Tracer technique to measure in vivo chemical transport rates within an implantable cell transplantation device.

abstract：:Persistent corneal wounds result from numerous eye disorders, and to date, available treatments often fail to accelerate reepithelialization, the key initial step in wound healing. To speed reepithelialization, we explored a cell-transfer transplant method utilizing polydimethylsiloxane (PDMS) contact lenses to delive...

journal_title：Cell transplantation

authors： Pino CJ,Haselton FR,Chang MS

更新日期：2005-01-01 00:00:00

abstract：:Procurement of multipotential neuroglial stem cells is possible with the addition of epidermal growth factor (EGF). Stem cells will differentiate into neurons and glia upon the removal of EGF from the culture medium. We have previously characterized the neuronal differentiation of stem cells derived from long-term cul...

journal_title：Cell transplantation

authors： Chiang YH,Silani V,Zhou FC

更新日期：1996-03-01 00:00:00

abstract：:The neurorestorative effects of exogenous neurturin (NTN) delivered directly into the putamen via multiport catheters were studied in 10 MPTP-lesioned rhesus monkeys expressing stable parkinsonism. The parkinsonian animals were blindly assigned to receive coded solutions containing either vehicle (n = 5) or NTN (n = 5...

journal_title：Cell transplantation

authors： Grondin R,Zhang Z,Ai Y,Ding F,Walton AA,Surgener SP,Gerhardt GA,Gash DM

更新日期：2008-01-01 00:00:00

abstract：:In previous work, we engineered functional cell sheets using bone marrow-derived mesenchymal stem cells (BM-MSCs) to promote islet graft survival. In the present study, we hypothesized that a cell sheet using dermal fibroblasts could be an alternative to MSCs, and then we aimed to evaluate the effects of this cell she...

journal_title：Cell transplantation

authors： Matsushima H,Kuroki T,Adachi T,Kitasato A,Ono S,Tanaka T,Hirabaru M,Kuroshima N,Hirayama T,Sakai Y,Soyama A,Hidaka M,Takatsuki M,Kin T,Shapiro J,Eguchi S

更新日期：2016-01-01 00:00:00

abstract：:Addition of rIL-6 to IL-6-dependent B9 cells starved for IL-6 for 16-20 h stimulated a vigorous proliferative response. Glucocorticoids (GCs), in a concentration-dependent manner, inhibited rIL-6-stimulated proliferation of B9 cells This inhibition was specific for the GCs, evident by the capacity of the GCs, dexameth...

journal_title：Cell transplantation

authors： Almawi WY,Tamim H

更新日期：2001-03-01 00:00:00

abstract：:We have recently documented that oral Linomide (quinoline-3-carboxamide) prevents autoimmune insulitis, islet destruction, and diabetes in NOD mice treated at an early stage (5 wk of age) of the disease. In this report, we show that treatment of female NOD mice with advanced disease (age 23-24 wk) by syngeneic islet t...

journal_title：Cell transplantation

authors： Slavin S,Weiss L,Xia W,Gross DJ

更新日期：1996-11-01 00:00:00

abstract：:Previous studies in humans with type 1 diabetes mellitus (T1D) and in nonobese diabetic mice have investigated the beneficial immunomodulatory potential of aerobic physical activity. Performing high volume of aerobic exercise may favorably regulate autoimmunity in diabetes. We tested whether increased physical activit...

journal_title：Cell transplantation

authors： Adamo M,Codella R,Casiraghi F,Ferrulli A,Macrì C,Bazzigaluppi E,Terruzzi I,Inverardi L,Ricordi C,Luzi L

更新日期：2017-01-24 00:00:00

abstract：:In a companion article, we describe the engineering and characterization of pituitary GH3 cell clones stably transfected with a furin-cleavable human insulin cDNA (InsGH3 cells). This article describes the performance of InsGH3 (clones 1 and 7) cell grafts into streptozotocin (STZ)-induced diabetic nude mice. Subcutan...

journal_title：Cell transplantation

authors： Davalli AM,Galbiati F,Bertuzzi F,Polastri L,Pontiroli AE,Perego L,Freschi M,Pozza G,Folli F,Meoni C

更新日期：2000-11-01 00:00:00

abstract：:The development of cell- and gene-based strategies for regenerative medicine offers a therapeutic option for the repair and potential regeneration of damaged cardiac tissue post-myocardial infarction (MI). Human umbilical cord subepithelial cell-derived stem cells (hUC-SECs), human bone marrow-derived mesenchymal stem...

journal_title：Cell transplantation

authors： Winters AA,Bou-Ghannam S,Thorp H,Hawayek JA,Atkinson DL,Bartlett CE,Silva FJ,Hsu EW,Moreno AP,Grainger DA,Patel AN

更新日期：2016-01-01 00:00:00

abstract：:Intrauterine inflammation is a significant cause of injury to the developing fetal brain. Using a preterm fetal sheep model of in utero infection, we asked whether human amnion epithelial cells (hAECs) were able to reduce inflammation-induced fetal brain injury. Surgery was undertaken on pregnant sheep at ∼105 days ge...

