Abstract：
CONTEXT:Galectin-3, a member of the lectin family, was shown to be expressed in normal distal tubular cells and in renal cell carcinomas (RCC). However, its diagnostic and prognostic significance in RCC is as yet undefined. OBJECTIVES:To describe the expression of Galectin-3 among different histologic subtypes of renal neoplasms and to determine their diagnostic and prognostic significances. DESIGN:The expression of Galectin-3 was evaluated in 217 renal neoplasms by tissue microarray and immunohistochemistry with semiquantitative analysis. RESULTS:Strong expression of Galectin-3 was observed in 92 of 217 of renal neoplasms (42.4%). Although 22 of 23 oncocytomas (95.7%) and 19 of 21 chromophobe RCCs (90.5%) express Galectin-3, only 4 of 32 papillary RCCs (12.5%) and 47 of 137 clear cell RCCs (34.3%) express Galectin-3, suggesting that it may be used as a potential diagnostic marker. Galectin-3 expression was seen in 55% of high-grade (Fuhrman nuclear grades 3 and 4) versus 21% low-grade (grades 1 and 2) clear cell RCCs (P < .001). CONCLUSIONS:This study confirms that Galactin-3 is strongly overexpressed in renal cell neoplasms of distal tubular differentiation, that is, oncocytoma and chromophobe RCCs, suggesting it might be used as a possible differential diagnostic tool for renal cell neoplasm with oncocytic or granular cells. Furthermore, we observed a strong association of overexpression of Galectin-3 and high nuclear grade in clear cell RCC. These results also suggest a possible pivotal role for Galectin-3 in the differentiation and prognosis of clear cell RCC.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Dancer JY,Truong LD,Zhai Q,Shen SSdoi
10.1043/2008-0392-OAR1.1subject
Has Abstractpub_date
2010-01-01 00:00:00pages
90-4issue
1eissn
0003-9985issn
1543-2165pii
10.1043/2008-0392-OAR1.1journal_volume
134pub_type
杂志文章abstract：CONTEXT:The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland. OBJECTIVE:To develop an algorithmic approach to the diagnosis of pancreatic neoplasms that simplifies their pathologic evalu...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165-133.3.454
更新日期：2009-03-01 00:00:00
abstract：CONTEXT:-Multiple sources have identified challenges that training programs face in preparing graduates for the "real world" practice of pathology, and many training programs have sought to decrease the gap between skills acquired during training and those required in practice. However, there exists the possibility tha...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/arpa.2015-0138-CP
更新日期：2017-02-01 00:00:00
abstract：CONTEXT:Epidermal growth factor receptor (EGFR) mutations have been identified as predictors of response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer. OBJECTIVE:To investigate the relationship of EGFR mutation status to the histologic subtype of adenocarcinoma according to the new International Ass...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/arpa.2013-0376-OA
更新日期：2014-10-01 00:00:00
abstract：:Basal cell carcinoma arising from the nipple of the breast is an uncommon malignancy, with only a handful of cases reported in the literature. The diagnosis is, however, important because basal cell carcinoma in this location can mimic breast cancer, may behave aggressively, and there is a relative lack of consensus i...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165(2004)128<792:PBCCOT>2.0.CO;2
更新日期：2004-07-01 00:00:00
abstract：:We report a case of endometrial metaplasia of the endocervix, which was associated with tubal and squamous metaplasias. The similarity to normal endometrial glands and its benign nature should be recognized, and over-diagnosis of endocervical glandular dysplasia should be avoided. ...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with a poor prognosis that may be confused with less aggressive diseases, such as small lymphocytic lymphoma and follicular lymphoma. In many cases immunophenotyping, particularly analysis of reactivity for CD5 and CD10, is an important adjunct to morphology that us...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165(2008)132[1346:AUCOMC]2.0.CO;2
更新日期：2008-08-01 00:00:00
abstract：:A case of Rocky Mountain spotted fever complicated by gangrene of the extremities required amputation and showed persistent rickettsial infection in the margins of the gangrene at 5 and 7 weeks after onset of illness. Rickettsial organisms were demonstrated by immunoperoxidase staining in the viable endothelial cells ...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：CONTEXT:Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases. OBJECTIVE:To further differentiate GISTs from melanoma, we investigated expression of melanoma markers in GISTs using a well-characterized set of gast...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2008)132[1302:EOMAIE]2.0.CO;2
更新日期：2008-08-01 00:00:00
abstract：:Amplification of the human epidermal growth factor receptor 2/neu (HER2/neu) gene and overexpression of the HER2 protein (HER2) have been shown to occur in gastric and gastroesophageal junction adenocarcinoma in a number of studies. With a dismal survival rate, patients with these cancers stand to benefit from the ide...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.5858/arpa.2011-0168-RS
更新日期：2012-06-01 00:00:00
abstract：:Intravenously (IV) injected Evans blue dye consistently accumulates at particular areas in aortas of normal swine. Theses areas are also where IV injected tracer cholesterol accumulates. We studied the ultrastructural characteristics of blue vs nonblue areas in the abdominal aortas of both control and atherosclerotic ...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
abstract：CONTEXT:Obesity is associated with sleep disordered breathing and cardiovascular morbidity, but the relationship between pulmonary hypertension, heart disease, and obesity is unknown. OBJECTIVE:To determine the prevalence of pulmonary and cardiovascular disease in obese subjects undergoing autopsy at a large medical c...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2008)132[1397:PACCOO]2.0.CO;2
更新日期：2008-09-01 00:00:00
abstract：:Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to t...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/2010-0144-CRR1
更新日期：2011-08-01 00:00:00
abstract：CONTEXT:Recent discoveries have expanded the spectrum of nonneoplastic pulmonary lymphoproliferative disorders and have provided new insights into their pathogenesis and treatment. OBJECTIVE:To review the thoracic manifestations of immunoglobulin (Ig) G4-related sclerosing disease and summarize current concepts and di...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165-134.5.691
