[Pharmacokinetics of statins].

Abstract:

:Statins are lipid lowering agents that promote their effects on plasma lipids through the inhibition of HMG-CoA reductase, a crucial enzyme in the cascade of cholesterol synthesis, leading to reduction of tissue cholesterol pool and consequently, to an upregulation of the LDL receptor expression. There are considerable differences among statins regarding some pharmacokinetic properties, such as the coefficient of hydrophilicity, via liver metabolism (especially regarding P450 cytochrome and isoenzymes), plasma half-life and efficacy of serum lipid changes. They may also differ regarding interactions with other drugs that share the same pathway of metabolism. Recently, many pleiotropic effects have been reported with these drugs, such as anti-inflammatory properties, improvement in endothelial function and benefits on hemostasis.

journal_name

Arq Bras Cardiol

authors

Fonseca FA

doi

/S0066-782X2005002400003

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

9-14

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2005002400003

journal_volume

85 Suppl 5

pub_type

杂志文章
  • [Study of the autonomic behavior of escape rhythms in congenital atrioventricular block].

    abstract:PURPOSE:To study the autonomic behavior of the escape rhythm in congenital complete heart block (CCHB), using heart rate variability (HRV). METHODS:A group of 10 asymptomatic patients with CCHB and narrow QRS was studied, 7 females; mean age = 14 +/- 9 years. The following time domain indexes were analyzed from a 24 h...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Boghossian SH,Maia IG,Seidler G,Costa AM,Cruz Filho F,Alves PA

    更新日期:1994-06-01 00:00:00

  • October issue of 2012, vol. 99(4), pages 1-10.

    abstract::[This corrects the article doi: 10.5935/abc.20120401]. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20190091

    authors:

    更新日期:2019-06-06 00:00:00

  • [Diabetes mellitus and ischemie heart disease. Comparison by gender].

    abstract:PURPOSE:To test the association between diabetes mellitus and ischaemic heart disease (IHD) in males and females, after adjusting for known confounders and/or modifiers of effect. METHODS:The study was designed as a case-control and the period of data collection was one year (March/93 until February/94). The associati...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: de Moraes SA,de Souza JM

    更新日期:1996-02-01 00:00:00

  • Cardiovascular risks in adolescents with different degrees of obesity.

    abstract:BACKGROUND:There have been few studies on cardiovascular risk factors in adolescents with different degrees of obesity. OBJECTIVE:To evaluate metabolic effects associated with different degrees of obesity in adolescents and their impact on cardiovascular risks. METHODS:Cross-sectional study of 80 obese adolescents, d...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2010005000166

    authors: Lavrador MS,Abbes PT,Escrivão MA,Taddei JA

    更新日期:2011-03-01 00:00:00

  • Takotsubo cardiomyopathy causing transitory ventricular dysfunction.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

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    authors: Alves AA,Kowatsch I,Tsutsui JM,Nicolau JC,Lima MF,Mathias W Jr

    更新日期:2008-03-01 00:00:00

  • Atrioventricular pacemaker. Incidence and causes of reprogramming in long-term follow-up.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Martinelli M,de Arruda Melo S,Nishióka SA,Pedrosa AA,de Siqueira SF,Costa R,Sosa E

    更新日期:2001-01-01 00:00:00

  • Physical Stress Echocardiography: Prediction of Mortality and Cardiac Events in Patients with Exercise Test showing Ischemia.

    abstract::Background: Studies have demonstrated the diagnostic accuracy and prognostic value of physical stress echocardiography in coronary artery disease. However, the prediction of mortality and major cardiac events in patients with exercise test positive for myocardial ischemia is limited. Objective: To evaluate the effecti...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20140144

    authors: Araujo AC,Santos BF,Calasans FR,Pinto IM,Oliveira DP,Melo LD,Andrade SM,Tavares ID,Sousa AC,Oliveira JL

    更新日期:2014-11-01 00:00:00

  • Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure.

    abstract:BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inflammatory markers used as prognostic factors in various diseases. The aims of this study were to compare the PLR and the NLR of heart failure (HF) patients with those of age-sex matched controls, to evaluate the predictive val...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.5935/abc.20150126

    authors: Durmus E,Kivrak T,Gerin F,Sunbul M,Sari I,Erdogan O

    更新日期:2015-12-01 00:00:00

  • Mitral valve repair with a malleable bovine pericardium ring.

    abstract:OBJECTIVE:To describe a surgical procedure utilizing a malleable bovine pericardium ring in mitral valve repair and clinical and Doppler echocardiographic results. METHODS:Thirty-two (25 female and 7 male) patients, aged between 9 and 66 (M=36.4+/-17.2) years, were studied over a 16-month period, with 100% follow-up. ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2000001100003

    authors: Volpe MA,Braile DM,Vieira RW,Souza DR

    更新日期:2000-11-01 00:00:00

  • [24-hour blood pressure in normotensive elderly women and elderly women with white-coat hypertension].

