[Phenytoin pharmacokinetics in young and older adults].

Abstract:

:To study the effect of old age on phenytoin pharmacokinetics, twelve young and nine old adults aged 21.7 +/- 1.8 and 71.8 +/- 4.9 years respectively, were studied. No significant differences of phenytoin indicating the drug distribution and elimination does not change with aging. After oral administration, significant differences were observed between young and old adults for absorption, measured through oral residence half time (36.89 +/- 5.07 h in young and 29.25 +/- 8.64 h in old adults p < 0.05), absorption half time (6.91 +/- 3.6 vs 3.29 +/- 2.35 h) and maximal concentration (1.45 +/- 0.37 vs 2.0 +/- 0.79 micrograms/ml). However, absolute bioavailability of the drug was not different in both age groups (72.9 and 67.6% in young and old adults respectively). It is concluded that no modifications of phenytoin dosage are necessary in elderly people.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Estruch J,Galdames D,Martinetti A,Saavedra I

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

1106-9

issue

10

eissn

0034-9887

issn

0717-6163

journal_volume

120

pub_type

杂志文章
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    authors: Ligueros M,Cruz Coke R,Neira S,Saavedra H,Kramer V,Prieto JC,Gelman M,Saavedra A,Nuñez A,Pescio S

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  • [Cerebrovascular disease in a Neurologic Intermediate Care Unit in Chile. Analysis of 459 consecutive patients].

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    authors: Solari G S,Ríos B JC

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    更新日期:1993-09-01 00:00:00

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    authors: Obregón A,Fuentes J,Pettinelli P

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  • [Prognostic factors for gastric cancer without lymph node involvement].

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    authors: Tapia O,Villaseca M,Bellolio E,Araya JC,Roa JC

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  • [Scientific ethics and frozen embryos].

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    authors: Valenzuela CY

    更新日期:2001-05-01 00:00:00

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  • [Cholesterol and triglycerides in atherosclerosis: epidemiologic and physiopathologic considerations].

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  • [Microsatellite instability among patients with colorectal cancer].

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  • [Hemolysis, serositis and exanthema induced by Mycoplasma pneumoniae infection. Report of one case].

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  • [Clinical features of major depressive disorders treated in secondary health care facilities in Chile].

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