Abstract：
:This study reports on our experience with whole herpes simplex vaccines in Bulgaria for a period of 17 years. More than 1,500 immunized patients with herpes ophtalmicus showed a reduction of the recovery period, reduced number of the recurrences and reduced risk of visual damage. More than 14,000 patients suffering from other forms of herpes diseases for a longer period showed reduced recovery period and recurrence frequency in over 95% of the cases. Whole vaccines were well tolerable with no side effects. This report emphasizes the usefulness of whole herpes vaccines.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Dundarov S,Andonov Psubject
Has Abstractpub_date
1994-08-01 00:00:00pages
205-8issue
4eissn
0001-723Xissn
1336-2305journal_volume
38pub_type
临床试验,杂志文章相关文献
ACTA VIROLOGICA文献大全abstract：:The effect of storage conditions on the serological activity of two strains of potato virus S (PVS), Andean and the ordinary, was studied by ELISA. Virus purificates, infected leaves and their homogenates, stored in lyophilized, frozen and dissolved form at various temperatures were tested. Virus purificates were most...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Thirty four chemical compounds were injected into rabies infected mice by intramuscular (i.m.) route. Twenty four compounds such as well known therapeutic agents: amantadine, lipacids, phenol compounds, didemnin-B, procaine, nucleosides analogues (ribavirin, tiazofurin, pyrazofurin) had no effect. Two compounds had a ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:To elucidate epidemiological interference between respiratory syncytial (RSV) and influenza viruses, the influence of influenza A (HlN1) virus on the growth of RSV was examined. Although RSV grew in MDCK cells, coinfection with influenza A virus led to a reduction of progeny RSV. The degree of growth interference depe...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:A gene bank of Rickettsia prowazekii strain E constructed in the phage vector lambda EMBL4 was screened for antigen production with anti-R. prowazekii serum. One of the immunoreactive clones, grown at 37 degrees C exhibited the expression of at least two antigens of molecular weight (M(r)) 37 kD and 14 kD. Subcloning ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Two Infectious bursal disease virus (IBDV) isolates, NP1SSH and NP2K were obtained from a severe infectious bursal disease (IBD) outbreak in Nepal in 2002. The hypervariable (HV) region of VP2 gene (1326 bp) of the isolates was generated by RT-PCR and sequenced. The obtained nucleotide sequences were compared with tho...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:A resistant influenza virus has been obtained during successive passages of influenza A virus in 10 to 11-day-old chick embryos (CE) in the presence of 2-(1'-amino-ethyl)-bicyclo(2.2.1) heptane chlorohydrate possessing a high antiviral activity. The virus resistance to the inhibitor was not lost after one passage in t...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The achievements and perspectives of genetic manipulations are described aiming at preparation of first generation subunit vaccines based on the synthesis in bacterial and eukaryotic cells of full-sized virion proteins expressing the main antigenic determinants. The preparation of such vaccines in bacterial cells seem...
journal_title：Acta virologica
pub_type： 杂志文章,评审
doi：
更新日期：1985-05-01 00:00:00
abstract：:Neopterin and soluble CD14 (sCD14) are detected at high levels in hepatitis C virus (HCV) infections. We aimed to evaluate the role of these plasma immune activation biomarkers, for the indirect assessment of immune activation status of patients with low anti-HCV reactivity and a HCV infection. Low anti-HCV reactivity...
journal_title：Acta virologica
pub_type： 杂志文章,多中心研究
doi：10.4149/av_2017_304
更新日期：2017-01-01 00:00:00
abstract：:Cauliflower mosaic virus (CaMV) - a plant pararetrovirus that naturally causes diseases in Brassicaceae and Solanaceae plant hosts worldwide - has been detected by PCR for the first time in herbarium samples of Usnea sp. lichens. The virus's presence in these lichens did not result in any micro- or macromorphological ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2016_02_196
更新日期：2016-06-01 00:00:00
abstract：:Phages are excellent models for studying the mechanism of DNA replication in prokaryotes. Identification of phage proteins involved in phage DNA replication is the first prerequisite for elucidation of the phage replication module. We focused on replication proteins gp41 (a putative helicase from SF2 superfamily), gp4...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2014_02_152
更新日期：2014-01-01 00:00:00
abstract：:A noninfectious soluble antigen fraction of goat poxvirus (GPV) fractionated by ammonium sulfate precipitation was tested for its suitability as coating antigen in an indirect enzyme-linked immunosorbent assay (ELISA). Accordingly, an avidin-biotin ELISA for the detection of GPV antibodies was optimized and evaluated ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Human respiratory syncytial virus (HRSV) is a leading pathogen causing lower respiratory tract infections in infants and young children worldwide. In line with the development of an effective vaccine against HRSV, a domain of the fusion (F) glycoprotein of HRSV was produced and its immunogenicity and antigenic propert...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2010_03_181
更新日期：2010-01-01 00:00:00
