Pleiotropic antibiotic resistance mutations associated with ribosomes and ribosomal subunits in Mycobacterium smegmatis.

abstract：:We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combi...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin E,Stanek RJ,Mufson MA

更新日期：2003-03-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:Twenty strains of Staphylococcus aureus isolated from patients with endocarditis were examined in vitro for susceptibility to rifampin, nafcillin, and vancomycin and to combinations of rifampin with nafcillin or vancomycin. Minimum bactericidal concentrations of rifampin ranged from 0.0031 to 0.0125 mug/ml, of nafcill...

journal_title：Antimicrobial agents and chemotherapy

authors： Tuazon CU,Lin MY,Sheagren JN

更新日期：1978-05-01 00:00:00

abstract：:Gentamicin entrapped within stable multilamellar liposomes was used to treat mice after they were infected per os with Salmonella dublin. Of 10 mice, 8 survived after a single intravenous (i.v.) injection of 2 mg of gentamicin liposomes per kg compared with 0 of 10 treated with the same amount of free gentamicin. All ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fierer J,Hatlen L,Lin JP,Estrella D,Mihalko P,Yau-Young A

更新日期：1990-02-01 00:00:00

abstract：:We have studied the aminoglycoside resistance gene, which confers high levels of resistance to both amikacin and gentamicin, that is carried by plasmid pSTI1 in the PER-1 beta-lactamase-producing strain of Salmonella enterica serovar Typhimurium previously isolated in Turkey. This gene, called aac(6')-Ib(11), was foun...

journal_title：Antimicrobial agents and chemotherapy

authors： Casin I,Hanau-Berçot B,Podglajen I,Vahaboglu H,Collatz E

更新日期：2003-02-01 00:00:00

abstract：:Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental in...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T,Kamimura T,Okada N,Sakamoto H,Fukada S,Nakamoto S,Yokota Y,Miki K

更新日期：1976-07-01 00:00:00

abstract：:While the neuraminidase (NA) inhibitor oseltamivir is currently our first line of defense against a pandemic threat, there is little information about whether in vitro testing can predict the in vivo effectiveness of antiviral treatment. Using a panel of five H5N1 influenza viruses (H5 clades 1 and 2), we determined t...

journal_title：Antimicrobial agents and chemotherapy

authors： Govorkova EA,Ilyushina NA,McClaren JL,Naipospos TS,Douangngeun B,Webster RG

更新日期：2009-07-01 00:00:00

abstract：:Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the...

journal_title：Antimicrobial agents and chemotherapy

authors： Jekle A,Yoon J,Zuck M,Najafi R,Wang L,Shiau T,Francavilla C,Rani SA,Eitzinger C,Nagl M,Anderson M,Debabov D

更新日期：2013-02-01 00:00:00

abstract：:We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes simplex virus types 1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Kushner NL,Hartline CB,Williams-Aziz SL,Harden EA,Zhou S,Zemlicka J,Prichard MN

更新日期：2005-03-01 00:00:00

abstract：:Acinetobacter baumannii has emerged as a serious problematic pathogen due to the ever-increasing presence of antibiotic resistance, demonstrating a need for novel, broad-spectrum antimicrobial therapeutic options. Antimicrobial nanoemulsions are emulsified mixtures of detergent, oil, and water (droplet size, 100 to 80...

journal_title：Antimicrobial agents and chemotherapy

authors： Hwang YY,Ramalingam K,Bienek DR,Lee V,You T,Alvarez R

更新日期：2013-08-01 00:00:00

abstract：:Vancomycin has been associated with acute kidney injury in preclinical and clinical settings; however, the precise exposure profiles associated with vancomycin-induced acute kidney injury have not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kid...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Donnell JN,Rhodes NJ,Lodise TP,Prozialeck WC,Miglis CM,Joshi MD,Venkatesan N,Pais G,Cluff C,Lamar PC,Briyal S,Day JZ,Gulati A,Scheetz MH

更新日期：2017-10-24 00:00:00

abstract：:The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased b...

journal_title：Antimicrobial agents and chemotherapy

authors： Chun YS,Park NH

更新日期：1987-02-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally experience rapid reinfection of their new liver graft. Current treatment protocols do not prevent graft reinfection and, in addition, an accelerated disease progression is observed. In the present study, we have evaluated a novel st...

journal_title：Antimicrobial agents and chemotherapy

authors： Meuleman P,Albecka A,Belouzard S,Vercauteren K,Verhoye L,Wychowski C,Leroux-Roels G,Palmer KE,Dubuisson J

