Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin.

abstract：:Calcineurin inhibitors such as cyclosporin A (CsA) and FK506 have been used in solid organ and hematopoietic stem cell transplantations to suppress immune function. However, these immunosuppresants are associated with severe endothelial dysfunction. We investigated whether CsA and FK506 induce endothelial dysfunction ...

journal_title：Cellular signalling

authors： Eguchi R,Kubo S,Ohta T,Kunimasa K,Okada M,Tamaki H,Kaji K,Wakabayashi I,Fujimori Y,Ogawa H

更新日期：2013-09-01 00:00:00

abstract：:We observed on different tissues and organisms a biological response after exposure to pulsed low frequency and low amplitude electric or electromagnetic fields but the precise mechanism of cell response remains unknown. The aim of this publication is to understand, using bioinformatics, the biological relevance of pr...

journal_title：Cellular signalling

authors： Collard JF,Hinsenkamp M

更新日期：2015-05-01 00:00:00

abstract：:Dynamin, a 100 kD GTPase, is necessary for the normal development and function of mammalian neural tissue. In neurons, it is necessary for the biogenesis of synaptic vesicles, and in other cell types dynamin has a general and important role in clathrin mediated receptor endocytosis. Different isoforms function as mole...

journal_title：Cellular signalling

authors： Scaife RM,Margolis RL

更新日期：1997-09-01 00:00:00

abstract：:The type II epithelial-mesenchymal transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on sig...

journal_title：Cellular signalling

authors： Desai P,Yang J,Tian B,Sun H,Kalita M,Ju H,Paulucci-Holthauzen A,Zhao Y,Brasier AR,Sadygov RG

更新日期：2015-07-01 00:00:00

abstract：:This review is intended to discuss recent developments in the molecular pharmacology of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes. After a brief historical development, we will focus on the more contemporary issues having to do with this receptor family. Emphasis will be put on recent data regarding the cl...

journal_title：Cellular signalling

authors： Guarino RD,Perez DM,Piascik MT

更新日期：1996-08-01 00:00:00

abstract：:An important therapeutic method of glioblastoma, the most common primary brain tumor, is radiotherapy. However, several studies reported recently that radiation could also promote the invasion and migration of malignant tumor. Herein, we have identified that a significant increase of migration and invasiveness of huma...

journal_title：Cellular signalling

authors： Xiong Y,Ji W,Fei Y,Zhao Y,Wang L,Wang W,Han M,Tan C,Fei X,Huang Q,Liang Z

更新日期：2017-01-01 00:00:00

abstract：:Calmodulin (CaM) antagonists, trifluoperazine (TFP) or calmidazolium (R24571), dose-dependently inhibited cAMP and folic acid (FA) chemotaxis in Dictyostelium. Developing, starved, and refed cells were compared to determine if certain CaM-binding proteins (CaMBPs) and CaM-dependent phosphorylation events could be iden...

journal_title：Cellular signalling

authors： Gauthier ML,O'Day DH

更新日期：2001-08-01 00:00:00

abstract：:Recent global incidences and mortality rates have placed colorectal cancer (CRC) at third and second positions, respectively, among both sexes of all ages. Resistance during chemotherapy is a big problem in the treatment and disease-free survival of CRC patients. Discovery of new anticancer drug(s) is a time taking pr...

journal_title：Cellular signalling

authors： Dhiman DK,Sanyal SN,Vaish V

更新日期：2020-12-01 00:00:00

abstract：:Regulators of G protein signalling (RGS) proteins are united into a family by the presence of the RGS domain which serves as a GTPase-activating protein (GAP) for various Galpha subunits of heterotrimeric G proteins. Through this mechanism, RGS proteins regulate signalling of numerous G protein-coupled receptors. In a...

journal_title：Cellular signalling

authors： Sethakorn N,Yau DM,Dulin NO

更新日期：2010-09-01 00:00:00

abstract：:By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

journal_title：Cellular signalling

authors： Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

更新日期：2016-05-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress activated by perturbations in ER homeostasis induces the unfolded protein response (UPR) with chaperon Grp78 as the key activator of UPR signalling. The aim of UPR is to restore normal ER function; however prolonged or severe ER stress triggers apoptosis of damaged cells to ensure pro...

journal_title：Cellular signalling

authors： Kyriakakis E,Philippova M,Joshi MB,Pfaff D,Bochkov V,Afonyushkin T,Erne P,Resink TJ

