High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels.


OBJECTIVE:To compare umbilical cord and maternal serum peak gentamicin concentration, gentamicin elimination, and clinical outcomes between women who received once-daily compared with standard, thrice-daily dosing for clinical chorioamnionitis. METHODS:We randomly assigned 38 laboring women, at least 34 weeks gestation, with clinical chorioamnionitis, into 1 of 2 gentamicin dosing groups: 5.1 mg/kg every 24 hours (once-daily; n = 18), or 120 mg followed by 80 mg every 8 hours (standard; n = 20). We measured maternal serum peak and delivery gentamicin concentrations and cord serum levels at delivery. Polynomial curve fitting was used to summarize gentamicin elimination. We also compared maternal and neonatal outcomes. RESULTS:Demographic characteristics of the 2 groups were similar. Median maternal peak gentamicin levels were higher with once-daily (18.2 microg/mL) compared with standard dosing (7.1 microg/mL) (P < .001). Maternal serum levels decreased below 2 microg/mL by 10 hours in the once-daily group and by 5 hours in the standard dosing group. Extrapolated peak cord serum levels were 6.9 microg/mL in the once-daily and 2.9 microg/mL in the standard dosing arm. Cord levels decreased below 2 microg/mL by 10 hours in the once-daily and by 5 hours in the standard dosing group. We found no differences in maternal or neonatal outcomes. CONCLUSION:Peak maternal serum gentamicin levels ranged from 13 to 25 microg/mL after a dose of 5.1 mg/kg. Single-dose gentamicin resulted in fetal serum peak levels that were closer to optimal neonatal values. Gentamicin clearance in the term fetus was similar to published values for the newborn infant. No adverse effects of high-dose therapy were noted.


Obstet Gynecol


Locksmith GJ,Chin A,Vu T,Shattuck KE,Hankins GD




Has Abstract


2005-03-01 00:00:00














  • What is new in intrauterine devices? Best articles from the past year.

    abstract::This month, we focus on current research about intrauterine devices. Dr. Hurd discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hurd WW

    更新日期:2013-10-01 00:00:00

  • Vaginal evisceration.

    abstract::Although vaginal laceration following sexual trauma is a well-reported entity, vaginal evisceration appears to be a rare occurrence. This paper presents 2 cases of vaginal evisceration recently managed at the Bronx Municipal Hospital Center and a review of the literature. Etiologic factors and management are discussed...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Friedel W,Kaiser IH

    更新日期:1975-03-01 00:00:00

  • Thrombosis in a pregnant hemophilia A carrier after intrapartum recombinant factor VIII.

    abstract:BACKGROUND:Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome. CASE:A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Russell Z,Riconda D,Pollack L,O'Leary TD,Carlan SJ

    更新日期:2005-04-01 00:00:00

  • Control of intractable atonic postpartum hemorrhage by 15-methyl prostaglandin F2 alpha.

    abstract::Severe intractable atonic postpartum hemorrhage can be treated by either uterine packing or surgical techniques. However, certain prostaglandins possess properties of potential value for the control of postpartum uterine atony. Two hundred fifty micrograms 15-methyl prostaglandin F2 alpha (15-methyl PGF2 alpha) was gi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Toppozada M,El-Bossaty M,El-Rahman HA,El-Din AH

    更新日期:1981-09-01 00:00:00

  • ACOG Committee Opinion #295: pain relief during labor.

    abstract::Pain management should be provided whenever medically indicated. The American Society of Anesthesiologists (ASA) and the American College of Obstetricians and Gynecologists (ACOG) believe that women requesting epidural analgesia during labor should not be deprived of this service based on their insurance or inadequate...

    journal_title:Obstetrics and gynecology

    pub_type: 指南,杂志文章,实务指引



    更新日期:2004-07-01 00:00:00

  • Poor perinatal outcome associated with retained cerclage in patients with premature rupture of membranes.

