Abstract:
OBJECTIVE:To study whether human chorionic gonadotropin concentrations during pregnancy or combinations of human chorionic gonadotropin and other angiogenic factors, soluble fms-like tyrosine kinase 1 and placental growth factor (PlGF), are associated with preeclampsia risk. DESIGN:Nested case-control study. SETTING:Population cohort of pregnant women. SAMPLE:A total of 121 cases of preterm (<37 weeks) and 158 cases of term preeclampsia (≥37 weeks of gestation) and 356 women without preeclampsia (controls). METHODS:Women with preeclampsia were identified by linkage to the Medical Birth Registry of Norway. Concentrations of human chorionic gonadotropin, soluble fms-like tyrosine kinase 1 and PlGF were measured in maternal serum samples collected in each trimester of pregnancy. MAIN OUTCOME MEASURES:Odds ratios of preterm and term preeclampsia. RESULTS:High human chorionic gonadotropin concentrations (highest quartile) in the first trimester were associated with reduced risk for preterm preeclampsia (OR 0.3, 95% CI 0.1-0.9), compared with low human chorionic gonadotropin (lowest quartile), whereas high human chorionic gonadotropin concentrations in the second trimester were associated with increased risk for preterm preeclampsia (OR 4.0, 95% CI 1.8-8.9). High human chorionic gonadotropin concentrations in the third trimester were associated with increased risk for term preeclampsia (OR 4.8, 95% CI 1.8-13.3). Concentrations of human chorionic gonadotropin above the median value combined with PlGF below the median in the second trimester were associated with very high risk for preterm preeclampsia (OR 36.9, 95% CI 8.2-165.8). CONCLUSIONS:The results suggest an important role of human chorionic gonadotropin in the pathophysiological processes that lead to preeclampsia. The combined association of human chorionic gonadotropin and PlGF indicates a possible synergism between underlying biological pathways.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Asvold BO,Eskild A,Vatten LJdoi
10.1111/aogs.12363subject
Has Abstractpub_date
2014-05-01 00:00:00pages
454-62issue
5eissn
0001-6349issn
1600-0412journal_volume
93pub_type
杂志文章abstract:INTRODUCTION:Balanced information before prenatal diagnosis (PND) aims to help expectant parents to make an informed choice. However, it is important that the information does not increase the expectant parents' psychological distress. The aim was to examine psychological distress among expectant parents, before and af...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13195
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:To compare a 48 hour non surgical policy in the management of spontaneous abortion with a policy of routine, universal uterine curettage. METHODS:A prospective, observational study on 354 women admitted to hospital with spontaneous abortion. Of these, 225 who had retained products of conception were treated...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The increase in the numbers of women fearing childbirth and requesting cesarean sections call for new forms of antenatal treatment. METHODS:Finnish nulliparous women experiencing severe fear of childbirth (experimental group, n = 102) attended 5 group sessions with a psychologist, once together with a midwi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1080/00016340600756920
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:External cephalic version (ECV) is accepted as a means of reducing the rate of breech presentation at term. Routine use of tocolysis prior to an ECV has been described to increase its success rate. The study's objective was to evaluate the efficacy of oral nifedipine as a tocolytic agent prior to ECV, and to...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340801996598
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Women with endometriosis have reduced health-related quality of life (HRQoL). However, comparisons to the general population and other patient groups are lacking. MATERIAL AND METHODS:The present cross-sectional questionnaire study included 157 women with endometriosis, 156 women from the general populati...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13427
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The effect of physical training on bone mineral density (BMD) in women with endometriosis treated with gonadotropin-releasing hormone (GnRH) analogs was studied. METHODS:Nineteen Caucasian premenopausal women aged 23-38 years were included in the study. The subjects were all treated with 21.6 mg goserelin d...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.0001-6349.2005.00558.x
更新日期:2005-04-01 00:00:00
abstract::First catch urine (FCU) from 751 asymptomatic adolescent female high school students, with sexual debut, were screened for the presence of Chlamydia trachomatis (Group A). The prevalence of C. trachomatis infection in Group A was 2.1% (16/751). In Group B, 619 asymptomatic adolescent females attending a youth and a fa...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349409013397
更新日期:1994-01-01 00:00:00
abstract:AIM:To investigate the development in women's attitude to hormone replacement therapy, and the change in views concerning positive and negative effects. METHODS:National cohort study based on telephone interviews in 1990 and 1997, of women randomly sampled from the Norwegian telephone book (n=1019 and 1003). The same ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of three different doses of Nestorone progestin administered by implants for relief of pain, as well as bleeding patterns and symptoms in women with endometriosis. DESIGN:An open clinical study without a control group. PATIENTS:Twenty-one women in whom endometriosis was diagnosed an...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-02-01 00:00:00
abstract::The incidence of birth has been determined for each hour of the day for all births in Norway in 1968-1977 of fetuses of 16 weeks of gestation or older, with resident mothers. The 24-hour incidence variations of births (A) with spontaneous onset and parturition, (B) with spontaneous onset, but delivery intervention, (C...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155754
更新日期:1983-01-01 00:00:00
abstract::Persistently elevated levels of serum human chorionic gonadotropin (hCG) in women call for a tumor investigation, if pregnancy can be ruled out. We present a case of increased hCG concentrations for 1 1/2 years. Radiolabelled antibody directed against the hCG molecule indicated the source of production to be a chorioc...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909020999
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The aim was to construct a new symphysis-fundus (SF) height growth chart, based on ultrasound-dated singleton pregnancies. METHODS:We made a population-based study of all women, from the catchment areas of three district antenatal clinics, who registered for antenatal care during 1986. The growth of the SF ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349509021174
