Fate and mobility of pharmaceuticals in solid matrices.

Abstract:

:The sorption and mobility of six pharmaceuticals were investigated in two soil types with different organic carbon and clay content, and in bacterial biomass (aerobic and anaerobic). The pharmaceuticals examined were carbamazepine, propranolol, diclofenac sodium, clofibric acid, sulfamethoxazole and ofloxacin. The sorption experiments were performed according to the OECD test Guideline 106. The distribution coefficients determined by this batch equilibrium method varied with the pharmaceutical tested and the solid matrix type. Ofloxacin was particularly strongly adsorbed (except of the case of using anaerobic biomass for the solid matrix) while clofibric acid was found to be weakly adsorbed. The fate of pharmaceuticals in soil was also assessed using lysimeters. Important parameters that were studied were: the pharmaceutical loading rate and the hydraulic loading rate for adsorption and the rate and duration of a "rain" event for desorption. Major differences in the mobility of the six pharmaceuticals were observed and correlated with the adsorption/desorption properties of the compounds.

journal_name

Chemosphere

journal_title

Chemosphere

authors

Drillia P,Stamatelatou K,Lyberatos G

doi

10.1016/j.chemosphere.2005.01.032

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

1034-44

issue

8

eissn

0045-6535

issn

1879-1298

pii

S0045-6535(05)00174-8

journal_volume

60

pub_type

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