    abstract:OBJECTIVE:To evaluate the role of immediate cerclage removal versus retention in patients experiencing premature rupture of the membranes remote from term (PROM). METHODS:Thirty patients with prophylactic cerclage experiencing PROM at 24-32 weeks were managed expectantly after either immediate removal in 20 (67%) or r...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Ludmir J,Bader T,Chen L,Lindenbaum C,Wong G

    更新日期:1994-11-01 00:00:00

  • Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins.

    abstract:OBJECTIVE:To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS:A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conizat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Reich O,Pickel H,Lahousen M,Tamussino K,Winter R

    更新日期:2001-03-01 00:00:00

  • Intrapartum fetal cardiac arrhythmias.

    abstract::Fifteen cases of fetal cardiac arrhythmia were detected by direct fetal electrocardiogram (FECG) during intrapartum fetal monitoring. The frequency of arrhythmia of 12.4/1000 monitored births. Thirteen of the arrhythmias were supraventricular. Atrial bigeminy was the most commonly observed arrhythmia, followed by atri...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Young BK,Katz M,Klein SA

    更新日期:1979-10-01 00:00:00

  • Factors predisposing to and outcome of gestational diabetes.

    abstract::Two hundred thirteen women with abnormal glucose tolerance tests (GTTs) were diagnosed over 9 years by a screening program involving the total antenatal population. Each subject was matched for age, parity, and ethnic group with a control. The gestational diabetics were subdivided into classes A1 or A2 based on the fa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Maresh M,Beard RW,Bray CS,Elkeles RS,Wadsworth J

    更新日期:1989-09-01 00:00:00

  • Changes in thyroid function tests during danazol therapy.

    abstract::Danazol is a synthetic steroid with antigonadotropic properties useful in treating endometriosis, especially in young infertile women. Prior to its availability for clinical use in September 1976, thyroid function studies other than thyroid-stimulating hormone (TSH), which was normal, had not been reported. Soon after...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Graham RL,Gambrell RD Jr

    更新日期:1980-03-01 00:00:00

  • A trial of prophylactic cefamandole in extended gynecologic surgery.

    abstract::A double-blind randomized trial of antibiotic prophylaxis was performed with 49 patients undergoing extended pelvic surgery for adenocarcinoma of the endometrium. In this series infections of the Hemovac drain site(s) were most common (8 of 10 infections); only 1 serious infection, pelvic cellulitis, occurred. Short-t...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Creasman WT,Hill GB,Weed JC Jr,Gall SA

    更新日期:1982-03-01 00:00:00

  • Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder.

    abstract:OBJECTIVE:To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder. METHODS:The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27-46 years, mean 37.7 years) and 51 healthy control subjects...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Dhingra V,Magnay JL,O'Brien PM,Chapman G,Fryer AA,Ismail KM

    更新日期:2007-10-01 00:00:00

  • Implementing Couple's Human Immunodeficiency Virus Testing and Counseling in the Antenatal Care Setting.

    abstract:OBJECTIVE:To describe a pilot implementation of couple's human immunodeficiency virus (HIV) testing and counseling in an antenatal care clinic in the United States. METHODS:We used a cross-sectional study design. Couples were recruited from an antenatal care clinic of a large, urban, tertiary medical center, and were ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Momplaisir F,Finley E,Wolf S,Aaron E,Inoyo I,Bennett D,Seyedroudbari S,Groves A

    更新日期:2020-09-01 00:00:00

  • Cost of transferring one through five embryos per in vitro fertilization cycle from various payor perspectives.

    abstract:OBJECTIVE:We sought to examine the costs of transferring one through five embryos per in vitro fertilization cycle from each of three perspectives: society, the infertile couple, and the insurer. METHODS:Data from the 2003 Assisted Reproductive Technology Report was used to create Markov decision analytic models strat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Little SE,Ratcliffe J,Caughey AB

    更新日期:2006-09-01 00:00:00

  • Anthropometric assessment of body size differences of full-term male and female infants.

