当前位置： SCI文献检索 > BIOCHEMICAL PHARMACOLOGY期刊下所有文献 > Methylxanthine and non-xanthine phosphodiesterase inhibitors. Their effects on adenosine uptake and the low Km cyclic AMP phosphodiesterase in intact rat adipocyte.

Methylxanthine and non-xanthine phosphodiesterase inhibitors. Their effects on adenosine uptake and the low Km cyclic AMP phosphodiesterase in intact rat adipocyte.

Abstract：

:The effects of methylxanthines and non-xanthine phosphodiesterase-inhibitors on the low Km cyclic AMP phosphodiesterase of intact rat adipocytes were studied. Methylxanthines and papaverine stimulated rather than inhibited the enzyme when intact adipocytes were incubated in their presence. The effect of papaverine was not abolished by adenosine deaminase and was enhanced by adenosine. On the other hand, the effect of xanthine inhibitors and adenosine do not enhance each other. The difference in behaviour of these inhibitors could not be explained by their effects on adenosine uptake at the concentrations studied. Both agents inhibited adenosine uptake when measured after 15 sec and 10 min, with methylisobutylxanthine (MIX) having a greater inhibitory effect than papaverine only if uptake was measured after 15 sec. Effects similar to that of adenosine with the inhibitors on phosphodiesterase were obtained with insulin, which has been shown to act through a similar or related mechanism to that of adenosine. This was not the case with lipolytic agents whose effects were not potentiated by either MIX or papaverine. Under certain conditions the degree of stimulation of the enzyme was in fact decreased. Thus lipolytic and antilipolytic agents probably stimulated phosphodiesterase through distinct mechanisms.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Wong EH,Ooi SO

doi

10.1016/0006-2952(85)90012-7

subject

Has Abstract

pub_date

1985-08-15 00:00:00

pages

2891-6

issue

16

eissn

0006-2952

issn

1873-2968

pii

0006-2952(85)90012-7

journal_volume

34

pub_type

杂志文章

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