更新日期：2010-09-01 00:00:00

abstract：:Protein kinase D3 is a novel member of the serine/threonine kinase family PKD. The regulatory region of PKD contains a tandem repeat of C1 domains designated C1a and C1b that bind diacylglycerol and phorbol esters, and are important membrane targeting modules. Here, we investigate the activities of individual C1 domai...

journal_title：Cellular signalling

authors： Anderson G,Chen J,Wang QJ

更新日期：2005-11-01 00:00:00

abstract：:We investigate the mechanisms underlying the intracellular calcium pulse that occurs in response to extracellular adenosine triphosphate (ATP) in osteoclasts. We find that pre-loading of GDP-beta-S abolishes the response in Ca(2+)-free medium, demonstrating an internal release of Ca2+ via a pathway that involves a G p...

journal_title：Cellular signalling

authors： Yu H,Ferrier J

更新日期：1994-11-01 00:00:00

abstract：:Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thu...

journal_title：Cellular signalling

authors： Pei F,Liu J,Zhang L,Pan X,Huang W,Cen X,Huang S,Jin Y,Zhao Z

更新日期：2021-02-01 00:00:00

abstract：:The endogenous circadian clock functions to maintain optimal physiological health through the tissue specific coordination of gene expression and synchronization between tissues of metabolic processes throughout the 24 hour day. Individuals face numerous challenges to circadian function on a daily basis resulting in s...

journal_title：Cellular signalling

authors： Parnell AA,De Nobrega AK,Lyons LC

更新日期：2020-12-25 00:00:00

abstract：:Endogenous reactive oxygen species (ROS) control is important for the maintenance of self-renewal of embryonic stem (ES) cells. Although miRNAs have been found to be critically involved in the regulation of the self-renewal, whether miRNAs can regulate the signaling axis to control ROS in ES cells is unclear. Here we ...

journal_title：Cellular signalling

authors： Xu Z,Zhang L,Fei X,Yi X,Li W,Wang Q

更新日期：2014-07-01 00:00:00

abstract：:Mice lacking the gene for suppressor of cytokine signaling 1 (SOCS1) show defective homeostasis of T lymphocytes due to accumulation of CD8(+) T cells, resulting at least partly from dysregulated IL-15 signaling. IL-15 alone does not stimulate proliferation of naïve CD8 T cells, but can synergize with IL-21 to induce ...

journal_title：Cellular signalling

authors： Gagnon J,Ramanathan S,Leblanc C,Ilangumaran S

更新日期：2007-04-01 00:00:00

abstract：:In this report, we examined the role of activin in the regulation of cell growth inhibition of human hepatocarcinoma cells. Using RNase protection assay for various cell cycle regulators and Western blotting experiments, we show that activin treatment of HepG2 cells leads to increased gene expression of the cyclin-dep...

journal_title：Cellular signalling

authors： Ho J,de Guise C,Kim C,Lemay S,Wang XF,Lebrun JJ

更新日期：2004-06-01 00:00:00

abstract：:Induction of apoptosis in Hep3B hepatoma cells by transforming growth factor beta 1 (TGF-beta 1) was accompanied by the activation of interleukin-1-beta-converting-enzyme-like proteases, which have recently been renamed as caspases. The caspase inhibitor ZVAD-FMK, which has a broader specificity for caspase family pro...

journal_title：Cellular signalling

authors： Hung WC,Chang HC,Chuang LY

更新日期：1998-07-01 00:00:00

abstract：:CD45 is a leukocyte specific transmembrane glycoprotein and a receptor-like protein tyrosine phosphatase (PTP). CD45 can be expressed as several alternatively spliced isoforms that differ in the extracellular domain. The isoforms are regulated in a cell type and activation state-dependent manner, yet their function ha...

journal_title：Cellular signalling

authors： Saunders AE,Johnson P

更新日期：2010-03-01 00:00:00

abstract：:We analyse the role of the G proteins in regulating collagen gene expression by measuring collagen alpha 1(I) mRNA levels in cultured hepatic stellate cells in basal conditions and after stimulating or inhibiting the major intracellular signalling pathways. Stimulation of Gs protein and adenylyl cyclase or the additio...

journal_title：Cellular signalling

authors： Solís-Herruzo JA,Hernández I,De la Torre P,García I,Sánchez JA,Fernández I,Castellano G,Muñoz-Yagüe T

