Abstract:
:We have examined the in vivo sites of action for topoisomerases II in the 87A7 heat shock locus as a function of gene activity. When the hsp70 genes are induced, there is a dramatic redistribution of topoisomerase II in the locus which parallels many of the observed alterations in chromatin structure. In addition to changes in the topoisomerase II distribution within the locus, we find topoisomerase II localized around the putative domain boundaries scs and scs'. During recovery, when the chromatin fiber of the locus recondenses, the major sites of action for topoisomerase II appear to be located within the two hsp70 genes and in the intergenic spacer separating the two genes.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Udvardy A,Schedl Pdoi
10.1128/mcb.13.12.7522subject
Has Abstractpub_date
1993-12-01 00:00:00pages
7522-30issue
12eissn
0270-7306issn
1098-5549journal_volume
13pub_type
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