Abstract：
:Levofloxacine is a fluoroquinolone presenting good anti-pneumococcal activity, including against strains with reduced sensitivity to penicillin. Four randomized controlled studies have compared the efficacy of levofloxacine versus other antibiotics (amoxacillin-clavulanic acid, amoxicillin, ceftriaxone, ceftriaxone plus cefuroxime +/- erythromycin) for the treatment of acute community-acquired pneumonia in adults. Grouping the 1,738 analyzable patients in these four studies, a meta-analysis was performed on the sub-group of 275 patients with documented pneumococcal infection (86 with bacteriemia) in order to compare the efficacy of levofloxacine with that of the comparer antibiotics. The trials were homogeneous, allowing the meta-analysis. The overall rate of clinical success was 88.6% in the levofloxacine group and 86.7% in the comparer group. The interval of confidence for the difference in the rate of estimated clinical success was between -5.65% and +9.39%. Bacteriologically, the rate of eradication was 90.2% and 90.4% respectively with an interval of confidence for the difference between -7.83% and +7.36%. The results of this meta-analysis confirmed that the efficacy of levofloxacine for the treatment of acute community-acquired pneumococcal pneumonia is not inferior to that of the comparers; the interval of confidence for the difference in the estimated rate of success did not include the breaking point of non-inferiority (-10% set for the clinical studies) and included zero.
journal_name
Rev Pneumol Clinjournal_title
Revue de pneumologie cliniqueauthors
Bru JP,Leophonte P,Veyssier Psubject
Has Abstractpub_date
2003-12-01 00:00:00pages
348-56issue
6eissn
0761-8417issn
1776-2561pii
MDOI-RPC-12-2003-59-6-0761-8417-101019-ART2journal_volume
59pub_type
杂志文章,meta分析abstract：:Pulmonary hypertension is a serous condition which, after a long history as an orphan disease, has raised renewed interest due to the development of efficacious therapeutic options including lung transplantation and continuous infusion of prostacycline. Bilateral endarteriectomy of the pulmonary arteries is another po...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/s0761-8417(04)73480-x
更新日期：2004-04-01 00:00:00
abstract：:Thymolipoma is an uncommon benign tumor of the thymus. Asymptomatic, it is an incidental discovery. Pathogenesis remains controversial. We report a new case in a 36-year-old woman that was discovered on a chest x-ray ordered for pneumonia. The MRI findings suggested the diagnosis which was confirmed at the pathology e...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:There are three hypotheses to explain the relation between allergens and other factors and the onset of atopy: the hygiene hypothesis, the TH2 like hypothesis and the allergenic hypothesis. None of them have been confirmed. It seems necessary to wait for the results of prospective studies before giving recommendations...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2003-04-01 00:00:00
abstract：:A necroscopic study, conducted in the Pathology Department of the Centre Hospitalier Universitaire (CHU) de Treichville in Abidjan, included 70 seropositive subjects who died in the Pneumophtisiology Department. We attempted to determine the different pulmonary affections occurring during infection with the human immu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Pleomorphic carcinoma is a rare malignancy belonging to the family of nonsmall cell lung cancers. A 40-year-old man, a smoker, was hospitalized for thoracic pain and dry cough with a deteriorating general condition. The imaging showed a "drop ball" of both lungs. The pathological evidence was obtained by lung biopsy u...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2010.04.002
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION:In spite of recommendations of the highest level of proof (rank A), the respiratory rehabilitation remains very widely sub-prescribed by general practitioners, who are nevertheless in the front line in the care and the follow-up of the patients affected by BPCO. MATERIAL AND METHODS:Semi-qualitative study...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:The presence of D-dimers in the serum reflects fibrin formation and lysis. If the serum D-dimer level is lower than a threshold level which depends on the assay technique (usually 500 micrograms/l), pulmonary embolism can be excluded with a predictive value of 95%. This makes D-dimer assay an ideal screening tool for ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：:We present 4 cases of endobronchial lipomas observed in our department over the last fifteen years. Histological diagnosis was obtained in all cases after endobronchoscopy and biopsy. Endobronchial exeresis was possible in one patient, lobectomy was required in a second. For the other two patients, surgery was not per...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Pulmonary amyloidoma or nodular amyloidosis is a localized form of amyloidosis, which can mimic a bronchopulmonary carcinoma. This form of amyloidosis may be associated to an infectious, a systemic disease or a lymphoma. OBSERVATION:We describe the case of a 36-year-old patient whose past medical history ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2012.05.001
更新日期：2012-10-01 00:00:00
abstract：:It is generally accepted that glucocorticoids are ulcerogenic. The different pharmacological, biological and clinical arguments on which this opinion is founded are reviewed. It is concluded that, particularly in pneumology, none of them is sufficiently sound to justify the prophylactic measures generally systematical...
