Abstract：
:The prevention of secondary vascular events is of paramount importance in patients with a history of stroke or transient ischemic attack (TIA). Most cardiologists are aware of the benefits of clopidogrel plus aspirin versus those of other antiplatelet regimens in patients with acute coronary syndrome. Using a representative post-stroke patient as an example, this article reviews data evaluating the effectiveness of antiplatelet regimens in preventing secondary vascular events in stroke and TIA patients. These results differ from those seen in clinical trials of acute coronary syndrome patients. Clinical studies provide little evidence that clopidogrel, with or without aspirin, is more efficacious in this setting than aspirin alone. Moreover, the increased risk of bleeding episodes with clopidogrel and aspirin in combination probably outweighs any small reductions in secondary event risk. In contrast, extended-release dipyridamole (ER-DP) plus aspirin reduces secondary stroke risk to a significantly greater extent (23% relative risk reduction) than aspirin alone. Currently available clinical trial data support the use of ER-DP plus aspirin, but not clopidogrel plus aspirin, to prevent secondary vascular events after stroke or TIA.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Gebel JM Jrdoi
10.1016/j.jacc.2005.04.058subject
Has Abstractpub_date
2005-09-06 00:00:00pages
752-5issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(05)01279-9journal_volume
46pub_type
杂志文章abstract：OBJECTIVES:This analysis sought to estimate the risk ratio for cancer incidence and cancer-related mortality associated with the use of calcium channel blocking agents (CCBs) in a large group of patients with chronic coronary heart disease (CHD). BACKGROUND:Recent publications contend that the use of short-acting CCBs...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(98)00008-4
更新日期：1998-03-15 00:00:00
abstract：OBJECTIVES:The goal of this work was to explore the treatment and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) age > or =90 years. BACKGROUND:The elderly are often excluded from clinical trials of NSTE-ACS and are underrepresented in clinical registries. METHODS:We used data ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.01.066
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVES:Theophylline has been shown to delay the onset of myocardial ischemia and to prolong exercise duration. The present study was done to evaluate the mechanisms and actions of intravenous theophylline on the onset of ischemia and exercise duration. BACKGROUND:The ischemic threshold may be altered by the differ...
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pub_type： 临床试验,杂志文章,随机对照试验
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abstract：OBJECTIVES:The objective of this investigation was to define for the first time the cardiorenal and humoral actions of repeated short-term administration of subcutaneous (SQ) brain natriuretic peptide (BNP) administration during the evolution of experimental heart failure. BACKGROUND:The rationale of this study was ba...
journal_title：Journal of the American College of Cardiology
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doi：10.1016/s0735-1097(00)00911-6
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to determine the frequency of mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes in consecutive patients with a clinical diagnosis of familial combined hyperlipidemia (FCH) in a nonresearch setting. BACKGROUND:The lipid phenotype frequent...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2008.06.050
更新日期：2008-11-04 00:00:00
abstract：OBJECTIVES:The current study was designed to examine whether ubiquitin expression is higher in unstable than in stable lesions of patients with acute coronary syndrome (ACS). BACKGROUND:The ubiquitin system has been identified as the nonlysosomal pathway of protein degradation; it is involved in a number of biologic p...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(02)02564-0
更新日期：2002-12-04 00:00:00
abstract：OBJECTIVES:We sought to determine whether different stages of coronary artery disease (CAD) are associated with distinct differentiation patterns of activated T cells. BACKGROUND:Atherosclerosis is an inflammatory disease. However, little is known about specific inflammatory cell activation in atherosclerosis, for exa...
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doi：10.1016/j.jacc.2005.03.040
更新日期：2005-06-21 00:00:00
abstract：:Thirty-eight patients who had inducible sustained ventricular tachycardia during baseline programmed electrical stimulation underwent electrophysiologic testing after both intravenous and oral administration of procainamide. Each had presented clinically with documented sustained ventricular tachycardia or out of hosp...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(91)90651-o
更新日期：1991-06-01 00:00:00
abstract：OBJECTIVES:To examine the effect of a polymeric-based periadventitial delivery of a nitric oxide (NO)-releasing diazeniumdiolate, spermine/NO (SPER/NO), on balloon injury-induced neointimal hyperplasia in rat ileofemoral arteries. BACKGROUND:Reduced local bioavailability and adverse side effects limit systemic adminis...
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doi：10.1016/s0735-1097(99)00543-4
更新日期：2000-02-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/s0735-1097(86)80285-6
更新日期：1986-01-01 00:00:00
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更新日期：2021-01-05 00:00:00
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pub_type： 杂志文章
doi：10.1016/0735-1097(93)90698-z
更新日期：1993-02-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/0735-1097(95)00508-0
更新日期：1996-03-01 00:00:00
abstract：:To assess left ventricular diastolic filling in amyloid heart disease, 17 patients with familial amyloid polyneuropathy and 20 normal subjects were examined by radionuclide angiography. None of the patients showed clinical evidence of restrictive cardiomyopathy. All but two patients had normal left ventricular ejectio...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(89)90547-0
更新日期：1989-01-01 00:00:00
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doi：10.1016/s0735-1097(97)00432-4
更新日期：1998-01-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(96)00481-0
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES:This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare b...
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pub_type： 杂志文章
doi：10.1016/j.jacc.2016.12.036
更新日期：2017-03-21 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1016/j.jacc.2003.08.053
更新日期：2004-02-18 00:00:00
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pub_type： 杂志文章
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更新日期：2007-10-16 00:00:00
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更新日期：2010-06-29 00:00:00
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更新日期：2003-06-04 00:00:00
abstract：BACKGROUND:Randomized controlled trials comparing short- (≤6 months) with long-term (≥1 year) dual antiplatelet therapy (DAPT) after drug-eluting stent(s) (DES) placement have been insufficiently powered to detect significant differences in the risk of major adverse cardiac events (MACE). OBJECTIVES:This study sought ...
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更新日期：2015-03-24 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2014-10-21 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF)>35%. ...
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pub_type： 杂志文章
doi：10.1016/j.jacc.2010.01.061
更新日期：2010-07-13 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90370-5
更新日期：1990-09-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(98)00348-9
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVES:This study was designed to establish the direct vascular effects of apelin in vivo in man. BACKGROUND:Apelin is the endogenous ligand for the previously orphaned G-protein-coupled receptor, APJ. This novel pathway is widely expressed in the cardiovascular system and is emerging as an important mediator of c...
journal_title：Journal of the American College of Cardiology
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doi：10.1016/j.jacc.2008.06.013
更新日期：2008-09-09 00:00:00
