Optimization and validation of a dissolution test for selegiline hydrochloride tablets by a novel rapid HPLC assay using a monolithic stationary phase.

abstract：:The development of a new HPLC-UV diode array procedure applied to follow the hydrolytic degradation of two well-known 4-nitrophenyl-1,4-dihydropyridine derivatives, nitrendipine and nisoldipine is reported. Hydrolysis of each drug were carried out in ethanol/Britton-Robinson buffer at different pHs, stored into amber ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Alvarez-Lueje A,Sturm J,Squella JA,Núñez-Vergara LJ

更新日期：2002-06-01 00:00:00

abstract：:As new metabolic pathways of cocaine were recently identified, a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously determine cocaine and nine cocaine-related metabolites in whole blood samples. One-step solid phase extraction was used to extract all of th...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Chen X,Zheng X,Ding K,Zhou Z,Zhan CG,Zheng F

更新日期：2017-02-05 00:00:00

abstract：:Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc., of pharmaceuticals. In this article, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Erny GL,Cifuentes A

更新日期：2006-02-24 00:00:00

abstract：:Four microemulsion liquid chromatography (MELC) systems and one micellar liquid chromatography (MLC) system have been evaluated as potential high-throughput screening platforms capable of modeling the partitioning behaviors of drug compounds in an n-octanol/water system and predicting their lipophilicity (i.e., log P ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Xu L,Li L,Huang J,Yu S,Wang J,Li N

更新日期：2015-01-01 00:00:00

abstract：:In this paper a novel electrochemical sensor based on nickel carbide (Ni3C) nanoparticles as a new modifier was constructed. Ni3C nanoparticle was synthesized and characterized by scanning electron microscopy, X-ray diffraction and first-principles study. Electrochemical impedance spectroscopy (EIS) and cyclic voltamm...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Torkashvand M,Gholivand MB,Taherpour AA,Boochani A,Akhtar A

更新日期：2017-05-30 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) injectable products are a key commodity for reproductive health and are available in the global market from a variety of manufacturing sources. Depending on the climatic zone conditions of the destination country for product use, MPA injectables are at risk of exposure to adverse tran...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Jenkins D,Harmon CL,Jia X,Kesselring A,Hatcher D,Grayson K,Ayres J

更新日期：2020-08-05 00:00:00

abstract：:A method based on capillary electrophoresis with electrochemical detection has been developed for the separation and determination of paeoniflorin, sucrose, paeonoside, glucose, and fructose in Moutan Cortex for the first time. Effects of several important factors such as the concentration of NaOH, separation voltage,...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Chen G,Zhang L,Zhu Y

更新日期：2006-04-11 00:00:00

abstract：:The urinary excretion of 2-hydroxyphenylacetic acid (2HPAA) was studied in human volunteers after oral and parenteral doses of coumarin. The presence of 2HPAA in the urine was confirmed by gas chromatography mass spectroscopy (GC MS). Mass spectra of reference material and samples are presented. The determination of 2...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Meineke I,Desel H,Kahl R,Kahl GF,Gundert-Remy U

更新日期：1998-07-01 00:00:00

abstract：:We describe a simple method for evaluating the inhibition of collagen IV degradation by cathepsin B with a surface plasmon resonance (SPR) biosensor. The change in the SPR signal decreased with an increase in the concentration of cathepsin B inhibitors. The order of the inhibitory constant (Ki) obtained by the SPR met...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Shoji A,Suenaga Y,Hosaka A,Ishida Y,Yanagida A,Sugawara M

更新日期：2017-10-25 00:00:00

abstract：:A sensitive and specific method for the determination of bifendate in human plasma was developed, based on high-performance liquid chromatography (HPLC)-mass spectrometry (MS). The samples were extracted from plasma with diethyl ether, followed by separation and evaporation after addition of internal standard diazepam...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhou L,Gu L,Wang Y,Liang J

更新日期：2006-03-03 00:00:00

abstract：:Drugs of long-term use may cause the accumulation of chemical compounds in human body. Therefore, the evaluation and structure characterization of synthesis and degradation impurities is substantial to guarantee drug safety and successful pharmaceutical therapy. The present work evaluated the anticoagulant rivaroxaban...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wingert NR,dos Santos NO,Nunes MA,Gomes P,Müller EI,Flores ÉM,Steppe M

