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Intrathymic inoculation of donor HLA class I-derived peptide generates donor-specific CD4+CD25+ regulatory T cells.

Abstract：

:CD4(+)CD25(+) regulatory T cells are selected in the thymus to control autoreactive thymic escapees preventing autoimmunity that cannot be achieved by negative selection or deletion alone, thus playing an important role in the maintenance of immunological homeostasis. Not only significant in preventing autoimmunity, CD4(+)CD25(+) regulatory T cells have also been shown to be involved in allograft tolerance in organ transplantation. We have formerly introduced two lines of HLA class I transgenic mice to elucidate the role of HLA class I molecules in transplantation biology. Using a heterotopic cardiac transplantation model, we show herein that intrathymic inoculation of donor HLA class I-derived synthetic peptide results in the generation of CD4(+)CD25(+) regulatory T cells, which induce graft specific tolerance without any preconditioning of the recipient or use of immunosuppressive drugs. This study provides evidence of the novel therapeutic potential of CD4(+)CD25(+) regulatory T cells for clinical transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Tamura S,Beck Y,Ando Y,Tahara H

doi

10.1016/j.transproceed.2004.12.046

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

40-2

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)01484-8

journal_volume

37

pub_type

杂志文章

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