Abstract：
:Chemotherapy (CT) combined with surgery in non-small cell lung cancers has been studied for a number of years. It can be used prior to or following surgery (adjuvant). A long rather unfruitful period ended with the meta-analysis of the Non-Small Cell Cancer Collaborative Group, published in the British Medical Journal in 1995 that suggested an increase in survival of 5% at 5 years with the addition of adjuvant chemotherapy to surgery. Since this publication, arguments have accumulated in favour of this combination. Phase II studies have shown the feasibility of pre-surgical CT. A randomised trial in France showed a near 10% improvement in survival at 5 years, approaching statistical significance, and that this beneficial effect was further enhanced in the early stages of cancer. Excess post-surgical morbidity and mortality, even though non-significant, emphasizes the need for an effective but less toxic CT than the mitomycine-ifosfamide-cisplatin combination initially selected. In the field of adjuvant CT, the arguments in favour of the association have accumulated with the positive results of 3 studies, the IALT trial, the BR10 trial of the Canadian National Cancer Institute and the 9633 trial of the CALGB, with the latter two studies presented this year at the American Society of Clinical Oncology meeting. Four other pre-surgery CT trials are ongoing, but their results will not be available for several years. When choosing optimal timing among the various CT administration methods, before or after surgery, the arguments are in favour of pre-surgery CT: the possibility of assessing the chemosensitivity of the tumor, permitting the early withdrawal of treatment if it fails (presently in 40% of patients), the enhanced acceptability of CT by the patients, and the increase in resectability of the tumours. Conversely, however, one must note the greater difficulty for staging and the increase in post-surgical risks, basically in N2 patients, which will gradually lead to its replacement by the use of 3rd generation CT.
journal_name
Rev Pneumol Clinjournal_title
Revue de pneumologie cliniqueauthors
Depierre Asubject
Has Abstractpub_date
2004-11-01 00:00:00pages
3S31-6issue
5 Pt 2eissn
0761-8417issn
1776-2561pii
MDOI-RPC-11-2004-60-5-C2-0761-8417-101019-ART07journal_volume
60pub_type
杂志文章,评审abstract：:A marked increase in the morbidity and mortality of a large number of broncho-pulmonary diseases has been documented in relation to smoking. The influence of tobacco smoking on various respiratory conditions. is discussed: incidence, severity or natural history modification of some respiratory illnesses: obstructive l...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2018.04.009
更新日期：2018-06-01 00:00:00
abstract：:Among the epithelial tumours of the thymus, thymic carcinomas are rare, involving more aggressive locoregional behaviour and a poor prognosis. More than one-third of cases present lymph node metastasis during an evaluation of the extension of a primitive mediastinal tumour of thymic origin. The authors report an unusu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.10.002
更新日期：2010-10-01 00:00:00
abstract：:Castleman disease is a rare lymph nodes disease whose name covers different clinical presentations. The most frequent histology is the hyaline vascular localized form. In this case, Castleman disease occurs in young adults, and is localized to the mediastinum in one third of the cases. The disease is often asymptomati...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2013.09.001
更新日期：2013-12-01 00:00:00
abstract：:We report 8 cases of thoracic actinomycosis, a disease which is now uncommon owing to the widespread use of antibiotics and which is caused by anaerobic filamentous bacteria living as saprophytes in natural cavities. Recent pathogenetic data, such as propagation by continuity or blood stream, as well as bacteriologica...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:The author reports his experience of electrocoagulation used to remove tumoral obstruction of the trachea and primary bronchi. Endoscopic electrocoagulation using a fibrobronchoscope is a useful method. Its results and its cost are of interest, as confirmed by experience in 17 patients. ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Pneumonias occupy a prominent situation among lower respiratory tract infections where they are remarkable for their potential mortality and for our relative knowledge of the responsible micro-organisms. Analysis and synthesis of each series published must answer several questions, such as: what are the lung diseases ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:Digital ulcers usually reflect focal ischemia due to a microangiopathy, its causes are diverse. In women, it first suggests a connective tissue disease whereas in men, a diffuse arteriopathy. Acral ischemia till necrosis is a rare form of a paraneoplasia. We report about a man with a metastatic lung cancer revealed by...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2012.06.007
更新日期：2012-12-01 00:00:00
abstract：:The number of organ transplantations in France is constantly and impressively increasing, but this progress remains insufficient. Compared with other European countries, France ranks first as regards the number of heart transplantations performed in 1984 but is lagging behind as regards kidney transplantations. Since ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Opsoclonus-myoclonus syndrome was observed in a patient treated for small-cell lung cancer. Opsoclonus presented as anarchic involuntary eye movements associated with myoclonies of the limbs and trunk. Opsoclonus-myoclonus is exceptional and a specific expression among several paraneoplastic manifestations described i...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:A study devised to evaluate the effects of chronic exposure to tobacco smoke on the health of a population of non-smokers was conducted in a prison. Fourteen volunteers among male, non-smoking prisoners in good health and without history of lung disease were put for thirty days in a cell that was already occupied by t...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:This questionnaire survey was conducted to assess delivery of asthma drugs in community pharmacies in Abidjan, Ivory Coast. Participation rate was 88.69%. All participants stated they provide care for asthma patients either during acute episodes or between acute episodes. It was found that a considerable number of pat...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the clinical, radiographic, and ultrasonographic aspects of mediastinal nodal tuberculosis and ascertain its clinical course in the era of HIV infection. PATIENTS AND METHODS:We reviewed retrospectively 39 patients referred to the Ouédraogo Yalgado National Hospital...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：:The authors report a case of febrile pancytopenia of tuberculous origin with a normal chest X-ray at the outset. The diagnosis was virtually confirmed by bone marrow biopsy, even before the result of AAFB cultures. The course was rapidly favorable under the influence of triple anti-tuberculous therapy, with normalisat...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：UNLABELLED:The management of localized non-small cell lung cancer (NSCLC) has been modified over the last decades, with induction therapies being increasingly recommended as a prerequisite to surgical resection. However, the relative impact of chemo- and chemoradiotherapy on tumours' pathology and patients' survival is...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2013.12.008