journal_title：Revue de pneumologie clinique
pub_type： 临床试验,杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Radiological explorations of the thorax raise a certain number of risks for the mother and infant which should be well recognized by the pneumologist. Irradiation is the major risk and can be evaluated in comparison with other risks of radiation. We recall the dosimetric system based on the effective dose expressed in...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1999-10-01 00:00:00
abstract：:The number of adolescents and young adults with chronic diseases has increased dramatically over the last decade. This led paediatric teams to organize the transition to adult centres with the aim to ensure the quality of care and prognosis, adherence to survey and treatment. To promote a good work and family life is ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2015.03.001
更新日期：2016-02-01 00:00:00
abstract：:Over a 6 years' period (1980-1986), 272 patients with chronic respiratory disease were admitted for respiratory failure to the same intensive care unit. The series was characterized by the high mean age of the patients (69.3 years) and by the high proportion of those who were ventilated (75%); 33.7% of the patients di...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Few studies have described pulmonary non-infectious diseases (PNID) in patients with common variable immunodeficiency (CVID). Indeed the most frequent complications in these patients are infectious. The aim of our study is to analyze the characteristics of PNID in a retrospective study of patients with CVID of two pne...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.06.005
更新日期：2011-09-01 00:00:00
abstract：:Chemotherapy (CT) combined with surgery in non-small cell lung cancers has been studied for a number of years. It can be used prior to or following surgery (adjuvant). A long rather unfruitful period ended with the meta-analysis of the Non-Small Cell Cancer Collaborative Group, published in the British Medical Journal...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:Primary tumors are relatively rare in the pleura. Histological types include mesothelioma, epitheliod, biphasic or sarcomatoid tumors as well as primary lymphoma and mesenchymatous tumors which include solitary fibrous tumor, epithelioid hemangioendothelioma and angiosarcoma and synovialosarcoma. We detail here the ne...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/s0761-8417(06)75420-7
更新日期：2006-04-01 00:00:00
abstract：:Efficacy and tolerance of home non-invasive ventilation (NIV) must be assessed by using objective criteria (clinical evaluation, arterial blood gases, oxymetry, and research of side effects such as air leaks, skin problems, etc). In this article, we describe a procedure for long-term follow-up of home NIV. We also sug...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.07.006
更新日期：2009-08-01 00:00:00
abstract：:Intrathoracic coelomic cysts are benign embryonic tumors with a mesothelial lining. The aim of this work was to review possible localizations (pleuropericardic and other), the remaining surgical indications, and the current situation of minimally invasive techniques. We reviewed retrospectively, 28 cases of intrathora...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Congenital tuberculosis is an uncommon but probably underestimated disease. All cases occurring in developing countries are not published. Twenty-nine cases have been published in the English literature since 1980. The diagnosis of congenital tuberculosis is different from post-natal tuberculosis and is based on recen...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:Castleman's disease is a rare orphan disease. The prevalence is estimated at less than 1/100 000. Respirologists may encounter this disease when its thoracic manifestations occur. CASE REPORT:The authors report two cases of Castleman's disease with two different thoracic involvements. The first patient wa...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2008.12.004
更新日期：2009-04-01 00:00:00
abstract：INTRODUCTION:Neurogenic mediastinal tumors are tumors develop at the expense of peripheral nerve elements of the mediastinum, the sympathetic nervous tissue and paraganglia. The series that we propose has the distinction of a high frequency of malignant forms and a wealth of clinical symptomatology. METHODS:This is a ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2016.05.002
更新日期：2016-10-01 00:00:00
abstract：:Inoperable non- microcellular primary bronchial carcinomas have been reputed up to now to be chemo-resistant. The introduction of Cis-platinum into a polychemotherapy protocol leads to revision of this concept. The authors report the preliminary results of a polychemotherapy protocol (including Cis-platinum, Vindesine...
journal_title：Revue de pneumologie clinique
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:In some Tunisian cities, especially semi-urbanized, the exposure to the smoke produced during combustion of the biomass, main source of pollution of indoor air, remains prevalent among non-smoking women. AIM:To assess the relationship between exposure to biomass smoke and the presence of obstructive venti...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2016.10.004
更新日期：2017-04-01 00:00:00
abstract：:Mediastinal hemangiomas are rare tumours occurring more often in children and young adults. A new case is reported in a 21 years old male who had an anterior mediastinal mass detected on a routine chest roentgenogram. Pre-operative investigations including CT, venous digital angiography, MRI did not aid in the right d...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:The presence of non-caseating epitheloid cell granulomas in biopsy material is still one of the most important factors in establishing the diagnosis of sarcoidosis. Since Carlens introduced mediastinoscopy as a diagnostic procedure in these cases the use of liver biopsy or bronchoscopic biopsy has decreased because of...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Among the epithelial tumours of the thymus, thymic carcinomas are rare, involving more aggressive locoregional behaviour and a poor prognosis. More than one-third of cases present lymph node metastasis during an evaluation of the extension of a primitive mediastinal tumour of thymic origin. The authors report an unusu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.10.002
更新日期：2010-10-01 00:00:00
abstract：:We describe a mediastinal myxoid liposarcoma in a 47-year-old man who developed recurrent lung infection, treated by surgery associated with radiotherapy. The report of this case and a review of literature bring the authors to outline the epidemiological, clinical and therapeutic profile of this rare tumor. ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：INTRODUCTION:Post-traumatic diaphragmatic hernia is a particular lesion in traumatology that may be neglected. Thus, the diagnosis may be delayed for a few days to several months and only be made following a complication. The left diaphragmatic cupola is the most touched. Tension fecopneumothorax following diaphragmati...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2008.10.004
更新日期：2009-02-01 00:00:00
abstract：:Lung transplantation is now considered a valid option in the management of end-stage respiratory failure. The postoperative period remains a key stage that will influence the average long-term prognosis of the patients. Primary graft failure, postoperative bleeding, infection, acute rejection and complications linked ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2010.12.005
更新日期：2010-02-01 00:00:00
abstract：:The most frequent benign lesions of the pleura created by asbestos are fibro-hyaline plaques, i.e. thick areas of collagen located on the parietal pleura and gradually becoming calcified. Less common is benign pleural effusion the cause of which is not always easy to determine. To these must be added an extensive pleu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