更新日期：2011-11-01 00:00:00

abstract：:Gram-negative bacteria cause approximately 70% of the infections in intensive care units. A growing number of bacterial isolates responsible for these infections are resistant to currently available antibiotics and to many in development. Most agents under development are modifications of existing drug classes, which ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hernandez V,Crépin T,Palencia A,Cusack S,Akama T,Baker SJ,Bu W,Feng L,Freund YR,Liu L,Meewan M,Mohan M,Mao W,Rock FL,Sexton H,Sheoran A,Zhang Y,Zhang YK,Zhou Y,Nieman JA,Anugula MR,Keramane el M,Savariraj K,

更新日期：2013-03-01 00:00:00

abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:Although acetylsalicylic acid does not itself induce interferon, acetylsalicylic acid was found to significantly enhance the production of both human alpha interferon and human gamma interferon when added with the appropriate inducers to cultures of human peripheral blood mononuclear cells. The mechanisms associated w...

journal_title：Antimicrobial agents and chemotherapy

authors： Yousefi S,Chiu J,Carandang G,Archibeque EG,Vaziri N,Cesario TC

更新日期：1987-01-01 00:00:00

abstract：:We undertook a prospective, randomized comparison of oral ciprofloxacin with standard parenteral therapies for the treatment of biopsy-proven osteomyelitis caused by susceptible organisms. Following surgical debridement, the ciprofloxacin patients received 750 mg twice a day, and the other patients received a broad-sp...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez GG

更新日期：1990-01-01 00:00:00

abstract：:Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, w...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang G,Kamalakaran S,Dhand A,Huang W,Ojaimi C,Zhuge J,Yee LL,Mayigowda P,Surendraiah PK,Dimitrova N,Fallon JT

更新日期：2014-08-01 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embC...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Q,Xiao TY,Liu HC,Zhao XQ,Liu ZG,Li YN,Zeng H,Zhao LL,Wan KL

更新日期：2017-12-21 00:00:00

abstract：:The nonnucleoside reverse transcriptase inhibitor UC781 is under development as a potential microbicide to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1). Two gel formulations of UC781 (0.1% and 1.0%) were evaluated in a range of preclinical safety assessments, including systemic absorption...

journal_title：Antimicrobial agents and chemotherapy

authors： Patton DL,Sweeney YT,Balkus JE,Rohan LC,Moncla BJ,Parniak MA,Hillier SL

更新日期：2007-05-01 00:00:00

abstract：:A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Simon GL,Snydman DR,Tally FP,Gorbach SL

更新日期：1980-07-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:Stenotrophomonas maltophilia is a multidrug-resistant organism increasingly isolated from the lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 CF patients underwent planktonic and biofilm susceptibility testing against 9 different antibiotics, alone and in double antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu K,Yau YC,Matukas L,Waters V

更新日期：2013-03-01 00:00:00

abstract：:Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1,10-phenanthrolene, but not endoproteinase inhibitors, blocked enzymatic...

journal_title：Antimicrobial agents and chemotherapy

authors： Okhuysen PC,Chappell CL,Kettner C,Sterling CR

更新日期：1996-12-01 00:00:00

abstract：:In a dose-ranging study of amprenavir (formerly 141W94), an inhibitor of the protease enzyme of human immunodeficiency virus (HIV) type 1, single-dose and steady-state pharmacokinetic parameters were estimated from plasma samples collected on day 1 and during week 3, respectively. Amprenavir was administered on either...

journal_title：Antimicrobial agents and chemotherapy

authors： Sadler BM,Gillotin C,Lou Y,Stein DS

更新日期：2001-01-01 00:00:00

abstract：:The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

更新日期：2017-08-24 00:00:00

abstract：:LYS228 is a novel monobactam with potent activity against Enterobacteriaceae LYS228 is stable to metallo-β-lactamases (MBLs) and serine carbapenemases, including Klebsiella pneumoniae carbapenemases (KPCs), resulting in potency against the majority of extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Blais J,Lopez S,Li C,Ruzin A,Ranjitkar S,Dean CR,Leeds JA,Casarez A,Simmons RL,Reck F

更新日期：2018-09-24 00:00:00

abstract：:The generation rate constants for the steady-state growth of antibiotic-inhibited Escherichia coli have the same formal dependency on concentration for deoxylincomycin, lincomycin (phase I), erythromycin, clindamycin, and U24729A. They may be kinetically classified as a group A, in which the first three compounds comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Garrett ER,Heman-Ackah SM

更新日期：1973-11-01 00:00:00