Identification of a novel member of the family Betaflexiviridae from the hallucinogenic plant Salvia divinorum.

Abstract:

:Betaflexiviridae is a family of plant-infecting RNA viruses with 11 recognized genera, of which genomes have diverse organization with three to six open reading frames (ORFs). A genome sequence of a novel Betaflexiviridae species, named Salvia divinorum RNA virus 1 (SdRV1), was identified in Salvia divinorum, herbal mint plant with hallucinogenic properties. The SdRV1 genome was predicted to have four ORFs encoding a replicase polyprotein (REP), a movement protein (MP), a coat protein (CP), and a putative nucleic acid-binding protein (NBP). Phylogenetic analyses based on the REP, MP, and CP sequences indicated that SdRV1 is most closely related to members of the genus Citrivirus. However, the genome organization of SdRV1 is the same as that of the genus Prunevirus. Moreover, the SdRV1 NBP had greatest sequence similarity with members of the genus Carlavirus. A complex evolutionary history involving ancestors of these three genera might have resulted in the unique phylogenetic position of SdRV1, which could be considered the founding member of a new genus in the family Betaflexiviridae. The genome sequence of SdRV1 might be useful for studies on the evolution of Betaflexiviridae. Keywords: Salvia divinorum RNA virus 1; Betaflexiviridae; Salvia divinorum.

journal_name

Acta Virol

journal_title

Acta virologica

authors

Goh CJ,Hahn Y

doi

10.4149/av_2019_401

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

373-379

issue

4

eissn

0001-723X

issn

1336-2305

journal_volume

63

pub_type

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