Abstract:
OBJECTIVES:The objective of this investigation was to define for the first time the cardiorenal and humoral actions of repeated short-term administration of subcutaneous (SQ) brain natriuretic peptide (BNP) administration during the evolution of experimental heart failure. BACKGROUND:The rationale of this study was based on BNP as a vasodilating, natriuretic, renin-inhibiting and lusitropic peptide of cardiac origin. METHODS:First, we defined the cardiorenal and humoral responses to acute low and high dose (5 microg/kg or 25 microg/kg) of SQBNP in experimental heart failure to establish the acute efficacy of an SQ delivery. Second, we characterized the response to 10 days of repeated short-term administration of BNP during the evolution of experimental heart failure produced by rapid ventricular pacing. RESULTS:Plasma BNP and 3',5'-cyclic guanosine monophosphate rapidly increased and peaked at 30 min after acute SQBNP administration with increases in urinary sodium excretion, urine flow and renal blood flow in association with reductions in cardiac filling pressures. After 10 days of repeated short-term administration of SQBNP, cardiac output was increased and systemic vascular resistance and pulmonary capillary wedge pressure were decreased, as compared with untreated dogs with heart failure. CONCLUSIONS:This study demonstrated for the first time that repeated short-term administration of SQ BNP administration for 10 days during the evolution of left ventricular dysfunction in a canine model results in an improvement in cardiovascular hemodynamics. This investigation supports a potential novel strategy for the chronic administration of BNP in the therapeutics of heart failure.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Chen HH,Grantham JA,Schirger JA,Jougasaki M,Redfield MM,Burnett JC Jrdoi
10.1016/s0735-1097(00)00911-6subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1706-12issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(00)00911-6journal_volume
36pub_type
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(94)90395-6
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abstract:OBJECTIVES:We evaluated the prevalence and prognostic significance of transient myocardial ischemia despite beta-adrenergic blockade in patients with coronary artery disease. BACKGROUND:Persistence of transient ischemia despite therapy may correspond to a subset of high risk patients with coronary disease. The impact ...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0735-1097(96)00050-2
更新日期:1996-06-01 00:00:00
abstract::Twenty-five patients with aortic insufficiency and eight asymptomatic control subjects underwent radionuclide ventriculography at rest and during dynamic and isometric exercise to clarify the mechanisms for preservation of exercise capacity in aortic insufficiency. Regardless of symptomatic state or severity of regurg...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(84)80435-0
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abstract:OBJECTIVES:We sought to identify single nucleotide polymorphisms associated with mild statin-induced side effects. BACKGROUND:Statin-induced side effects can interfere with therapy. Single nucleotide polymorphisms in cytochrome P450 enzymes impair statin metabolism; the reduced function SLCO1B1*5 allele impairs statin...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2009.04.053
更新日期:2009-10-20 00:00:00
abstract::The utility of ergonovine testing for coronary artery spasm was assessed in 3,447 patients with angiographically insignificant (less than 50% diameter stenosis) or no coronary artery disease. No patients clinically had Prinzmetal's variant angina. Overall, 4% had a positive ergonovine test result, defined by spasm cau...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(92)90145-d
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更新日期:2012-01-03 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jacc.2007.06.018
更新日期:2007-09-25 00:00:00
abstract:OBJECTIVES:This study sought to investigate whether right atrial pressure could be used to estimate pericardial pressure during positive end-expiratory pressure (PEEP). BACKGROUND:Because of elevated intrathoracic pressure during PEEP, pulmonary capillary wedge pressure may not accurately reflect left ventricular prel...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0735-1097(95)00420-3
更新日期:1996-01-01 00:00:00
abstract::Although many drugs have inhibitory effects on platelet function, none of them inhibits all of the mechanisms that may be involved in the various forms of thrombosis. Choice of suitable drugs is hampered by lack of full knowledge concerning the reactions that make the major contributions to the formation of arterial t...
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pub_type: 杂志文章,评审
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更新日期:1986-12-01 00:00:00
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更新日期:1996-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-07-03 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-06-02 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1016/j.jacc.2008.06.037
更新日期:2008-09-30 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(99)00068-6
更新日期:1999-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(84)80028-5
更新日期:1984-02-01 00:00:00
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更新日期:2018-08-28 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2004.02.045
更新日期:2004-06-02 00:00:00
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更新日期:2010-03-09 00:00:00
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更新日期:2016-08-09 00:00:00
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更新日期:2012-01-31 00:00:00
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更新日期:1988-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(96)00539-6
更新日期:1997-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(02)01964-2
更新日期:2002-07-17 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
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更新日期:2013-08-20 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-05-21 00:00:00
abstract:OBJECTIVES:This study evaluated technetium-99m (Tc-99m) teboroxime kinetics in postischemic and partially necrotic myocardium with complete and low flow reperfusion using an isolated perfused rat heart model. BACKGROUND:Technetium-99m teboroxime has been proposed for use in the early diagnosis of reperfusion after thr...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(96)00159-3
更新日期:1996-08-01 00:00:00
abstract::Left ventricular thrombus complicating myocardial infarction was diagnosed by two-dimensional echocardiography in 119 patients. The infarct site was anterior in 98 patients and inferior in 11. Systemic embolism occurred in 26 patients (stroke in 18, lower limb embolism in 7 and mesenteric embolism in 1). A protruding ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(85)80336-3
更新日期:1985-06-01 00:00:00
abstract:OBJECTIVES:This study considers the array of pulmonary-systemic connections made by the levoatriocardinal vein. The primary and associated lesions that play a role in forming this vein are examined, and echocardiography is discussed as a method for its rapid identification. BACKGROUND:The levoatriocardinal vein is a p...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/0735-1097(95)00283-X
更新日期:1995-10-01 00:00:00