High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels.

Abstract:

OBJECTIVE:To compare umbilical cord and maternal serum peak gentamicin concentration, gentamicin elimination, and clinical outcomes between women who received once-daily compared with standard, thrice-daily dosing for clinical chorioamnionitis. METHODS:We randomly assigned 38 laboring women, at least 34 weeks gestation, with clinical chorioamnionitis, into 1 of 2 gentamicin dosing groups: 5.1 mg/kg every 24 hours (once-daily; n = 18), or 120 mg followed by 80 mg every 8 hours (standard; n = 20). We measured maternal serum peak and delivery gentamicin concentrations and cord serum levels at delivery. Polynomial curve fitting was used to summarize gentamicin elimination. We also compared maternal and neonatal outcomes. RESULTS:Demographic characteristics of the 2 groups were similar. Median maternal peak gentamicin levels were higher with once-daily (18.2 microg/mL) compared with standard dosing (7.1 microg/mL) (P < .001). Maternal serum levels decreased below 2 microg/mL by 10 hours in the once-daily group and by 5 hours in the standard dosing group. Extrapolated peak cord serum levels were 6.9 microg/mL in the once-daily and 2.9 microg/mL in the standard dosing arm. Cord levels decreased below 2 microg/mL by 10 hours in the once-daily and by 5 hours in the standard dosing group. We found no differences in maternal or neonatal outcomes. CONCLUSION:Peak maternal serum gentamicin levels ranged from 13 to 25 microg/mL after a dose of 5.1 mg/kg. Single-dose gentamicin resulted in fetal serum peak levels that were closer to optimal neonatal values. Gentamicin clearance in the term fetus was similar to published values for the newborn infant. No adverse effects of high-dose therapy were noted.

journal_name

Obstet Gynecol

authors

Locksmith GJ,Chin A,Vu T,Shattuck KE,Hankins GD

doi

10.1097/01.AOG.0000151106.87930.1a

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

473-9

issue

3

eissn

0029-7844

issn

1873-233X

pii

105/3/473

journal_volume

105

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVE:To estimate the population risks of maternal and infant complications with the birth of macrosomic (at least 4000 g) compared with normal weight infants. METHODS:Term, singleton infants were identified from the state of Washington's birth event records database for 1990. Diagnosis codes from the Internal Cla...

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    doi:10.1016/s0029-7844(98)00224-5

    authors: Gregory KD,Henry OA,Ramicone E,Chan LS,Platt LD

    更新日期:1998-10-01 00:00:00

  • Alcohol abuse during pregnancy: changes in frequency in a large urban hospital.

    abstract::The reported frequency of alcohol abuse during pregnancy was studied in a large urban public hospital in Dallas, Texas. During 1977-1980, 5602 pregnant women were surveyed and 0.7% (95% confidence interval 0.6-0.8%) reported abusing alcohol during pregnancy. In 1987, 1.4% (95% confidence interval 1.3-1.5%) of 1032 pre...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Little BB,Snell LM,Gilstrap LC 3rd,Gant NF,Rosenfeld CR

    更新日期:1989-10-01 00:00:00

  • Aggressive Angiomyxoma of the Vulva and Bladder.

    abstract:BACKGROUND:Aggressive angiomyxoma is a rare, locally infiltrative tumor, frequently occurring in female patients. Although wide local excision is considered standard therapy, radical surgery may be needed. CASE:A 49-year-old woman presented with an aggressive angiomyxoma involving the vulva and bladder. Given the horm...

