From PET detectors to PET scanners.

abstract：PURPOSE:In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats. METHODS:Fifteen male Lewis rats with different stages of renal dysfunction ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Forrer F,Valkema R,Bernard B,Schramm NU,Hoppin JW,Rolleman E,Krenning EP,de Jong M

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:Aortic metabolic activity is suggested to correlate with presence and progression of aneurysmal disease, but has been inadequately studied. This study investigates the 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in a population of infra-renal abdominal aortic aneurysms (AAA), compared to a matched non...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Barwick TD,Lyons OT,Mikhaeel NG,Waltham M,O'Doherty MJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Reduced presynaptic dopaminergic activity plays an important role in the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). In this study, we investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of LID onset. METHODS:From among 412 drug...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yoo HS,Chung SJ,Chung SJ,Moon H,Oh JS,Kim JS,Hong JY,Ye BS,Sohn YH,Lee PH

更新日期：2018-03-01 00:00:00

abstract：:The aims of this study were to assess the potential of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) for tumor grading in chondrosarcoma patients and to evaluate the role of standardized uptake value (SUV) as a parameter for prediction of patient outcome. FDG PET imaging was performed in 31 pat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brenner W,Conrad EU,Eary JF

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Artificial neural networks (ANN) might help to diagnose coronary artery disease. This study aimed to determine whether the diagnostic accuracy of an ANN-based diagnostic system and conventional quantitation are comparable. METHODS:The ANN was trained to classify potentially abnormal areas as true or false base...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Kudo T,Nakata T,Kiso K,Kasai T,Taniguchi Y,Matsuo S,Momose M,Nakagawa M,Sarai M,Hida S,Tanaka H,Yokoyama K,Okuda K,Edenbrandt L

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:It is a matter of controversy whether prophylactic lymph node dissection improves prognosis and survival in papillary thyroid carcinoma (PTC) patients without suspicion of lymph node metastases either clinically or on ultrasonography. It is possible that in such patients the use of lymphatic mapping and sentine...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pelizzo MR,Rubello D,Boschin IM,Piotto A,Paggetta C,Toniato A,De Salvo GL,Giuliano A,Mariani G,Casara D

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:The aim of this short communication is to outline our experience in policies and processes of a nuclear medicine service during the COVID-19 outbreak in Singapore. METHODS:We describe the key considerations of policies and processes that have been implemented in our nuclear medicine service since the first cas...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lam WW,Loke KS,Wong WY,Ng DC

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of (15)O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and my...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tuffier S,Legallois D,Belin A,Joubert M,Bailliez A,Redonnet M,Agostini D,Manrique A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Familial adenomatous polyposis (FAP) is characterised by colonic and duodenal adenomatous polyps that carry a risk of malignant transformation. Malignant degeneration of duodenal adenomas is difficult to detect. We speculated that 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography (FDG-PET) might...

journal_title：European journal of nuclear medicine and molecular imaging

authors： van Kouwen MC,Drenth JP,van Krieken JH,van Goor H,Friederich P,Oyen WJ,Nagengast FM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is cor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Choo IL,Carter SF,Schöll ML,Nordberg A

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To assess the radiation dosimetry and biodistribution of (99m)Tc-labeled ethylene dicysteine deoxyglucose ((99m)Tc-EC-DG) in patients with non-small-cell lung cancer (NSCLC). METHODS:Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of (99m)Tc-EC-DG (925 MBq) in seven NSCLC patients. Ra...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schechter NR,Erwin WD,Yang DJ,Kim EE,Munden RF,Forster K,Taing LC,Cox JD,Macapinlac HA,Podoloff DA

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS:Seven physicians independently interpreted 97 MPS stud...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tägil K,Bondouy M,Chaborel JP,Djaballah W,Franken PR,Grandpierre S,Hesse B,Lomsky M,Marie PY,Poisson T,Edenbrandt L

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to map treatment-induced (99m)Tc-Hynic-rh-annexin V uptake in normal tissues using co-registration of SPECT and CT. METHODS:Nineteen patients (11 male, 8 female, mean age 57 years) with various malignant tumours (12 lymphomas, four non-small cell lung cancers and three head and ne...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kartachova MS,Valdés Olmos RA,Haas RL,Hoebers FJ,van den Brekel MW,van Zandwijk N,Herk Mv,Verheij M

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Radioembolisation is part of the multimodal treatment of hepatocellular carcinoma (HCC) at specialist liver centres. This study analysed the impact of prior treatment on tolerability and survival following radioembolisation. METHODS:This was a retrospective analysis of 325 consecutive patients with a confirmed...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sangro B,Maini CL,Ettorre GM,Cianni R,Golfieri R,Gasparini D,Ezziddin S,Paprottka PM,Fiore F,Van Buskirk M,Bilbao JI,Salvatori R,Giampalma E,Geatti O,Wilhelm K,Hoffmann RT,Izzo F,Iñarrairaegui M,Urigo C,Cappelli A,

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The aim of this prospective study is to evaluate the combined use of fluorine-18 fluorodeoxyglucose ((18) F-FDG) and fluorine-18 sodium fluoride ((18) F-NaF) PET/CT in the skeletal assessment of patients with multiple myeloma (MM) and to compare the efficacy of these two PET tracers regarding detection of mye...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sachpekidis C,Goldschmidt H,Hose D,Pan L,Cheng C,Kopka K,Haberkorn U,Dimitrakopoulou-Strauss A

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the feasibility of assessing dopamine transporter binding after treatment with methylphenidate in the rat using a recently developed high-resolution small animal single-photon emission computed tomograph (TierSPECT) and [123I]FP-CIT. METHODS:[123I]FP-CIT was administere...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nikolaus S,Wirrwar A,Antke C,Arkian S,Schramm N,Müller HW,Larisch R

