Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension.

Abstract:

:The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.

journal_name

Vision Res

journal_title

Vision research

authors

Rejdak R,Kohler K,Kocki T,Shenk Y,Turski WA,Okuno E,Lehaci C,Zagorski Z,Zrenner E,Schuettauf F

doi

10.1016/j.visres.2003.11.003

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

655-60

issue

7

eissn

0042-6989

issn

1878-5646

pii

S0042698903006977

journal_volume

44

pub_type

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