Inhibition of restenosis by beraprost sodium (a prostaglandin I2 analogue) in the atherosclerotic rabbit artery after angioplasty.

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:Conscious dogs were given diltiazem hydrochloride (DTZ) orally for 5 successive days at doses of 1, 3, and 10 mg/kg/day. During the 5th day, cardiovascular responses were monitored at various timed intervals after dosing. Arterial blood was sampled concomitantly for drug analysis. DTZ produced a dose-related decrease ...

journal_title：Journal of cardiovascular pharmacology

authors： Browne RK,Dimmitt DC,Miller LD,Korol B

更新日期：1983-05-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:Endothelium-derived relaxing factors (EDRFs) and prostacyclin (PGI2) released from endothelial cells are potent vasodilators; endothelin-1 and thromboxane A2 may be their physiological antagonists. Interactions between these vasodilators and vasoconstrictors were studied in isolated intramyocardial porcine coronary ar...

journal_title：Journal of cardiovascular pharmacology

authors： Noll G,Bühler FR,Yang Z,Lüscher TF

更新日期：1991-07-01 00:00:00

abstract：:We assessed the contribution of angiotensin-(1-7) [Ang-(1-7)] to captopril-induced cardiovascular protection in spontaneously hypertensive rats (SHRs) chronically treated with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (SHR-l). NG-nitro-L-arginine methyl ester (80 mg/L) administration for 3 ...

journal_title：Journal of cardiovascular pharmacology

authors： Benter IF,Yousif MH,Al-Saleh FM,Raghupathy R,Chappell MC,Diz DI

更新日期：2011-05-01 00:00:00

abstract：:Spontaneously hypertensive stroke-prone rats suffer spontaneous strokes partly as a result of abnormal cerebrovascular development. This model exhibits prehypertensive, typical hypertensive and malignant hypertensive stages. We had observed that vascular endothelial growth factor and its receptors, kinase domain regio...

journal_title：Journal of cardiovascular pharmacology

authors： Jesmin S,Sakuma I,Togashi H,Yoshioka M,Hattori Y,Kitabatake A,Miyauchi T

更新日期：2004-11-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：UNLABELLED:Oxidative stress is an important risk factor in the pathogenesis of atherosclerosis. Angiotensin-converting enzyme (ACE) inhibitors attenuate atherosclerosis and oxidative stress in animal models. Omapatrilat, a VasoPeptidase-inhibitor, selectively inhibits both Neutral-Endo-Peptidase (NEP) and ACE. OBJECTI...

journal_title：Journal of cardiovascular pharmacology

authors： Hayek T,Hamoud S,Keidar S,Pavlotzky E,Coleman R,Aviram M,Kaplan M

更新日期：2004-01-01 00:00:00

abstract：:The present study was undertaken to investigate the interaction between endothelin-1 (ET-1) and norepinephrine (NE) on contractile regulation in dog ventricular myocardium. ET-1 alone did not elicit any inotropic response in isolated dog ventricular trabeculae (37 degrees C, 0.5 Hz). In the presence of NE at a high co...

journal_title：Journal of cardiovascular pharmacology

authors： Chu L,Endoh M

更新日期：2000-01-01 00:00:00

abstract：:The long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) is severely limited by the high incidence of vascular restenosis. Endothelin-1 (ET-1) has been implicated in the pathogenesis of this response, since circulating levels of this potent smooth-muscle mitogen are elevated after PTCA. Therefor...

journal_title：Journal of cardiovascular pharmacology

authors： Douglas SA,Ohlstein EH

更新日期：1993-01-01 00:00:00

abstract：:Exposure of endothelial cells (ECs) to thrombin or cytokines leads to major changes in their biochemical properties, which confer procoagulant activities. Stimulated ECs express the procoagulant glycoprotein tissue factor (TF). Although some TF is expressed on the apical surface of the cells, most is deposited as a cr...

journal_title：Journal of cardiovascular pharmacology

authors： Leclerc NE,Haan-Archipoff G,Lenoble M,Beretz A

更新日期：1995-01-01 00:00:00

abstract：:We investigated the effect of fenofibrate on lipoprotein(a)levels in hypertriglyceridemic patients and the parameters relating to its effect. Patients with a triglyceride level >/=300 mg/dL or with a triglyceride level >/=200 mg/dL and a high density lipoprotein cholesterol level

journal_title：Journal of cardiovascular pharmacology

authors： Ko HS,Kim CJ,Ryu WS

更新日期：2005-10-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:The equilibrating process of catecholamines (CAs) between plasma and red blood cells (RBC) was studied by measuring their erythrocyte/plasma concentration gradient (E/P ratio); ratio of E/P > 1 for a given amine was considered the consequence of its accumulation in or on RBC. We studied in vitro human blood obtained f...

journal_title：Journal of cardiovascular pharmacology

authors： Azoui R,Vignon D,Safar M,Cuche JL

更新日期：1994-04-01 00:00:00

abstract：:Endothelin (ET) may play an important role in the pathogenesis of vasoconstriction and acute renal failure after aortic cross-clamping (ACC). However, the relative contribution of the ET(A) and ET(B) receptors to the physiopathology of ischemic acute renal failure is poorly understood. This study was carried out to ev...

