Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy.

Abstract:

:We report a water-clear cell adenoma of the parathyroid gland, a lesion which to our knowledge has not been described previously. Like its rare but well-described hyperplastic counterpart, water-clear cell hyperplasia, this adenoma is composed of cells with abundant foamy-to-granular cytoplasm and mild nuclear pleomorphism. The cells form glandular structures and cell nests separated by fine fibrovascular septae. The tumor cells stain positively with anti-parathyroid hormone and show characteristic glassy and flocculate material by electron microscopy. Unlike water-clear cell hyperplasia, water-clear cell adenoma is a solitary lesion that compresses the residual nonneoplastic parathyroid gland.

journal_name

Arch Pathol Lab Med

authors

Grenko RT,Anderson KM,Kauffman G,Abt AB

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1072-4

issue

11

eissn

0003-9985

issn

1543-2165

journal_volume

119

pub_type

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