A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.


BACKGROUND:A focal cortical cryogenic brain injury has been reported to reduce the brain pentobarbital concentrations needed to prevent movement in response to pain in rats. This occurred despite any apparent behavioral changes in the awake animals. To determine whether this was true with other anesthetics, the authors determined the minimum alveolar concentration (MAC) for halothane in normothermic, normocarbic ventilated Sprague-Dawley rats previously subjected to a freezing injury of the parietal cortex. METHODS:Injury was produced in halothane-anesthetized rats by applying a cold (-70 degrees C), 4-mm-diameter brass rod to the exposed dura for 5 or 15 s. Animals then were studied 3 days after injury, a time when cerebral metabolism in the ipsilateral hemisphere reaches a minimum. Minimum alveolar concentration was determined using a tail-clamp stimulus, combined with end-tidal anesthetic sampling. In addition, exploratory activity was measured by the open field test just before MAC determination, and spontaneous nocturnal motility was monitored by an electronic motion sensor during the night before testing. RESULTS:In normal animals subjected only to preparatory surgery, MAC was 1.10 +/- 0.07% (mean +/- SD). Almost identical values were found in rats subjected to 5- and 15-s cryogenic injuries (1.11 +/- 0.07% and 1.08 +/- 0.06%, respectively). There were no intergroup differences in open field test results or in spontaneous nocturnal activity. CONCLUSIONS:These results indicate that a focal cortical brain injury that has no obvious neurologic or behavioral effects in the awake rat does not alter halothane requirements.






Todd MM,Weeks JB,Warner DS




Has Abstract


1993-07-01 00:00:00












  • Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia.

    abstract:BACKGROUND:Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C>T, 1298A>C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia. This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop hig...


    pub_type: 杂志文章


    authors: Nagele P,Zeugswetter B,Wiener C,Burger H,Hüpfl M,Mittlböck M,Födinger M

    更新日期:2008-07-01 00:00:00

  • A new noninvasive method to measure blood pressure: results of a multicenter trial.

    abstract:BACKGROUND:Blood pressure (BP) monitoring with arterial waveform display requires an arterial cannula. We evaluated a new noninvasive device, Vasotrac (Medwave, Arden Hills, MN) that provides BP measurements approximately every 12-15 beats and displays pulse rate and a calibrated arterial waveform for each BP measureme...


    pub_type: 杂志文章,多中心研究


    authors: Belani K,Ozaki M,Hynson J,Hartmann T,Reyford H,Martino JM,Poliac M,Miller R

    更新日期:1999-09-01 00:00:00

  • Plasma protein binding of thiopental in patients with impaired renal or hepatic function.

    abstract::Binding of thiopental to proteins in plasma from healthy, cirrhotic, and uremic subjects was studied using equilibrium dialysis. In plasma from healthy volunteers 28.0 plus or minus 0.9 per cent of thiopental was unbound. In plasma from patients with hepatic disease 53.0 plus or minus 2.1 per cent was unbound, while i...


    pub_type: 杂志文章


    authors: Ghoneim MM,Pandya H

    更新日期:1975-05-01 00:00:00

  • The effect of isoflurane-induced hypotension on cerebral blood flow and cerebral metabolic rate for oxygen in humans.

    abstract::Deliberate hypotension was induced with isoflurane (mean inspired concentration 2.3 +/- 1.0%) in 12 patients undergoing craniotomy for clipping of cerebral aneurysms. Global cerebral blood flow (CBF) was measured before, during, and after hypotension. Arterio-venous O2 content difference was measured concomitantly, an...


    pub_type: 杂志文章


    authors: Newman B,Gelb AW,Lam AM

    更新日期:1986-03-01 00:00:00

  • A comparison of the effects of halothane and tetrodotoxin on the regional repolarization characteristics of canine Purkinje fibers.

    abstract::The effects of halothane, tetrodotoxin (TTX), veratridine (VTD), and alterations of extracellular calcium ion concentration [Ca++]0) on regional differences of canine Purkinje fiber action potential duration (APD50 and APD90) were investigated in vitro at a paced rate of 75 beats per min. Under control conditions (n =...


    pub_type: 杂志文章


    authors: Turner LA,Marijic J,Kampine JP,Bosnjak ZJ

    更新日期:1990-12-01 00:00:00

  • Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.

    abstract:BACKGROUND:The degree to which intrathecally administered morphine can alleviate hypersensitivity in animals after peripheral nerve injury is controversial, and the mechanisms by which morphine works in these circumstances are uncertain. In normal animals, morphine induces adenosine release, and in vitro data suggest t...


    pub_type: 杂志文章


    authors: Zhang Y,Conklin DR,Li X,Eisenach JC

    更新日期:2005-02-01 00:00:00

  • Multiport epidural catheters: does the air test work?