    abstract:BACKGROUND:Changes in the behavior of the circadian rhythm can be deleterious, leading to target-organ damage, which suggests that they can have a prognostic significance and, eventually, can also demand therapeutic intervention. OBJECTIVE:To describe and compare the circadian rhythms of blood pressure (BP) in normote...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2010005000010

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    更新日期:2010-04-01 00:00:00

  • Atypical presentation of Kommerell's diverticulum.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0066-782x2009001200026

    authors: Barranhas AD,Indiani JM,Marchiori E,Santos AA,Rochitte CE,Nacif MS

    更新日期:2009-12-01 00:00:00

  • [Myocardial morphometric study in protein-energy malnourished adults].

    abstract:PURPOSE:To compare cardiac muscle cells width and cardiomyocyte lipofuscin pigment presence between malnourished and non-malnourished necropsied adults. METHODS:Out of 315 necropsy protocols of adults randomly chosen, those with edema, ascitis, systemic arterial hypertension, chronic liver disease, and heart disease w...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: da Cunha DF,Pedrini CH,Sousa JC,dos Reis MA,Ramos SG,da Cunha SF,Teixeira Vde P

    更新日期:1998-11-01 00:00:00

  • [Cardiovascular response to Stroop test: comparison between the computerized and verbal tests].

    abstract:BACKGROUND:The Stroop test requires the individual to respond to specific elements of a stimulus, whereas inhibiting more automated processes. OBJECTIVE:To compare the cardiovascular reactivity induced by the computerized version of the Stroop word-color test TESTINPACS with the traditional version based on the readin...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2010005000006

    authors: Barbosa DF,Prada FJ,Glanner MF,Nóbrega Ode T,Córdova CO

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  • [Risk factors in elderly patients selected by primary care physicians for hypolipemic treatment].

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Barretto AC,Wajngarten M,Gebara OC,do Serro Azul JB,Pierri H,Nussbacher A,Pivotto L,Bellotti G,Pileggi F

    更新日期:1996-08-01 00:00:00

  • [Percutaneous transluminal angioplasty of the left main coronary artery in acute myocardial infarction].

    abstract::Percutaneous transluminal coronary angioplasty is unusual in acute myocardial infarction after left main coronary artery occlusion. We applied this therapy in two cases. The first, a 54-year-old man, submitted to mechanical reperfusion and left main coronary artery angioplasty 145 minutes after the beginning of the sy...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Napchan BP,Caramelli B,Tranchesi Júnior B,Arie S,De Oliveira SA,Bellotti G,Pileggi F

    更新日期:1990-08-01 00:00:00

  • [Early exercise test after acute myocardial infarction].

    abstract:PURPOSE:To study the predischarge exercise testing importance in determining prognosis after acute myocardial infarction (AMI). PATIENTS AND METHODS:Treadmill exercise testing was performed in 50 stable and without complications patients with AMI, just before hospital discharge; there were 43 men and 7 women, mean age...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Escosteguy CC,da Rocha MC,Moura MV,Carvalho Mde A

    更新日期:1991-03-01 00:00:00

  • Physical training in Becker muscular dystrophy associated with heart failure.

    abstract::Becker muscular dystrophy (BMD) integrates dystrophy occurring due to genetic mutations that express the dystrophin protein in chromosome X. The onset of neuromuscular symptoms usually precedes the impairment of cardiac function, and may conversely happen by heart failure (HF). Physical training is well established in...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2011001500016

    authors: Roque JM,Carvalho VO,Pascoalino LN,Ferreira SA,Bocchi EA,Guimarães GV

    更新日期:2011-12-01 00:00:00

  • [Percutaneous transluminal coronary angioplasty after orthotopic heart transplantation].

    abstract::We report the case of 22 year-old male who developed coronary artery disease two years after orthotopic cardiac transplantation, manifested as congestive heart failure NYHA functional class III. The left ventricular radioisotopic evaluation at rest revealed worsening of left ventricular ejection fraction from 50% to 3...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Bocchi EA,Vilas-Boas F,Pedrosa AA,Bacal F,Fiorelli A,Ariê S,Stolf N,Bellotti G,Jatene A,Pileggi F

    更新日期:1994-03-01 00:00:00

  • Cardiac involvement in total generalized lipodystrophy (Berardinelli- Seip syndrome).

    abstract::Total generalized lipodystrophy (Berardinelli - Seip Syndrome) is a rare hereditary disease characterized by insulin-resistant diabetes mellitus and a small quantity of adipose tissue and is of unknown origin. Common cardiovascular alterations related to this syndrome are cardiac hypertrophy and arterial hypertension....