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis and have, therefore, been integrated in the World Health Organization (WHO) classification in 2016. The aim of this study was to characterize static and dynamic...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Verger A,Stoffels G,Bauer EK,Lohmann P,Blau T,Fink GR,Neumaier B,Shah NJ,Langen KJ,Galldiks N

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:The primary objective was the evaluation of Gallium 68 (68Ga)-prostate-specific membrane antigen (PSMA)-11 positron emission tomography/computed tomography (PET/CT) detection rate, for identifying the site of prostate cancer (PCa) relapse (local vs systemic), stratifying the population according to different...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ceci F,Castellucci P,Graziani T,Farolfi A,Fonti C,Lodi F,Fanti S

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:For the assessment of folate-based radiopharmaceuticals, human nasopharyngeal KB carcinoma cells are traditionally used although nasopharyngeal cancer is rare. On the other hand, the folate receptor (FR) is frequently overexpressed on diverse cancer types, the highest frequency (>90%) being on ovarian carcinoma...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Müller C,Schubiger PA,Schibli R

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. METHODS:Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Acampa W,Caprio MG,Nicolai E,Liuzzi R,De Luca S,Capasso E,Luongo L,Petretta M,Cuocolo A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Bone metastases are responsible for most of the morbidity associated with hormone-refractory prostate cancer (HRPC). 153Sm-ethylenediaminetetramethylene phosphonate (153Sm-EDTMP) has been approved for palliation of painful skeletal metastases. We retrospectively investigated the possible synergistic effect o...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ricci S,Boni G,Pastina I,Genovesi D,Cianci C,Chiacchio S,Orlandini C,Grosso M,Alsharif A,Chioni A,Di Donato S,Francesca F,Selli C,Rubello D,Mariani G

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is used for (re)staging prostate cancer (PCa) and as a biomarker for evaluating response to therapy, but lacks established response criteria. A panel of PCa experts in nuclear medicine, radiology, and/or urolog...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fanti S,Goffin K,Hadaschik BA,Herrmann K,Maurer T,MacLennan S,Oprea-Lager DE,Oyen WJ,Rouvière O,Mottet N,Bjartell A

更新日期：2021-02-01 00:00:00

abstract：:(124)I-PET/CT has a high clinical potential in patients with differentiated thyroid cancer (DTC). Two aspects deserve special mention: staging of recurrent or residual disease and pretherapy dosimetry. Used in combination (124)I-PET and CT allows foci of highly specific (124)I uptake to be localized with a low radiati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Freudenberg LS,Jentzen W,Stahl A,Bockisch A,Rosenbaum-Krumme SJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Alzheimer's disease (AD) is a primary degenerative disease that progressively affects all brain functions, with devastating consequences for the patient, the patient's family and society. Rest regional cerebral blood flow (rCBF) could have a strategic role in differentiating between AD patients and normal contr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sundström T,Elgh E,Larsson A,Näsman B,Nyberg L,Riklund KA

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:This study aims to reveal the feasibility and potential of molecular connectivity based on neurotransmission in comparison with the metabolic connectivity with an application to dopaminergic pathways. For this purpose, we propose to compare the neurotransmission connectivity findings using 123I-FP-CIT SPEC...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Verger A,Horowitz T,Chawki MB,Eusebio A,Bordonne M,Azulay JP,Girard N,Guedj E

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Extracapsular spread (ECS) to the cervical lymph nodes is a major adverse prognostic factor in oral cavity squamous cell carcinoma (OSCC). We prospectively examined the value of FDG PET immediately before postoperative radiotherapy/concurrent chemoradiotherapy (pre-RT/CCRT PET) to detect residual/relapsing dise...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Liao CT,Fan KH,Lin CY,Wang HM,Huang SF,Chen IH,Kang CJ,Ng SH,Hsueh C,Lee LY,Lin CH,Yen TC

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The aim of this study is to report on a collective of 20 children from Belarus who had developed papillary thyroid carcinoma with pulmonary metastases after the Chernobyl disaster. In all children fractionated radioiodine therapy (RIT) was ceased before achieving complete remission due to a lack of further effe...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Biko J,Reiners C,Kreissl MC,Verburg FA,Demidchik Y,Drozd V

更新日期：2011-04-01 00:00:00

abstract：:Oesophageal scintigraphy has been used for more than 25 years and allows quantifiable, safe, rapid, non-invasive and well-tolerated assessment of oesophageal transit time and function. As technology improves, more complex image analysis is becoming possible. Many studies have addressed its usefulness in assessing oeso...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Stacey B,Patel P

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Our aim was to assess whether 18F-NaF PET/CT is able to predict progression of the CT calcium score. METHODS:Between August 2007 and November 2015, 34 patients (18 women, 16 men; age, mean ± standard deviation, 57.5 ± 13.9 years; age range 19-78 years) with malignancy or orthopaedic disease were enrolled in th...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ishiwata Y,Kaneta T,Nawata S,Hino-Shishikura A,Yoshida K,Inoue T

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies (bsMAb) and a radiolabeled peptide reduces the radiation dose to normal tissues. Here we report the accuracy of an (111)In-labeled pretherapy test dose for personalized dosing of (177)Lu-labeled IMP288 following pretargeting with the anti-CEA × an...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schoffelen R,Woliner-van der Weg W,Visser EP,Goldenberg DM,Sharkey RM,McBride WJ,Chang CH,Rossi EA,van der Graaf WT,Oyen WJ,Boerman OC

更新日期：2014-08-01 00:00:00