更新日期：2010-05-01 00:00:00
abstract：CONTEXT:The addition of cetuximab to first-line chemotherapy substantially prolonged survival in patients with advanced non-small cell lung cancer whose tumors expressed high levels of epidermal growth factor receptor (EGFR; immunohistochemistry score of ≥200 on a scale of 0-300). OBJECTIVE:To evaluate the interobserv...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/arpa.2012-0605-OA
更新日期：2013-09-01 00:00:00
abstract：:Typical cerebellar or spinal cord hemangioblastoma is often solitary and has a benign clinical course, whereas disseminated hemangioblastomatosis is extremely rare. We report a 75-year-old man with disseminated "leptomeningeal" hemangioblastomatosis and concurrent paraneoplastic limbic encephalitis who died of this di...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2008)132[104:IELHAP]2.0.CO;2
更新日期：2008-01-01 00:00:00
abstract：:Aspiration biopsy cytology (ABC) specimens were obtained from 540 patients by transrectal biopsy because of suspicious lesions or metastases from occult carcinoma. Although poorly differentiated prostatic carcinoma had previously presented few diagnostic problems by ABC, cells from well-differentiated adenocarcinoma h...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：CONTEXT:It is recommended that hemoglobin (Hb) A1c (Hb A1c) not be used to assess average glycemia in patients who have altered red blood cell life span. OBJECTIVE:To investigate the frequency of reporting an Hb A1c value for Hb variant samples that do not include Hb A. DESIGN:Hb A1c samples (n = 500) were procured a...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/arpa.2012-0714-OA
更新日期：2013-12-01 00:00:00
abstract：:This study shows that the endothelial cell turnover over the early porcine atherosclerotic lesion is more or less uniform in distribution. This is contrary to the findings in White Carneau pigeons where the increased endothelial cell turnover has a zonal pattern, being much greater at the lesion edge. The difference i...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:Duodenal-type follicular lymphoma (D-FL) is a newly recognized entity in the 2016 World Health Organization classification update. It has an immunophenotype similar to that of other FLs and usually carries the typical t(14;18)(q32;q21) translocation. However, unlike other FLs, D-FL is almost always diagnosed at a low ...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.5858/arpa.2016-0519-RS
更新日期：2018-04-01 00:00:00
abstract：:The Autopsy Committee of the College of American Pathologists has prepared this guideline in conjunction with representatives of other organizations to assist pathologists in the performance of autopsies. The guideline is to be regarded as being primarily an educational tool. Application of these recommendations on au...
journal_title：Archives of pathology & laboratory medicine
pub_type： 指南,杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:While the level of marrow reticulin may be a factor that is used when the presence of a hematologic disorder is being considered, to our knowledge no study has graded the amount of reticulin present in normal iliac bone marrow. Grading reticulin stains of bone biopsy specimens from 100 hematologically normal patients ...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors. It is composed of cells resembling modified smooth muscle cells of the normal glomus body. The glomus body, a thermoregulator, is a specialized form of arteriovenous anastomosis localized in dermal and precoccygeal soft tissue...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2
更新日期：2008-09-01 00:00:00
abstract：:A 35-year-old man with hematuria had a polypoid bladder lesion, which on microscopic examination was a fibroepithelial polyp containing numerous stromal cells with atypical, hyperchromatic nuclei. The polyp resembled those encountered in the lower female genital tract and other sites and must be distinguished from sar...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Multiple lymphomatous polyposis (MLP) is an uncommon type of primary non-Hodgkin gastrointestinal (GI) B-cell lymphoma characterized by the presence of multiple polyps along the GI tract. Malignant cells of MLP have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma (...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2003)127<1028:ARCOML>2.0.CO;2
更新日期：2003-08-01 00:00:00
abstract：:The clinical and pathologic features of a case of postoperative spindle-cell nodule within the endometrium are reported, a lesion hitherto undescribed in this site. The nodule was found in the hysterectomy specimen from a 75-year-old woman, 2 1/2 weeks after a dilatation and curettage had revealed a well-differentiate...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:Levamisole-induced vasculitis is a characteristic cutaneous vasculitis syndrome associated with the use of levamisole-adulterated cocaine. Patients will typically present with a painful, purpuric rash in a retiform or stellate pattern with or without central necrosis involving the extremities, trunk, nasal tip, digits...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.5858/arpa.2014-0107-RS
更新日期：2015-08-01 00:00:00
abstract：CONTEXT:Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations). OBJECTIVE:To investigate morphologic features that can help predict the aggressiveness of these...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2006)130[1673:ACCCDD]2.0.CO;2
更新日期：2006-11-01 00:00:00
abstract：:The evolution of proteinuria in rabbits with experimentally induced chronic serum sickness was followed up longitudinally by analytical and quantitative assays. The results suggest that sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) is a more sensitive index of kidney malfunction than are total-p...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:A pathogenetic relationship between hepatic manifestations of alpha 1-antitrypsin deficiency (AATD) and hepatocellular carcinoma has previously been suggested but not established. We encountered three patients with hepatocellular carcinoma (HCC) and nonneoplastic hepatocytes containing globules positive for alpha 1-an...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:We report a case of rupture of a saccular pulmonary artery aneurysm with fatal hemopericardium in a 29-year-old man who also had persistent ductus arteriosus with severe pulmonary hypertension. Histologic examination of the pulmonary artery showed cystic medionecrosis similar to that observed in patients with ruptured...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1992-02-01 00:00:00
