The effect of octreotide on hepatic ischemia-reperfusion injury in a rabbit model.


BACKGROUND:Hepatic ischemic-reperfusion injury (HIRI) is a major cause of morbidity and mortality following liver surgery. Octreotide (Oct) has been reported to improve hepatocellular energy metabolism in a rat HIRI model. This study was designed to evaluate whether Oct could protect the liver of rabbits against ischemic-reperfusion (I/R) injury. METHODS:Twenty-four adult New Zealand rabbits were randomly divided into a sham operated group (Control), an ischemia/reperfusion group (I/R), and an ischemia/reperfusion + Oct pretreatment group (I/R + Oct). The hemodynamic (mean arterial pressure [MAP] and heart rate [HR]) changes, liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], and lactate dehydrogenase [LDH]) release, inflammatory cytokines (tumor necrosis factor [TNF]α and interleukin [IL]-1β) levels, and endotoxin (ETX) levels were measured during I/R. RESULTS:Compared with the Control group, the MAP decreased and HR increased in I/R and I/R + Oct groups at ischemia 15 minutes (P < .05) but were less in the I/R + Oct group relative to the I/R group (P < .05). ALT, AST, LDH, IL-1β, and ETX levels were increased in the I/R and I/R + Oct groups at ischemia 30 minutes (P < .05), however, the increase was lower in the I/R + Oct group relative to the I/R group (P < .05). Bcl-2 expression in the I/R + Oct group was higher compared with other groups (P < .05) and Bax expression in the I/R group was reduced compared with other groups (P < .05). Hepatocellular damage in the I/R + Oct group appeared to be less than in the I/R group by microscopy. CONCLUSIONS:Oct pretreatment attenuated hemodynamic changes and decreased liver enzyme changes induced by HIRI in a rabbit model. The protection mechanisms of Oct may be related to reduced ETX levels, down-regulation of the inflammatory cytokines TNFα and IL-1β, and inhibition of hepatocellular apoptosis, as well as the modulation of the mitochondrion-mediated Bcl-2/Bax apoptosis pathway. Based on our study it appears that Oct may be useful in decreasing liver injury after liver surgery and/or transplantation and may serve as a promising agent against HIRI.


Transplant Proc


Yang J,Sun H,Takacs P,Zhang Y,Liu J,Chang Y,Candiotti KA




Has Abstract


2013-07-01 00:00:00














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    abstract::Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on int...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Cámara-Lemarroy CR,Guzmán-de la Garza FJ,Cordero-Pérez P,Alarcón-Galván G,Ibarra-Hernández JM,Muñoz-Espinosa LE,Fernández-Garza NE

    更新日期:2013-07-01 00:00:00

  • A laparoscopic approach to allograft nephrectomy and bilateral native nephrectomy: a case report.

    abstract:INTRODUCTION:Laparoscopic surgery is rapidly emerging as the standard of care for a variety of urological conditions, even among patients who have undergone prior renal transplantation. We describe the technique of bilateral native nephrectomy and allograft nephrectomy by laparoscopy. CASE REPORT:A 32-year-old man wit...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Branco AW,Filho AJ,Kondo W,De George MA,Rangel M,De Carvalho RM,Noda RW

    更新日期:2005-06-01 00:00:00

  • Significance of cytomegalovirus prophylaxis strategies and development of cancer in kidney transplant recipients.

    abstract::Cytomegalovirus (CMV) infection is one of the most common complications among kidney transplant recipients; two approaches preventing this complication are currently available: universal prophylaxis (UP) and pre-emptive therapy (PT). Despite some differences, similar effectiveness and safety have been proven in severa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Osorio JC,Medina RD,Patiño N,Ricaurte L,Moreno L,Lozano E

    更新日期:2011-11-01 00:00:00

  • Efficacy of ICAM-1 antisense oligonucleotide in pancreatic islet transplantation.

    abstract::Significant islet allograft prolongation was achieved by ICAM-1/LFA-1 blockade. ICAM-1 antisense oligonucleotide IP-3082 was effective in improving islet function as well as prolonging graft survival. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Katz SM,Browne B,Phan T,Wang ME,Bennett CF,Stepkowski SM,Kahan BD

    更新日期:1995-12-01 00:00:00

  • Smoking following renal transplantation in Hungary and its possible deleterious effect on renal graft function.

    abstract::Smoking is a known risk factor for kidney damage and also influences graft function following renal transplantation. Because smoking habits following kidney transplantation are not systematically evaluated, we analyzed them in a single center in Hungary. The survey was conducted among 402 randomly selected kidney graf...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gombos P,Langer RM,Korbely R,Varga M,Kaposi A,Dinya E,Müller V

