Abstract：
:Normoalbuminuric insulin-dependent diabetic (IDDM) patients may present higher rates of urinary albumin excretion after submaximal exercise at a standard intensity. To evaluate whether the urinary albumin excretion of IDDM patients is increased after maximal and submaximal exercise when exercise intensities are adjusted according to individual lactate thresholds, 16 normoalbuminuric IDDM patients (mean time from diagnosis 8 years) and 13 normal controls exercised for 20 min at intensities corresponding to 90% of the first and second lactate thresholds and to maximal tolerance on different days. Urinary albumin excretion, blood lactate concentration, heart rate and blood pressure were measured. Metabolic and cardiovascular responses to submaximal and maximal exercise were similar for patients and controls. After exercise at 90% of the first lactate threshold neither patients or controls demonstrated significant changes in urinary albumin excretion. After exercise at 90% of the second lactate threshold both patients and controls demonstrated a similar increase in urinary albumin excretion. After maximal exercise both patients and controls demonstrated marked and similar elevation in the urinary albumin excretion. There was a significant correlation (r = 0.74, P < 0.001) between blood lactate levels at the end of exercise and the decimal logarithm of post-exercise urinary albumin excretion of the diabetic patients. Thus, when exercise intensities are adjusted for lactate thresholds, normoalbuminuric IDDM patients present normal intensity-related urinary albumin excretion during exercise. These data suggest that previously observed differences in exercise induced albuminuria in IDDM patients might be related to inappropriate standardization of submaximal exercise intensities.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Bertoluci MC,Friedman G,Schaan BD,Ribeiro JP,Schmid Hdoi
10.1016/0168-8227(93)90117-nsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
217-25issue
3eissn
0168-8227issn
1872-8227pii
0168-8227(93)90117-Njournal_volume
19pub_type
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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更新日期：2011-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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更新日期：2020-10-06 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2019-05-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2012.09.017
更新日期：2012-11-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
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更新日期：2002-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2005-03-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2005-04-01 00:00:00
