Identification of an HP1 phage protein required for site-specific excision.

abstract：:The identification, isolation and characterization of a new Aspergillus nidulans positive-acting gene metR, which encodes a transcriptional activator of sulphur metabolism, is reported. metR mutants are tight auxotrophs requiring methionine or homocysteine for growth. Mutations in the metR gene are epistatic to mutati...

journal_title：Molecular microbiology

authors： Natorff R,Sieńko M,Brzywczy J,Paszewski A

更新日期：2003-08-01 00:00:00

abstract：:The alternative sigma factor sigma 54 is required for transcription of nitrogen fixation genes in Klebsiella pneumoniae and other diazotrophs. The nif genes, and other E sigma 54-dependent genes whose products are necessary for a wide range of processes, are postively regulated. A unifying model that is well supported...

journal_title：Molecular microbiology

authors： Buck M,Cannon W

更新日期：1992-06-01 00:00:00

abstract：:The heptacistronic dnaK heat shock operon of Bacillus subtilis consists of the genes hrcA, grpE, dnaK, dnaJ, orf35, orf28 and orf50. It is controlled by the CIRCE/HrcA operator/repressor system and specifies three primary transcripts, two of which are processed into three different products. We have analysed the regul...

journal_title：Molecular microbiology

authors： Homuth G,Mogk A,Schumann W

更新日期：1999-06-01 00:00:00

abstract：:The Plasmodium falciparum genome sequence has boosted hopes for a new era of malaria research and for the application of comprehensive molecular knowledge to disease control, but formidable obstacles remain: approximately 60% of the predicted P. falciparum proteins have no known functions or homologues, and most life ...

journal_title：Molecular microbiology

authors： Su XZ,Wootton JC

更新日期：2004-09-01 00:00:00

abstract：:We report here the identification and characterization of a member of the Myxococcus xanthus SdeK signal transduction pathway, BrgE. This protein was identified as an SdeK-interacting component using a yeast two-hybrid screen, and we further confirmed this interaction by the glutathione S-transferase (GST) pulldown as...

journal_title：Molecular microbiology

authors： Pham VD,Shebelut CW,Zumstein EJ,Singer M

更新日期：2005-08-01 00:00:00

abstract：:The secretion of numerous proteins during vegetative growth of Myxococcus xanthus, and the multicellular development cycle induced upon starvation of these bacteria, are partially interrelated in so far as mutants impaired in extracellular protein production are unable to undergo development. We have cloned and sequen...

journal_title：Molecular microbiology

authors： Laval-Favre K,Letouvet-Pawlak B,Friedrich T,Alexandre J,Guespin-Michel JF

更新日期：1997-03-01 00:00:00

abstract：:We have shown previously that deletion of the Saccharomyces cerevisiae UMP1 gene encoding the 20S proteasome maturase causes sensitivity to UV radiation. In the current report, we have extended this finding to show that mutations specifically compromising chymotrypsin-like or trypsin-like activity of 20S proteasome pe...

journal_title：Molecular microbiology

authors： Podlaska A,McIntyre J,Skoneczna A,Sledziewska-Gojska E

更新日期：2003-09-01 00:00:00

abstract：:Cyanobacteria respond to changes in light or nutrient availability by modifications in their photosynthetic light harvesting antenna. In unicellular cyanobacteria a small polypeptide (NblA) is required for phycobilisome degradation following environmental stresses. In the filamentous strain Tolypothrix sp. PCC 7601 th...

journal_title：Molecular microbiology

authors： Luque I,Ochoa De Alda JA,Richaud C,Zabulon G,Thomas JC,Houmard J

更新日期：2003-11-01 00:00:00

abstract：:Iron is a critical nutrient for the growth and survival of most bacterial species. Accordingly, much attention has been paid to the mechanisms by which host organisms sequester iron from invading bacteria and how bacteria acquire iron from their environment. However, under oxidative stress conditions such as those enc...

journal_title：Molecular microbiology

authors： Frawley ER,Fang FC

更新日期：2014-08-01 00:00:00

abstract：:In clinical isolates of Enterobacter cloacae, resistance to the newer beta-lactam antibiotics often results from overproduction of a cephalosporinase encoded by the beta-lactam-inducible ampC gene. Regulation of ampC is controlled by the divergently expressed activator gene, ampR, and a second unlinked locus. In this ...

journal_title：Molecular microbiology

authors： Honoré N,Nicolas MH,Cole ST

更新日期：1989-08-01 00:00:00

abstract：:Temperate phage P2 has the capacity to function as a helper for the defective, unrelated, satellite phage P4. In the absence of a helper, P4 can either lysogenize its host or establish itself as a plasmid. For lytic growth, P4 requires the structural genes, packaging and lysis functions of the helper. P4 can get acces...

