Abstract:
BACKGROUND:Interleukin (IL)-18 is a proinflammatory cytokine involved in the regulation of cell-mediated and innate immune responses to infection, trauma, and inflammation. Elevated levels of IL-18 have been noted to correlate with organ dysfunction after injury. This study evaluates the relationship between IL-18 promoter polymorphisms and the development of sepsis after injury. METHODS:DNA was extracted from peripheral leukocytes of trauma patients with an injury severity score of 16 or greater. Patient clinical course was followed for the development of sepsis as an endpoint. Two SNPs (-607bp and -137bp) were amplified using polymerase chain reaction. Alleles were identified via agarose gel separation. Genotypes were then determined and correlated with patient data. Postinjury IL-18 levels were determined by enzyme-linked immunoassay. RESULTS:Sixty-six patients were evaluated; 36 (52%) developed sepsis. Each SNP had 2 alleles and 3 genotypes. The SNP at -607bp had an allelic frequency of 59% for C and 41% for A; whereas -137bp was a G 79% of the time and a C 21% of the time. Individually, each SNP had no direct correlation between the patient's genotype and development of infection. However, when the -607bp CA genotype was combined with the -137bp GC genotype (CA/GC), only 4 patients (27%) developed sepsis (P =.02). CONCLUSIONS:This study supports the conclusion that IL-18 genetic promoter polymorphisms correlate with the development of postinjury sepsis. Further investigation is needed to identify the impact of variation in genotype across a range of genes involved in connected regulatory pathways.
journal_name
Surgeryjournal_title
Surgeryauthors
Stassen NA,Breit CM,Norfleet LA,Polk HC Jrdoi
10.1067/msy.2003.248subject
Has Abstractpub_date
2003-08-01 00:00:00pages
351-6issue
2eissn
0039-6060issn
1532-7361pii
S0039606003002162journal_volume
134pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS:Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Orga...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.04.039
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Thromboprophylaxis aims to reduce venous thromboembolism but has the potential to increase bleeding. We sought to evaluate the risk of venous thromboembolism and transfusion after major abdominopelvic procedures and to quantify the association of the procedure with venous thromboembolism. METHODS:The Americ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.05.050
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Sodium diphenylhydantoin (DpH) (phenytoin) was first introduced as an antiepileptic in 1938. One of its side effects, gingival hyperplasia, prompted investigation into the possible application of this drug as a promoter of wound healing. Since the late 1950s phenytoin has been used in a variety of clinical s...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::To further define the clinicopathologic features and determinants of survival, we reviewed the cases of 110 patients with primary hepatic malignancy managed surgically between 1975 and 1986. Presenting signs of symptoms were pain (57%), fatigue (48%), abdominal mass (40%), and weight loss (33%). Twenty-six percent of ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Because high calcium concentration in vitro stimulates muscle proteolysis, calcium has been implicated in the pathogenesis of increased muscle breakdown in different catabolic conditions. Protein breakdown in skeletal muscle is increased during sepsis, but the effect of sepsis on muscle calcium uptake and content is n...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::The relationship between the cyclosporine A (CSA) dose and rejection of varying lengths of small-bowel grafts was studied in a rat heterotopic microsurgical small-bowel transplantation model involving a haploidentical strain combination. When Lewis X Brown Norway F1 hybrid (LBN) small-bowel grafts were transplanted in...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::An occlusion of the superior vena cava by a tumor thrombus extending into the right atrium was diagnosed in three patients with a follicular thyroid cancer. All patients showed the typical clinical picture of the superior vena cava syndrome. A right parasternal thoracotomy was performed for preparation of the major ve...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::To determine whether intraoperative urinary output was predictive of postoperative renal function, mean urinary output and lowest hourly urinary output were measured in 137 patients during operation for aortic reconstruction. Pulmonary capillary wedge pressure was kept within normal limits. If urinary output was less ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract::Peripheral parenteral nutrition avoids the use of central lines and is a useful means of nutritional support for selected patients. Amino acids alone have been used for peripheral parenteral nutrition and have been shown to give near nitrogen equilibrium. The addition of small amounts of dextrose to amino acids furthe...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1982-10-01 00:00:00
abstract::Human beta-2 microglobulin (beta-2 M) is released into body fluids as a result of cell turnover, excreted by the kidney, and catabolized in the proximal tubule. Urinary excretion rates constitute a sensitive index of renal tubular function. The beta-2 M urine-to-serum ratio was measured in 25 patients with primary hyp...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract::With the aim of developing guidelines for investigation and management of adrenal incidentalomas, 2066 patients with adrenal masses were analyzed from a total of 61,054 computerized tomographic (CT) scans done from 1985 through 1989. Excluding patients with previous or concurrent malignancies, adrenal tumors localized...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF) and melphalan for advanced extremity malignancies achieves significant complete response rates. To study molecular mechanisms underlying this response, a nude rat ILP model with a human melanoma xenograft was developed. METHODS:NIH1286 hum...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2003.113
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:The world's poorest 2 billion people, benefit from no more than about 3.5% of the world's operative procedures. The burden of surgical disease is greatest in Africa, where operations could save many lives. Previous facility-based studies have described operative procedure caseloads, but prospective studies i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.03.022
