Abstract:
:It has recently been claimed that older genes tend to evolve more slowly than newer ones (Alba and Castresana 2005). By simulation of genes of equal age, we show that the inverse correlation between age and rate is an artifact caused by our inability to detect homology when evolutionary distances are large. Since evolutionary distance increases with time of divergence and rate of evolution, homologs of fast-evolving genes are frequently undetected in distantly related taxa and are, hence, misclassified as "new." This misclassification causes the mean genetic distance of 'new' genes to be overestimated and the mean genetic distance of "old" genes to be underestimated.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Elhaik E,Sabath N,Graur Ddoi
10.1093/molbev/msj006subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1-3issue
1eissn
0737-4038issn
1537-1719pii
msj006journal_volume
23pub_type
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更新日期:2017-04-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a003982
更新日期:2002-01-01 00:00:00
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doi:10.1093/oxfordjournals.molbev.a026307
更新日期:2000-02-01 00:00:00
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/molbev/mst100
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pub_type: 杂志文章
doi:10.1093/molbev/msq346
更新日期:2011-05-01 00:00:00
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更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-11-01 00:00:00
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journal_title:Molecular biology and evolution
pub_type: 杂志文章
doi:10.1093/oxfordjournals.molbev.a026358
更新日期:2000-05-01 00:00:00
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