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    doi:10.1097/AOG.0000000000002254

    authors: Song M,Glasgow M,Murugan P,Rivard C

    更新日期:2017-10-01 00:00:00

  • Repair techniques for obstetric anal sphincter injuries: a randomized controlled trial.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.AOG.0000218693.24144.bd

    authors: Fernando RJ,Sultan AH,Kettle C,Radley S,Jones P,O'Brien PM

    更新日期:2006-06-01 00:00:00

  • Laparoscopy in 100 women with chronic pelvic pain.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Kresch AJ,Seifer DB,Sachs LB,Barrese I

    更新日期:1984-11-01 00:00:00

  • Diagnosis of a supernumerary ovary with human chorionic gonadotropin.

    abstract::The preoperative diagnosis of ectopic ovarian tissue has been reported only once in the literature. In the present case, differential ovarian and adrenal testing was used to diagnose and aberrant ovarian source of persistently elevated plasma estrogen in a patient who had undergone bilateral oophorectomy and adrenalec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Kosasa TS,Griffiths CT,Shane JM,Leventhal JM,Naftolin F

    更新日期:1976-02-01 00:00:00

  • Perinatal implications of shoulder dystocia.

    abstract:OBJECTIVE:To assess the antecedents of shoulder dystocia, the risk of recurrence, and the perinatal morbidity associated with the different maneuvers used for its management. METHODS:We conducted a 10-year (1980-1989) retrospective case record review of all instances of shoulder dystocia in a teaching maternity hospit...

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    pub_type: 杂志文章

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    更新日期:1995-07-01 00:00:00

  • The process of resident selection: a view from the residency director's desk.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(94)00388-T

    authors: Taylor CA,Weinstein L,Mayhew HE

    更新日期:1995-02-01 00:00:00

  • Colposcopic examination of the cervix of cebus monkeys.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Tunca J,Palmer A,Nahmias A,Mihalik K,Naib Z,London W,Sever J

    更新日期:1978-11-01 00:00:00

  • Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2006-07-01 00:00:00

  • What Is New in Validation and Simulation Training?: Best Articles From the Past Year.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003592

    authors: Buek J

    更新日期:2019-12-01 00:00:00

  • Differences in postpartum weight retention between black and white mothers.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Parker JD,Abrams B

    更新日期:1993-05-01 00:00:00

  • Timing of the postpartum Papanicolaou smear.

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    更新日期:1994-05-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2006-08-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(94)00231-2

    authors: Bobrowski RA,Jones TB

    更新日期:1995-05-01 00:00:00

  • Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To estimate whether progestin-induced endometrial shedding, before ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCOS). METHODS:A secondary analysis of the data from 626 women with...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/AOG.0b013e31824da35c

    authors: Diamond MP,Kruger M,Santoro N,Zhang H,Casson P,Schlaff W,Coutifaris C,Brzyski R,Christman G,Carr BR,McGovern PG,Cataldo NA,Steinkampf MP,Gosman GG,Nestler JE,Carson S,Myers EE,Eisenberg E,Legro RS,Eunice Kennedy Shr

    更新日期:2012-05-01 00:00:00

  • Case-control study of cancer of the vulva.

    abstract::A case-control study of 209 vulvar cancer patients and 348 community controls allowed assessment of risk factors for this rare tumor. As with cervical cancer, risk increased with the number of reported lifetime sexual partners, with five or more partners associated with two- to threefold increases in risk compared wit...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Brinton LA,Nasca PC,Mallin K,Baptiste MS,Wilbanks GD,Richart RM

    更新日期:1990-05-01 00:00:00

  • Corpus luteum formation in the fetus.

    abstract::A well-developed corpus luteum was found at autopsy in a premature infant who died 26 hours post partum. Intrauterine pituitary-gonadal development and regulation are briefly reviewed and a possible mechanism of intrauterine fetal ovulation is presented. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Miles PA,Penney LL

    更新日期:1983-04-01 00:00:00

  • Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen.

    abstract:OBJECTIVE:To assess the estrogenic effect of tamoxifen and associated pathologic changes of the endometrium in postmenopausal breast cancer patients. METHODS:The endometrium of 103 gynecologically asymptomatic postmenopausal breast cancer patients was examined. Fifty-one had been treated with tamoxifen and 52 had not ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Lahti E,Blanco G,Kauppila A,Apaja-Sarkkinen M,Taskinen PJ,Laatikainen T

    更新日期:1993-05-01 00:00:00

  • The use of quinidine sulfate throughout pregnancy.

