Abstract:
BACKGROUND:It is well known that a large proportion of first-trimester spontaneous abortions is caused by chromosomal disorders. The present study represents a unique material and the success rate of the karyotyping was high. METHODS:Chromosomal analysis from chorionic villus sampling of 259 of 304 consecutive first-trimester miscarriages in the Uppsala County, Sweden is presented. RESULTS AND CONCLUSIONS:An abnormal karyotype was found in 61% of the cases. Autosomal trisomies were most frequently detected (in 37% of the karyotyped samples), followed by polyploidies (9%) and monosomy X (6%). Cases with an extra sex chromosome constituted approximately 5% of the karyotyped abortions, with a remarkable high frequency of 47,XXY (3.4%), that is approximately 40 times greater the prevalence of Klinefelter syndrome among live birth. Similar to autosomal chromosome abnormalities, present finding indicates that the majority of sex chromosome abnormalities do not survive to term. Autosomal trisomies and an extra X-chromosome in males (47,XXY) were associated with an advanced maternal age, whereas monosomy X as well as polyploidy changes seems to be inversely related to the age of the mother. The single most common aberration was trisomy 16, which was found in 14% of the chromosomally abnormal abortions.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Ljunger E,Cnattingius S,Lundin C,Annerén Gdoi
10.1111/j.0001-6349.2005.00882.xsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
1103-7issue
11eissn
0001-6349issn
1600-0412pii
AOG882journal_volume
84pub_type
杂志文章abstract:INTRODUCTION:The objective of this study was to assess the effectiveness and potential benefits of the use of long-acting recombinant follicle-stimulating hormone (FSH) in a random-start protocol for fertility preservation in women with cancer. MATERIAL AND METHODS:This is a retrospective before-and-after study perfor...
journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:2017-08-01 00:00:00
abstract:STUDY OBJECTIVE:To examine who may benefit from estrogen replacement therapy from a quality of life (QoL) perspective, taking both disease-specific and general aspects at baseline into account. DESIGN:A double-blind multi-center randomized placebo-controlled prospective study. The subjects were randomized to receive e...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.3109/00016348509158214
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journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Family history of diabetes is regarded as a risk factor for gestational glucose intolerance. Most selective screening policy includes family history as an indication of oral glucose tolerance test. However, few studies had evaluated the actual incidence of glucose intolerance in this group of women. METHODS...
journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:1984-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:1989-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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更新日期:2011-11-01 00:00:00
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