更新日期：2014-02-01 00:00:00
abstract：:Levofloxacine is a fluoroquinolone presenting good anti-pneumococcal activity, including against strains with reduced sensitivity to penicillin. Four randomized controlled studies have compared the efficacy of levofloxacine versus other antibiotics (amoxacillin-clavulanic acid, amoxicillin, ceftriaxone, ceftriaxone pl...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,meta分析
doi：
更新日期：2003-12-01 00:00:00
abstract：:Breathlessness induced by external resistances (diaphragms with orifice size of 20, 15, 10, 7.5 and 5 mm) introduced in the ventilatory circuit of a spirometer and the corresponding parameters of a maximal flow-volume loop have been studied. 10 healthy subjects (5 men, 5 women), free from any acute or chronic cardiore...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The most frequent benign lesions of the pleura created by asbestos are fibro-hyaline plaques, i.e. thick areas of collagen located on the parietal pleura and gradually becoming calcified. Less common is benign pleural effusion the cause of which is not always easy to determine. To these must be added an extensive pleu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Despite the dramatic decline in the incidence of tuberculosis during the last decades, the disease remains a significant public health problem especially in developing countries. Chest wall tuberculosis is a very rare location. Clinically, it can present as a pyogenic abscess or soft tumor, making diagnosis difficult,...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2014.12.006
更新日期：2015-10-01 00:00:00
abstract：:Gaucher's disease is a not exceptional lysosomial disease in Tunisia. Type 1 is by far the most common one. Pulmonary involvement is considered to be rare in type 1 Gaucher's disease. Pulmonary hypertension, infiltration of the lungs with Gaucher cells, and severe hypoxemia due to intrapulmonary arterial-venous shunts...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.07.002
更新日期：2012-02-01 00:00:00
abstract：:Intrathoracic coelomic cysts are benign embryonic tumors with a mesothelial lining. The aim of this work was to review possible localizations (pleuropericardic and other), the remaining surgical indications, and the current situation of minimally invasive techniques. We reviewed retrospectively, 28 cases of intrathora...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:We describe a mediastinal myxoid liposarcoma in a 47-year-old man who developed recurrent lung infection, treated by surgery associated with radiotherapy. The report of this case and a review of literature bring the authors to outline the epidemiological, clinical and therapeutic profile of this rare tumor. ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:The authors present a case of nephrotic syndrome due to focal-segmental glomerulosclerosis, occurring three years after thymectomy and myasthenia gravis. Twenty-three other cases of nephrotic syndrome associated with thymoma and myasthenia gravis have been reported in the literature. The nephrotic syndrome may be rela...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2009.06.003
更新日期：2009-10-01 00:00:00
abstract：:Lambert-Eaton syndrome is a myasthenia-like syndrome of paraneoplastic origin which is often associated with anaplastic small-cell lung cancer. It seems to be an autoimmune disease responsible for a deficit of acetylcholine ejection in the motor end plate. On the occasion of two recent cases, we review the clinical, p...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:The impact of nosocomial tuberculosis remains poorly known. There is a real risk that is relatively higher when the probability of community acquisition declines. Diagnosis is difficult due to the natural history of tuberculosis infection so that most cases of nosocomial contamination result in infection without disea...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：:Four patients in status asthmaticus and with alveolar hypoventilation were given a helium-oxygen (He-O2) mixture to breathe during 4 hours. Clinical improvement and return to normal of arterial blood gas levels were rapid and dramatic in all patients. The He-O2 mixture, which is a low density gas, causes a reduction i...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Surgery is the most effective treatment of lung cancer provided that there is complete resection. Even though the results in the early stages of small cell lung cancers (SCLC) are encouraging, many oncologists still consider SCLC a contra-indication. The authors report their experience. They retrospectively reviewed t...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.02.001
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:In spite of recommendations of the highest level of proof (rank A), the respiratory rehabilitation remains very widely sub-prescribed by general practitioners, who are nevertheless in the front line in the care and the follow-up of the patients affected by BPCO. MATERIAL AND METHODS:Semi-qualitative study...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Small cell lung cancers were a clinical entity of severe prognosis until the nineteen eighties, time at which their frequent chemosensitivity was demonstrated. Around 90% of objective responses, in the case of complete response, lead to remission. Although still rare, remission depends on the ability of the treatment ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:Recent studies on smoking conducted in the ivory coast have been sparse despite increasingly aggressive tobacco company campaigns. The purpose of this prospective study was to examine the influence of medical specialty on patient knowledge, attitude and smoking behavior among people consulting three university hospita...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/s0761-8417(04)72102-1
更新日期：2004-09-01 00:00:00
abstract：:The authors studied 13 cases of arrhythmia following pneumonectomy in a series of 94 pneumonectomies performed in the Thoracic Surgery Unit. The arrhythmias essentially consisted of atrial fibrillation which was well tolerated haemodynamically. It generally occurred in ambulant patients on about the 5th postoperative ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
