Abstract:
OBJECTIVE:In vitro and animal studies suggest that antitumor effect of chemotherapeutic agents may be enhanced by antioxidants. Therefore, we initiated a clinical study to test the efficacy of high-dose multiple antioxidants (vitamins C, E and beta carotene) as an adjunct to chemotherapy (paclitaxel and carboplatin) in non-small-cell lung cancer. METHODS:136 patients of stage IIIb and stage IV NSCLC were randomized to receive chemotherapy (paclitaxel and carboplatin) alone (chemotherapy arm, n = 72) or chemotherapy in combination with ascorbic acid 6100 mg/day, dl-alpha-tocopherol (vitamin E) 1050 mg/day and beta-carotene 60 mg/day (combination arm, n = 64). Survival were calculated by the Kaplan-Meier method and compared using the log-rank test. RESULTS:An overall response rate (RR) of 33% was observed in chemotherapy arm with 24 patients showing a partial response (PR) and none showing a complete response (CR). In combination arm the overall RR was 37% with 24 patients showing PR and two showing CR. The median survival times in chemotherapy arm and combination arm were nine and 11 months respectively. The overall survival (OS) rates in chemotherapy arm and combination arm at one year were 32.9% and 39.1%, and at two years, 11.1% and 15.6% respectively. None of these differences were statistically significant (p = 0.20). Toxicity profiles were similar in both arms. CONCLUSIONS:These results do not support the concern that antioxidants might protect cancer cells from the free radical damage induced by chemotherapy. Larger trials are needed to demonstrate whether high-dose multiple antioxidants in conjunction with chemotherapy increase the response rates and/or survival time in advanced lung cancer.
journal_name
J Am Coll Nutrjournal_title
Journal of the American College of Nutritionauthors
Pathak AK,Bhutani M,Guleria R,Bal S,Mohan A,Mohanti BK,Sharma A,Pathak R,Bhardwaj NK,Prasad KN,Kochupillai Vdoi
10.1080/07315724.2005.10719438subject
Has Abstractpub_date
2005-02-01 00:00:00pages
16-21issue
1eissn
0731-5724issn
1541-1087pii
24/1/16journal_volume
24pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:NutriBee was the first clinical nutrition intervention designed to bring the Institute of Medicine recommendations for 20 hours of experiential nutrition-themed learning to grades 4-7 into club and camp settings. We piloted NutriBee to assess acceptability and impact among early adolescents in diverse and dis...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2015.1110507
更新日期:2016-07-01 00:00:00
abstract::The weight loss of 16 obese patients (greater than 130% ideal body weight) who participated for three months in a comprehensive, multidisciplinary weight reduction program was studied. Patients were divided into two groups based on the reported time of onset of their obesity. Childhood-onset obesity was defined in thi...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1982.10718986
更新日期:1982-01-01 00:00:00
abstract::Objective: Nonalcoholic steatohepatitis (NASH) has become a prominent liver disease in contemporary society because of the changing dieting styles. Complicated syndromes often accompanied by obesity and diabetes makes no standard treatment for NASH. Therefore, we investigated the potential role of Antrodia cinnamomea ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2020.1779850
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Intravenous administration of magnesium sulphate (MgSO(4)) is a very effective and safe treatment for torsades de pointes (TdP) associated with acquired long QT syndrome (LQTS) in adults. Discussed here is the efficacy of MgSO(4) for TdP in children with congenital and acquired LQTS. METHODS:The optimal MgS...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719388
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Reproducibility of the relative dose response test (RDR), a test designed to measure vitamin A status, was tested in 23 Belizean children, 5-8 years after 2-week interval during which no treatment was given. METHODS:As required for the RDR test, serum retinol concentrations were determined before and 5 hours...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1996.10718623
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:We tested the hypothesis that pectin, a source of dietary fiber that delays gastric emptying, increases satiety. METHODS:Male (n = 49) and female (n = 25) US Army employees within normal weight limits were fasted overnight then fed 448 mL of orange juice on 2 separate days followed 4 hours later by 0.473 L o...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1997.10718708
更新日期:1997-10-01 00:00:00
abstract::Diabetes, the most common metabolic disease, is responsible for the deaths of over 300,000 Americans annually. The incidence of the disease increases with age and since the U.S. population is graying, prevalence is also increasing. Obesity and family history are strong predictors of diabetes. The etiology of Type II d...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1987.10720203
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:The link between stress-related increases in inflammatory markers, hepcidin, and iron status are poorly understood, especially in developing countries like India. The aim of the study was to examine the relationship between adolescent life-event stress (ALES), inflammatory markers, and its association with he...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2013.875417
更新日期:2014-01-01 00:00:00
abstract::The paper "Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?" by TC Wallace, which was published in the Journal of the American College of Nutrition highlights the importance of adequate magnesium (Mg) supply in relation to COVID-19. Wallace notes that Mg deficiency is associ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2020.1816230
更新日期:2020-10-16 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the hypothesis that 8-week eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation improves peripheral muscle performance by concentric contractions (CONs) of elbow flexors in humans. METHODS:Sixteen healthy men were randomly administered with EPA and DHA ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/07315724.2018.1470042
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Goji fruit extracts, methanol (MGE) and hexane (HGE), were subjected to evaluation as potential source of phenolic antioxidants and antiradical activity. METHODS:Some phenolic compounds (gallic, protocatechuic, vanillic, chlorogenic, coumaric, caffeic and ferulic acid and catechin and rutin), vitamin C and c...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2016.1142404
更新日期:2016-11-01 00:00:00
abstract::To study the role of diet as a risk factor for coronary heart disease (CHD), 463 adults (25-65 years, 419 males) at risk of or with CHD were assigned to group A (n = 231) receiving a cardiovasoprotective diet or group B (n = 232) receiving a normal diet in a randomized, single-blind fashion. Age, sex, risk factors and...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1992.10718242
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the effect of dietary restriction on tissue distribution of vitamin B-6 vitamers and activities of vitamin B-6 metabolizing enzymes in rats. METHODS:Male rats were subjected to a 40% dietary restriction for 10, 20 or 40 weeks. The tissue vitamin B-6 vitamer concentrati...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1999.10718842
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Magnesium (Mg) deficiency has been shown to increase substance P release and induce a pro-inflammatory response that can be attenuated with the administration of a substance P-antagonist. Neurogenic inflammation has also been implicated in traumatic brain injury (TBI), a condition where brain intracellular fr...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2004.10719398
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:Replacing dietary refined carbohydrates (CHO) with protein may impact appetite and glucose and lipid metabolism in metabolically at-risk individuals. The objectives of this study were to assess the effects of consumption of a lean pork-containing, high-protein (pPro) breakfast versus a refined-CHO-rich breakf...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1396266
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Although it is well known that consumption of whole-grain foods with higher fiber content results in beneficial health effects, most Americans usually prefer bread made with white flour. Changes in bread texture and undesirable intestinal responses have been reported as reasons for avoiding consumption of who...
