Abstract：
:To examine how rod and cone function are differentially affected during retinal degeneration, and after subretinal cell grafting, we obtained light- and dark-adaptation curves by recording threshold multiunit responses from the superior colliculus of anesthetized rats. Unoperated RCS dystrophic and non-dystrophic rats were used and the effects of subretinal grafting in dystrophic rats of cells known to limit photoreceptor degeneration were examined. The adaptation curves showed that rod function was severely compromised in unoperated dystrophic RCS rats at low luminance levels, even as early as 21 days of age and that cone thresholds became gradually elevated over time. While cell transplantation preserved both rod and cone photoreceptors, rod function did not recover, although further deterioration of cone threshold responses was prevented. This raises concern that measures of outer nuclear layer thickness may not in themselves be an accurate measure of visual capabilities and efficacy of a restoration strategy.
journal_name
Vision Resjournal_title
Vision researchauthors
Girman SV,Wang S,Lund RDdoi
10.1016/j.visres.2004.08.023subject
Has Abstractpub_date
2005-02-01 00:00:00pages
343-54issue
3eissn
0042-6989issn
1878-5646pii
S0042-6989(04)00431-6journal_volume
45pub_type
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