Abstract:
:Although there are many types of epilepsy of both genetic and acquired forms, temporal lobe epilepsy (TLE) with hippocampal sclerosis is probably the single most common human epilepsy, and the one most intensely studied. Despite a wealth of descriptive data obtained from patient histories, imaging techniques, electroencephalographic recording, and histological studies, the epileptogenic process remains poorly understood. Progress toward understanding the etiology of an acquired neurological disorder is largely dependent on the degree to which experimental animal models reflect the human condition. Recent observations suggest that significant disparities exist between the features of human TLE with hippocampal sclerosis and those of animal models that involve prolonged status epilepticus to initiate the epileptogenic process. TLE most commonly involves patients with focal seizures who exhibit limited and often asymmetrical brain damage, did not experience status epilepticus prior to the onset of epilepsy, and who appear relatively normal on neurological examination. Conversely, animals subjected to prolonged status epilepticus exhibit severe brain damage, behavioral abnormalities, and frequent generalized seizures. In addition, although many TLE patients exhibit an atrophic hippocampus that may, or may not, be a source of spontaneous seizures, hippocampal damage in animals subjected to status epilepticus is an inconsistent and often minor part of a much greater constellation of damage to other brain structures. Furthermore, many patients exhibit developmental structural abnormalities that presumably play a role in the clinical etiology, whereas most animal models involve severe insults in initially normal laboratory rats. Although much has been learned using the current animal models, the available data suggest the need for a critical reappraisal of the assumptions underlying their use, and the need to develop experimental preparations that may more closely model the human epileptic state.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Sloviter RSdoi
10.1016/j.crvi.2004.10.010subject
Has Abstractpub_date
2005-02-01 00:00:00pages
143-53issue
2eissn
1631-0691issn
1768-3238pii
S1631-0691(04)00244-6journal_volume
328pub_type
杂志文章,评审abstract::Tomato seedlings grown on nitric medium and treated with various cadmium concentrations (0 to 50 microM) were used. Results obtained show that cadmium remains predominantly located in the roots, which then seem to play the role of trap-organs. Increasing cadmium concentration in the medium leads particularly to a decr...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2006.06.008
更新日期:2006-10-01 00:00:00
abstract::This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish Lagocephalus lagocephalus collected along the Tunisian coast. Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of L. lagocephalus. Control rats received...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.05.005
更新日期:2008-08-01 00:00:00
abstract::More than 5 years after the description of the first cases of variant Creutzfeldt-Jakob disease (vCJD), there is still great uncertainty about the size of the vCJD epidemic in the United Kingdom (UK), although the most recent predictions based on statistical modelling are more optimistic than the previous ones. The nu...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/s1631-0691(02)01410-5
更新日期:2002-01-01 00:00:00
abstract::The first veterinary school in the world was created in Lyon in 1761 by an equerry, Claude Bourgelat (1712-1779), a man renowned for his skill in horsemanship and horse medicine, a man fully able to understand the issues of his time. Aware of the scope of the physiocratic movement and of the need to improve the health...
journal_title:Comptes rendus biologies
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.crvi.2012.02.005
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abstract::Citrus trees are subject to several abiotic constraints such as salinity. Providing new rootstocks more tolerant is thus a requirement. In this article, we investigated salt stress tolerance of three tetraploid rootstock genotypes when compared to their respective diploid rootstocks (Poncirus trifoliata, Carrizo citra...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.06.007
更新日期:2008-09-01 00:00:00
abstract::The larvicidal activity of ethanolic leaf extracts from two Artemisia species, Artemisia campestris var. glutinosa and A. molinieri, on mosquito Culex pipiens Linnaeus (Diptera, Culicidae) larvae was investigated. Since A. molinieri is a rare and protected species confined to temporary ponds of Southern France, its to...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2011.10.003
更新日期:2012-01-01 00:00:00
abstract::In this study, we investigate skull size and shape differentiation between sibling species of Mastomys with the aim to characterize and discriminate three sympatric species found in West Africa: M. huberti, M. erythroleucus and M. natalensis. A total of 133 genetically determined specimens were used for the morphometr...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.11.004
更新日期:2009-05-01 00:00:00
abstract::Potato is the fourth staple food in the world, following rice, wheat, and maize, whereas tubers contain high quality of starch, relatively high amounts of vitamin C and many other important substances. It also contains relatively good quality of protein (about 3 to 6% of the dried weight) and patatin, and 11S globulin...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2013.09.002
更新日期:2013-09-01 00:00:00
abstract::We present the pollen analysis of a new sedimentary sequence taken at La Pouretère ( 1720 m), in the mountain vegetation zone of the Marcadau valley (central Pyrenees). The Lateglacial and Holocene chronology is supported by six 14C-dating results. The complementary analysis of some vegetal macroremains, stomata, poll...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2004.02.001
