Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.

abstract：:An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10...

journal_title：Molecular and cellular biology

authors： Feinstein SI,Mory Y,Chernajovsky Y,Maroteaux L,Nir U,Lavie V,Revel M

更新日期：1985-03-01 00:00:00

abstract：:The imprinted expression of the H19 and Igf2 genes in the mouse is controlled by an imprinting control center (ICR) whose activity is regulated by parent-of-origin differences in methylation. The only protein that has been implicated in ICR function is the zinc-finger protein CTCF, which binds at multiple sites within...

journal_title：Molecular and cellular biology

authors： Katz DJ,Beer MA,Levorse JM,Tilghman SM

更新日期：2005-05-01 00:00:00

abstract：:We utilized the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) in vivo to understand how the interaction of the glucocorticoid receptor (GR) with a nucleosome-assembled promoter allows access of factors required for the transition from a repressed promoter to a derepressed, transcriptionally competent pro...

journal_title：Molecular and cellular biology

authors： Sheldon LA,Smith CL,Bodwell JE,Munck AU,Hager GL

更新日期：1999-12-01 00:00:00

abstract：:It is well established that steroid receptor function requires interaction with coactivators. However, the mechanisms through which steroid receptors elicit precise assembly of coactivator complexes and the way the steroid activation signal is transduced remain elusive. Using a T47D cell line stably integrated with a ...

journal_title：Molecular and cellular biology

authors： Li X,Wong J,Tsai SY,Tsai MJ,O'Malley BW

更新日期：2003-06-01 00:00:00

abstract：:Differentiation of skeletal muscle involves withdrawal of myoblasts from the cell cycle, fusion to form myotubes, and the coordinate expression of a variety of muscle-specific gene products. Fibroblast growth factor and type beta transforming growth factor specifically inhibit myogenesis; however, the transmembrane si...

journal_title：Molecular and cellular biology

authors： Olson EN,Spizz G,Tainsky MA

更新日期：1987-06-01 00:00:00

abstract：:Exposure of monocytic cells to bacterial lipopolysaccharide (LPS) activates the NF-kappa B/Rel family of proteins and leads to the rapid induction of inflammatory gene products, including tissue factor (TF). TF is the primary cellular initiator of the coagulation protease cascades. Here we report the characterization ...

journal_title：Molecular and cellular biology

authors： Oeth PA,Parry GC,Kunsch C,Nantermet P,Rosen CA,Mackman N

更新日期：1994-06-01 00:00:00

abstract：:Members of the cytokine receptor superfamily have structurally similar extracellular ligand-binding domains yet diverse cytoplasmic regions lacking any obvious catalytic domains. Many of these receptors form ligand-induced oligomers which are likely to participate in transmembrane signaling. A constitutively active (f...

journal_title：Molecular and cellular biology

authors： Watowich SS,Hilton DJ,Lodish HF

更新日期：1994-06-01 00:00:00

abstract：:The androgen receptor (AR) is a nuclear hormone receptor superfamily member that conveys both trans repression and ligand-dependent trans-activation function. Activation of the AR by dihydrotestosterone (DHT) regulates diverse physiological functions including secondary sexual differentiation in the male and the induc...

journal_title：Molecular and cellular biology

authors： Fu M,Wang C,Wang J,Zhang X,Sakamaki T,Yeung YG,Chang C,Hopp T,Fuqua SA,Jaffray E,Hay RT,Palvimo JJ,Jänne OA,Pestell RG

更新日期：2002-05-01 00:00:00

abstract：:The muscle LIM protein (MLP) and cofilin 2 (CFL2) are important regulators of striated myocyte function. Mutations in the corresponding genes have been directly associated with severe human cardiac and skeletal myopathies, and aberrant expression patterns have often been observed in affected muscles. Herein, we have i...

journal_title：Molecular and cellular biology

authors： Papalouka V,Arvanitis DA,Vafiadaki E,Mavroidis M,Papadodima SA,Spiliopoulou CA,Kremastinos DT,Kranias EG,Sanoudou D

更新日期：2009-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, transcriptional activation mediated by the GAL4 regulatory protein is repressed in the absence of galactose by the binding of the GAL80 protein, an interaction that requires the carboxy-terminal 28 amino acids of GAL4. The homolog of GAL4 from Kluyveromyces lactis, LAC9, activates transcri...

