Abstract:
:To study the effect of old age on phenytoin pharmacokinetics, twelve young and nine old adults aged 21.7 +/- 1.8 and 71.8 +/- 4.9 years respectively, were studied. No significant differences of phenytoin indicating the drug distribution and elimination does not change with aging. After oral administration, significant differences were observed between young and old adults for absorption, measured through oral residence half time (36.89 +/- 5.07 h in young and 29.25 +/- 8.64 h in old adults p < 0.05), absorption half time (6.91 +/- 3.6 vs 3.29 +/- 2.35 h) and maximal concentration (1.45 +/- 0.37 vs 2.0 +/- 0.79 micrograms/ml). However, absolute bioavailability of the drug was not different in both age groups (72.9 and 67.6% in young and old adults respectively). It is concluded that no modifications of phenytoin dosage are necessary in elderly people.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Estruch J,Galdames D,Martinetti A,Saavedra Isubject
Has Abstractpub_date
1992-10-01 00:00:00pages
1106-9issue
10eissn
0034-9887issn
0717-6163journal_volume
120pub_type
杂志文章abstract::This is the conference given by Jorge Mardones, Emeritus Professor of the University of Chile on the occasion of receiving the Juvenal Hernández award. A biographical trace of Professor Mardones scientific career and its motivations, including his relation to outstanding Chilean scientists is included. A remembrance o...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::Dual-photon bone densitometry of the lumbar spine and hips was performed in 11 patients (9 females) with asymptomatic primary hyperparathyroidism and in 11 control subjects. The age was 54.7 +/- 14.8 years. The asymptomatic state of the disease was established by the absence of clinical or radiologic evidence of renal...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::The author reminds the reform of medical education of 1945 in which he participated as a student. It was approved by the Decree #201 of april 2, introducing Chilean medicine into a new era of modernity. The reform was planned and conducted by professors Hernán Alessandri (1900-1980) and Alejandro Garretón (1900-1980) ...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patients risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there a...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000800011
更新日期:2016-08-01 00:00:00
abstract::We studied plasma lipoproteins in 2 groups of 50 women each, one with a high (A) and the other low socio-economic status (B). Age, caloric intake, energy output and weight for height relation were comparable in both groups. A significant difference was found in plasma levels of triglycerides (A = 138.9 vs B = 104.8 mg...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant ge...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:HCAM or CD44 is a multifunctional cell adhesion molecule, related to cell-cell, cell-extracellular matrix interactions and involved in tumor invasion. AIM:To study the importance of CD44 expression in subserous gallbladder carcinoma. MATERIAL AND METHODS:One hundred five samples (93 female) of subserous ga...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::Medicine is progressively loosing its prestige and efficacy and needs to rebuild the moral values that maintain the tacit social contract subscribed between doctors and patients. This altruistic commitment to serve people has been devaluated by changes in health systems, by advances in knowledge and by social and econ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000500016
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Stroke is the second cause of mortality and the first cause of morbidity in Chile and worldwide. Nowadays there is a major interest in introducing new therapies applying evidence based medicine for these patients. AIM:To describe the clinical profile of patients attended after a stroke, to determine stroke ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005001100002
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Professional Social Responsibility is now imperative for the practice of medicine. However, there are no instruments to assess it among physicians. AIM:To construct and evaluate the factorial structure and reliability of a questionnaire designed to measure socially responsible behavior in physicians. MATER...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000100014
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Inferior vena cava (IVC) filters are used to prevent massive pulmonary embolism in cases where anticoagulation is contraindicated or has failed. It is usually implanted below the renal veins. In a few cases it is necessary to deploy the filter above them, with theoretical risk of secondary renal failure. AI...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008001200005
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The pathophysiological hallmark of the hepatorenal syndrome (HRS) is renal vasoconstriction. Doppler ultrasonography can be used to assess the vascular resistance in small renal intraparenchymal vessels through analysis of the Doppler waveform by a parameter termed Resistive Index (RI). We postulated that th...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acu...