journal_title：Molecular microbiology

authors： Liu T,Renberg SK,Haggård-Ljungquist E

更新日期：1998-12-01 00:00:00

abstract：:In Escherichia coli, RecA protein regulates the DNA damage-inducible survival-enhancing SOS response. Mutant allele recA730, which causes constitutive SOS expression, is lethal at high temperatures in B/r, a derivative of wild-type B, but not in K-12 or in certain B/r--K-12 hybrids. We present evidence that killing is...

journal_title：Molecular microbiology

authors： Kirchner J,Lim D,Witkin EM,Garvey N,Roegner-Maniscalco V

更新日期：1992-10-01 00:00:00

abstract：:Many fundamental cellular processes depend on enzymes that utilize chemical energy to catalyse unfavourable reactions. Certain classes of ATPases provide a particularly vivid example of the process of energy conversion, employing cycles of nucleotide turnover to move and/or rearrange biological polymers such as protei...

journal_title：Molecular microbiology

authors： Thomsen ND,Berger JM

更新日期：2008-09-01 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) is a leading cause of infant diarrhoea. EPEC mediates several effects on host epithelial cells, including activation of signal-transduction pathways, cytoskeletal rearrangement along with pedestal and attaching/effacing lesion formation. It has been previously shown that the EP...

journal_title：Molecular microbiology

authors： Kenny B,Lai LC,Finlay BB,Donnenberg MS

更新日期：1996-04-01 00:00:00

abstract：:In addition to being the major citric acid cycle aconitase in Escherichia coli the aconitase B protein (AcnB) is also a post-transcriptional regulator of gene expression. The AcnB proteins represent a distinct branch of the aconitase superfamily that possess a HEAT-like domain (domain 5). The HEAT domains of other pro...

journal_title：Molecular microbiology

authors： Tang Y,Guest JR,Artymiuk PJ,Green J

更新日期：2005-06-01 00:00:00

abstract：:The genes encoding cholera toxin, the principal virulence factor of Vibrio cholerae, are part of the circular single-stranded DNA genome of CTXphi. In toxigenic V. cholerae strains, the CTXphi genome is typically found in integrated arrays of tandemly arranged CTX prophages. Infected cells that lack a chromosomal inte...

journal_title：Molecular microbiology

authors： Moyer KE,Kimsey HH,Waldor MK

更新日期：2001-07-01 00:00:00

abstract：:Neisseria meningitidis controls the expression of several genes involved in host adaptation by a process known as phase variation. The phase variation frequency of haemoglobin (Hb) receptors among clinical isolates of serogroups A, B and C differed drastically, ranging from approximately 10(-6) to 10(-2) cfu-1. Freque...

journal_title：Molecular microbiology

authors： Richardson AR,Stojiljkovic I

更新日期：2001-05-01 00:00:00

abstract：:The psaBCA locus of Streptococcus pneumoniae encodes a putative ABC Mn2+-permease complex. Downstream of the operon is psaD, which may be co-transcribed and encodes a thiol peroxidase. Previously, there has been discordance concerning the phenotypic impact of mutations in the psa locus, resolution of which has been co...

journal_title：Molecular microbiology

authors： McAllister LJ,Tseng HJ,Ogunniyi AD,Jennings MP,McEwan AG,Paton JC

更新日期：2004-08-01 00:00:00

abstract：:The plasmid encoded LlaI R/M system from Lactococcus lactis ssp. lactis consists of a bidomain methylase, with close evolutionary ties to type IIS methylases, and a trisubunit restriction complex. Both the methylase and restriction subunits are encoded on a polycistronic 6.9 kb operon. In this study, the 5' end of the...

journal_title：Molecular microbiology

authors： O'Sullivan DJ,Klaenhammer TR

更新日期：1998-03-01 00:00:00

abstract：:The minimum time (E) required for a new pair of replication origins (oriCs) produced upon initiating a round of replication to be ready to initiate the next round after one cell mass doubling, the 'eclipse', is explained in terms of a minimal distance (l(min)) that the replication forks must move away from oriC before...

journal_title：Molecular microbiology

authors： Zaritsky A,Vischer N,Rabinovitch A

更新日期：2007-01-01 00:00:00

abstract：:Cellulosomes are key for lignocellulosic biomass degradation in cellulolytic Clostridia. Better understanding of the mechanism of cellulosome regulation would allow us to improve lignocellulose hydrolysis. It is hypothesized that cellulosomal protease inhibitors would regulate cellulosome architecture and then lignoce...