    更新日期:2010-07-01 00:00:00

  • Gender bias in renal transplantation: are women alone donating kidneys in India?

    abstract::Previous studies have shown that women not only donate live-related and unrelated kidneys more often, but are also less likely to receive a live kidney than men. Few data are, however, available from developing countries. To study a possible gender imbalance in living donor (LD) renal transplantation in India, we retr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bal MM,Saikia B

    更新日期:2007-12-01 00:00:00

  • Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients.

    abstract:OBJECTIVES:Alloreactive T cells recognize antigens via direct and indirect pathways. The competency of costimulatory molecules on antigen-presenting cells (APC) is important. An active form of vitamin D (1,25(OH)(2)D(3), calcitriol) inhibits APC cell maturation and expression of costimulatory molecules. Herein we studi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Ardalan MR,Maljaei H,Shoja MM,Piri AR,Khosroshahi HT,Noshad H,Argani H

    更新日期:2007-05-01 00:00:00

  • Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program.

    abstract::This paper reviews the formulation and evolution of the ethical component in one of the earliest clinical composite tissue allograft (CTA) programs, the hand transplantation program in Louisville, Kentucky, USA. The purpose was to derive lessons and define principles to give guidance for future programs and introducti...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Tobin GR,Breidenbach WC,Klapheke MM,Bentley FR,Pidwell DJ,Simmons PD

    更新日期:2005-03-01 00:00:00

  • Liver transplantation in management of alveolar echinococcosis: two case reports.

    abstract::Hepatic alveolar echinococcosis is an infectious disease caused by the larval stage of Echinococcus multilocularis, which grows primarily in the liver of an infected person and develops as a tumorlike lesion. In advanced cases, the organisms infiltrate every organ neighboring the liver and spread hematogenously to dis...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Moray G,Shahbazov R,Sevmis S,Karakayali H,Torgay A,Arslan G,Savas N,Yilmaz U,Haberal M

    更新日期:2009-09-01 00:00:00

  • Pulse Oximeter Usefulness for Blood Pressure Monitoring in Patients Implanted With Latest-Generation Continuous-Flow Device HeartMate 3.

    abstract:INTRODUCTION:The measurement of blood pressure (BP) and the management of hypertension in patients with continuous-flow ventricular assist devices (CF-VADs) can present unique challenges. Patients with CF-VADs often do not have a palpable pulse, and therefore traditional blood pressure measurement by auscultation or au...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章


    authors: Montalto A,Palermo A,Gherli R,Cammardella A,Contento C,Piazza V,Musumeci F

    更新日期:2019-01-01 00:00:00

  • A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

    abstract:BACKGROUND:Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate (CHIP) with equivalent functional and inflammator...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Buchko MT,Himmat S,Aboelnazar NS,Stewart CJ,Hatami S,Dromparis P,Adam B,Freed DH,Nagendran J

    更新日期:2020-12-01 00:00:00

  • Investigation of the Causes and Risk Factors of Previous End-Stage Renal Disease in Kidney Transplant Recipients.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is a pathophysiological process with many etiologic causes, often leading to end-stage renal disease (ESRD). The distribution of the causes that lead to ESRD varies by country, race, and sex. Renal failure may be prevented by determining these differences and reducing the risk fa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Aksoy N,Şelimen D

    更新日期:2020-01-01 00:00:00

  • The role of dendritic cells in the gastrointestinal field effect.

    abstract:INTRODUCTION:Intestinal manipulation leads to local bowel wall inflammation that subsequently spreads over the entire gastrointestinal tract. Previously, this gastrointestinal field effect had been demonstrated by us in a rodent model. We herein postulated an immunologic mechanism mediated by activated leukocytes. The ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Koscielny A,Boerner T,Wehner S,Kurts C,Kalff JC

    更新日期:2006-07-01 00:00:00

  • Bacteriocins from lactic acid bacteria increases tumor necrosis factor-alpha expression in a rat kidney model of chronic rejection.

    abstract::Chronic allograft dysfunction is the primary cause of graft loss after the first posttransplantation year. Bacteriocins are biologically active proteins exhibiting antimicrobial properties against other bacterial species, which are usually closely related to the producer organism. The objective of our study was to det...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zhu LH,Li C,Wu JA,Liang JG,Shi YF

    更新日期:2008-12-01 00:00:00

  • Bacterial Infections During Hospital Stay and Their Impact on Mortality After Lung Transplantation: A Single-Center Study.

