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Evidence for active Wnt signaling during postresection intestinal adaptation.

Abstract：

BACKGROUND:In the intestine, Wnt proteins are powerful regulators of cell proliferation, differentiation, and adhesion. Mutations of the adenomatous polyposis coli (APC) gene elevate nuclear beta-catenin and provoke intestinal tumor formation. We sought to determine whether Wnt signaling is involved in adaptive response to massive small bowel resection (SBR). METHODS:Male Min mice with a mutation of the APC gene and wild-type controls underwent a 50% proximal SBR or sham operation. After 3 days, villus height, crypt depth, and rates of proliferation and apoptosis were recorded in the remnant ileum. RESULTS:After SBR, villus height and enterocyte proliferation were significantly greater in the Min mice. Western blotting demonstrated resection-induced increases in beta-catenin, c-Myc, and E-cadherin after SBR, which was more pronounced in Min mice. CONCLUSIONS:Mutation of the APC gene and augmented Wnt signaling in the intestine results in an enhanced adaptive response to massive SBR. These data, for the first time, implicate an important role for Wnt signaling during the pathogenesis of resection-induced intestinal adaptation.

journal_name

J Pediatr Surg

journal_title

Journal of pediatric surgery

authors

Bernal NP,Stehr W,Zhang Y,Profitt S,Erwin CR,Warner BW

doi

10.1016/j.jpedsurg.2005.03.021

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1025-9; discussion 1029

issue

6

eissn

0022-3468

issn

1531-5037

pii

S0022346805002162

journal_volume

40

pub_type

杂志文章

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