journal_title：Cell transplantation

authors： Yawno T,Sabaretnam T,Li J,McDonald C,Lim R,Jenkin G,Wallace EM,Miller SL

更新日期：2017-04-13 00:00:00

abstract：:Glucocorticoids (GCs) are used as immunosuppressive and antiinflammatory agents in organ transplantation and in treating autoimmune diseases and inflammatory disorders. GCs were shown to exert their antiproliferative effects directly through blockade of certain elements of an early membrane-associated signal transduct...

journal_title：Cell transplantation

authors： Almawi WY,Hess DA,Rieder MJ

更新日期：1998-11-01 00:00:00

abstract：:Although cells isolated from fetal liver are one of the major sources for liver tissue engineering, it is still very difficult to induce them to fully differentiate in vitro into mature hepatocytes. We therefore investigated the effects of nicotinamide (NA), dimethyl sulfoxide (DMSO), and oncostatin M (OSM) on differe...

journal_title：Cell transplantation

authors： Sakai Y,Jiang J,Kojima N,Kinoshita T,Miyajima A

更新日期：2002-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is a major clinical problem that still has no established treatment. We investigated the efficacy of cultured human peripheral blood mononuclear cells (PBMNCs) for AKI. Ischemia/reperfusion injury (IRI) was used to induce AKI in male nonobese diabetic (NOD/severe combined immunodeficiency) mi...

journal_title：Cell transplantation

authors： Ohtake T,Kobayashi S,Slavin S,Mochida Y,Ishioka K,Moriya H,Hidaka S,Matsuura R,Sumida M,Katagiri D,Noiri E,Okada K,Mizuno H,Tanaka R

更新日期：2018-03-01 00:00:00

abstract：:For clinical islet transplantation, isolated islets deteriorate rapidly in culture, although culturing islets prior to transplantation provides flexibility for evaluation of isolated islets and pretreatment of patients. In the present study, we compared human fresh islets to cultured islets with in vitro and in vivo ...

journal_title：Cell transplantation

authors： Noguchi H,Naziruddin B,Jackson A,Shimoda M,Ikemoto T,Fujita Y,Chujo D,Takita M,Peng H,Sugimoto K,Itoh T,Kobayashi N,Onaca N,Levy MF,Matsumoto S

更新日期：2012-01-01 00:00:00

abstract：:It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump...

journal_title：Cell transplantation

authors： Fisher WE

更新日期：1999-09-01 00:00:00

abstract：:The present study was designed to evaluate the clinical outcome of cell-based therapy with cultured adipose derived stromal cells (ASCs) for the treatment of cutaneous manifestations in patients affected by systemic sclerosis (SSc). ASCs have an extraordinary developmental plasticity, including the ability to undergo ...

journal_title：Cell transplantation

authors： Scuderi N,Ceccarelli S,Onesti MG,Fioramonti P,Guidi C,Romano F,Frati L,Angeloni A,Marchese C

更新日期：2013-01-01 00:00:00

abstract：:"Proof-of-principle" that cell replacement therapy works for neurodegeneration has been reported, but only using donor cells collected from fetal brain tissue obtained from surgical terminations of pregnancy. Surgical terminations of pregnancy represent an increasingly limited supply of donor cells due to the tendenc...

journal_title：Cell transplantation

authors： Kelly CM,Precious SV,Torres EM,Harrison AW,Williams D,Scherf C,Weyrauch UM,Lane EL,Allen ND,Penketh R,Amso NN,Kemp PJ,Dunnett SB,Rosser AE

更新日期：2011-01-01 00:00:00

abstract：:Human skin contains keratinocytes in the epidermis. Such cells share their ectodermal origin with the central nervous system (CNS). Recent studies have demonstrated that terminally differentiated somatic cells can adopt a pluripotent state, or can directly convert its phenotype to neurons, after ectopic expression of ...

journal_title：Cell transplantation

authors： Tenorio-Mina A,Cortés D,Esquivel-Estudillo J,López-Ornelas A,Cabrera-Wrooman A,Lara-Rodarte R,Escobedo-Avila I,Vargas-Romero F,Toledo-Hernández D,Estudillo E,Acevedo-Fernández JJ,Tapia JS,Velasco I

更新日期：2021-01-01 00:00:00

abstract：:Cell escape occurs after intramyocardial injection for treatment of myocardial infarction (MI) and then the migrated cells might be entrapped by extracardiac organs. We investigated the fate of migrated bone marrow-derived mesenchymal stromal cells (MSCs) and their impact on lung, liver, and spleen. MI model was creat...

journal_title：Cell transplantation

authors： Wang W,Jin P,Wang L,Yang Z,Hu S,Gao B,Zhang H

更新日期：2010-01-01 00:00:00

abstract：:One of the serious obstacles of the aortopathies research is a considerable shortage of human aortic smooth muscle cells (SMCs), which can be used to model the disease. SMC in most cases come from the whole aorta of transplant donors, which are rather difficult to access. In the course of coronary artery bypass graft ...