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0066-782x2000000900006

    authors: Viégas RF,Diniz RV,Viégas TM,Lira EB,Almeida DR

    更新日期:2000-09-01 00:00:00

  • Effect of levosimendan in patients with severe systolic heart failure and worsening renal function.

    abstract:BACKGROUND:Levosimendan, a calcium sensitizer, increases the sensitivity of the heart to calcium, thus increasing myocardial contractility without a rise in intracellular calcium. It was recently shown that levosimendan is beneficial in improving renal function. However, it remains to be established that the beneficial...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2012005000048

    authors: Zorlu A,Yücel H,Yontar OC,Karahan O,Tandogan I,Katrancioglu N,Yilmaz MB

    更新日期:2012-06-01 00:00:00

  • Recurrence of atrial septal defect in three generations.

    abstract::Beginning with a patient presenting with an atrial septal defect (ASD) of the secundum type, the genealogy was identified in four affected individuals who belonged to three successive generations of the same family. The defects were visually confirmed in all individuals and were found to be anatomically similar. No ot...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x1999000800009

    authors: Ferreira C,Farah LM,Póvoa RM,Luna Filho B,Costa A,Ferreira Filho C

    更新日期:1999-08-01 00:00:00

  • Why do we need randomized and epidemiological studies on cardiovascular disease? Evidence-based cardiology VII.

    abstract::Over the last two decades the results of randomized clinical studies, which are powerful aids for correctly assessing therapeutical strategies, have consolidated cardiological practice. In addition, scientifically interesting hypotheses have been generated through the results of epidemiological studies. Properly condu...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,评审

    doi:10.1590/s0066-782x1999000300002

    authors: Avezum A,Rossi Neto JM,Piegas L

    更新日期:1999-03-01 00:00:00

  • [Reduction of central sleep apnea in heart failure patients with beta-blockers therapy].

    abstract:BACKGROUND:Sleep apneas are frequent in patients with heart failure (HF). Estimate of the pre-beta blocker age (BB) point out to 45% of central apneas in these patients. OBJECTIVE:Assess the influence of BB in central apneas and their interference in the quality of sleep and life of patients with heart failure. METHO...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:

    authors: Silva CP,Lorenzi-Filho G,Marcondes B,Osmundo G Jr,Mangini S,Freitas AF Jr,Pires PV,Bocchi EA,Bacal F

    更新日期:2010-02-01 00:00:00

  • Acute myocardial infarction: clinical and epidemiological profile and factors associated with in-hospital death in the municipality of Rio de Janeiro.

    abstract:OBJECTIVE:To study the factors associated with the risk of in-hospital death in acute myocardial infarction in the Brazilian public health system in Rio de Janeiro, Brazil. METHODS:Sectional study of a sample with 391 randomly drawn medical records of the hospitalizations due to acute myocardial infarction recorded in...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2003000600003

    authors: Escosteguy CC,Portela MC,Medronho Rde A,de Vasconcellos MT

    更新日期:2003-06-01 00:00:00

  • Elevated Heart Rate is Associated with Cardiac Denervation in Patients with Heart Failure: A 123-Iodine-MIBG Myocardial Scintigraphy Study.

    abstract:Background::In the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT), heart rate (HR) reduction with ivabradine was associated with improved survival and reduced hospitalizations in patients with heart failure (HF). The mechanisms by which elevated HR increases mortality are not fully unde...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章,随机对照试验

    doi:10.5935/abc.20160166

    authors: Villacorta AS,Villacorta H Junior,Souza JS,Teixeira JA,Muradas MC,Alves CR,Precht BC,Porto P,Ubaldo L,Mesquita CT,Nóbrega AC

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  • Characteristics and identification of sites of chagasic ventricular tachycardia by endocardial mapping.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x1999000400006

    authors: Távora MZ,Mehta N,Silva RM,Gondim FA,Hara VM,de Paola AA

    更新日期:1999-04-01 00:00:00

  • Multivessel percutaneous treatment of Takayasu arteritis.

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    pub_type: 杂志文章

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    更新日期:2006-11-01 00:00:00

  • Metabolic abnormalities, antiretroviral therapy and cardiovascular disease in elderly patients with HIV.

    abstract::One of the most recent phenomena related to the acquired immunodeficiency syndrome (AIDS) is the emergence of a new vulnerable population: the elderly. One of the factors that account for this increase is the development of combination antiretroviral therapy (ART), which has provided better quality of life and life ex...

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    pub_type: 杂志文章,评审

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  • Mild stunting is associated with higher blood pressure in overweight adolescents.

    abstract:BACKGROUND:Studies have shown that pre/postnatal undernutrition leads to higher risk of non communicable diseases such as diabetes, hypertension and obesity in adulthood. OBJECTIVE:To determine whether overweight adolescents with mild stunting [height-for-age Z scores (HAZ) in the range <-1 to ≥ -2] have higher blood ...

    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.1590/s0066-782x2011005000115

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  • Knowledge about the Disease and the Practice of Physical Activity in Children and Adolescents with Congenital Heart Disease.

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    journal_title:Arquivos brasileiros de cardiologia

    pub_type: 杂志文章

    doi:10.36660/abc.20180417

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    更新日期:2020-06-01 00:00:00