journal_title：Molecular microbiology

authors： Xu T,Li Y,He Z,Zhou J

更新日期：2014-02-01 00:00:00

abstract：:IscU is a central component of the ISC machinery and serves as a scaffold for de novo assembly of Fe-S clusters. The dedicated chaperone system composed of the Hsp70-chaperone HscA and the J-protein cochaperone HscB synergistically interacts with IscU and facilitates cluster transfer from IscU to recipient apo-protein...

journal_title：Molecular microbiology

authors： Sato S,Matsushima Y,Kanazawa M,Tanaka N,Fujishiro T,Kunichika K,Nakamura R,Tomioka H,Wada K,Takahashi Y

更新日期：2020-11-17 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium capable of complex developmental processes involving vegetative swarming and fruiting body formation. Social (S-) gliding motility, one of the two motility systems used by M. xanthus, requires at least two cell surface structures: type IV pili (TFP) and extracellular pol...

journal_title：Molecular microbiology

authors： Yang Z,Lux R,Hu W,Hu C,Shi W

更新日期：2010-06-01 00:00:00

abstract：:The Myxococcus xanthus gene, pkn9, encodes a protein that contains significant homology with eukaryotic Ser/Thr protein kinases. The pkn9 gene was singled out of a previously identified family of kinase genes by amplification techniques that displayed differences in kinase gene expression during selected periods of th...

journal_title：Molecular microbiology

authors： Hanlon WA,Inouye M,Inouye S

更新日期：1997-02-01 00:00:00

abstract：:DnaA protein (a trans-acting element) and its binding sequence, DnaA-box: (a cis-acting element) are two elements essential for the initiation of chromosomal replication in Escherichia coli and other enteric bacteria. Recently these two elements have been found to be conserved in three Gram-positive bacteria (Bacillus...

journal_title：Molecular microbiology

authors： Yoshikawa H,Ogasawara N

更新日期：1991-11-01 00:00:00

abstract：:Periplasmic Cu,Zn-superoxide dismutases (Cu,Zn-SODs) are implicated in bacterial virulence. It has been proposed that some bacterial P(1B)-type ATPases supply copper to periplasmic cupro-proteins and such transporters have also been implicated in virulence. Here we show that either of two P(1B)-type ATPases, CopA or G...

journal_title：Molecular microbiology

authors： Osman D,Patterson CJ,Bailey K,Fisher K,Robinson NJ,Rigby SE,Cavet JS

更新日期：2013-02-01 00:00:00

abstract：:An essential early event in Shigella and Salmonella pathogenesis is invasion of non-phagocytic intestinal epithelial cells. Pathogen entry is triggered by the delivery of multiple bacterial effector proteins into target mammalian cells. The Shigella invasion plasmid antigen B (IpaB), which inserts into the host plasma...

journal_title：Molecular microbiology

authors： Hume PJ,McGhie EJ,Hayward RD,Koronakis V

更新日期：2003-07-01 00:00:00

abstract：:Fourteen Rhodobacter capsulatus mutants unable to grow with xanthine as sole nitrogen source were isolated by random Tn5 mutagenesis. Five of these Tn5 insertions were mapped within two adjacent chromosomal EcoRI fragments hybridizing to oligonucleotides synthesized according to conserved amino acid sequences of eukar...

journal_title：Molecular microbiology

authors： Leimkühler S,Kern M,Solomon PS,McEwan AG,Schwarz G,Mendel RR,Klipp W

更新日期：1998-02-01 00:00:00

abstract：:Transcript degradation is a key step in gene regulation. In eukaryotes, mRNA decay is generally initiated by removal of the poly(A) tail mediated by the Ccr4-Caf1-Not complex. Deadenylated transcripts are then rapidly degraded, primarily via the decapping-dependent pathway. Components of this pathway can be localized ...

journal_title：Molecular microbiology

authors： Morozov IY,Jones MG,Spiller DG,Rigden DJ,Dattenböck C,Novotny R,Strauss J,Caddick MX

更新日期：2010-04-01 00:00:00

abstract：:The Bordetella pertussis wlb locus (wlbpe, formerly bpl) is required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS. The equivalent loci in Bordetella bronchiseptica (wlbbr) and Bordetella parapertussis (wlbpa) were identifie...

journal_title：Molecular microbiology

authors： Allen AG,Thomas RM,Cadisch JT,Maskell DJ

更新日期：1998-07-01 00:00:00