    abstract::A gravid patient was given quinidine sulfate for idiopathic ventricular tachycardia. The serum levels of quinidine remained stable throughout pregnancy. At delivery, maternal and neonatal quinidine levels were equivalent, while the level in the amniotic fluid was significantly elevated. Explanations for the latter inc...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hill LM,Malkasian GD Jr

    更新日期:1979-09-01 00:00:00

  • Estradiol, estrone, and gonadotropin levels after use of vaginal estradiol.

    abstract::The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulat...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Martin PL,Greaney MO,Burnier AM,Brooks PM,Yen SS,Quigley ME

    更新日期:1984-04-01 00:00:00

  • Cloacal dysgenesis.

    abstract::Cloacal dysgenesis is a rare anomaly. Fifty cases have been reported in the literature. This condition differs from the usual imperforate anus. The diagnosis, evaluation, and therapeutic management require an understanding of the embryogenesis of the cloaca. The presence at birth of a single interlabial orifice or an ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Okonkwo JE,Crocker KM

    更新日期:1977-07-01 00:00:00

  • The effect of intraabdominal irrigation at cesarean delivery on maternal morbidity: a randomized trial.

    abstract::To determine if intraabdominal irrigation with normal saline at cesarean delivery is associated with increased maternal morbidity. One hundred ninety-six women undergoing routine cesarean delivery at at least 37 weeks' gestation were prospectively randomized to receive 500-1000 mL of normal saline intraabdominal irrig...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0029-7844(02)02466-3

    authors: Harrigill KM,Miller HS,Haynes DE

    更新日期:2003-01-01 00:00:00

  • Uterine suspension through the laparoscope.

    abstract::We present a series of 20 patients who underwent uterine suspension performed through a laparoscope, as part of conservative treatment for infertility and pelvic pain. The operative technique is easily mastered by a skilled laparoscopist who is prepared to deal with intra- or postoperative complications. Avulsion of t...

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    pub_type: 杂志文章

    doi:10.1097/00006250-197805000-00011

    authors: Mann WJ,Stenger VG

    更新日期:1978-05-01 00:00:00

  • United States Medical Licensure Examination step 1 scores and obstetrics-gynecology clerkship final examination.

    abstract:OBJECTIVE:To determine if scores from first attempts at the United States Medical Licensure Examination step 1 correlated with obstetrics-gynecology examination scores and identified students at risk of failure. METHODS:All students in obstetrics-gynecology clerkships at the University of Illinois at Chicago from July...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(99)00477-9

    authors: Myles TD

    更新日期:1999-12-01 00:00:00

  • Pregnancy associated with Friedreich ataxia.

    abstract::The pregnancy of a woman with Friedreich ataxia was complicated by the onset of preterm labor and preeclampsia. Administration of magnesium sulfate (MgSO4.7H2O) in the usual intravenous dosage resulted in the dramatic development of profound motor weakness and respiratory distress. Magnesium acts to antagonize the act...

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    pub_type: 杂志文章

    doi:

    authors: Bruner JP,Yeast JD

    更新日期:1990-11-01 00:00:00

  • Glycosylated hemoglobins in normal pregnancy: sequential changes and relation to birth weight.

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    doi:

    authors: Hanson U,Hagenfeldt L,Hagenfeldt K

    更新日期:1983-12-01 00:00:00

  • Testosterone-producing solitary ovarian cyst with luteinized stromal-cell hyperplasia.

    abstract:BACKGROUND:Hormone production is a characteristic associated with the presence of solid tumors in the ovary. We present a case of a solitary ovarian cyst producing large amounts of testosterone and presenting with rapid onset of hirsutism. CASE:A woman presented approximately 6 months postpartum with irregular menses ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Goudas VT,Wasty F,Pardanani B,Ying YK

    更新日期:1996-05-01 00:00:00

  • A five-year experience with terbutaline for preterm labor: low rate of severe side effects.

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    pub_type: 杂志文章

    doi:

    authors: Ingemarsson I,Bengtsson B

    更新日期:1985-08-01 00:00:00

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