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Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.

Abstract：

:The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice. Cimetidine (400-1000 mg/kg, i.p.) induced dose-dependent tonic convulsion. Muscimol, AOAA and DABA effectively protected mice against cimetidine-induced seizures. Bicuculline and picrotoxin significantly potentiated the seizures induced by cimetidine and effectively antagonized the protective effects of muscimol, AOAA and DABA against the seizures. Diazepam and phenobarbitone significantly protected the mice against cimetidine-induced seizures while phenytoin and strychnine did not significantly alter the seizures. These results indicate that the attenuation of central gamma-aminobutyric acid neurotransmission may underlie cimetidine-induced seizures in mice.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Amabeoku GJ,Chikuni O

doi

10.1016/0006-2952(93)90606-w

subject

Has Abstract

pub_date

1993-12-14 00:00:00

pages

2171-5

issue

12

eissn

0006-2952

issn

1873-2968

pii

0006-2952(93)90606-W

journal_volume

46

pub_type

杂志文章

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