Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non small cell lung cancer.

Abstract:

OBJECTIVE:In vitro and animal studies suggest that antitumor effect of chemotherapeutic agents may be enhanced by antioxidants. Therefore, we initiated a clinical study to test the efficacy of high-dose multiple antioxidants (vitamins C, E and beta carotene) as an adjunct to chemotherapy (paclitaxel and carboplatin) in non-small-cell lung cancer. METHODS:136 patients of stage IIIb and stage IV NSCLC were randomized to receive chemotherapy (paclitaxel and carboplatin) alone (chemotherapy arm, n = 72) or chemotherapy in combination with ascorbic acid 6100 mg/day, dl-alpha-tocopherol (vitamin E) 1050 mg/day and beta-carotene 60 mg/day (combination arm, n = 64). Survival were calculated by the Kaplan-Meier method and compared using the log-rank test. RESULTS:An overall response rate (RR) of 33% was observed in chemotherapy arm with 24 patients showing a partial response (PR) and none showing a complete response (CR). In combination arm the overall RR was 37% with 24 patients showing PR and two showing CR. The median survival times in chemotherapy arm and combination arm were nine and 11 months respectively. The overall survival (OS) rates in chemotherapy arm and combination arm at one year were 32.9% and 39.1%, and at two years, 11.1% and 15.6% respectively. None of these differences were statistically significant (p = 0.20). Toxicity profiles were similar in both arms. CONCLUSIONS:These results do not support the concern that antioxidants might protect cancer cells from the free radical damage induced by chemotherapy. Larger trials are needed to demonstrate whether high-dose multiple antioxidants in conjunction with chemotherapy increase the response rates and/or survival time in advanced lung cancer.

journal_name

J Am Coll Nutr

authors

Pathak AK,Bhutani M,Guleria R,Bal S,Mohan A,Mohanti BK,Sharma A,Pathak R,Bhardwaj NK,Prasad KN,Kochupillai V

doi

10.1080/07315724.2005.10719438

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

16-21

issue

1

eissn

0731-5724

issn

1541-1087

pii

24/1/16

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Nasr NJ,Kaminski MV Jr,Sriram K

    更新日期:1982-01-01 00:00:00

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    abstract::Objective: Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary society because of the changing dieting styles. Complicated syndromes often accompanied by obesity and diabetes makes no standard treatment for NASH. Therefore, we investigated the potential role of Antrodia cinnamomea ...

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    更新日期:2020-07-13 00:00:00

  • Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome.

    abstract:BACKGROUND:Intravenous administration of magnesium sulphate (MgSO(4)) is a very effective and safe treatment for torsades de pointes (TdP) associated with acquired long QT syndrome (LQTS) in adults. Discussed here is the efficacy of MgSO(4) for TdP in children with congenital and acquired LQTS. METHODS:The optimal MgS...

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    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719388

    authors: Hoshino K,Ogawa K,Hishitani T,Isobe T,Eto Y

    更新日期:2004-10-01 00:00:00

  • Reproducibility of relative dose response (RDR) test and serum retinol and retinyl ester concentrations in children after a 2-week interval.

    abstract:OBJECTIVE:Reproducibility of the relative dose response test (RDR), a test designed to measure vitamin A status, was tested in 23 Belizean children, 5-8 years after 2-week interval during which no treatment was given. METHODS:As required for the RDR test, serum retinol concentrations were determined before and 5 hours...

    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1996.10718623

    authors: Apgar J,Makdani D,Sowell AL,Gunter EW,Hegar A,Rao D,Smith JC

    更新日期:1996-10-01 00:00:00

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    abstract:OBJECTIVE:We tested the hypothesis that pectin, a source of dietary fiber that delays gastric emptying, increases satiety. METHODS:Male (n = 49) and female (n = 25) US Army employees within normal weight limits were fasted overnight then fed 448 mL of orange juice on 2 separate days followed 4 hours later by 0.473 L o...

