Abstract:
:Histomorphometrical assessment of regenerated peripheral nerves is a very common goal of many studies in experimental microsurgery. In this paper, the main critical issues in nerve fiber sampling for quantitative morphological assessment are addressed. The equal opportunity rule, i.e., the basic paradigm of random sampling, is described, together with an explanation of how sampling errors, in the selection of histologic fields and of the nerve fibers inside them, can produce a bias in quantitative estimates. Finally, some practical suggestions on how to cope with the most common sampling errors are provided, in order to help researchers obtain reliable histomorphometrical data on peripheral nerve fibers.
journal_name
Microsurgeryjournal_title
Microsurgeryauthors
Geuna S,Gigo-Benato D,Rodrigues Ade Cdoi
10.1002/micr.10199subject
Has Abstractpub_date
2004-01-01 00:00:00pages
72-6issue
1eissn
0738-1085issn
1098-2752journal_volume
24pub_type
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