journal_title:Revista medica de Chile
pub_type:
doi:10.4067/S0034-98872017000400013
更新日期:2017-04-01 00:00:00
abstract::The first and so far the only form of isolated growth hormone deficiency to accede to molecular genetic analysis is IGHD 1A, which has an autosomal recessive mode of inheritance. Several sizes of growth hormone gene deletions, ranging from 6.7 to 8.5 Kb are responsible for IGHD 1A. It has been reported that children w...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:Annually, acute bronchiolitis (AB) occurrence peaks during winter and is probably associated with air pollution. AIM:To relate the number of ambulatory consultations, emergency and hospital admission due to AB with climatic factors and air pollution. PATIENTS AND METHODS:Patients of less than 1 year old wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::A toxicology testing is the search by the laboratory of the possible etiologic agents that can cause poisoning. Given the wide variety of substances that can poison a person, the laboratories should work coordinated with the emergency wards in order to determine the appropriate tests menu and the required turn around ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009001000018
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Sepsis-induced acute kidney injury (AKI) is an early and frequent organ dysfunction, associated with increased mortality. AIM:To evaluate the impact of macrohemodynamic and microcirculatory changes on renal function and histology during an experimental model of intra-abdominal sepsis. MATERIAL AND METHODS:...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000500001
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:There is consensus in promoting the selective use of glucocorticoids (GC) in the peri-operative period of transsphenoidal surgery (TE) for pituitary adenomas (PA). AIM:To evaluate the safety of a selective glucocorticoid administration protocol and the usefulness of immediate postoperative cortisol levels a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000900004
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The Chilean population has inadequate lifestyles and high prevalence of chronic diseases. AIM:To analyze eating behaviors, nutritional status and history of previous diseases, in students of higher education. MATERIAL AND METHODS:Cross-sectional study in students of 54 higher education centers across the c...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872012001200008
更新日期:2012-12-01 00:00:00
abstract::The aim of this work was to analyze the global incidence of congenital malformations at the Maternity of University of Chile Clinical Hospital in the periods between 1971 and 1977 and between 1982 and 1992. A significant and sustained increase in incidence was observed in the first period from 10.64 per 1000 born aliv...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:High calorie foods, especially high in sugar and sodium may have an addictive potential. Experimental rats are able to develop symptoms and neurochemical changes, comparable to those observed in drug abuse, when they are exposed intermittently to sucrose. AIM:To evaluate the association between nutritional ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000500006
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The absence of lymph node involvement (N0) in gastric cancer is associated with a better survival. However some N0 gastric tumors still have a bad prognosis. AIM:To study demographic and morphological variables associated with prognosis in N0 gastric carcinoma. MATERIAL AND METHODS:Review of pathological r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000400003
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Scientific Ethics is the theory and praxis of decisions. Philosophical Ethics is presented as the theory and praxis of the good. As the good differs among cultures, Philosophical Ethics is dependent on the endo-cultural good conception. The decision (included that one of adhesion or not to a world vision) de...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::Master of Internal Medicine is the highest award granted by the Chilean Society of Internal Medicine (Sociedad Médica de Santiago) to its members. Since this award was instituted, in 1981, the Society has given it periodically to the most distinguished Chilean physicians. All nominees are considered a model as a physi...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:/S0034-98872007001100015
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) generates a hypercoagulable state with an increased thrombin generation and raised levels of thrombin-antithrombin complexes, which results in a high risk of stroke and thromboembolism. AIM:To evaluate the anticoagulant effect of rivaroxaban by anti-Xa factor activity and its correl...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016000900002
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Acute bacterial meningitis (ABM) is a serious disease that needs rapid diagnosis for an accurate treatment. The most important etiological agents are: Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b. Overall pathogen detection rate in patients with ABM in Chile is 83%. AIM...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000300009
更新日期:2008-03-01 00:00:00
abstract::Increased cholesterol levels above 200 mg/dl, LDL levels above 130 mg/dl and total cholesterol/HDL ratio above 4.5 in males and above 5.0 in females are recognized as indicators of increased risk of atherosclerosis. Risk associated to increased triglyceride levels (above 200 mg/dl) must be judged in relation to associ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:In patients with colorectal carcinoma, insertions or deletions of short sequences of DNA, a phenomenon called microsatellite instability, are observed. AIM:To look for microsatellite instability and mutations of MLH1 and MSH2 gene mutations in patients with colorectal carcinoma. MATERIAL AND METHODS:Ten pa...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006001000002
更新日期:2006-10-01 00:00:00
abstract::Mycoplasma infections have extrapulmonary manifestations that may be associated with respiratory symptoms and may have skin, heart, gastrointestinal, rheumatologic, neurologic, hematologic involvement. Cold agglutinin mediated autoimmune hemolytic anemia is the most common hematological manifestation. We report a 27-y...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014001000015
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Depression is considered the second leading cause of disability worldwide. AIM:To describe the clinical characteristics and the evolution of major depressive disorder (MDD) in secondary care. To evaluate the association between socio-demographic and clinic variables with the first or recurrent major depress...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872017000300007
更新日期:2017-03-01 00:00:00