更新日期:2015-07-01 00:00:00
abstract::The smuggling of illicit drugs by concealing them within the human body has become a widespread practice. Those individuals who transport packaged drugs are commonly known as "body packers" or "mules". "Body stuffers," on the other hand, are individuals who emergently place the contraband in a body orifice when they s...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:In living donor liver transplantation, variations in donor vascular anatomy, recipient portal vein thrombosis, short donor vessel length, and reconstitution of the anterior sector outflow in right lobe grafts often make complex and innovative vascular reconstructions necessary, which require the use of exten...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.10.008
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Bioresorbable membranes composed of hyaluronic acid and carboxymethylcellulose (HA/CMC) are the most effective method to prevent intra-abdominal adhesions; however, their efficacy may be limited to the site of application. Previous studies in our laboratory have shown that the intraperitoneal administration ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.01.024
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Rapid intraoperative parathyroid hormone (RI-PTH) assay is used to guide adequacy of resection during operation for hyperparathyroidism. We compared the RI-PTH assay (15 minutes) with a standard PTH assay, determined whether the PTH half-life varied between patients, and constructed a kinetic analysis of the...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2099.101835
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:We determined the effect of infusing the iron chelator deferoxamine complexed to hetastarch on the degree of lung dysfunction and systemic abnormalities produced by a severe smoke exposure. METHODS:Adult sheep were given a smoke exposure under anesthesia that produced a peak carboxyhemoglobin between 40% an...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80121-8
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:K-ras oncogene mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in their molecular pathogenesis. However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear. This study evaluates pancre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90181-1
更新日期:1997-01-01 00:00:00
abstract::Seven surgically proven cases of a traumatic rupture of the right hemidiaphragm with a hepatic herniation were preoperatively diagnosed by radionuclide liver-spleen imagings, and they were retrospectively analyzed. All injuries resulted from blunt traumatic injury including automobile accidents, and there were associa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Serum concentrations of fatty acid binding protein 4, an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study were to assess relationships among Roux-en-Y gastric bypass, intensive lifestyle modification and medical man...
journal_title:Surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.surg.2018.08.007
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess validity of a human factors error assessment method for evaluating resident performance during a simulated operative procedure. METHODS:Seven postgraduate year 4-5 residents had 30 minutes to complete a simulated laparoscopic ventral hernia (LVH) repair on day 1 of a nati...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.04.010
更新日期:2015-11-01 00:00:00
abstract::Serial determinations of human thymus-dependent (T) and bone marrow-dependent (B) peripheral blood lymphocytes were performed to detect changes in activity of these rosette-forming cells in five groups of patients: controls; chronic renal failure (CRF) patients; dialysis patients receiving pretransplant splenectomy; 5...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:For the normal resolution of an acute inflammatory response, neutrophil (PMN) apoptosis is essential to maintain immune homeostasis and to limit inappropriate host tissue damage. A delay in PMN apoptosis has been implicated in the pathogenesis of the systemic inflammatory response syndrome (SIRS). Dopamine, ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::An expandable intraluminal graft mounted coaxially over an angioplasty balloon catheter was used in dog arteries. The graft, a wire mesh tube that has the ability to retain its expanded shape, opposes elastic recoil of the arterial wall after maximum balloon inflation. Eighteen grafts were placed in the abdominal aort...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Intraoperative parathyroid hormone (IOPTH) monitoring is well-established in operation for primary hyperparathyroidism (HPT). In diseases where total parathyroidectomy (tPx) is a treatment option its reliability to predict postoperative residual parathyroid hormone (PTH) remains in question. METHODS:Thirty-...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.02.003
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Both weight loss and gastrointestinal surgery for obesity can cause liver disease, making their role in the treatment of obesity-related liver disease controversial. METHODS:Six hundred eighty-nine severely obese women (n=551) and men (n=138), BMI=47+/-9 kg.m(-2) (mean+/-SD), without known liver disease, un...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2003.10.003
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic techniques are being used increasingly in the repair of ventral hernias and offer the potential benefits of a shorter hospital stay, decreased wound complications, and possibly a lower recurrence rate. Despite good results from high-volume centers, significant complications may occur with this a...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.06.054
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The Affordable Care Act aims to improve patient outcomes. Race/ethnicity and insurance status impact outcomes after traumatic brain injury. We sought to gauge the Affordable Care Act's effect on outcomes after traumatic brain injury, as graded by race/ethnicity and insurance status. METHODS:The National Tra...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.09.006
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Follicular thyroid cancer is a heterogeneous disease including follicular and Hürthle cell and tumors with and without vascular and major capsular invasion. Analyses of prognosis and risk groups have been criticized for not taking these differences into account. METHODS:Retrospective analysis was done of 24...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00