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Basiliximab: efficacy and tolerability in adults and children.

Abstract：

UNLABELLED:An open, single arm, prospective clinical trial to assess the efficacy and safety of basiliximab (Simulect) combined with cyclosporine microemulsion (Neoral), steroids, and azathioprine was performed in four centers in Chile, two adult and two pediatric. The 23 patients who were enrolled were followed for 12 months. There were four acute rejection episodes (three adults and one child) and three graft losses (two adults and one child) during the study. Renal function in both adult and pediatric patients at 6 and 12 months was good. Basiliximab was well tolerated. The incidence of infections was low, with only one CMV infection. There were no deaths. CONCLUSIONS:The incidence of acute rejection episodes among renal allograft recipients treated with basiliximab is low, showing that the drug is well tolerated. In particular the number of CMV infections is extremely low.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Mocarquer A,Pinto V,Buckel E,Lagos E,Pefaur J,Ramirez K,Morales J,Rosatti P,Elberg A,Simulect Multicenter Study Group of Chile.

doi

10.1016/j.transproceed.2003.09.098

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

2518-9

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041134503009837

journal_volume

35

pub_type

临床试验,杂志文章,多中心研究

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