更新日期：2016-05-10 00:00:00

abstract：:A sensitive and simple liquid chromatography-mass spectrometry (LC-MS) method has been developed and validated for the quantification of solamargine, a steroidal glycoalkaloid, in rat plasma. Vincristine was selected as the internal standard. Sample preparation involved simple liquid-liquid extraction by ethyl acetate...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zheng X,Xu L,Liang Y,Xiao W,Xie L,Zhang Y,Zhao L,Cao L,Chen J,Wang G

更新日期：2011-07-15 00:00:00

abstract：:Total plasma homocysteine (tHcy) in children may be an useful biochemical marker for genetic risk of premature cardiovascular disease. We reported a rapid, isocratic HPLC method able to process very small amount of newborn plasma samples. A blood sample from heel capillary circulation was collected, using a heparinize...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bartesaghi S,Accinni R,De Leo G,Cursano CF,Campolo J,Galluzzo C,Vegezzi PG,Parodi O

更新日期：2001-03-01 00:00:00

abstract：:A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma, using liquiritin as the internal standard. Plasma samples extracted with a solid-phase extraction procedure were separated...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Tong L,Zhou D,Gao J,Zhu Y,Sun H,Bi K

更新日期：2012-01-25 00:00:00

abstract：:A specific and reliable liquid chromatography-electrospray ionization-tandem mass spectrometry method was developed for the simultaneous determination of tetrahydropalmatine (THP), tetrahydroberineper (THB), tetrahydrocoptisine (THC) and corydaline (CDL) in rat plasma using jatrorrhizine as internal standard. Plasma s...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Wang S,Liu L,Wang L,Jiang P,Xiang L,Zhang W,Liu R

更新日期：2013-01-01 00:00:00

abstract：:In this study the authors developed a real-time Process Analytical Technology (PAT) of a coating process by applying in-line Raman spectroscopy to evaluate the coating weight gain, which is a quantitative analysis of the film coating layer. The wide area illumination (WAI) Raman probe was connected to the pan coater f...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kim B,Woo YA

更新日期：2018-05-30 00:00:00

abstract：:Health benefits of wine, especially with red wine, have been linked to the presence of a wide range of phenolic antioxidants. Thus, the aim of this study was to develop a simple, high performance thin layer chromatographic (HPTLC) method combined with high resolution digital plate images to visually compare multiple w...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Agatonovic-Kustrin S,Hettiarachchi CG,Morton DW,Razic S

更新日期：2015-01-01 00:00:00

abstract：:A simple and sensitive liquid chromatography/tandem mass spectrometry method was developed and validated for the quantification of rosuvastatin in human plasma. After being treated with acetic acid and tetrabutyl ammonium hydroxide, the analyte was extracted by simple one-step liquid-liquid extraction with the interna...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lan K,Jiang X,Li Y,Wang L,Zhou J,Jiang Q,Ye L

更新日期：2007-06-28 00:00:00

abstract：:Antioxidants are added to foods and drugs to inhibit their oxidation. As these additives are somewhat toxic, it is necessary to control the amount added to any food or drug. Liquid chromatography (LC) is a powerful tool for this purpose. Many antioxidants are electroactive molecules which enables the advantages of ele...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Boussenadji R,Porthault M,Berthod A

更新日期：1993-01-01 00:00:00

abstract：:Zishen Yutai Pills (ZYP) is a well-known Chinese patent medicine which has been used to prevent recurrent miscarriage and treat threatened abortion in China. In this study, a comprehensive strategy combining ultrahigh performance liquid chromatography coupled with charged aerosol detector (UHPLC-CAD) fingerprint and m...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cao J,Lei T,Wu S,Li H,Deng Y,Lin R,Ning N,Geng C,Wang S,Wu X,Li P,Wang Y

