Abstract:
:The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.
journal_name
Vision Resjournal_title
Vision researchauthors
Rejdak R,Kohler K,Kocki T,Shenk Y,Turski WA,Okuno E,Lehaci C,Zagorski Z,Zrenner E,Schuettauf Fdoi
10.1016/j.visres.2003.11.003subject
Has Abstractpub_date
2004-03-01 00:00:00pages
655-60issue
7eissn
0042-6989issn
1878-5646pii
S0042698903006977journal_volume
44pub_type
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