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    pub_type: 杂志文章

    doi:10.1080/07315724.1997.10718708

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    更新日期:1997-10-01 00:00:00

  • Dietary sugars and carbohydrate metabolism in type II diabetes.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,评审

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    authors: Hallfrisch J

    更新日期:1987-10-01 00:00:00

  • Adolescent life-event stress in boys is associated with elevated IL-6 and hepcidin but not hypoferremia.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2013.875417

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    更新日期:2014-01-01 00:00:00

  • Magnesium and COVID-19 - Some Further Comments - A Commentary on Wallace TC. Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition? J Am Coll Nutr. 2020;1-9. doi:10.1080/07315724.2020.1785971. Cited in: PMID: 32649272

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2020.1816230

    authors: Micke O,Vormann J,Kisters K

    更新日期:2020-10-16 00:00:00

  • Eicosapentaenoic Acid-Rich Fish Oil Supplementation Inhibits the Decrease in Concentric Work Output and Muscle Swelling of the Elbow Flexors.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/07315724.2018.1470042

    authors: Ochi E,Yanagimoto K,Morishima T,Tsuchiya Y

    更新日期:2019-02-01 00:00:00

  • Bioactive Compounds and Antioxidant Properties of Goji fruits (Lycium barbarum L.) Cultivated in Serbia.

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1992-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1080/07315724.1999.10718842

    authors: Wei IL

    更新日期:1999-04-01 00:00:00

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2004.10719398

    authors: Vink R,Donkin JJ,Cruz MI,Nimmo AJ,Cernak I

    更新日期:2004-10-01 00:00:00

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    authors: Palacios OM,Edirisinghe I,Wilcox ML,Burton-Freeman B,Xiao D,Maki KC

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  • The effect of particle size of whole-grain flour on plasma glucose, insulin, glucagon and thyroid-stimulating hormone in humans.

    abstract:OBJECTIVE:Although it is well known that consumption of whole-grain foods with higher fiber content results in beneficial health effects, most Americans usually prefer bread made with white flour. Changes in bread texture and undesirable intestinal responses have been reported as reasons for avoiding consumption of who...

    journal_title:Journal of the American College of Nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Behall KM,Scholfield DJ,Hallfrisch J

    更新日期:1999-12-01 00:00:00

  • Association between dietary patterns and serum leptin-to-adiponectin ratio in apparently healthy adults.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2014.880389

    authors: Jafari-Vayghan H,Tarighat-Esfanjani A,Jafarabadi MA,Ebrahimi-Mameghani M,Ghadimi SS,Lalezadeh Z

    更新日期:2015-01-01 00:00:00

  • Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2019.1691955

    authors: Lee S

    更新日期:2020-08-01 00:00:00

  • Whole blood ionized magnesium in the healthy neonate.

    abstract:OBJECTIVE:We aimed to determine the normal range of ionized magnesium (IMg2+) concentration at birth and 24 hours of life in the healthy, term (37 to 41 weeks old) neonate. METHODS:Cord blood was obtained from the umbilical vein of 30 patients. In addition, blood was obtained from 32 infants at 24 hours of life. Whole...

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    pub_type: 杂志文章

    doi:10.1080/07315724.1997.10718670

    authors: Cook LA,Mimouni FB

    更新日期:1997-04-01 00:00:00

  • Uricogenic potential of selected cooked foods in rats.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

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    authors: Brulé D,Sarwar G,Savoie L

    更新日期:1990-06-01 00:00:00

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

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    authors: Nuttall FQ,Gannon MC,Wald JL,Ahmed M

    更新日期:1985-01-01 00:00:00

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.2016.1156036

    authors: Breusing N,Lagerpusch M,Engstler AJ,Bergheim I,Mueller MJ,Bosy-Westphal A

    更新日期:2017-01-01 00:00:00

  • Food away from home, sugar-sweetened drink consumption and juvenile obesity.

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    pub_type: 杂志文章

    doi:10.1080/07315724.2003.10719333

    authors: Gillis LJ,Bar-Or O

    更新日期:2003-12-01 00:00:00

  • The Fat-to-Lean Mass Ratio Is Associated with Hyperinsulinemia in Healthy Mexican Adolescents.

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    pub_type: 杂志文章

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  • Early lesions of atherosclerosis in childhood and youth: natural history and risk factors.

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    pub_type: 杂志文章,评审

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    authors: Strong JP,Malcom GT,Newman WP 3rd,Oalmann MC

    更新日期:1992-06-01 00:00:00

  • Descriptors of alcohol consumption among noninstitutionalized nonalcoholic elderly.

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

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    journal_title:Journal of the American College of Nutrition

    pub_type: 杂志文章

    doi:10.1080/07315724.1988.10720233

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    更新日期:1988-04-01 00:00:00

  • Improper supplementation habits of folic acid intake by Hungarian pregnant women: improper recommendations.

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    doi:10.1080/07315724.2008.10719731

    authors: Bognár M,Ponyi A,Hauser P,Müller J,Constantin T,Jakab Z,Schuler D,Garami M

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  • Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children.

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