    abstract:INTRODUCTION:The aim of the study was to assess the impact of bacterial infection during hospital stay on long-term follow-up. MATERIALS AND METHODS:This was a retrospective single-center study of 97 recipients of lung transplantations performed between December 2004 and June 2016 at a single center. Information about...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wojarski J,Ochman M,Medrala W,Kulaczkowska Z,Karolak W,Maruszewski M,Urlik M,Wozniak-Grygiel E,Sioła M,Latos M,Biniszkiewicz P,Pyrc K,Zeglen S

    更新日期:2018-09-01 00:00:00

  • Liver transplant combined with heart transplant in severe heterozygous hypercholesterolemia: report of the first case and review of the literature.

    abstract::Familial hypercholesterolemia (FH) is a dominant inherited disease of low-density lipoprotein (LDL) metabolism caused by mutations of LDL receptors mainly located in the liver. This metabolic disorder is responsible for severe cardiovascular disease, from coronary lesions to chronic heart failure (CHF). Liver transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Alkofer BJ,Chiche L,Khayat A,Deshayes JP,Lepage A,Saloux E,Reznik Y

    更新日期:2005-06-01 00:00:00

  • Use of high-dose human immune globulin in highly sensitized patients on the kidney transplant waiting list: one center's experience.

    abstract:INTRODUCTION:Transplant rates are low among highly sensitized patients with preformed anti-HLA antibodies, because of the additional immunologic barrier, the increased risk of rejection, and the greater chance of early graft loss. Intravenous infusion of pooled human immune globulin (IVIG) is immunomodulatory, neutrali...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gozdowska J,Urbanowicz A,Perkowska-Ptasinska A,Michalska K,Chmura A,Szmidt J,Durlik M

    更新日期:2009-10-01 00:00:00

  • Initial experience with lung transplantation in Estonia.

    abstract:BACKGROUND:A lung transplant program in Estonia was initiated in cooperation with the Medical University of Vienna. The first lung transplantation for an Estonian patient was performed in Vienna on April 28, 2009. The waiting list in Estonia was opened on May 28, 2010; the first transplantation was performed on October...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Laisaar T,Savisaar M,Parm P,Sõrmus A,Kuum U,Ruusalepp A,Jakobson E,Küüsvek A,Klepetko W

    更新日期:2013-04-01 00:00:00

  • Renal amyloidosis followed more than 5 years: report of 12 cases.

    abstract::Renal involvement with amyloidosis is common but causes patient survival to be poor, rarely reaching 5 years. In this study, we retrospectively reviewed clinical and biological characteristics as well as treatments and outcomes of patients with renal amyloidosis followed for more than 5 years. Between 1975 and 2003, 4...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kaaroud H,Boubaker K,Béji S,Abderrahim E,Moussa FB,Turki S,Goucha R,Hedri H,El Younsi F,Kheder A,Maiz HB

    更新日期:2004-07-01 00:00:00

  • Excessive portal flow causes graft nonfunction in small size liver transplantation: an experimental study in pigs.

    abstract::We investigated the effects of portocaval shunt (PCS) on excessive portal flow in producing sinusoidal microcirculatory injury in small-for-size liver transplants in pigs. The posterior segment of a whole liver (25%) was transplanted orthotopically. The pigs were divided two groups: group A, graft with PCS (n = 11), a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wang HS,Enomoto Y,Usuda M,Miyagi S,Asakura T,Masuoka H,Fukushima K,Aiso T,Narita T,Yamaya H,Sekiguchi S,Kawagishi N,Sato A,Ohkohchi N,Satomi S

    更新日期:2005-01-01 00:00:00

  • Impact of Skin Cancer Awareness on Prophylactic Behavior Among Renal Transplant Recipients.

    abstract:BACKGROUND:Renal transplant recipients (RTRs) have a risk for skin cancer. The most important risk factor, and the only one that depends on patient behavior, is the exposure to ultraviolet light. The aim of this study was to assess the level of skin cancer awareness and its impact on preventative behavior among RTRs. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Imko-Walczuk B,Graczyk M,Korban M,Kiełbowicz M,Dębska-Ślizień A,Rutkowski B

    更新日期:2016-06-01 00:00:00

  • Renal function and tubular phosphate handling in long-term cyclosporine- and tacrolimus-based immunosuppression in kidney transplantation.

    abstract::The aim of the study was to assess impaired tubular phosphate reabsorption and renal function among patients on cyclosporine- or tacrolimus-based immunosuppression for 2 years after kidney transplantation. Among 60 cadaveric kidney allograft recipients observed for 48 months, 40 received cyclosporine, azathioprine, an...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Falkiewicz K,Kamińska D,Nahaczewska W,Boratyńska M,Owczarek H,Klinger M,Woźniak M,Patrzałek D,Szyber P

    更新日期:2006-01-01 00:00:00

  • A preliminary study on the feasibility of gene expression profile of rhesus monkey detected with human microarray.