更新日期:2004-04-01 00:00:00
abstract::Sleep disorders have a high prevalence: around 20% of insomniacs, 10% hypersomnolent including 2 to 4% of sleep disordered breathing in the general adult population. The low availability of sleep centres implies the research of alternative recording techniques in the natural setting of the patient. The objective was t...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/s1631-0691(02)01437-3
更新日期:2002-04-01 00:00:00
abstract::The Mediterranean stone pine Pinus pinea L. (gymnosperm, Pinaceae) is much appreciated for its seed production, widely used in food preparation in the Mediterranean Basin. Seeds contain 25% proteins on a dry-weight basis. Pinus pinea accumulate globulins as major storage proteins in seeds (75% of total storage protein...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2007.03.011
更新日期:2007-05-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2016.04.005
更新日期:2016-07-01 00:00:00
abstract::The shoot apical meristem is a population of stem cells which controls the initiation of leaves, flowers and branches during the entire life of the plant. Although we have gained significant new insight in the nature of the genetic networks and cellular processes that control meristem function, major questions have re...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2009.09.008
更新日期:2009-11-01 00:00:00
abstract::In this paper we consider cell cycle models for which the transition operator for the evolution of birth mass density is a simple, linear dynamical system with a stochastic perturbation. The convolution model for a birth mass distribution is presented. Density functions of birth mass and tail probabilities in n-th gen...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2003.05.002
更新日期:2004-03-01 00:00:00
abstract::To infer the anatomical evolution of the Hymenophyllaceae (filmy ferns) and to test previously suggested scenarios of regressive evolution, we performed an exhaustive investigation of stem anatomy in the most variable lineage of the family, the trichomanoids, using a representative sampling of 50 species. The evolutio...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2011.07.009
更新日期:2011-12-01 00:00:00
abstract::The polymorphism of the mitochondrial gene cytochrome oxidase III was studied in the Mediterranean octopus, Octopus vulgaris Cuvier, 1797. A total of 202 specimens from seven sampling sites were analysed with the aim of elucidating patterns of genetic structure in the central Mediterranean Sea and to give an insight i...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2012.10.004
更新日期:2012-10-01 00:00:00
abstract::The paper provides a mathematical study of a model of urban dynamics, adjusting to an ecological model proposed by Lotka and Volterra. The model is a system of two first-order non-linear ordinary differential equations. The study proposed here completes the original proof by using the main tools such as a Lyapunov fun...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2004.09.006
更新日期:2004-11-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2015.10.002
更新日期:2016-01-01 00:00:00
abstract::Apoptosis and inflammation are important cellular processes that are highly regulated through specific protein-protein interactions (PPI). Proteins involved in these signaling cascades often carry PPI domains that belong to the death-domain superfamily. This includes the structurally well-characterized Death Domain (D...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2004.08.006
更新日期:2004-12-01 00:00:00
abstract::Clinically very heterogeneous, breast cancer prognosis and treatment response are difficult to predict with the current prognostic histoclinical parameters. Mammary oncogenesis remains poorly understood. DNA array technology allows the simultaneous analysis of the mRNA expression levels of thousands of genes in biolog...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2003.09.010
更新日期:2003-10-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/j.crvi.2010.12.007
更新日期:2011-03-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2014.05.003
更新日期:2014-07-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2012.03.013
更新日期:2012-04-01 00:00:00
abstract::Domestication is the process of organism evolution under selection by humans, and as such has been a model for studying adaptation since Charles Darwin. Here we review recent studies on the genomics of adaptation and domestication syndrome in two cheese-making fungal lineages, Penicillium roqueforti used for maturing ...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.5802/crbiol.15
更新日期:2020-10-09 00:00:00
abstract::This article demonstrates how that the effectiveness of nervous system in doing the computations essential to an organism can be based on using algorithms that are readily implemented by nervous system 'device biophysics'. Collective effects and collective algorithms that exploit their dynamics provide powerful potent...
journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/s1631-0691(03)00017-9
更新日期:2003-02-01 00:00:00
abstract::The soil macrofauna of a pure beech (PS) and a mixed beech-hornbeam (MS) stand was recorded using a sample design spatially explicit at stand level. Humic epipedon morphological and chemical properties, relative irradiance, soil bulk density, and the specific composition of the litter in MS were also investigated. The...
journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2004.10.008
更新日期:2005-01-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2005.12.004
更新日期:2006-02-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2014.07.007
更新日期:2014-10-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章
doi:10.1016/j.crvi.2008.08.011
更新日期:2008-11-01 00:00:00
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journal_title:Comptes rendus biologies
pub_type: 杂志文章,评审
doi:10.1016/s1631-0691(03)00006-4
更新日期:2003-01-01 00:00:00