    abstract:OBJECTIVE:To determine gender-specific differences in anthropometric characteristics of full-term male and female infants. METHODS:Twelve hundred five term newborn infants were examined. All measures of length and skinfold thickness were performed in a standardized manner. RESULTS:After adjusting for confounding vari...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Copper RL,Goldenberg RL,Cliver SP,DuBard MB,Hoffman HJ,Davis RO

    更新日期:1993-02-01 00:00:00

  • Lidocaine spray compared with submucosal injection for reducing pain during loop electrosurgical excision procedure: a randomized controlled trial.

    abstract:OBJECTIVE:To examine the effectiveness of lidocaine spray compared with conventional lidocaine submucosal injection during a loop electrosurgical excision procedure (LEEP). METHODS:Women undergoing LEEP for any degrees of cervical intraepithelial neoplasia were invited to participate. The participants were randomly as...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验


    authors: Vanichtantikul A,Charoenkwan K

    更新日期:2013-09-01 00:00:00

  • Management of interstitial ectopic pregnancies with a combined intra-amniotic and systemic approach.

    abstract:BACKGROUND:Approximately 2% of all pregnancies are ectopic; of these, 4% are interstitial or cervical. There exists no clear consensus as to whether surgical or medical management is superior. CASE:We present three cases of advanced nonfallopian tube ectopic pregnancies from 6 to 8 weeks of gestation. Our first two ca...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Swank ML,Harken TR,Porto M

    更新日期:2013-08-01 00:00:00

  • Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries.

    abstract:OBJECTIVE:To estimate the incidence of surgical-site infection with use of chlorhexidine-alcohol compared with povidone-iodine among women undergoing cesarean deliveries. METHODS:This was a retrospective cohort review of 1,000 consecutive cases in women who underwent cesarean delivery over a 1-year interval. The prima...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Menderes G,Athar Ali N,Aagaard K,Sangi-Haghpeykar H

    更新日期:2012-11-01 00:00:00

  • Group A streptococcal puerperal sepsis preceded by positive surveillance cultures.

    abstract:BACKGROUND:Screening of pregnant women for vaginal and rectal carriage of group B streptococci may also identify group A streptococcal carriers. The clinical significance of prenatal group A streptococcal carriage is unknown. CASES:Two women developed group A streptococcal puerperal sepsis after delivery at one hospit...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Stefonek KR,Maerz LL,Nielsen MP,Besser RE,Cieslak PR

    更新日期:2001-11-01 00:00:00

  • Individualized treatment of stage I carcinoma of the vulva.

    abstract::A series of 117 patients with stage I squamous cell carcinoma of the vulva was followed for 3 to 21 years. Twenty recurrences (17.1%) were found, 12 in the vulva or vagina, 7 in the groin, and 1 in a patient who developed distant metastases. Invasion of tumor cells in lymph or blood vessels was found in operative spec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Iversen T,Abeler V,Aalders J

    更新日期:1981-01-01 00:00:00

  • Placental insufficiency is characterized by platelet activation in the fetus.

    abstract:OBJECTIVE:To investigate whether activation of circulating platelets was present in the fetal and maternal circulation in cases with vascular disease in the fetal-umbilical-placental circulation as identified by umbilical artery Doppler study. METHODS:We studied 20 mother-fetus pairs with an abnormal umbilical artery ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Trudinger B,Song JZ,Wu ZH,Wang J

    更新日期:2003-05-01 00:00:00

  • Cyclic changes of peritoneal fluid parameters in normal and infertile patients.

    abstract::This study compared peritoneal fluid volume, macrophage count, and macrophage concentration by diagnosis and cycle week of 426 patients undergoing laparoscopy. Patient diagnosis and cycle week had no significant interaction. Peritoneal fluid volume was dependent upon cycle week and diagnostic group, but macrophage cou...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Syrop CH,Halme J

    更新日期:1987-03-01 00:00:00

  • Two-year outcome of infants weighing 600 grams or less at birth and born 1994 through 1998.