journal_title：Journal of cardiovascular pharmacology

authors： Roux S,Qiu C,Sprecher U,Osterwalder R,Clozel JP

更新日期：1999-08-01 00:00:00

abstract：:Results of previous studies indicate that monophosphoryl lipid A (MLA) reduces myocardial infarct size when administered 24 but not 1 h before a prolonged period of regional ischemia in dogs and rabbits. This cardioprotective effect of MLA could be reversed by the administration of the adenosine triphosphate (ATP)-sen...

journal_title：Journal of cardiovascular pharmacology

authors： Elliott GT,Mei DA,Gross GJ

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVES:To identify and quantify the stimulatory and inhibitory activity of endothelial factors on Arginine vasopressin (AVP)-induced contractions. METHODS:In a standard organ bath set-up for isometric force recording, rabbit isolated renal artery rings were exposed to cumulative concentrations of AVP. Experiments ...

journal_title：Journal of cardiovascular pharmacology

authors： Streefkerk JO,Pfaffendorf M,van Zwieten PA

更新日期：2003-12-01 00:00:00

abstract：:Left ventricular dysfunction in systemic sclerosis may be due in part to myocardial ischemia caused by a disturbance in coronary microcirculation. We evaluated the pharmacodynamic effect of the calcium channel blocker nicardipine on left ventricular function assessed by radionuclide ventriculography in 20 patients wit...

journal_title：Journal of cardiovascular pharmacology

authors： Kahan A,Devaux JY,Amor B,Menkès CJ,Weber S,Guérin F,Venot A,Strauch G

更新日期：1990-02-01 00:00:00

abstract：:In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

journal_title：Journal of cardiovascular pharmacology

authors： Seiler L,Matyas S,Fleckenstein-Grün G

更新日期：1999-05-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:Bay k 8644, a new dihydropyridine calcium channel activator has been shown to have positive inotropic and vasoconstrictor properties following intravenous (i.v.) administration. In the present study, intracoronary administration of Bay k 8644 was used to isolate drug effects on regional myocardial blood flow and contr...

journal_title：Journal of cardiovascular pharmacology

authors： Pelc LR,Gross GJ,Brooks HL,Warltier DC

更新日期：1986-11-01 00:00:00

abstract：:The clinical pharmacokinetics and pharmacodynamics of enalapril and its de-esterified active metabolite, MK 422, were determined in eight patients with congestive cardiomyopathy and five patients with hypertension. After administration of single doses of 2.5, 5, and 10 mg enalapril in the congestive heart failure pati...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JB,Taylor A,Abernethy D,O'Meara M,Farmer J,Young J,Nelson E,Pool J,Mitchell JR

更新日期：1985-07-01 00:00:00

abstract：:Endogenous as well as synthetic cannabinoids have potent vasodilatory actions in a variety of vascular preparations. Their precise mechanism of action is as yet unclear, but several studies point to the activation of type 1 vanilloid (TRPV1) receptors on primary afferent perivascular nerves, stimulating the release of...

journal_title：Journal of cardiovascular pharmacology

authors： Breyne J,Vanheel B

更新日期：2006-02-01 00:00:00

abstract：:Hemodynamic responses to sarafotoxin (SFTX6) peptides and endothelin-1 (ET-1) were compared in the anesthetized cat. SFTX6a and ET-1 at a dose of 0.3 nmol/kg i.v. produced a biphasic change in arterial pressure characterized by an initial decrease followed by a secondary increase in pressure. In contrast, similar dose...

journal_title：Journal of cardiovascular pharmacology

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:Antihypertensive medications are the most efficient drugs in achieving regression of myocardial hypertrophy in both clinical studies and animal models of hypertension. Nevertheless, there is a lack of clear and concise comparative study of their effects on the modulation of cardiomyocyte morphology and function. Here,...

journal_title：Journal of cardiovascular pharmacology

authors： Cagalinec M,Kyselovic J,Blaskova E,Bacharova L,Chorvat D Jr,Chorvatova A

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Guanfu base A (GFA) and Guanfu base G (GFG) are chemicals isolated from Aconitum coreanum. The potassium channel encoded by the human ether-a-go-go related gene (HERG) plays an important role in repolarization of the cardiac action potential. The purpose of the present study was to investigate the effects of...

journal_title：Journal of cardiovascular pharmacology

authors： Huang X,Yang Y,Zhu J,Xu D,Peng J,Liu J

更新日期：2012-01-01 00:00:00

abstract：:ATP utilization (delta approximately P) during an isometric contraction has been studied in terms of both measurements of oxygen consumption and lactate production as well as of the tissue nucleotide and metabolite levels. The contribution of breakdown of preformed ATP and phosphocreatine (PCr) pools to delta approxim...

journal_title：Journal of cardiovascular pharmacology

authors： Paul RJ,Krisanda JM,Lynch RM

更新日期：1984-01-01 00:00:00

abstract：:The bronchopulmonary and pressor effects of endothelin-1 (ET-1), a newly described vasoconstrictor peptide produced by endothelial cells, were investigated in the guinea pig. Intravenous injection of ET-1 (1 nmol/kg) induced an increase in pulmonary inflation pressure (PIP) as well as an important and sustained increa...

journal_title：Journal of cardiovascular pharmacology

authors： Braquet P,Touvay C,Lagente V,Vilain B,Pons F,Hosford D,Chabrier PE,Mencia-Huerta JM

更新日期：1989-01-01 00:00:00