Topotecan-induced bronchiolitis.

Abstract:

:Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one other case of lung toxicity in a patient taking topotecan has been reported. The authors describe the development of obliterative bronchiolitis, as evidenced by radiographic and pulmonary function testing abnormalities, in a 61-year-old woman who presented with dyspnea, and who was receiving topotecan for peritoneal carcinomatosis.

journal_name

South Med J

journal_title

Southern medical journal

authors

Edgerton CC,Gilman M,Roth BJ

doi

10.1097/00007611-200407000-00018

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

699-701

issue

7

eissn

0038-4348

issn

1541-8243

journal_volume

97

pub_type

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