journal_title：Molecular and cellular biology

authors： Salmeron JM Jr,Langdon SD,Johnston SA

更新日期：1989-07-01 00:00:00

abstract：:We have shown previously that transcription of the Drosophila homeotic gene Antennapedia results in four major RNA species which differ in long 5'- and 3'-untranslated sequences. The protein-coding portion of these transcripts, however, is located in exons common to all. Using RNase protection assays and further cDNA ...

journal_title：Molecular and cellular biology

authors： Stroeher VL,Gaiser JC,Garber RL

更新日期：1988-10-01 00:00:00

abstract：:Bright/Arid3a has been characterized both as an activator of immunoglobulin heavy-chain transcription and as a proto-oncogene. Although Bright expression is highly B lineage stage restricted in adult mice, its expression in the earliest identifiable hematopoietic stem cell (HSC) population suggests that Bright might h...

journal_title：Molecular and cellular biology

authors： Webb CF,Bryant J,Popowski M,Allred L,Kim D,Harriss J,Schmidt C,Miner CA,Rose K,Cheng HL,Griffin C,Tucker PW

更新日期：2011-03-01 00:00:00

abstract：:Avian leukosis virus (ALV)-induced neoplasias are commonly found associated with integrations of proviral DNA in proximity to the myc gene. However, studies suggest that other genetic events are necessary for the complete neoplastic phenotype. A cell line (HP46) derived from an ALV-induced tumor has been analyzed and ...

journal_title：Molecular and cellular biology

authors： Kabrun N,Bumstead N,Hayman MJ,Enrietto PJ

更新日期：1990-09-01 00:00:00

abstract：:Neural retina leucine zipper (Nrl), a key basic motif leucine zipper (bZIP) transcription factor, modulates rod photoreceptor differentiation by activating rod-specific target genes. In searching for factors that might couple with Nrl to modulate its transcriptional activity through posttranslational modification, we ...

journal_title：Molecular and cellular biology

authors： Kim JW,Jang SM,Kim CH,An JH,Choi KH

更新日期：2012-05-01 00:00:00

abstract：:The chromatin structure of TDH3, one of three genes encoding glyceraldehyde phosphate dehydrogenases in Saccharomyces cerevisiae, was analyzed by nuclease digestion. A large hypersensitive region was found at the TDH3 promoter extending from the RNA initiation site at position -40 to position -560. This hypersensitive...

journal_title：Molecular and cellular biology

authors： Pavlović B,Hörz W

更新日期：1988-12-01 00:00:00

abstract：:Unintended DNA rearrangements in a differentiating lymphocyte can have severe, oncogenic consequences, but the mechanisms for avoiding pathogenic outcomes in V(D)J recombination are not well understood. The first level at which fidelity is instituted is in discrimination by the recombination proteins between authentic...

journal_title：Molecular and cellular biology

authors： Agard EA,Lewis SM

更新日期：2000-07-01 00:00:00

abstract：:We have characterized features of the site recognized by a double-stranded DNA endonuclease, I-SceII, encoded by intron 4 alpha of the yeast mitochondrial COX1 gene. We determined the effects of 36 point mutations on the cleavage efficiency of natural and synthetic substrates containing the Saccharomyces capensis I-Sc...

journal_title：Molecular and cellular biology

authors： Wernette C,Saldanha R,Smith D,Ming D,Perlman PS,Butow RA

更新日期：1992-02-01 00:00:00

abstract：:The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart failure and prematur...

journal_title：Molecular and cellular biology

authors： Princen F,Bard E,Sheikh F,Zhang SS,Wang J,Zago WM,Wu D,Trelles RD,Bailly-Maitre B,Kahn CR,Chen Y,Reed JC,Tong GG,Mercola M,Chen J,Feng GS

更新日期：2009-01-01 00:00:00

abstract：:The PKC1 gene of Saccharomyces cerevisiae encodes a homolog of mammalian protein kinase C that is required for normal growth and division of yeast cells. We report here the isolation of the yeast MKK1 and MKK2 (for mitogen-activated protein [MAP] kinase-kinase) genes which, when overexpressed, suppress the cell lysis ...

journal_title：Molecular and cellular biology

authors： Irie K,Takase M,Lee KS,Levin DE,Araki H,Matsumoto K,Oshima Y

更新日期：1993-05-01 00:00:00

abstract：:Eukaryotic splicing factors belonging to the SR family are essential splicing factors consisting of an N-terminal RNA-binding region and a C-terminal RS domain. They are believed to be involved in alternative splicing of numerous transcripts because their expression levels can influence splice site selection. We have ...