更新日期：1998-03-01 00:00:00

abstract：:Growing evidence shows that chronic inflammation drives the progression of colorectal cancer (CRC). Cyclooxygenase-2 (COX-2) is one of the most important inflammatory genes involved in solid tumor metastasis. Epidermal growth factor receptor (EGFR) also plays a key role in cancer cell development. We compared the expr...

journal_title：Cellular signalling

authors： Wang JY,Chen BK,Wang YS,Tsai YT,Chen WC,Chang WC,Hou MF,Wu YC,Chang WC

更新日期：2012-01-01 00:00:00

abstract：:Glioblastoma, the most lethal form of brain cancer, is characterized by fast growth, migration and invasion of the surrounding parenchyma, with epithelial-to-mesenchymal transition (EMT)-like process being mostly responsible for tumour spreading and dissemination. A number of actors, including cadherins, vimentin, tra...

journal_title：Cellular signalling

authors： Cutone A,Colella B,Pagliaro A,Rosa L,Lepanto MS,Bonaccorsi di Patti MC,Valenti P,Di Bartolomeo S,Musci G

更新日期：2020-01-01 00:00:00

abstract：:Suppressor of fused (SUFU) is an essential negative regulator of the mammalian Hedgehog (HH) signaling pathway and its loss is associated with cancer development. On a cellular level, endogenous SUFU can mainly be detected in the cytoplasm and the nucleus. However, immunostaining of pancreatic cancer specimen revealed...

journal_title：Cellular signalling

authors： Tariki M,Wieczorek SA,Schneider P,Bänfer S,Veitinger S,Jacob R,Fendrich V,Lauth M

更新日期：2013-12-01 00:00:00

abstract：:Cdc25 and Ras are two proteins required for cAMP signalling in the budding yeast Saccharomyces cerevisiae. Cdc25 is the guanine nucleotide exchange protein that activates Ras. Ras, in turn, activates adenylyl cyclase. Cdc25 has a Src homology 3 (SH3) domain near the N-terminus and a catalytic domain in the C-terminal ...

journal_title：Cellular signalling

authors： Mintzer KA,Field J

更新日期：1999-02-01 00:00:00

abstract：:The immune modulator FTY720 is phosphorylated in vivo to FTY720 phosphate (FTY-P), which activates four sphingosine 1-phosphate (S1P) receptors including S1P(3). Upon activation with S1P, S1P(3) couples to G(i)- and G(q)-protein-dependent signalling pathways. Here we show that FTY-P selectively activates the S1P(3)-me...

journal_title：Cellular signalling

authors： Sensken SC,Stäubert C,Keul P,Levkau B,Schöneberg T,Gräler MH

更新日期：2008-06-01 00:00:00

abstract：:Both canonical Wnt/beta-catenin and TGFbeta/Smad signaling pathways coordinately regulate pattern formation during embryogenesis as well as tumor progression. Evidence of cross-talk between these two pathways has been reported. Here we demonstrated that the Activin-like kinase 4 (Alk4)/Smad2 pathway facilitates the tr...

journal_title：Cellular signalling

authors： Hirota M,Watanabe K,Hamada S,Sun Y,Strizzi L,Mancino M,Nagaoka T,Gonzales M,Seno M,Bianco C,Salomon DS

更新日期：2008-09-01 00:00:00

abstract：:PRK1/PKN is a member of the protein kinase C (PKC) superfamily of serine/threonine protein kinases. Despite its important role as a RhoA effector, limited information is available regarding how this kinase is regulated. We show here that the last seven amino acid residues at the C-terminus is dispensable for the catal...

journal_title：Cellular signalling

authors： Lim WG,Zhu Y,Wang CH,Tan BJ,Armstrong JS,Dokland T,Yang H,Zhu YZ,Teo TS,Duan W

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Chemoresistance is one of the main obstacles in the therapy of human cancers, including colorectal cancer (CRC). Long non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (lncRNA HAND2-AS1) has been demonstrated to be associated with CRC. However, the function of HAND2-AS1 in 5-Fluor...

journal_title：Cellular signalling

authors： Jiang Z,Li L,Hou Z,Liu W,Wang H,Zhou T,Li Y,Chen S

更新日期：2020-02-01 00:00:00

abstract：:Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as molecular switches in a variety of signaling pathways following stimulation of cell surface receptors. RhoGTPases regulate numerous cellular processes including cytoskeleton organization, gene transcription, cell proliferation, mi...

journal_title：Cellular signalling

authors： Lazer G,Katzav S

更新日期：2011-06-01 00:00:00