    abstract:OBJECTIVES:A pig-to-monkey transplant model was initiated to investigate the outcome of pig-to-human xenotransplantation. Though monkey is close to human in biology and physiology, the genetic differences between the two species remains unclear. This study sought to compare the gene expressions of three tissues from hu...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lu YR,Wang LN,Jin X,Chen YN,Cong C,Yuan Y,Li YC,Tang WD,Li HX,Wu XT,Li YP,Wang L,Cheng JQ

    更新日期:2008-03-01 00:00:00

  • Porcine endothelial cell activation in hDAF pig hearts transplanted in baboons with prolonged survival and lack of rejection.

    abstract::Depletion of anti-alphaGal antibodies before and after transplantation with GAS 914, a polylysine containing alphaGal epitopes, together with immunosuppression, has been shown to prevent acute humoral xenograft rejection (AHXR) in hDAF pig-to-baboon xenotransplantation. This therapy was associated with low levels of s...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Doménech N,Diaz T,Moscoso I,Centeno A,Lopez-Pelaez E,Manez R

    更新日期:2003-08-01 00:00:00

  • Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations.

    abstract:AIMS:We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen. METHODS:Eight patients received 12 islet infusions in 5 IAK and 3 SIK procedures. Median age was 51 ye...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Berney T,Bucher P,Mathe Z,Andres A,Bosco D,Mage R,Toso C,Oberholzer J,Becker C,Philippe J,Bühler L,Morel P

    更新日期:2004-05-01 00:00:00

  • Family Function in Pediatric Liver Transplant Recipients Residing In a Developing Country.

    abstract:BACKGROUND:Pediatric liver transplantation (LT) can affect recipients' family function; however, inconsistent results between studies exist, and data from developing nations are sparse. We aimed to evaluate family function and identify factors associated with suboptimal function in pediatric LT recipients. METHODS:A c...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Butsriphum N,Getsuwan S,Prabpram W,Chuthapisith J,Tanpowpong P,Lertudomphonwanit C,Treepongkaruna S

    更新日期:2020-04-01 00:00:00

  • Predictors of Mortality in Living Donor Liver Transplantation.

    abstract:BACKGROUND:Egypt has the highest prevalence of the world hepatitis C virus (HCV) load. Hence, the problem of end-stage liver disease (ESLD) is considered a huge burden on the community. Living donor liver transplantation (LDLT) is the only source of donation in Egypt till now. Survival rates had shown significant impro...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Elkholy S,Mogawer S,Hosny A,El-Shazli M,Al-Jarhi UM,Abdel-Hamed S,Salah A,El-Garem N,Sholkamy A,El-Amir M,Abdel-Aziz MS,Mukhtar A,El-Sharawy A,Nabil A

    更新日期:2017-01-01 00:00:00

  • Holmium Intraductal Laser Lithotripsy of Biliary Stones in Liver Grafts.

    abstract:BACKGROUND:Biliary stones after liver transplantation (LT) rarely occur but a focus on those complications and their treatment is needed. PATIENTS AND METHODS:In total, 390 adult patients who underwent an LT from July 2004 to July 2014 entered the study. Biliary complications and notably biliary stones after LT were i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Maggi U,Paone G,Lauro R,Fornoni G,Chierici A,Nencioni M,Caruso A,Rossi G

    更新日期:2016-03-01 00:00:00

  • Peginterferon and ribavirin in patients with HCV cirrhosis after liver transplantation.

    abstract::The objective of the study was to assess the efficacy of antiviral therapy in patients with hepatitis C virus (HCV) recurrence after liver transplantation (OLT). We included 30 patients of mean age 56 years, who experienced HCV recurrence after OLT. Mean time from OLT to the beginning of therapy was 57 months (median:...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Moreno Planas JM,Rubio Gonzalez E,Boullosa Graña E,Garrido Botella A,Barrios Peinado C,Lucena Poza JL,Jiménez Garrido M,Sanchez Turrion V,Cuervas-Mons Martinez V

    更新日期:2005-06-01 00:00:00

  • Brain death affects the hepatic immunogenicity of pigs.

    abstract:OBJECTIVE:The purpose of this study was to observe how the brain-death state affects the hepatic immunogenicity of pigs. MATERIALS AND METHODS:Twelve healthy ChangBai pigs were allocated randomly to 2 groups: control group (n = 6) with Foley catheter balloon placed intracalvarium for 24 hours only versus brain-death g...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zhang S,Zhu C,Wu Y,Zhai W,Shi J,Song Y,Li J,Li Z,Zhang G

    更新日期:2008-09-01 00:00:00