journal_title：Molecular and cellular biology

authors： Jumaa H,Guénet JL,Nielsen PJ

更新日期：1997-06-01 00:00:00

abstract：:Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to control gene expression programs governing lineage allocation in hematopoiesis. Enforced expression of GFI1B in K562 erythroleukemia cells favors erythroid over m...

journal_title：Molecular and cellular biology

authors： McClellan D,Casey MJ,Bareyan D,Lucente H,Ours C,Velinder M,Singer J,Lone MD,Sun W,Coria Y,Mason CC,Engel ME

更新日期：2019-06-13 00:00:00

abstract：:Keratins K5 and K14 form the extensive intermediate filament network of mitotically active basal cells in all stratified epithelia. We have explored the regulatory mechanisms governing cell-type-specific and differentiation stage-specific expression of the human K5 gene in transiently transfected keratinocytes in vitr...

journal_title：Molecular and cellular biology

authors： Byrne C,Fuchs E

更新日期：1993-06-01 00:00:00

abstract：:The roles of PDZ domain-containing proteins such as Dlg and Scrib have been well described for Drosophila; however, their requirement for mammalian development is poorly understood. Here we show that Dlg, Scrib, MAGI1, MAGI3, and MPDZ are expressed in the mouse ocular lens. We demonstrate that the increase in prolifer...

journal_title：Molecular and cellular biology

authors： Nguyen MM,Nguyen ML,Caruana G,Bernstein A,Lambert PF,Griep AE

更新日期：2003-12-01 00:00:00

abstract：:Glucocorticoids are among the most potent and effective agents for treating inflammatory diseases and hematological cancers. However, subpopulations of patients are often resistant to steroid therapy, and determining the molecular mechanisms that contribute to glucocorticoid resistance is thus critical to addressing t...

journal_title：Molecular and cellular biology

authors： Ramamoorthy S,Cidlowski JA

更新日期：2013-05-01 00:00:00

abstract：:We report in vivo analysis of histone and RNA polymerase II (pol II) occupancy at the 601 element, which functions as a strong in vitro nucleosome-positioning element and transcriptional pause site. Surprisingly, nucleosomes were not strongly positioned over the 601 element inserted either within a yeast chromosomal o...

journal_title：Molecular and cellular biology

authors： Perales R,Zhang L,Bentley D

更新日期：2011-08-01 00:00:00

abstract：:The first intron of the human collagen alpha 1(I) gene contains several positively and negatively acting elements. We have studied the transcription of collagen-human growth hormone fusion genes, containing deletions and rearrangements of collagen intronic sequences, by transient transfection of chick tendon fibroblas...

journal_title：Molecular and cellular biology

authors： Bornstein P,McKay J,Liska DJ,Apone S,Devarayalu S

更新日期：1988-11-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a Ser/Thr (S/T) protein kinase, which controls mRNA translation initiation by modulating phosphorylation of the translational regulators PHAS-I and p70(S6K). Here we show that in vitro mTOR is able to phosphorylate these two regulators at comparable rates. Both (S/T)P sites,...

journal_title：Molecular and cellular biology

authors： McMahon LP,Choi KM,Lin TA,Abraham RT,Lawrence JC Jr

更新日期：2002-11-01 00:00:00

abstract：:Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-b...

journal_title：Molecular and cellular biology

authors： Mathur M,Tucker PW,Samuels HH

更新日期：2001-04-01 00:00:00

abstract：:S-Tubercidinylhomocysteine (STH) is a structural analog of S-adenosylhomocysteine and a potent inhibitor of S-adenosylmethionine-dependent methyltransferase reactions. We investigated the effects of STH on HeLa cell mRNA metabolism. Dual labeling studies reveal that STH dramatically inhibits the methylation of HeLa mR...

journal_title：Molecular and cellular biology

authors： Camper SA,Albers RJ,Coward JK,Rottman FM

更新日期：1984-03-01 00:00:00

abstract：:A cDNA encoding a novel Krüppel-type zinc finger protein, FKLF, was cloned from fetal globin-expressing human fetal erythroid cells. The deduced polypeptide sequence composed of 512 amino acids revealed that, like Sp1 and EKLF, FKLF has three contiguous zinc fingers at the near carboxyl-terminal end. A long amino-term...

journal_title：Molecular and cellular biology

authors： Asano H,Li XS,Stamatoyannopoulos G

更新日期：1999-05-01 00:00:00