当前位置： SCI文献检索 > ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA期刊下所有文献 > A quality of life perspective on who benefits from estradiol replacement therapy.

A quality of life perspective on who benefits from estradiol replacement therapy.

Abstract：

STUDY OBJECTIVE:To examine who may benefit from estrogen replacement therapy from a quality of life (QoL) perspective, taking both disease-specific and general aspects at baseline into account. DESIGN:A double-blind multi-center randomized placebo-controlled prospective study. The subjects were randomized to receive either transdermal estradiol or placebo for 12 weeks. QoL measures were disease-specific and generic. LOCATION:University hospital, teaching hospital and private practice. MATERIAL:Post-menopausal volunteering Swedish women (n = 223) with mild to severe climacteric symptoms, as clinically evaluated by the Kupperman's Index. RESULTS:All QoL assessments showed highly significant improvement in the estradiol group in comparison with the placebo group. The women receiving placebo treatment also improved, but their improvement reached a peak at six weeks of treatment and then declined. In the estradiol group the improvement continued throughout the 12 weeks. After 12 weeks of treatment the change in the placebo-treated group was smaller on the disease-specific scales than on the generic scales and the Kupperman's Index. A high correlation was seen between the baseline score for a certain QoL assessment and the change in this score during treatment. The most striking result was that the mean change in QoL for the two groups was statistically significant for almost any pre-treatment QoL status. CONCLUSIONS:Women with slightly, moderately or severely diminished QoL status would benefit from estrogen treatment during the climacteric period. A similar tendency was seen in women with mild symptoms at baseline.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Karlberg J,Mattsson LA,Wiklund I

doi

10.3109/00016349509024430

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

367-72

issue

5

eissn

0001-6349

issn

1600-0412

journal_volume

74

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA文献大全
  • If nuchal translucency screening is combined with first-trimester serum screening the need for fetal karyotyping decreases.

    abstract：BACKGROUND:This case-control study was performed to evaluate whether adding first-trimester maternal serum testing to nuchal translucency measurement would improve the antenatal detection of Down's syndrome and decrease the number of women offered fetal karyotyping. METHODS:In the Swedish Nuchal Translucency Trial (th...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1080/00016340500523701

    authors： Marsk A,Grunewald C,Saltvedt S,Valentin L,Almström H

    更新日期：2006-01-01 00:00:00

  • Chromosomal anomalies in first-trimester miscarriages.

    abstract：BACKGROUND:It is well known that a large proportion of first-trimester spontaneous abortions is caused by chromosomal disorders. The present study represents a unique material and the success rate of the karyotyping was high. METHODS:Chromosomal analysis from chorionic villus sampling of 259 of 304 consecutive first-t...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/j.0001-6349.2005.00882.x

    authors： Ljunger E,Cnattingius S,Lundin C,Annerén G

    更新日期：2005-11-01 00:00:00

  • Double embryo transfer gives good pregnancy and live birth rates in poor responders with a modest increase in multiple birth rates: results from an observational study.

    abstract：OBJECTIVE:The aim of this study was to compare pregnancy and live birth rates in poor responders when transferring one or two embryos. Poor responders were defined as having four or fewer oocytes retrieved in combination with a high dose of gonadotrophins. DESIGN:Retrospective, observational study. SETTING:Reproducti...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/j.1600-0412.2011.01139.x

    authors： Jonsdottir I,Lundin K,Bergh C

    更新日期：2011-07-01 00:00:00

  • Is it worth reducing twins to singletons after IVF-ET? A retrospective cohort study using propensity score matching.

    abstract：INTRODUCTION:Many studies have shown that multifetal reduction of high-order multiple pregnancies results in improved pregnancy outcomes. However, whether conducting elective fetal reduction from dichorionic twins after in vitro fertilization (IVF) is worthwhile remains controversial. This study aimed to determine whet...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.13640

    authors： Luo L,Fan XZ,Jie HY,Gao Y,Chen M,Zhou C,Wang Q

    更新日期：2019-10-01 00:00:00

  • Sexual function and somatopsychic reactions after local excision of vulvar intra-epithelial neoplasia.

    abstract：:Eighteen patients, under the age of 60 years, who have been treated with local excision of the vulva, participated in the study in which sexual function and somatopsychic reactions were evaluated by personal interviews. Furthermore both objective and subjective cosmetic results were registered. After this type of oper...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349209007969

    authors： Thuesen B,Andreasson B,Bock JE

    更新日期：1992-02-01 00:00:00

  • Preinductive cervical ripening with PgE2 gel in term pregnant women with ultrasonically diagnosed intra-uterine growth-retarded fetuses.

