Generation of the e-wave of the electroretinogram in the frog retina.

Abstract:

:The e-wave and a delayed-OFF increase in extracellular K+ concentration are both maximum in the distal half of the inner plexiform layer. These responses also have similar latency, time-course, intensity-dependence, surround properties, and sensitivity to tetrodotoxin. Current source-density analysis of the e-wave reveals a current sink through the proximal retina, a source at the retinal surface, and, in some cases, a weaker source in the mid-retina. These results suggest a model for e-wave generation: delayed-OFF activity in proximal neurons releases K+, which enters Muller cells in the inner plexiform layer; a current exists Muller cells primarily via their endfeet, and the return flow through extracellular space produces the e-wave.

journal_name

Vision Res

journal_title

Vision research

authors

Karwoski CJ,Newman EA

doi

10.1016/0042-6989(88)90136-8

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

1095-105

issue

10

eissn

0042-6989

issn

1878-5646

pii

0042-6989(88)90136-8

journal_volume

28

pub_type

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