randomized Controlled Trial.

    abstract:BACKGROUND:The main cause of unsuccessful peripheral radial artery catheterization using traditional palpation is imprecisely locating the arterial center. The authors evaluated factors causing disparities between the arterial centers determined by palpation versus ultrasound. The authors applied them to create and tes...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0000000000001263

    authors: Nakayama Y,Inagaki Y,Nakajima Y,Sessler DI,Mukai N,Ogawa S,Mizobe T,Sawa T

    更新日期:2016-10-01 00:00:00

  • Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain.

    abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000002229

    authors: Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

    更新日期:2018-07-01 00:00:00

  • Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance.

    abstract:BACKGROUND:Intraoperative remifentanil infusions have been associated with postoperative opioid-induced hyperalgesia and tolerance. Using a previously identified subpopulation of spinal neurons that displays an augmentation in N-methyl-D-aspartate (NMDA) receptor current after chronic morphine, investigations were unde...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0b013e31817f4c5d

    authors: Zhao M,Joo DT

    更新日期:2008-08-01 00:00:00

  • Effects of halothane on the sarcoplasmic reticulum Ca2+ stores and contractile proteins in rabbit pulmonary arteries.

    abstract:BACKGROUND:The authors' purpose of this study was to elucidate the mechanisms of direct effects of halothane on the contractile proteins and Ca2+ release from the sarcoplasmic reticulum Ca2+ stores using isolated skinned strips (sarcolemma permealized with saponin) from rabbit pulmonary arteries. METHODS:The sarcoplas...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199804000-00031

    authors: Su JY,Tang LJ

    更新日期:1998-04-01 00:00:00

  • The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.

    abstract::The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198704000-00015

    authors: Marshall C,Kim SD,Marshall BE

    更新日期:1987-04-01 00:00:00

  • Performance assessment in airway management training for nonanesthesiology trainees: an analysis of 4,282 airway procedures performed at a level-1 trauma center.

    abstract:BACKGROUND:Although the use of an anesthesiology "airway" rotation to train the nonanesthesiologist is commonly employed, little data exist on the utility, clinical exposure, and outcomes of these programs. METHODS:A prospectively collected observational dataset of airway procedures completed by trainees in a 4-week, ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/ALN.0000000000000064

    authors: Grissom TE,Sappenfield J,Galvagno SM Jr,Cherry SV,Chang YC,Hu PF

    更新日期:2014-01-01 00:00:00

  • Muscular Tissue Oxygen Saturation and Posthysterectomy Nausea and Vomiting.

    abstract:BACKGROUND:Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea and vomiting in some patients. This trial tested the hypothesis that muscular tissue oxygen saturation-guided intraoperative care reduces postoperative nausea and vomiting. METHODS:This multicenter, pragma...

    journal_title:Anesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/ALN.0000000000003305

    authors: Li G,Tian DD,Wang X,Feng X,Zhang W,Bao J,Wang DX,Ai YQ,Liu Y,Zhang M,Xu M,Mu DL,Zhao X,Dai F,Yang JJ,Che X,Yanez D,Guo X,Meng L,iMODIPONV Research Group.

    更新日期:2020-08-01 00:00:00

  • Analysis of strategies to decrease postanesthesia care unit costs.

    abstract:BACKGROUND:The goal of this study was to identify interventions that anesthesiologists can make to decrease total costs of a postanesthesia care unit (PACU). METHODS:Data were collected retrospectively from patients who underwent ambulatory surgery at our tertiary care center. RESULTS:Supplies and medications account...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-199501000-00013

    authors: Dexter F,Tinker JH

    更新日期:1995-01-01 00:00:00

  • Cerebral oxygen saturation measured by near-infrared spectroscopy and jugular venous bulb oxygen saturation during arthroscopic shoulder surgery in beach chair position under sevoflurane-nitrous oxide or propofol-remifentanil anesthesia.

    abstract:BACKGROUND:We examined the effects of different anesthetics on cerebral oxygenation and systemic hemodynamics in patients undergoing surgery in beach chair position (BCP). Jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) were determined while patients were placed from...

    journal_title:Anesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/ALN.0b013e31825154d2

    authors: Jeong H,Jeong S,Lim HJ,Lee J,Yoo KY

    更新日期:2012-05-01 00:00:00

  • Lidocaine and pentylenetetrazol seizure thresholds in cats are not reduced after enflurane anesthesia.

    abstract::Some previous reports indicate that the excitability of the brain may be increased for days following enflurane anesthesia. The authors investigated this possibility in cats by determining whether or not pentylenetetrazol- (Metrazol) or lidocaine-seizure thresholds decreased after repeated enflurane exposure. The lido...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-198105000-00010

    authors: Heavner JE,Amory DW

    更新日期:1981-05-01 00:00:00

  • Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model.

    abstract:BACKGROUND:Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to selective, prolonged opening of the transient receptor potential V1 ion channel, which is localized mainly to C-fiber primary afferent nociceptive sensory neurons. Following work in laboratory animals, the authors explored the ...

    journal_title:Anesthesiology

    pub_type: 杂志文章

    doi:10.1097/00000542-200511000-00020

    authors: Brown DC,Iadarola MJ,Perkowski SZ,Erin H,Shofer F,Laszlo KJ,Olah Z,Mannes AJ

    更新日期:2005-11-01 00:00:00