    abstract：:Intra-uterine growth retardation (IUGR), often combined with other pregnancy-related complications, constitutes a rather common indication for labor induction. The objective of this prospective study was to evaluate a strict intracervical application of 0.5 mg PgE2 in gel for cervical ripening and labor induction. Eig...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349109007916

    authors： Almström H,Ekman G,Granström L

    更新日期：1991-01-01 00:00:00

  • Prognosis, recurrences and metastases correlated to histologic cell type in carcinoma of the uterine cervix.

    abstract：:An analysis of 230 patients treated with radiotherapy for cervical cancer stages I and II is presented. No positive correlation to cell type was found as regards the number of failures, recurrence rate or the frequency of regional or distant metastases. Although different biological behavior might be shown by cancers ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016347609156923

    authors： Johansson O,Johnsson JE,Lindberg JG,Sydsjö A

    更新日期：1976-01-01 00:00:00

  • A prospective study of women and girls undergoing fertility preservation due to oncologic and non-oncologic indications in Sweden-Trends in patients' choices and benefit of the chosen methods after long-term follow up.

    abstract：INTRODUCTION:In Scandinavian countries, programs for fertility preservation are offered free of charge at tertiary-care university hospitals to all patients facing treatments with risk of subsequent sterility. In this prospective study we aimed to investigate trends in female patients' choices after counseling and fert...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.13559

    authors： Rodriguez-Wallberg KA,Marklund A,Lundberg F,Wikander I,Milenkovic M,Anastacio A,Sergouniotis F,Wånggren K,Ekengren J,Lind T,Borgström B

    更新日期：2019-05-01 00:00:00

  • Vaginal application of a chemotherapeutic agent before legal abortion. A way of reducing infectious complication?

    abstract：:In an attempt to reduce the incidence of infectious complications after first trimester legal abortion 199 healthy, early pregnant women were treated with chloroquinaldol (SterosanR vaginal jelly) during six days before their vacuum aspiration. A group of 291 women served as control. In the treatment group 18 women (9...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016348109158123

    authors： Meirik O,Nilsson S,Nygren KG

    更新日期：1981-01-01 00:00:00

  • Attitudes toward surrogacy among doctors working in reproductive medicine and obstetric care in Sweden.

    abstract：INTRODUCTION:The aim of this study was to investigate attitudes and opinions towards surrogacy among physicians working within obstetrics and reproductive medicine in Sweden. MATERIAL AND METHODS:Physicians working within medically assisted reproduction (MAR), antenatal care and obstetrics were invited to participate ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章,评审

    doi：10.1111/aogs.13342

    authors： Stenfelt C,Armuand G,Wånggren K,Skoog Svanberg A,Sydsjö G

    更新日期：2018-09-01 00:00:00

  • Malpresentation in low- and middle-income countries: Associations with perinatal and maternal outcomes in the Global Network.

    abstract：INTRODUCTION:Uncertainty exists regarding the impact of malpresentation on pregnancy outcomes and the optimal mode of delivery in low- and middle-income countries. We sought to compare outcomes between cephalic and non-cephalic pregnancies. MATERIAL AND METHODS:Using the NICHD Global Network's prospective, population-...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.13502

    authors： Duffy CR,Moore JL,Saleem S,Tshefu A,Bose CL,Chomba E,Carlo WA,Garces AL,Krebs NF,Hambidge KM,Goudar SS,Derman RJ,Patel A,Hibberd PL,Esamai F,Liechty EA,Wallace DD,McClure EM,Goldenberg RL,NICHD Global Network for Wo

    更新日期：2019-03-01 00:00:00

  • Trends in the incidence and mortality of ovarian cancer in Denmark 1978-2002. Comparison with other Nordic countries.

    abstract：BACKGROUND:The Nordic countries are well-known high-incidence areas of ovarian cancer, but even within the Nordic countries, differences exist. METHODS:Focus in this descriptive epidemiological study is to assess developments in incidence and mortality of ovarian cancer in Denmark 1978-2002 and to make a comparison wi...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/j.0001-6349.2005.00878.x

    authors： Kjaerbye-Thygesen A,Huusom LD,Frederiksen K,Kjaer SK

    更新日期：2005-10-01 00:00:00

  • Maternal, fetal and amniotic fluid prolactin levels in term and post-term pregnancies.