journal_title：Cell transplantation

authors： Kostina D,Zverev D,Grebennik V,Gordeev M,Ignatieva E,Voronkina I,Kostareva A,Malashicheva A

更新日期：2017-10-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilizes peripheral blood stem cells (PBSCs) derived from bone marrow. We hypothesized that intraspinal transplantation of PBSCs mobilized by G-CSF could promote functional recovery after spinal cord injury. Spinal cords of adult nonobese diabetes/severe immunodeficiency ...

journal_title：Cell transplantation

authors： Takahashi H,Koda M,Hashimoto M,Furuya T,Sakuma T,Kato K,Okawa A,Inada T,Kamiya K,Ota M,Maki S,Takahashi K,Yamazaki M,Mannoji C

更新日期：2016-01-01 00:00:00

abstract：:The third-generation NOD/LtSz-scid/IL2Rγ(null) (NOD/SCID IL2Rγ(null)) mouse represents a significantly improved xenograft model allowing high levels of human leukocyte engraftment over extended follow up. One remaining limitation of this mouse model, however, is the low level of circulating human erythrocytes. We esta...

journal_title：Cell transplantation

authors： Hayakawa J,Hsieh MM,Anderson DE,Phang O,Uchida N,Washington K,Tisdale JF

更新日期：2010-01-01 00:00:00

abstract：:In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs) improved functional outcome in rats with chronic cerebral infarction. Based on this finding, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n = 15) and control group (n = 15)] with middle cer...

journal_title：Cell transplantation

authors： Chen DC,Lin SZ,Fan JR,Lin CH,Lee W,Lin CC,Liu YJ,Tsai CH,Chen JC,Cho DY,Lee CC,Shyu WC

更新日期：2014-01-01 00:00:00

abstract：:It is widely believed that human embryonic stem (huES) cells may represent a valid alternative to donor pancreata as a source of islets for transplantation. Much is known about the transcription factors whose sequential activation results in the generation of islets during pancreatic development. This knowledge has be...

journal_title：Cell transplantation

authors： Dominguez-Bendala J,Pastori RL,Ricordi C,Inverardi L

更新日期：2006-01-01 00:00:00

abstract：:Huntington's disease (HD) produces severe neurodegeneration in the striatum leading to disabling motor impairments, including the loss of control of skilled reaching movements. Fetal GABAergic transplants can physically replace the lost striatal cells but with only partial success in functional recovery. Here, we aime...

journal_title：Cell transplantation

authors： Klein A,Lane EL,Dunnett SB

更新日期：2013-01-01 00:00:00

abstract：:Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attrac...

journal_title：Cell transplantation

authors： Yu SJ,Soncini M,Kaneko Y,Hess DC,Parolini O,Borlongan CV

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer disease (AD) is a progressive neurodegenerative disease, which is characterized by loss of memory and cognitive function. In AD patients dysfunction of the cholinergic system is the main cause of cognitive disorders, and decreased activity of choline acetyltransferase (ChAT), an enzyme responsible for acety...

journal_title：Cell transplantation

authors： Park D,Joo SS,Kim TK,Lee SH,Kang H,Lee HJ,Lim I,Matsuo A,Tooyama I,Kim YB,Kim SU

更新日期：2012-01-01 00:00:00

abstract：:Addition of embryonic striatal tissue, usually as a combination of the lateral and medial ganglionic eminences, to intrastriatal mesencephalic grafts has previously been reported to enhance recovery of drug-induced rotational behavior in the host and to modify axonal fiber outgrowth from the grafted dopaminergic neuro...

journal_title：Cell transplantation

authors： Emgård-Mattson M,Karlsson J,Nakao N,Brundin P

更新日期：1997-05-01 00:00:00

abstract：:Gastric cancer (GC) is a leading cause of cancer-related death with poor prognosis. Growing evidence has shown that long noncoding ribonucleic acid (lncRNA) FEZ family zinc finger 1 antisense RNA 1(FEZF1-AS1), an "oncogene," regulates tumor progression and supports cancer stem cell. However, the tumorigenic mechanism ...

journal_title：Cell transplantation

authors： Hui Y,Yang Y,Li D,Wang J,Di M,Zhang S,Wang S

更新日期：2020-01-01 00:00:00

abstract：:Pluripotent stem cells, including human embryonic stem cells and induced pluripotent stem cells, have generated much excitement about their prospects for use in cell transplantation therapies. This is largely attributable to their virtually unlimited growth potential, their ability to be precisely genetically altered ...

journal_title：Cell transplantation

authors： Robinson AJ,Zhao G,Rathjen J,Rathjen PD,Hutchinson RG,Eyre HJ,Hemsley KM,Hopwood JJ

更新日期：2010-01-01 00:00:00