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Topical corticosteroids are frequently used drugs, but little is known of the exposure during pregnancy and birth outcome. METHODS:In a population-based follow-up study restricted to primigravida women, we examined the risk of low birth weight, malformations and other birth outcomes following pregnancy upon...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2002.810308.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Secondhand smoke (SHS) exposure harms pregnant women and the fetus. China has the world's largest number of smokers and a high male smoking prevalence rate. OBJECTIVE:To compare exposure to SHS among rural and urban Chinese non-smoking pregnant women with smoking husbands, and analyze factors associated wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016341003713851
更新日期:2010-01-01 00:00:00
abstract::This retrospective analysis compares laparoscopy versus culdoscopy results in the investigation of infertility. 52 women underwent culdoscopy; 49 women underwent laparoscopy. Then a change in method was made due to the acquisition of a cold-light laparoscopy. A third group of 73 women were examined with the new ins...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347409156901
更新日期:1974-01-01 00:00:00
abstract:INTRODUCTION:Accurate estimates and reliable classification of maternal deaths are imperative steps in the chain of actions targeted at reducing avoidable maternal mortality. The aims of this study were to estimate the maternal mortality ratio (MMR) in 10 Italian regions covering 77% of total national births and to ide...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13415
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Shoulder dystocia has remained an unpredictable and feared emergency in obstetrics. Some risk factors have been identified but nevertheless there is a lack of risk evaluation tools in clinical practice. The aim of this study was to evaluate the incidence and risk factors of shoulder dystocia in the Finnish...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.14022
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:To investigate the role of interleukin-1 related substances in amniotic fluid in normal term labor without intrauterine infection. METHODS:Amniotic fluid samples were collected from forty-one patients with various backgrounds. A novel pre-assay treatment using Frigen II was introduced to improve the recover...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::In a study of 1,955 primigravidae who gave birth to a live singleton baby, 227 (11.6%) scored 'positive' (7+) in an antenatal Health Questionnaire enquiring into pre-pregnancy emotional disturbances. This group of mothers had more frequent depression, and this was of longer duration after their delivery compared with ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809004190
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Clinical studies show that analysis of the fetal electrocardiographic (FECG) ST waveform at term gives important information on the myocardial response to intrapartum asphyxia. However, it is not known whether the preterm fetus responds in a similar fashion. The objective of the present study was to evaluate...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00594.x
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The rate of cesarean section (CS) is increasing in Sweden as well as in most of the industrialized world. One of the most common indications for emergency CS is protracted labor. To what extent fetal pelvic disproportion is a cause of protracted labor is unclear. The value of pelvimetry has been questioned. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600593521
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:This study compared healing of the scars after cesarean section during the first postpartum year using a single- or double-layer suturing technique. Scarring was assessed by a transvaginal ultrasound. We explored the appearance and localization of uterine scars with regard to the obstetric history. Our aim...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.13714
更新日期:2020-01-01 00:00:00
abstract::We report a case of galactorrhea in a normoprolactinemic fertile woman (30 years old) wearing a copper intra-uterine device (Gravigard). The Gravigard was first inserted in July 1977. In February 1979 our patient noted spontaneous galactorrhea, mainly on the left, but it was also present on the right, after breast pre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409156269
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To identify prognostic factors influencing the outcome of infertility treatment using intrauterine insemination with donor semen (IUI-D). DESIGN:Retrospective study of all patients undergoing IUI-D between August 1st, 1990 and July 31st, 1998. SETTING:University-affiliated infertility clinic. PATIENTS:Thre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.080004342.x
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Emergent cervical cerclage is often unsuccessful in patients with severely protruding fetal membranes for the following reasons: (1) difficulty in pushing the bulging membranes into the cervix; (2) risk of premature rupture of membranes during the operative procedures; and (3) displacement of the cerclage ta...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:This investigation was undertaken to study the conditions resulting in midtrimester fetal hydrops and to evaluate its overall prognosis as regards counseling purposes. MATERIAL AND METHODS:The etiology of midtrimester non-immune fetal hydrops was retrospectively evaluated as regards cases detected in single...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The Developmental Origins of Health and Disease hypothesis describes how early life environmental factors influence development in a way that impacts later health and disease risk. The hypothesis is supported by a large number of animal studies and a smaller number of observational studies in humans. Epigenetic variat...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.12431
更新日期:2014-11-01 00:00:00
abstract::A study was planned to evaluate the effect of Prostaglandin E2 pessaries in three different dosages in ripening the unfavourable cervix prior to the induction of labor. A single dose of PGE2 as pessary in the three different dosages was administered into the posterior vaginal fornix to ripen an unfavourable cervix wit...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.3109/00016348409156268
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To assess the fraction of women who have heard of human papillomavirus (HPV) in four Nordic countries (Denmark, Iceland, Norway, and Sweden) and to study the correlates of this awareness, just before the vaccines were released. DESIGN:Population-based cross-sectional study by means of a questionnaire. Settin...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802326373
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Treatment of adnexal torsion remains a clinical dilemma when future fertility is wanted. The purpose of this study was to evaluate the correlation between the pathological changes and the clinical characteristics on patients having torsion of the previously normal uterine adnexa which may help us decide whet...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2001.800111.x
更新日期:2001-01-01 00:00:00