    abstract：:Prolactin (PRL) levels in maternal serum, amniotic fluid and mixed cord blood from 11 women with post-term pregnancies and 64 women with normal term pregnancies were measured by immunoenzymetric assay in order to investigate their possible role in the onset of labor. No differences were found between term and post-ter...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349309013376

    authors： Demir N,Celiloglu M,Thomassen PA,Onvural A,Erten O

    更新日期：1993-04-01 00:00:00

  • Maternal deaths after elective cesarean section for breech presentation in the Netherlands.

    abstract：BACKGROUND AND METHODS:The cesarean section rate for term singleton breech babies in the Netherlands rose from 57 to 81% after the Term Breech Trial in 2000. The Dutch Maternal Mortality Committee registered and evaluated maternal mortality due to elective cesarean section for breech. RESULTS:Four maternal deaths afte...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1080/00016340601104054

    authors： Schutte JM,Steegers EA,Santema JG,Schuitemaker NW,van Roosmalen J,Maternal Mortality Committee Of The Netherlands Society Of Obstetrics.

    更新日期：2007-01-01 00:00:00

  • Second primary cancer after treatment of invasive carcinoma of the uterine cervix, compared with those arising after treatment for in situ carcinomas. An effect of irradiation? A cancer registry study.

    abstract：:A cancer registry cohort of 16,704 cases of invasive carcinoma of the uterine cervix and 56,116 cases of in situ carcinomas of the uterine cervix was followed up and second new primary cancers were recorded. The invasive carcinomas contributed 127,118 woman-years at risk and the in situ carcinomas contributed 453,362 ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349009006163

    authors： Pettersson F,Ryberg M,Malker B

    更新日期：1990-01-01 00:00:00

  • Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells.

    abstract：BACKGROUND:Both the estrogen receptor (ER) alpha and beta isoforms are expressed in the endothelium. The ER beta has been assigned a crucial role in normal vascular wall function. Prostacyclin has been ascribed a beneficial effect on vessel wall physiology. Isoflavones bind with higher affinity to ER beta. We investiga...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 临床试验,杂志文章

    doi：10.1080/j.1600-0412.2003.00178.x

    authors： García-Martínez MC,Hermenegildo C,Tarín JJ,Cano A

    更新日期：2003-08-01 00:00:00

  • Maternal serum triglycerides as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus.

    abstract：OBJECTIVE:To determine the contribution of maternal lipids in predicting large-for-gestational age (LGA) newborns born to women with gestational diabetes mellitus (GDM). DESIGN:Retrospective study. SETTING:Yonsei University Health System, Korea. POPULATION:A total of 104 women diagnosed with GDM between January 2000...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016341003605677

    authors： Son GH,Kwon JY,Kim YH,Park YW

    更新日期：2010-05-01 00:00:00

  • Spontaneous abortion: a prospective cohort study of younger women from the general population in Denmark. Validation, occurrence and risk determinants.

    abstract：OBJECTIVE:To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion. METHODS:We used interview data from a population-based prospective cohort ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1080/00016340500494887

    authors： Buss L,Tolstrup J,Munk C,Bergholt T,Ottesen B,Grønbaek M,Kjaer SK

    更新日期：2006-01-01 00:00:00

  • Improving reproductive long-term prognosis for women with a first ectopic pregnancy. A national controlled follow-up study.

    abstract：OBJECTIVE:To describe developments in reproductive long-term prognosis in women with a first ectopic pregnancy as compared with two control cohorts. DESIGN:Controlled cohort study. SETTING:Data were collected from four national Danish registries. POPULATION:All Danish women of reproductive age (15-49 years) through ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.12377

    authors： Egerup P,Kårhus LL,Skovlund CW,Lidegaard O

    更新日期：2014-05-01 00:00:00

  • An in vitro perfusion method for metabolic studies on human postmenopausal ovaries.

    abstract：:Five ovaries from four postmenopausal women undergoing bilateral oophorectomy for benign conditions were prepared for vascular perfusion for 1 to 5 hours in a recirculating system containing oxygenized (5% CO2 + 95% O2) synthethic bicarbonate buffered medium (Medium 199 + 4% bovine serum albumin + antibiotics). Two hi...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349009013331

    authors： Abrahamsson G,Janson PO,Kullander S

    更新日期：1990-01-01 00:00:00

  • Heart frequency of the fetus at birth.

    abstract：:Heart frequency was recorded in 10 infants during the delivery and the following day. It was found that during vaginal birth, in cephalic presentation, heart frequency decreased during the last 3 minutes before delivery of the head. In breech presentation the initial deceleration was shorter, while with cesarean secti...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016348609157369

    authors： Klebe JG,Espersen T,Poulsen EH

    更新日期：1986-01-01 00:00:00

  • Laparoscopic management of bowel endometriosis: resection margins as a predictor of recurrence.