journal_title:Journal of the American College of Nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/07315724.1999.10718893
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:Dietary patterns reflect diet and nutritional habits of individuals in a society. Various dietary patterns could influence leptin and adiponectin secretion from adipose tissue. These hormones are associated with metabolic diseases. It is suggested that the leptin-to-adiponectin (L/A) ratio might be a more use...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2014.880389
更新日期:2015-01-01 00:00:00
abstract::Objective: The age-related decline in handgrip strength (HGS) is an important indicator of weakening muscle strength concomitant with aging and sarcopenia. This study was to investigate the association between dietary patterns and HGS.Methods: In this cross-sectional study of 7,624 adults aged 19-64 years who were enr...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2019.1691955
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:We aimed to determine the normal range of ionized magnesium (IMg2+) concentration at birth and 24 hours of life in the healthy, term (37 to 41 weeks old) neonate. METHODS:Cord blood was obtained from the umbilical vein of 30 patients. In addition, blood was obtained from 32 infants at 24 hours of life. Whole...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1997.10718670
更新日期:1997-04-01 00:00:00
abstract::Samples of beefsteak, beef liver, haddock, and mushrooms were cooked by two methods: boiling and broiling. Growth and purine metabolism in rats fed diets containing 20% protein (N x 6.25) were studied for a period of 26 days. The cooked meats and fish were used as the sole source of dietary protein, while cooked mushr...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1990.10720376
更新日期:1990-06-01 00:00:00
abstract::The 12-hr profiles of plasma glucose and insulin concentrations in 26 normal subjects ingesting a diet high in carbohydrate, protein, or fat have been determined. The diets were isocaloric and were given as three identical meals 4 hrs apart. In males the high carbohydrate diet resulted in glucose profiles similar to t...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1985.10720086
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:Overfeeding with a high-fat and/or high-carbohydrate (CHO) diet is known to increase plasma concentrations of endotoxin (lipopolysaccharide [LPS]) that may lead to metabolic disturbances like insulin resistance. The impact of CHO quality (i.e., the glycemic index [GI]) independent of fat intake on metabolic e...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2016.1156036
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To identify if particular foods or food groups may be associated with obesity in children and adolescents and to determine if consuming food away from home (FAFH) has an effect on the nutritional quality of their diets. DESIGN:One-year cross-sectional study. SETTING/SUBJECTS:The obese subjects (n = 91) were...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2003.10719333
更新日期:2003-12-01 00:00:00
abstract::Objective: To evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to hyperinsulinemia in healthy adolescents.Methods: Apparently healthy adolescents aged 10 to 15 years that according to sex, age, and percentiles of body fat percent, were included and allocated into the groups with elevated (body fat perce...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2020.1752845
更新日期:2020-10-12 00:00:00
abstract::This paper traces the development of knowledge concerning early lesions of atherosclerosis and the relationship to risk factors in children, youth, and young adults. Autopsy studies have shown that atherosclerosis begins in childhood with the appearance of aortic fatty streaks. Aortic fatty streaks of some degree are ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章,评审
doi:10.1080/07315724.1992.10737984
更新日期:1992-06-01 00:00:00
abstract::This paper describes relationships between reported alcohol consumption and selected sociodemographic and health variables. Two hundred and four men and 367 women aged 60-95 years were examined as part of a nutritional status survey of elderly. Fifty-three percent of men and 44% of women reported drinking at least 2 g...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1990.10720388
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Among the various classes of processed starchy foods, wheat-based cereal products exhibit a wide range in glycemic and insulinemic responses. Understanding starch behavior during cooking and processing may help identify strategies that lower postprandial glycemia and insulinemia. OBJECTIVE:To determine the ...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2005.10719489
更新日期:2005-12-01 00:00:00
abstract::Foodstuffs produced and/or purchased locally were analyzed for Se. The effect of income and gender on Se intake and status of Utah County residents was evaluated by measurement of the following indicators: erythrocyte (RBC) and plasma Se concentration, and activity of Se-glutathione peroxidase (Se-GSH-Px) (EC 1.11.1.9...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.1988.10720233
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment ce...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2008.10719731
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Fatty acid profiles and desaturase (SCD-16, SCD018, D5D, D6D) and elongase (ELOVL6) enzyme activity have been associated with adiposity and metabolic disease. While this has been studied in adults, few studies have included children. The objective of this study was to evaluate these markers in children and i...
journal_title:Journal of the American College of Nutrition
pub_type: 杂志文章
doi:10.1080/07315724.2017.1347908
更新日期:2018-01-01 00:00:00