    abstract:OBJECTIVE:To assess the neurologic and developmental outcome at 2 years of age in preterm infants with birth weights 600 g or lower. METHOD:We conducted a retrospective review from January 1994 through December 1998 for placental histopathology, maternal factors, neonatal intensive care unit course, growth, neurologic...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Sweet MP,Hodgman JE,Pena I,Barton L,Pavlova Z,Ramanathan R

    更新日期:2003-01-01 00:00:00

  • Middle cerebral artery velocimetry: different clinical relevance depending on umbilical velocimetry.

    abstract:OBJECTIVE:To evaluate the role of cerebral velocimetry as a predictor of perinatal outcome in high-risk pregnancies. METHODS:Middle cerebral artery pulsatility index was measured in 576 high-risk pregnancies undergoing umbilical velocimetry. The results of both tests were evaluated with respect to the birth of small f...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Strigini FA,De Luca G,Lencioni G,Scida P,Giusti G,Genazzani AR

    更新日期:1997-12-01 00:00:00

  • Steroid hormone contraception and bone mineral density: a cross-sectional study in an international population. The WHO Study of Hormonal Contraception and Bone Health.

    abstract:OBJECTIVE:To evaluate relationships between bone mineral density and use of steroid hormonal contraceptives. METHODS:This was a multicenter cross-sectional study in seven centers in three regions of the developing world from April 1994 to June 1997. Women 30-34 years old attending family planning clinics, with at leas...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究


    authors: Petitti DB,Piaggio G,Mehta S,Cravioto MC,Meirik O

    更新日期:2000-05-01 00:00:00

  • Recurrent obstetric management mistakes identified by simulation.

    abstract:OBJECTIVE:To develop a simulation-based curricular unit for labor and delivery teams involved in obstetric emergencies to detect and address common mistakes. METHODS:A simulation-based curricular unit for hands-on training of four obstetric emergency scenarios was developed using high-tech mannequins and low-tech simu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Maslovitz S,Barkai G,Lessing JB,Ziv A,Many A

    更新日期:2007-06-01 00:00:00

  • Abortion training in Canadian obstetrics and gynecology residency programs.

    abstract:OBJECTIVE:To study abortion training in Canadian obstetrics and gynecology (ob-gyn) residency programs. METHODS:An anonymous questionnaire was sent to all postgraduate year (PGY)-4 and PGY-5 ob-gyn residents (n=130) and residency program directors (n=16) in Canada. The questionnaires inquired about demographic informa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Roy G,Parvataneni R,Friedman B,Eastwood K,Darney PD,Steinauer J

    更新日期:2006-08-01 00:00:00

  • Cordocentesis for the diagnosis and treatment of human fetal parvovirus infection.

    abstract::Human parvovirus B-19 infection was diagnosed by DNA hybridization in blood obtained by cordocentesis from two hydropic fetuses at 22 and 26 weeks' gestation; B-19-specific immunoglobulin M (IgM) in fetal blood was negative in both cases. Hematologic studies demonstrated severe anemia, which was treated by intravascul...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Peters MT,Nicolaides KH

    更新日期:1990-03-01 00:00:00

  • Practice Bulletin No. 159 Summary: Management of Preterm Labor.

    abstract::Preterm birth is the leading cause of neonatal mortality and the most common reason for antenatal hospitalization (1-4). In the United States, approximately 12% of all live births occur before term, and preterm labor preceded approximately 50% of these preterm births (5, 6). Although the causes of preterm labor are no...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章



    更新日期:2016-01-01 00:00:00

  • Etiology of prune belly syndrome: evidence of megalocystic origin in an early fetus.

    abstract:BACKGROUND:Prune belly syndrome is a rare and complicated condition affecting the genitourinary organs and abdominal wall. The etiology of abdominal musculature deficiency in prune belly syndrome is controversial. We present a case that should elucidate the etiology of this syndrome. CASE:A spontaneously aborted fetus...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Terada S,Suzuki N,Uchide K,Ueno H,Akasofu K

    更新日期:1994-05-01 00:00:00