更新日期：2020-11-30 00:00:00

abstract：:A novel method was developed for the determination of aucubin in rat serum by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with supramolecular solvent (SUPRAS)-based dispersive liquid-liquid microextraction (DLLME). The SUPRAS was prepared with pentanol as extraction solvent and tetrah...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lian X,Wang N,Ma L,Jiang H,Bai D,Xue H,Ma Q

更新日期：2020-07-15 00:00:00

abstract：:A micellar electrokinetic chromatographic (MEKC) method was developed for the quantification of lovastatin and simvastatin, cholesterol lowering agents in pharmaceutical dosage forms. Lovastatin and simvastatin were separated using an electrolyte system consisting of 12% acetonitrile (v/v) in 25 mM sodium borate buffe...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Srinivasu MK,Raju AN,Reddy GO

更新日期：2002-07-20 00:00:00

abstract：:Cationic Mn porphyrins are among the most potent catalytic antioxidants and/or cellular redox modulators. Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride (MnTE-2-PyPCl(5)) is the Mn porphyrin most studied in vivo and has successfully rescued animal models of a variety of oxidative stress-related diseas...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Pinto VH,Carvalhoda-Silva D,Santos JL,Weitner T,Fonseca MG,Yoshida MI,Idemori YM,Batinić-Haberle I,Rebouças JS

更新日期：2013-01-25 00:00:00

abstract：:Microgravity-induced memory deficiency seriously affects learning and memory ability of the astronaut during spaceflight, with few effective countermeasures. Panax ginseng C. A. Mey. has been used as a nootropic herb for thousands of years in Asian countries. Saponins are recognized as its major active components. Pre...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Feng L,Yue XF,Chen YX,Liu XM,Wang LS,Cao FR,Wang Q,Liao YH,Pan RL,Chang Q

更新日期：2016-06-05 00:00:00

abstract：:In order to facilitate correlation calculation and matrix-based resolution in comprehensive two-dimensional gas chromatography - mass spectrometry (GC × GC-MS) data-set, an intelligent clustering of modulation peaks (ICMP) algorithm was developed in this paper. ICMP is start with the second -dimension (2D) peak restri...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： He M,Zeng J,Peng G,Zhou Y,Cao W

更新日期：2021-02-05 00:00:00

abstract：:A method for the separation of polymerized impurities in meropenem has been developed by gel filtration chromatography (GFC). The chromatographic conditions included a Superdex peptide HR 10/30 column and the mobile phase consisting of 0.01 mol L(-1) sodium phosphate buffer (pH 7.0), at a flow rate of 0.8 mL min(-1). ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cai SY,Hu CQ

更新日期：2005-03-09 00:00:00

abstract：:Enantiomers of various solutes including several basic drugs and alpha-amino acids were analyzed by capillary electrophoresis in diluted human serum, and chloroquine and tryptophan were found to be well enantioseparated. In order to specify the protein responsible for enantioseparation, these drug enantiomers were ana...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Taga A,Du Y,Suzuki S,Honda S

更新日期：2003-01-01 00:00:00

abstract：:A simple, rapid and efficient microextraction method for the extraction and determination of some 2-pyrazoline derivative compounds in aqueous samples was developed. Microliter volumes of 1-undecanol were delivered to the surface of the aqueous sample and the sample was agitated for a desire time. The sample vial was ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sobhi HR,Yamini Y,Esrafili A,Adib M

更新日期：2008-12-01 00:00:00

abstract：:An UPLC-MS/MS method for the quantification of indirubin in lithium heparinized rat plasma was developed and validated according to current international guidelines. Indirubin was extracted from rat plasma by using Waters Ostro™ pass-through sample preparation plates. The method was validated with a LLOQ of 5.00ng/mL ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Jähne EA,Sampath C,Butterweck V,Hamburger M,Oufir M

更新日期：2016-09-05 00:00:00

abstract：:Determination of anthocyanins in fresh and concentrated juices can be a parameter for the assessment of authenticity and quality of blood orange juices. This work reports an HPLC/UV-Vis method developed for quantitative determination of anthocyanins in blood orange juices, by using a calibration curve obtained for sta...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mondello L,Cotroneo A,Errante G,Dugo G,Dugo P

更新日期：2000-08-01 00:00:00