Abstract：
:A polarographic study about how three anti-inflammatories, such as Aceclofenac, Tenoxicam and Droxicam behave, using tast polarography (TP) and differential pulse polarography (DPP) was carried out. These studies were always carried out in a media formed by Methanol-Britton-Robinson aqueous buffer (0.1M) (4:96 (v/v)) due to the low solubility of these drugs in water. A strong influence of pH on analytical signals was observed, showing that the optimal pH values were between 4 and 5. Using DPP in the optimal experimental conditions, a detection limit of 10 ppb for Tenoxicam and Droxicam and 52 ppb for Aceclofenac was reached. The DPP proposed method was successfully applied to the determination of the active compounds in commercial drugs.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Acuña JA,Vázquez MD,Tascón ML,Sánchez-Batanero Pdoi
10.1016/j.jpba.2004.04.018subject
Has Abstractpub_date
2004-09-21 00:00:00pages
157-62issue
1eissn
0731-7085issn
1873-264Xpii
S0731708504002122journal_volume
36pub_type
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