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    pub_type: 临床试验,杂志文章


    authors: Leighton BL,Topkis WG,Gross JB,Arkoosh VA,Lee SH,Huffnagle HJ,Huffnagle SL

    更新日期:2000-06-01 00:00:00

  • Complications of different ventilation strategies in endoscopic laryngeal surgery: a 10-year review.

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    pub_type: 杂志文章


    authors: Jaquet Y,Monnier P,Van Melle G,Ravussin P,Spahn DR,Chollet-Rivier M

    更新日期:2006-01-01 00:00:00

  • The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons.

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    pub_type: 杂志文章


    authors: Van den Berg RJ,Van Soest PF,Wang Z,Grouls RJ,Korsten HH

    更新日期:1995-06-01 00:00:00

  • Bupivacaine-induced cardiac arrhythmias in sheep.

    abstract::Controversy persists about the cardiac toxicity of bupivacaine if accidentally administered intravenously during regional anesthesia. Using awake, unanesthetized sheep, we evaluated the cardiac effects of low and high equivalent doses of lidocaine and bupivacaine given intravenously over 10 s. All animals convulsed wi...


    pub_type: 杂志文章


    authors: Kotelko DM,Shnider SM,Dailey PA,Brizgys RV,Levinson G,Shapiro WA,Koike M,Rosen MA

    更新日期:1984-01-01 00:00:00

  • Effect of halothane anesthesia on glucose utilization and production in adolescents.

    abstract:BACKGROUND:It should be possible to avoid variations in plasma glucose concentration during anesthesia by adjusting glucose infusion rate to whole-body glucose uptake. To study this hypothesis, we measured glucose utilization and production, before and during halothane anesthesia. METHODS:After an overnight fast, six ...


    pub_type: 杂志文章


    authors: Sbaï D,Jouvet P,Soulier A,Pénicaud L,Merckx J,Bresson JL

    更新日期:1995-05-01 00:00:00

  • Cervical spinal cord, root, and bony spine injuries: a closed claims analysis.

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    pub_type: 杂志文章


    authors: Hindman BJ,Palecek JP,Posner KL,Traynelis VC,Lee LA,Sawin PD,Tredway TL,Todd MM,Domino KB

    更新日期:2011-04-01 00:00:00

  • The effect of fentanyl anesthesia and intrathecal naloxone on neurologic outcome following spinal cord injury in the rat.

    abstract::Whereas opiate receptor agonists have resulted in spinal cord damage; opiate receptor antagonists have demonstrated protection against spinal cord injury. Because opioids are used in clinical anesthesia, the effect of an opiate antagonist was evaluated on neurologic outcome in a rat model of spinal cord injury occurri...


    pub_type: 杂志文章


    authors: Cole DJ,Drummond JC,Shapiro HM,Hertzog RE,Brauer FS

    更新日期:1989-09-01 00:00:00

  • Comparison of the TOFscan and the TOF-Watch SX during Recovery of Neuromuscular Function.

    abstract:WHAT WE ALREADY KNOW ABOUT THIS TOPIC:WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Quantitative neuromuscular monitoring is required to ensure neuromuscular function has recovered completely at the time of tracheal extubation. The TOFscan (Drager Technologies, Canada) is a new three-dimensional acceleromyograph...


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  • Postoperative pain facilitates nonthermoregulatory tremor.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1999-10-01 00:00:00

  • Effect of low-dose droperidol on the QT interval during and after general anesthesia: a placebo-controlled study.

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    authors: Schlobohm RM,Falltrick RT,Quan SF,Katz JA

    更新日期:1981-10-01 00:00:00

  • The "educated hand". Can anesthesiologists assess changes in neonatal pulmonary compliance manually?

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    pub_type: 杂志文章


    authors: Spears RS Jr,Yeh A,Fisher DM,Zwass MS

    更新日期:1991-10-01 00:00:00

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    abstract:BACKGROUND:Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on...


    pub_type: 杂志文章


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    更新日期:1997-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Ramamoorthy C,Kovarik WD,Winn RK,Harlan JM,Sharar SR

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  • Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model.

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    pub_type: 杂志文章


    authors: Honickel M,Braunschweig T,van Ryn J,Ten Cate H,Spronk HM,Rossaint R,Grottke O

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    pub_type: 杂志文章


    authors: Gordon MA,Urban MK,O'Connor T,Barash PG

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    pub_type: 杂志文章


    authors: Amakawa K,Adachi N,Liu K,Ikemune K,Fujitani T,Arai T

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    pub_type: 杂志文章


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    更新日期:2015-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Plested AJ,Wildman SS,Lieb WR,Franks NP

    更新日期:2004-02-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Baker MT,Naguib M

    更新日期:2005-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Lerman J,Oyston JP,Gallagher TM,Miyasaka K,Volgyesi GA,Burrows FA

    更新日期:1990-10-01 00:00:00

  • Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy.

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    pub_type: 杂志文章


    authors: Ossipov MH,Harris S,Lloyd P,Messineo E,Lin BS,Bagley J

    更新日期:1990-12-01 00:00:00