    abstract：OBJECTIVE:To evaluate possible predictive factors for recurrence after laparoscopic segmental bowel resection for bowel endometriosis. DESIGN:Cohort study. SETTING:Academic tertiary referral center. METHODS:95 symptomatic women with bowel endometriosis who underwent laparoscopic segmental bowel resection at the Endo...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.12490

    authors： Nirgianakis K,McKinnon B,Imboden S,Knabben L,Gloor B,Mueller MD

    更新日期：2014-12-01 00:00:00

  • Factors influencing delivery method in breech presentation.

    abstract：BACKGROUND:To study factors influencing delivery method in breech presentation. METHODS:Population based cohort study from The Medical Birth Registry of Norway, comprising all singleton deliveries in Norway, 1967-1994, 1,592,064 deliveries of which 45,921 (2.9%) were in breech presentation. RESULTS:The proportion of ...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：

    authors： Albrechtsen S,Rasmussen S,Dalaker K,Irgens LM

    更新日期：1998-04-01 00:00:00

  • Aromatase inhibitors: possible future applications.

    abstract：:In premenopausal women ovaries are the major sites of estrogen production, while in postmenopausal women estrogen is produced by aromatization of ovarian and adrenal androgens in extragonadal sites, mostly in adipose tissue. Aromatase is a cytochrome P450 hemoprotein-containing enzyme complex that catalyzes the rate-l...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章,评审

    doi：10.1111/j.0001-6349.2004.00562.x

    authors： Karaer O,Oruç S,Koyuncu FM

    更新日期：2004-08-01 00:00:00

  • Perforation of a malignant ovarian tumor into the recto-sigmoid colon.

    abstract：:Ovarian cancer often presents at an advanced stage, but tends to be an intra-peritoneal disease that respects peritoneal planes. Thus, colo-rectal perforation of the tumor is an extremely rare presentation. The surgical treatment of malignant colo-ovarian fistula should include complete cyto-reduction at the same time...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016349.2010.501857

    authors： Bats AS,Rockall AG,Singh N,Reznek RH,Jeyarajah A

    更新日期：2010-10-01 00:00:00

  • An incident of bilateral mastodynia after the menopause.

    abstract：:A 54-year-old postmenopausal woman is described who quite suddenly experienced intense tenderness and tension in both breasts lasting for about 3 weeks. Subsequently she had a uterine bleeding. Excessively increased levels of estradiol (peak value 2325 pmol/l) were found during the period of mastodynia. Seven months p...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.3109/00016348509156738

    authors： Kallner G

    更新日期：1985-01-01 00:00:00

  • Does single embryo transfer improve the obstetric and neonatal outcome of singleton pregnancy?

    abstract：:Singleton pregnancies following in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased risks of abnormal placentation, pre-eclampsia and preterm birth. These risks might partly be a consequence of the number of transferred embryos. In this commentary we summarize the res...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1080/00016340802307787

    authors： Poikkeus P,Tiitinen A

    更新日期：2008-01-01 00:00:00

  • Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers.

    abstract：:Ovulation-inducing drugs have been widely used for various types of infertility since the beginning of 1960s and their use increases day by day parallel to the success achieved in fertility treatment. However, the researches performed in the last two decades have begun to discuss about the safety of these drugs and th...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章,评审

    doi：10.1111/j.0001-6349.2004.00669.x

    authors： Ayhan A,Salman MC,Celik H,Dursun P,Ozyuncu O,Gultekin M

    更新日期：2004-12-01 00:00:00

  • Treatment of ilioinguinal nerve entrapment - a randomized controlled trial.

    abstract：OBJECTIVE:Neuralgic pain caused by entrapment of peripheral nerves can be a difficult clinical problem. The objective of the present study was to assess pain and quality of life in women with pain secondary to ilioinguinal nerve entrapment. DESIGN:In a controlled prospective crossover study, women with ilioinguinal ne...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1600-0412.2011.01194.x

    authors： Hahn L

    更新日期：2011-09-01 00:00:00

  • Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: a nested case-control study.

    abstract：OBJECTIVE:To study whether human chorionic gonadotropin concentrations during pregnancy or combinations of human chorionic gonadotropin and other angiogenic factors, soluble fms-like tyrosine kinase 1 and placental growth factor (PlGF), are associated with preeclampsia risk. DESIGN:Nested case-control study. SETTING:...

    journal_title：Acta obstetricia et gynecologica Scandinavica

    pub_type： 杂志文章

    doi：10.1111/aogs.12363

    authors： Asvold BO,Eskild A,Vatten LJ

    更新日期：2014-05-01 00:00:00