abstract：:In order to determine the definitive importance of T- and B-lymphocytes in immunity to Rickettsia conorii, mice genetically deficient in T-cells, B-cells, or both T- and B-cells were infected experimentally. T-lymphocytes rather than humoral antibodies were crucial to rickettsial clearance and a reduced mortality rate...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:A highly specific rabbit antiserum raised against anionic peroxidase (PRX) purified from cucumber (Cucumis sativus L., cv. Laura) cotyledons infected with tobacco necrosis virus (TNV) was used to further investigate the antigenic relatedness of peroxidases in the selected plant species. Immunoblot analysis using nativ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Haemagglutinin (HA) and fusion (F) proteins of peste-des-petits-ruminants virus (PPRV) and rinderpest virus (RPV) were purified by immunoaffinity chromatography. The purified proteins were characterized by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (SDS-PAGE). Rabbit hyperimmune sera ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:In 1986 five avian paramyxovirus (PMV) strains were isolated in embryonated chicken eggs from sick children with influenza. The strains were identified as PMV-2 serotype due to the close antigenic relationships between their HN-proteins and of the reference PMV-2 strains isolated from different birds all over the worl...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Genetic variation in Japanese encephalitis (JE) virus strains after various passage histories was examined by oligonucleotide fingerprints of the 42S genome RNA. The results indicated that genome changes occurred during passages of new virus isolates through cell lines or mouse brains, especially at earlier passage le...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:2-0-hexadecyl-glycero-3-phosphocholine (GPC) 1 mmol/l solution reduced the infectivity of red clover mottle virus (RCMV) by over 90%. The binding of GPC molecules to RCMV particles was investigated with 1H-nmr spectroscopy, which showed a striking interaction between virus particles and GPC molecules. In 10 mmol/l GPC...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:Over a 5-year observation period in a children-institution community, the severity of respiratory-syncytial (RS) virus infection varied within a broad range depending on biological properties of the circulating virus population. The type of virus population was characterized by a complex of biological features, namely...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:Replication of vaccinia virus DNA in chick embryo fibroblasts at a high multiplicity of infection started after 4-6 hr, reached a maximum at the 12th hr and was completed 18 hr after inoculation (p.i.). An analysis of newly synthesised DNAs in the period of the highest rate of synthesis revealed the formation of short...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Immobilization stress (hypokinesis) in Balb/c mice may aggravate asymptomatic infection with Langat virus (strain TP-21) as evidenced by 4-fold increased lethality in comparison with control animals. The virus levels in the spleen and brain of stressed and infected mice and the in vitro yield of the virus in immunocom...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：UNLABELLED:DNA vaccines containing the capsid precursor polypeptide P1 gene of foot-and-mouth disease virus (FMDV) alone or combined with the VP22 gene of bovine herpesvirus 1 (BVP22) as molecular adjuvant were constructed and used for immunization of BALB/c mice. The latter were challenged with FMDV and their humoral ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2012_02_111
更新日期：2012-01-01 00:00:00
abstract：:Studies on interaction between Herpes simplex virus 1 (HSV-1) and human fibroblasts KMB-17 have demonstrated that HSV-1 binding to the cell surface could induce a specific gene response. In this study, the HSV-1 stimulation-related gene 1 (HSRG1), a new so far unknown gene function of cellular response induced by a sp...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The discovery of respiratory tract involvement in the pathogenesis of foot-and-mouth disease (FMD) and the recognition of the role of inhalated aerosols in virus transfer opened new outlooks in the epizootology and prophylaxis of the disease. Nevertheless, FMD should be regarded for an infection transmitted by contami...
journal_title：Acta virologica
pub_type： 杂志文章,评审
doi：
更新日期：1983-07-01 00:00:00
abstract：:The activities, the temperature and pH optima of in vitro functioning and stability upon heating of virion transcriptase of 10 human influenza virus A strains differing in reactogenicity and isolated in different epidemiological situations, and of fowl plague virus (FVP) were compared. As compared with virion transcri...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:Identification of structural protein relationships is likely to be important for virus assembly and anti-WSSV strategies. In this paper, VP90 of white spot syndrome virus (WSSV) was characterized. Temporal-transcription analysis showed that VP90 is expressed in the late stage of WSSV infection. Far-western and matrix-...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2012_01_57
更新日期：2012-01-01 00:00:00
abstract：:We followed the viral kinetics and histopathological changes in different organs of immunocompetent mice infected orally with coxsackieviruses B3 (CVB3) Nancy strain and B4 (CVB4) JVB strain separately. The viruses used were not adapted to mouse organs. In the acute phase of infection, the viral kinetics indicated vir...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Betaflexiviridae is a family of plant-infecting RNA viruses with 11 recognized genera, of which genomes have diverse organization with three to six open reading frames (ORFs). A genome sequence of a novel Betaflexiviridae species, named Salvia divinorum RNA virus 1 (SdRV1), was identified in Salvia divinorum, herbal m...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2019_401
更新日期：2019-01-01 00:00:00
abstract：:The first confirmed evidence of scrapie in Slovakia was demonstrated in one sheep of the autochthonous Merino breed from the southeastern part of the country. The reported scrapie was diagnosed during compulsory transmissible spongiform encephalitis (TSE) screening of sheep over 9 months of age assigned for consumptio...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:A virus, designated Razdan, was isolated from Dermacentor marginatus ticks in the Armenian S.S.R. in 1973. The complement fixation tests revealed no antigenic relationships to 74 tick-borne arboviruses. The size of the virus is about 100 nm; it agglutinates goose erythrocytes at pH 5.5--7.0, is pathogenic for newborn,...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
